公开(公告)号：US07585676B2

公开(公告)日：2009-09-08

申请号：US12021343

申请日：2008-01-29

申请人： Kyriacos Mitrophanous ,  Mary Collins ,  Yasuhiro Takeuchi ,  Yasuhiro Ikeda

发明人： Kyriacos Mitrophanous ,  Mary Collins ,  Yasuhiro Takeuchi ,  Yasuhiro Ikeda

IPC分类号： C12N5/10 ,  C12N15/48 ,  C12N15/49 ,  C12N15/63 ,  C12N15/64 ,  C12N15/867 ,  A61K48/00

CPC分类号： C12N15/86 ,  A61K35/13 ,  A61K48/00 ,  C12N2740/13022 ,  C12N2740/13043 ,  C12N2740/16043

摘要： Provided herein is a retroviral vector comprising, and capable of expressing, a nucleotide of interest (NOI), wherein the NOI encodes an RNA or protein which is harmful to a cell.

摘要翻译： 本文提供了包含并能够表达目标核苷酸（NOI）的逆转录病毒载体，其中NOI编码对细胞有害的RNA或蛋白质。

公开(公告)号：US20080286869A1

公开(公告)日：2008-11-20

申请号：US12021343

申请日：2008-01-29

申请人： Kyriacos Mitrophanous ,  Mary Collins ,  Yasuhiro Takeuchi ,  Yasuhiro Ikeda

发明人： Kyriacos Mitrophanous ,  Mary Collins ,  Yasuhiro Takeuchi ,  Yasuhiro Ikeda

IPC分类号： C12N15/86

CPC分类号： C12N15/86 ,  A61K35/13 ,  A61K48/00 ,  C12N2740/13022 ,  C12N2740/13043 ,  C12N2740/16043

摘要： Provided herein is a retroviral vector comprising, and capable of expressing, a nucleotide of interest (NOI), wherein the NOI encodes an RNA or protein which is harmful to a cell.

摘要翻译： 本文提供了包含并能够表达目标核苷酸（NOI）的逆转录病毒载体，其中NOI编码对细胞有害的RNA或蛋白质。

公开(公告)号：US07351585B2

公开(公告)日：2008-04-01

申请号：US10654537

申请日：2003-09-02

申请人： Kyriacos Mitrophanous ,  Mary Collins ,  Yasuhiro Takeuchi ,  Yasuhiro Ikeda

发明人： Kyriacos Mitrophanous ,  Mary Collins ,  Yasuhiro Takeuchi ,  Yasuhiro Ikeda

IPC分类号： C12N5/10 ,  C12N15/48 ,  C12N15/49 ,  C12N15/63 ,  C12N15/64 ,  C12N15/867 ,  A61K48/00

CPC分类号： C12N15/86 ,  A61K35/13 ,  A61K48/00 ,  C12N2740/13022 ,  C12N2740/13043 ,  C12N2740/16043

摘要： Provided herein is a retroviral vector comprising, and capable of expressing, a nucleotide of interest (NOI), wherein the NOI encodes an RNA or protein which is harmful to a cell.

摘要翻译： 本文提供了包含并能够表达目标核苷酸（NOI）的逆转录病毒载体，其中NOI编码对细胞有害的RNA或蛋白质。

公开(公告)号：US20060258006A1

公开(公告)日：2006-11-16

申请号：US10654537

申请日：2003-09-02

申请人： Kyriacos Mitrophanous ,  Mary Collins ,  Yasuhiro Takeuchi ,  Yasuhiro Ikeda

发明人： Kyriacos Mitrophanous ,  Mary Collins ,  Yasuhiro Takeuchi ,  Yasuhiro Ikeda

IPC分类号： C12N15/867

CPC分类号： C12N15/86 ,  A61K35/13 ,  A61K48/00 ,  C12N2740/13022 ,  C12N2740/13043 ,  C12N2740/16043

摘要： Provided herein is a retroviral vector comprising, and capable of expressing, a nucleotide of interest (NOI), wherein the NOI encodes an RNA or protein which is harmful to a cell.

公开(公告)号：US20060257416A1

公开(公告)日：2006-11-16

申请号：US10560389

申请日：2004-06-14

申请人： J Palmowski ,  Lucien Lopes ,  Yasuhiro Ikeda ,  Vincenzo Cerundolo ,  Mary Collins

发明人： J Palmowski ,  Lucien Lopes ,  Yasuhiro Ikeda ,  Vincenzo Cerundolo ,  Mary Collins

IPC分类号： A61K39/00 ,  A61K39/38

CPC分类号： C12N15/86 ,  A61K2039/51 ,  A61K2039/5154 ,  A61K2039/5256 ,  A61K2039/53 ,  A61K2039/545 ,  C12N2740/16043

摘要： The invention relates to materials and methods for improved vaccination strategies and in particular to the use of lentivirus comprising nucleic acid encoding an antigen, or antigen presenting cells transduced with such lentivirus, to stimulate immune responses against the encoded antigen, in heterologous prime-boost vaccination regimes.

