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    4-Phenoxy-phenoxy-alkane-carboxylic acid derivatives and process for their manufacture
    9.
    发明授权
    4-Phenoxy-phenoxy-alkane-carboxylic acid derivatives and process for their manufacture 失效
    4-苯氧基 - 苯氧基 - 烷烃 - 羧酸衍生物及其制备方法

    公开(公告)号：US4238626A

    公开(公告)日：1980-12-09

    申请号：US905049

    申请日：1978-05-11

    申请人： Helmut Nahm ,  Ernold Granzer

    发明人： Helmut Nahm ,  Ernold Granzer

    IPC分类号： A61K31/19 ,  C07C37/05 ,  C07C43/263 ,  C07C43/29 ,  C07C51/09 ,  C07C59/68 ,  C07C59/70 ,  C07C69/712 ,  C07C69/736

    CPC分类号： C07C323/00 ,  C07C51/09 ,  C07C59/68

    摘要： Novel 4-phenoxy-phenoxy-alkane-carboxylic acid derivatives of the formula I ##STR1## in which R.sub.1 stands for hydrogen, methylthio, cyclopentyl, cyclohexyl, phenyl, methylcyclohexyl, ethylcyclohexyl, or R.sub.1 and R.sub.3 together stand for a --CH.dbd.CH--CH.dbd.CH-- bridge or--unless at least one of the substituents R.sub.2 to R.sub.8 stands for hydrogen, or if R.sub.9 stands for a radical having at least 2 carbon atoms--for chlorine,R.sub.2 and R.sub.3, independent of one another, each stands for hydrogen, chlorine or alkyl of 1 to 4 carbon atoms,R.sub.4 stands for hydrogen, chlorine, alkyl of 1 to 4 carbon atoms, cyclopentyl, cyclohexyl, methylcyclohexyl or R.sub.3 and R.sub.4 together stand for a --CH.dbd.CH--CH.dbd.CH-- bridge,R.sub.5, R.sub.6 and R.sub.7, independent of one another, each stands for hydrogen or alkyl of 1 to 4 carbon atoms,R.sub.8 stands for hydrogen, alkyl of 1 to 4 carbon atoms or allyl,R.sub.9 stands for alkyl of 1 to 10 carbon atoms or phenyl andX stands for hydrogen, the cation of a physiologically acceptable inorganic or organic base of a hydrocarbon radical of 1 to 10 carbon atoms, having a strong action on the lipide and cholesterine metabolism and a process for their manufacture.

    摘要翻译： R1代表氢，甲硫基，环戊基，环己基，苯基，甲基环己基，乙基环己基或R 1和R 3的新的4-苯氧基 - 苯氧基 - 烷 - 羧酸衍生物，其中R1代表氢，甲基， -CH = CH-桥或 - 除非取代基R2至R8中的至少一个代表氢，或者如果R9表示具有至少2个碳原子的基团，则对于氯，R 2和R 3彼此独立地，各自独立地 对于氢，氯或1至4个碳原子的烷基，R4代表氢，氯，1至4个碳原子的烷基，环戊基，环己基，甲基环己基或R3和R4一起代表-CH = CH-CH = CH- 桥，R5，R6和R7彼此独立，各代表氢或1-4个碳原子的烷基，R8代表氢，1-4个碳原子的烷基或烯丙基，R9代表1-10个碳原子的烷基 原子或苯基，X代表氢，生理上可接受的无机或有机碱的烃的阳离子 具有1至10个碳原子的基团，对脂质和胆固醇代谢具有强烈的作用及其制造方法。

    Pharmacologically active O-acyl-2,3-diaryl-3-halogeno-acryl-aldoximes
    10.
    发明授权
    Pharmacologically active O-acyl-2,3-diaryl-3-halogeno-acryl-aldoximes 失效
    药理活性的O-酰基-2,3-二芳基-3-卤代丙烯酰基肟

    公开(公告)号：US4056629A

    公开(公告)日：1977-11-01

    申请号：US716277

    申请日：1976-08-20

    申请人： Wilhelm Bartmann ,  Gerhard Beck ,  Ernold Granzer ,  Josef Musil ,  Hermann Teufel

    发明人： Wilhelm Bartmann ,  Gerhard Beck ,  Ernold Granzer ,  Josef Musil ,  Hermann Teufel

    IPC分类号： A61K20060101 ,  A61K31/15 ,  A61K31/215 ,  A61K31/27 ,  C07C20060101

    CPC分类号： C07D417/04

    摘要： A medicament consisting of or containing an O-acyl-2,3-diaryl-3-halogeno-acrylaldoxime of the formula I ##STR1## in which X represents a chlorine or bromine atom, R stands for an alkyl, alkenyl, alkoxy, alkenoxy or alkylamino group having from 1 to 12 carbon atoms each, or for an aryl, aryloxy, arylalkyl, arylalkoxy, arylamino or arylalkylamino group substituted optionally by 1 or 2 alkyl groups each having from 1 to 6 carbon atoms, and R.sup.1, R.sup.2, R.sup.3 and R.sup.4 are identical or different, each representing a hydrogen atom, a halogen atom or an alkyl or alkoxy group having each from 1 to 6 carbon atoms, a process for preparing them and a method for the treatment of disorders of the purine metabolism.

    摘要翻译： 由式I（I）的O-酰基-2,3-二芳基-3-卤代 - 丙烯醛肟组成或含有其中X表示氯或溴原子的药​​物，R代表烷基，烯基， 或具有1至12个碳原子的芳基，芳氧基，芳基烷基，芳基烷氧基，芳基氨基或芳基烷基氨基，任选地被1或2个具有1至6个碳原子的烷基取代的烷氧基，链烯氧基或烷基氨基， R2，R3和R4相同或不同，各自表示氢原子，卤素原子或具有1至6个碳原子的烷基或烷氧基，其制备方法和治疗嘌呤病症的方法 代谢。