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公开(公告)号：US20130029970A1
公开(公告)日：2013-01-31
申请号：US13383241
申请日：2010-07-09
申请人： Kevin Sprott , Jason Rohde , Takashi Nakai , Bo Peng , John Jeffrey Talley
发明人： Kevin Sprott , Jason Rohde , Takashi Nakai , Bo Peng , John Jeffrey Talley
IPC分类号： A61K31/5377 , A61K31/407 , A61K31/454 , A61K31/4439 , A61K31/4545 , A61K31/4178 , A61K31/422 , A61K31/496 , A61K31/541 , A61K31/553 , A61P25/00 , A61P37/00 , A61P29/00 , A61P25/30 , A61P25/18 , A61P25/28 , A61P27/02 , C12N5/07 , C07D495/04
CPC分类号： C07D495/04
摘要： The present disclosure relates to compounds of formula I useful as agonists of cannabinoid receptors. The disclosure also provides pharmaceutically acceptable compositions comprising the compounds of the disclosure and methods of using the compositions in the treatment of various disorders.
摘要翻译： 本公开涉及可用作大麻素受体激动剂的式I化合物。 本公开还提供药学上可接受的组合物，其包含本公开的化合物和使用该组合物治疗各种疾病的方法。
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公开(公告)号：US20130109721A1
公开(公告)日：2013-05-02
申请号：US13514343
申请日：2010-12-08
申请人： Kevin Sprott , John Jeffrey Talley , Jane Yang , Bo Peng
发明人： Kevin Sprott , John Jeffrey Talley , Jane Yang , Bo Peng
IPC分类号： C07D401/12 , A61K31/403 , C07D495/04 , A61K45/06 , A61K31/4439 , C07D207/333 , A61K31/40 , C07D209/52 , A61K31/407
CPC分类号： C07D401/12 , A61K31/40 , A61K31/403 , A61K31/407 , A61K31/4439 , A61K45/06 , C07D207/333 , C07D207/337 , C07D209/22 , C07D209/52 , C07D495/04
摘要： The present disclosure relates to N-benzyl pyrrole compounds of formula (I) useful as inhibitors of the enzyme Fatty Acid Amide Hydrolase (FAAH). The disclosure also provides pharmaceutically acceptable compositions comprising the compounds of the disclosure and methods of using the compositions in the treatment or prevention of various disorders.
摘要翻译： 本公开涉及可用作脂肪酸酰胺水解酶（FAAH）的酶的抑制剂的式（I）的N-苄基吡咯化合物。 本公开还提供了包含本公开的化合物和使用该组合物治疗或预防各种疾病的方法的药学上可接受的组合物。
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公开(公告)号：US08884020B2
公开(公告)日：2014-11-11
申请号：US12309993
申请日：2007-08-07
申请人： John Jeffrey Talley , Kevin Sprott , James Philip Pearson , G. Todd Milne , Wayne Schairer , Jane Yang , Charles Kim , Timothy Barden , Regina Lundrigan , Ara Mermerian , Mark G. Currie
发明人： John Jeffrey Talley , Kevin Sprott , James Philip Pearson , G. Todd Milne , Wayne Schairer , Jane Yang , Charles Kim , Timothy Barden , Regina Lundrigan , Ara Mermerian , Mark G. Currie
IPC分类号： C07D209/18 , C07D209/22 , C07D401/06
CPC分类号： C07D209/18 , C07D209/22 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/06 , C07D403/14 , C07D413/06 , C07D413/14 , C07D417/14 , C07D498/04
摘要： Indole derivatives that are useful for treating pain, inflammation and other conditions are described. Certain of the compounds are benzyl derivatives and others are benzoyl derivatives. The compounds are substituted at least at the 3 position of the indole.