摘要翻译： 本发明涉及用于改进疫苗接种策略的材料和方法，特别是涉及使用包含编码抗原的核酸的慢病毒的方法，或使用这种慢病毒转导的抗原呈递细胞，以异源初次加强免疫接种刺激针对所编码的抗原的免疫应答 政权。

公开(公告)号：US10047346B2

公开(公告)日：2018-08-14

申请号：US13058154

申请日：2009-08-10

申请人： Yasuhiro Ikeda ,  Andre Terzic ,  Timothy J. Nelson ,  Amber A. Mael ,  Almudena J. Martinez Fernandez ,  Satsuki Yamada

发明人： Yasuhiro Ikeda ,  Andre Terzic ,  Timothy J. Nelson ,  Amber A. Mael ,  Almudena J. Martinez Fernandez ,  Satsuki Yamada

IPC分类号： A01N63/00 ,  A61K48/00 ,  C12N5/074 ,  A61K35/12

摘要： This document provides methods and materials related to induced pluripotent stem cells. For example, induced pluripotent stem cells, compositions containing induced pluripotent stem cells, methods for obtaining induced pluripotent stem cells, and methods for using induced pluripotent stem cells are provided. In addition, methods and materials for using induced pluripotent stem cells to repair tissue (e.g., cardiovascular tissue) in vivo as well as methods and materials for using induced pluripotent stem cells to assess their therapeutic potential in appropriate animal models are provided.

公开(公告)号：US08866282B2

公开(公告)日：2014-10-21

申请号：US13586104

申请日：2012-08-15

申请人： Yasuhiro Ikeda ,  Yutaka Uematsu ,  Satoshi Muraoka

发明人： Yasuhiro Ikeda ,  Yutaka Uematsu ,  Satoshi Muraoka

IPC分类号： H01L23/52 ,  H04L25/02 ,  H05K1/02 ,  H01L49/02 ,  H01L23/12

CPC分类号： H01L28/20 ,  H01L23/12 ,  H01L23/5228 ,  H01L2224/16225 ,  H04L25/02 ,  H04L25/0272 ,  H04L25/0288 ,  H05K1/02 ,  H05K1/0234 ,  H05K1/0246 ,  H05K1/025 ,  H05K2201/10022 ,  H05K2201/10159

摘要： A slew rate of a signal transmitted between a semiconductor device having a small load capacitance and a semiconductor device having a large load capacitance is improved. When a signal is transmitted to the semiconductor device (for example, a memory device) having the large load capacitance, pre-emphasis is performed, and when a signal is transmitted to the semiconductor device (for example, a memory controller) having the small load capacitance, pre-emphasis is not performed or is slightly performed. By this, when the signal is transmitted to the memory device, blunting in signal rising due to the load capacitance is suppressed, and when the signal is transmitted to the memory controller, ringing due to the reflection of the signal is suppressed, and the slew rate of the data transmission is improved.

摘要翻译： 在具有小负载电容的半导体器件和具有大负载电容的半导体器件之间传输的信号的转换速率得到改善。 当信号被发送到具有大的负载电容的半导体器件（例如，存储器件）时，执行预加重，并且当信号被发送到具有小的负载电容的半导体器件（例如，存储器控制器） 负载电容，预加重不执行或略微执行。 由此，当信号被发送到存储装置时，由于负载电容而导致的信号上升的钝化被抑制，并且当信号被发送到存储器控制器时，由于信号的反射而被抑制的振铃 数据传输速率提高。

公开(公告)号：US20130207234A1

公开(公告)日：2013-08-15

申请号：US13586104

申请日：2012-08-15

申请人： Yasuhiro Ikeda ,  Yutaka Uematsu ,  Satoshi Muraoka

发明人： Yasuhiro Ikeda ,  Yutaka Uematsu ,  Satoshi Muraoka

IPC分类号： H01L49/02

CPC分类号： H01L28/20 ,  H01L23/12 ,  H01L23/5228 ,  H01L2224/16225 ,  H04L25/02 ,  H04L25/0272 ,  H04L25/0288 ,  H05K1/02 ,  H05K1/0234 ,  H05K1/0246 ,  H05K1/025 ,  H05K2201/10022 ,  H05K2201/10159

摘要： A slew rate of a signal transmitted between a semiconductor device having a small load capacitance and a semiconductor device having a large load capacitance is improved. When a signal is transmitted to the semiconductor device (for example, a memory device) having the large load capacitance, pre-emphasis is performed, and when a signal is transmitted to the semiconductor device (for example, a memory controller) having the small load capacitance, pre-emphasis is not performed or is slightly performed. By this, when the signal is transmitted to the memory device, blunting in signal rising due to the load capacitance is suppressed, and when the signal is transmitted to the memory controller, ringing due to the reflection of the signal is suppressed, and the slew rate of the data transmission is improved.