摘要翻译： 描述了可用于治疗疼痛，炎症和其它病症的吲哚衍生物。 某些化合物是苄基衍生物，而其它化合物是苯甲酰基衍生物。 该化合物至少在吲哚的3位被取代。
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公开(公告)号：US20100197708A1
公开(公告)日：2010-08-05
申请号：US12309993
申请日：2007-08-07
申请人： John Jeffrey Talley , Kevin Sprott , James Philip Pearson , G. Todd Milne , Wayne Schairer , Jane Yang , Charles Kim , Timothy Barden , Regina Lundrigan , Ara Mermerian , Mark G. Currie
发明人： John Jeffrey Talley , Kevin Sprott , James Philip Pearson , G. Todd Milne , Wayne Schairer , Jane Yang , Charles Kim , Timothy Barden , Regina Lundrigan , Ara Mermerian , Mark G. Currie
IPC分类号： A61K31/506 , C07D401/12 , A61K31/4439 , C07D209/22 , A61K31/4045 , C07D403/12 , A61P3/04 , A61P25/06 , A61P29/00 , A61P25/22 , A61P27/06 , A61P37/08 , A61P11/06
CPC分类号： C07D209/18 , C07D209/22 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/06 , C07D403/14 , C07D413/06 , C07D413/14 , C07D417/14 , C07D498/04
摘要： Indole derivatives that are useful for treating pain, inflammation and other conditions are described. Certain of the compounds are benzyl derivatives and others are benzoyl derivatives. The compounds are substituted at least at the 3 position of the indole.
摘要翻译： 描述了可用于治疗疼痛，炎症和其它病症的吲哚衍生物。 某些化合物是苄基衍生物，而其它化合物是苯甲酰基衍生物。 该化合物至少在吲哚的3位被取代。
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公开(公告)号：US20090264653A1
公开(公告)日：2009-10-22
申请号：US12097616
申请日：2006-12-18
申请人： Wilmin Bartolini , Brian M Cali , Barbara Chen , Yueh-Tyng Chien , Mark G. Currie , G. Todd Milne , James Philip Pearson , John Jeffrey Talley , Jane Yang , Craig Zimmerman , Charles Kim , Kevin Sprott , Timothy Barden , Regina Lundigran , Ara Mermerian
发明人： Wilmin Bartolini , Brian M Cali , Barbara Chen , Yueh-Tyng Chien , Mark G. Currie , G. Todd Milne , James Philip Pearson , John Jeffrey Talley , Jane Yang , Craig Zimmerman , Charles Kim , Kevin Sprott , Timothy Barden , Regina Lundigran , Ara Mermerian
IPC分类号： C07D413/14 , C07D209/04 , C07D235/00 , C07D403/04 , C07D215/02 , C07D471/02
CPC分类号： C07D209/42 , C07D209/30 , C07D401/06 , C07D409/06 , C07D417/06
摘要： Indoles that have activity as inhibitors of FAAH are described as are indoles and indole derivatives that have activity as inhibitors of DAO.
摘要翻译： 具有作为FAAH抑制剂活性的吲哚被描述为具有作为DAO抑制剂的活性的吲哚和吲哚衍生物。
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公开(公告)号：US20090118503A1
公开(公告)日：2009-05-07
申请号：US12143078
申请日：2008-06-20
IPC分类号： C07D413/02 , C07D401/12 , C07D209/04
CPC分类号： C07D401/12 , C07D209/18 , C07D209/32 , C07D401/14 , C07D403/06 , C07D409/06 , C07D413/06 , C07D413/14 , C07D417/14 , C07D498/04
摘要： Indole derivatives that are useful for treating pain, inflammation and other conditions are described. Certain of the compounds are benzyl derivatives and others are benzoyl derivatives. The compounds are substituted at least at the 3 position of the indole.
摘要翻译： 描述了可用于治疗疼痛，炎症和其它病症的吲哚衍生物。 某些化合物是苄基衍生物，而其它化合物是苯甲酰基衍生物。 该化合物至少在吲哚的3位被取代。
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公开(公告)号：US07960544B2
公开(公告)日：2011-06-14
申请号：US12097616
申请日：2006-12-18
申请人： Wilmin Bartolini , Brian M. Cali , Barbara Chen , Yueh-Tyng Chien , Mark G. Currie , G. Todd Milne , James Philip Pearson , John Jeffrey Talley , Jane Yang , Craig Zimmerman , Charles Kim , Kevin Sprott , Timothy Barden , Regina Lundigran , Ara Mermerian
发明人： Wilmin Bartolini , Brian M. Cali , Barbara Chen , Yueh-Tyng Chien , Mark G. Currie , G. Todd Milne , James Philip Pearson , John Jeffrey Talley , Jane Yang , Craig Zimmerman , Charles Kim , Kevin Sprott , Timothy Barden , Regina Lundigran , Ara Mermerian
IPC分类号： C07D403/06 , C07D239/26 , C07D471/04 , C07D401/06 , C07D271/06 , C07D271/10 , C07D417/06 , C07D413/06 , C07D263/32 , C07D261/08
CPC分类号： C07D209/42 , C07D209/30 , C07D401/06 , C07D409/06 , C07D417/06
摘要： Indoles that have activity as inhibitors of FAAH are described as are indoles and indole derivatives that have activity as inhibitors of DAO.
摘要翻译： 具有作为FAAH抑制剂的活性的吲哚被描述为具有作为DAO抑制剂的活性的吲哚和吲哚衍生物。
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公开(公告)号：US07153959B2
公开(公告)日：2006-12-26
申请号：US10374781
申请日：2003-02-25
申请人： Ashok S. Naraian , Michael Clare , Paul W. Collins , Joyce Zuowu Crich , Rajesh Devraj , Daniel L. Flynn , Lifeng Geng , Matthew J. Graneto , Cathleen E. Hanau , Gunnar J. Hanson , Susan J. Hartmann , Michael Hepperle , He Huang , Francis J. Koszyk , Shuyuan Liao , Suzanne Metz , Richard A. Partis , Thao D. Perry , Shashidhar N. Rao , Shaun Raj Selness , Michael S. South , Michael A. Stealey , John Jeffrey Talley , Michael L. Vazquez , Richard M. Weier , Xiangdong Xu , Ish K. Khanna , Yi Yu , Win Naing , Syaulan Yang
发明人： Ashok S. Naraian , Michael Clare , Paul W. Collins , Joyce Zuowu Crich , Rajesh Devraj , Daniel L. Flynn , Lifeng Geng , Matthew J. Graneto , Cathleen E. Hanau , Gunnar J. Hanson , Susan J. Hartmann , Michael Hepperle , He Huang , Francis J. Koszyk , Shuyuan Liao , Suzanne Metz , Richard A. Partis , Thao D. Perry , Shashidhar N. Rao , Shaun Raj Selness , Michael S. South , Michael A. Stealey , John Jeffrey Talley , Michael L. Vazquez , Richard M. Weier , Xiangdong Xu , Ish K. Khanna , Yi Yu , Win Naing , Syaulan Yang
IPC分类号： C07D401/04 , C07D401/14 , C07D413/02
CPC分类号： C07D409/14 , C07D401/04 , C07D401/14 , C07D403/04 , C07D405/14 , C07D413/14 , C07D417/14 , C07D453/02 , C07D471/04 , C07D473/00 , C07D487/04
摘要： A class of pyrazole derivatives is described for use in treating p38 kinase mediated disorders. Compounds of particular interest are defined by Formula IA wherein R1, R2, R3 and R4 are as described in the specification.