摘要翻译： 在具有小负载电容的半导体器件和具有大负载电容的半导体器件之间传输的信号的转换速率得到改善。 当信号被发送到具有大的负载电容的半导体器件（例如，存储器件）时，执行预加重，并且当信号被发送到具有小的负载电容的半导体器件（例如，存储器控制器） 负载电容，预加重不执行或略微执行。 由此，当信号被发送到存储装置时，由于负载电容而导致的信号上升的钝化被抑制，并且当信号被发送到存储器控制器时，由于信号的反射而被抑制的振铃 数据传输速率提高。

公开(公告)号：US08278284B2

公开(公告)日：2012-10-02

申请号：US11884738

申请日：2006-02-21

申请人： Masanori Miyazaki ,  Yoshikazu Yonemitsu ,  Yasuhiro Ikeda ,  Katsuo Sueishi ,  Toshiaki Tabata ,  Akihiro Iida ,  Yasuji Ueda ,  Mamoru Hasegawa

发明人： Masanori Miyazaki ,  Yoshikazu Yonemitsu ,  Yasuhiro Ikeda ,  Katsuo Sueishi ,  Toshiaki Tabata ,  Akihiro Iida ,  Yasuji Ueda ,  Mamoru Hasegawa

IPC分类号： A61K48/00 ,  A01N63/00 ,  C12P19/34

CPC分类号： A61K48/005 ,  A61K48/00 ,  C07K14/475 ,  C12N15/86 ,  C12N2740/15043 ,  C12N2740/15045 ,  C12N2810/6081

摘要： The present invention provides novel methods for treating diseases associated with apoptotic degeneration in ocular tissue cells by effective administration of pigment epithelium derived factor (PEDF). The present inventors studied PEDF as a means to prevent ganglion cell death, the final pathology of glaucoma. The present invention is particularly focused on SIV vectors for effective methods for delivering PEDF, and constructed an SIV-PEDF vector. When the SIV-PEDF vector was administered subretinally to an ischemia reperfusion model and NMDA-induced model, a significant suppression effect on ganglion cell death was observed. The present inventors therefore discovered that the SIV-PEDF vector is an effective pharmaceutical agent for treating diseases associated with apoptotic degeneration in ocular tissue cells, such as glaucoma.

摘要翻译： 本发明提供了通过有效施用色素上皮衍生因子（PEDF）来治疗与眼组织细胞凋亡变性相关的疾病的新方法。 本发明人研究了PEDF作为预防神经节细胞死亡，青光眼的最终病理学的手段。 本发明特别关注用于递送PEDF的有效方法的SIV载体，并构建了SIV-PEDF载体。 当将SIV-PEDF载体视觉上给予缺血再灌注模型和NMDA诱导的模型时，观察到对神经节细胞死亡的显着抑制作用。 因此本发明人发现SIV-PEDF载体是用于治疗与眼组织细胞如青光眼中凋亡变性相关的疾病的有效药剂。

公开(公告)号：US08052153B2

公开(公告)日：2011-11-08

申请号：US12096600

申请日：2006-12-20

申请人： Hiroshi Ebihara ,  Yasuhisa Arita ,  Yasuhiro Ikeda

发明人： Hiroshi Ebihara ,  Yasuhisa Arita ,  Yasuhiro Ikeda

IPC分类号： F16J15/32

CPC分类号： F16J15/3232

摘要： [PROBLEMS] A seal device where a seal lip reliably maintains shaft sealing relative to high-pressure fluid that is to be sealed and where the equivalent Mises stress occurring in the seal lip is reduced to extend the durable term of the seal lip longer.[MEANS FOR SOLVING PROBLEMS] A backup ring (2) has a tapered section (23) continuously extending from a fixation section (21) of the backup ring (2) and also has a forward end section (24). A rounded surface (E) with a curvature radius (R-1) is formed at least at a boundary (26) where a surface (D) of the tapered section (23) changes to a surface (F) of the forward end section (24). A portion of the surface (D) of the tapered surface (23), which portion is in contact with the rounded surface (E) at the boundary (26), is a projected curvature surface having a curvature radius greater than the curvature radius (R-1) of the boundary (26).

摘要翻译： 一种密封装置，其中密封唇相对于待密封的高压流体可靠地保持轴密封，并且其中在密封唇中发生的等效米塞斯应力减小，以延长密封唇的耐用期。 解决问题的手段备用环（2）具有从支撑环（2）的固定部（21）连续延伸的锥形部（23），并且还具有前端部（24）。 至少在锥形部分（23）的表面（D）变化到前端部分的表面（F）的边界（26）处形成具有曲率半径（R-1）的圆形表面（E） （24）。 锥形表面（23）的表面（D）的一部分在边界（26）处与圆形表面（E）接触的是曲率半径大于曲率半径的投影曲率表面（D） R-1）。