摘要翻译： 描述了一类吡唑衍生物用于治疗p38激酶介导的病症。 特别感兴趣的化合物由式IA定义，其中R 1，R 2，R 3和R 4是 如说明书中所述。
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公开(公告)号：US07071198B1
公开(公告)日：2006-07-04
申请号：US10840734
申请日：2004-05-05
申请人： Ashok S. Naraian , Michael Clare , Paul W. Collins , Joyce Zuowu Crich , Rajesh Devraj , Daniel L. Flynn , Lifeng Geng , Matthew J. Graneto , Cathleen E. Hanau , Gunnar J. Hanson , Susan J. Hartmann , Michael Hepperle , He Huang , Ish K. Khanna , Francis J. Koszyk , Shuyuan Liao , Suzanne Metz , Win Naing , Richard A. Partis , Thao D. Perry , Shashidhar N. Rao , Shaun Raj Selness , Michael S. South , Michael A. Stealey , John Jeffrey Talley , Michael L. Vazquez , John Walker , Richard M. Weier , Xiangdong Xu , Syaulan Yang , Yi Yu
发明人： Ashok S. Naraian , Michael Clare , Paul W. Collins , Joyce Zuowu Crich , Rajesh Devraj , Daniel L. Flynn , Lifeng Geng , Matthew J. Graneto , Cathleen E. Hanau , Gunnar J. Hanson , Susan J. Hartmann , Michael Hepperle , He Huang , Ish K. Khanna , Francis J. Koszyk , Shuyuan Liao , Suzanne Metz , Win Naing , Richard A. Partis , Thao D. Perry , Shashidhar N. Rao , Shaun Raj Selness , Michael S. South , Michael A. Stealey , John Jeffrey Talley , Michael L. Vazquez , John Walker , Richard M. Weier , Xiangdong Xu , Syaulan Yang , Yi Yu
IPC分类号： A61K31/506 , A61K31/4439 , C07D401/04
CPC分类号： C07D401/14 , C07D401/04 , C07D403/04 , C07D405/14 , C07D409/06 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D471/08 , C07D473/00 , C07D487/04 , C07D491/10 , C07D495/04
摘要： A class of pyrazole derivatives is described for use in treating p38 kinase mediated disorders. Compounds of particular interest are defined by Formula IA wherein R1, R2, R3 and R4 are as described in the specification.
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公开(公告)号：US06423713B1
公开(公告)日：2002-07-23
申请号：US09918481
申请日：2001-07-31
申请人： Ashok Anantanarayan , Michael Clare , Paul W. Collins , Joyce Zuowu Crich , Rajesh Devraj , Daniel L. Flynn , Lifeng Geng , Matthew J. Graneto , Cathleen E. Hanau , Gunnar J. Hanson , Susan J. Hartmann , Michael Hepperle , He Huang , Francis J. Koszyk , Shuyuan Liao , Suzanne Metz , Richard A. Partis , Thao D. Perry , Shashidhar N. Rao , Shaun Raj Selness , Michael S. South , Michael A. Stealey , John Jeffrey Talley , Michael L. Vazquez , Richard M. Weier , Xiangdong Xi , Ish K. Khanna , Yi Yu
发明人： Ashok Anantanarayan , Michael Clare , Paul W. Collins , Joyce Zuowu Crich , Rajesh Devraj , Daniel L. Flynn , Lifeng Geng , Matthew J. Graneto , Cathleen E. Hanau , Gunnar J. Hanson , Susan J. Hartmann , Michael Hepperle , He Huang , Francis J. Koszyk , Shuyuan Liao , Suzanne Metz , Richard A. Partis , Thao D. Perry , Shashidhar N. Rao , Shaun Raj Selness , Michael S. South , Michael A. Stealey , John Jeffrey Talley , Michael L. Vazquez , Richard M. Weier , Xiangdong Xi , Ish K. Khanna , Yi Yu
IPC分类号： A61K31496
CPC分类号： C07D409/14 , C07D401/04 , C07D401/14 , C07D403/04 , C07D405/14 , C07D413/14 , C07D417/14 , C07D453/02 , C07D471/04 , C07D473/00 , C07D487/04
摘要： A class of pyrazole derivatives is described for use in treating p38 kinase mediated disorders. Compounds of particular interest are defined by Formula IA wherein R1, R2, R3 and R4 are as described in the specification.
摘要翻译： 描述了一类吡唑衍生物用于治疗p38激酶介导的病症。 特别感兴趣的化合物由式IA定义，其中R1，R2，R3和R4如说明书中所述。
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