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公开(公告)号：US12059447B2
公开(公告)日：2024-08-13
申请号：US16988627
申请日：2020-08-08
发明人： Sean Farmer , Ken Alibek
CPC分类号： A61K36/53 , A61K9/0043 , A61K9/0075 , A61K9/0078 , A61K47/10 , A61K47/183
摘要： The present invention provides materials and methods for treating symptoms of neurological conditions. More specifically, the subject invention provides compositions and methods of their use for treating one or more symptoms and/or comorbidities of a neurological condition such as an infection, a neurodevelopmental disease, and/or a neurodegenerative disease. In preferred embodiments, the composition is administered to the subject via nasal administration.
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公开(公告)号：US11959062B2
公开(公告)日：2024-04-16
申请号：US18447387
申请日：2023-08-10
发明人： Sean Farmer , Paul S. Zorner , Ken Alibek , Kent Adams , Tyler Dixon
CPC分类号： C12M41/26 , C12M23/44 , C12M23/52 , C12M23/58 , C12M41/12 , C12N1/14 , C12N1/16 , C12N1/20 , C12P7/64 , C12P19/44 , Y02A40/10
摘要： The invention relates to systems and methods for effective production and use of microorganisms and/or the fermentation broth in which they are produced. Advantageously, the system is cost-effective, scalable, quick, versatile, efficacious, and helpful in reducing resistance to chemical compounds and residue that concerns consumers.
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公开(公告)号：US11890657B2
公开(公告)日：2024-02-06
申请号：US16792469
申请日：2020-02-17
IPC分类号： A61K35/742 , B09C1/10 , C07K14/32 , C12P1/04 , C12N1/20 , C12Q1/689 , A01N63/22 , C12N1/38 , C12N9/00 , C12R1/125
CPC分类号： B09C1/10 , A01N63/22 , C07K14/32 , C12N1/20 , C12N1/205 , C12N1/38 , C12P1/04 , C12Q1/689 , B09C2101/00 , C12N9/00 , C12Q2600/158 , C12R2001/125 , Y02W10/40 , A01N63/22 , A01N63/20 , A01N63/22 , A01N63/22 , A01N63/22 , A01N63/27 , A01N63/22 , A01N63/32 , A01N63/22 , A01N63/30
摘要： This present invention relates to compositions and methods of microbial enhanced oil recovery using Bacillus subtilis strains. The invention also relates to compositions and methods for performing oil degradation with Bacillus subtilis strains. The compositions and methods of the present invention are also used for enhanced commercial biosurfactant and enzyme production.
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公开(公告)号：US11890341B2
公开(公告)日：2024-02-06
申请号：US16871504
申请日：2020-05-11
发明人： Sean Farmer , Ken Alibek
摘要： The subject invention provides materials and methods for preventing, inhibiting or reducing biofilm formation and biofilm infections, in particular, in the respiratory tract of a subject. The invention utilizes growth by-products of beneficial microorganisms to enhance the effectiveness of biocidal substances in the treatment, disruption and/or prevention of biofilms. Advantageously, the subject invention is useful against antibiotic-resistant bacterial strains, such as MRSA, Helicobacter pylori, S. pneumoniae, P. aeruginosa and A. fumigatus.
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5.发明授权公开(公告)号：US11807810B2
公开(公告)日：2023-11-07
申请号：US17623075
申请日：2020-06-25
发明人： Sean Farmer , Ken Alibek , Karthik N. Karathur , Jonathan Rogers
摘要： The subject invention provides multi-functional biochemical compositions, as well as their use in enhancing oil recovery by, for example, enhancing traditional acid treatments. Advantageously, the compositions and methods of the subject invention are operationally-friendly, cost-effective, and environmentally-friendly approaches to enhancing oil recovery. More specifically, in preferred embodiments, the subject invention provides a multi-functional composition for enhanced oil recovery (EOR) comprising one or more concentrated acids that work in synergy with a combination of one or more surfactants, one or more chelating agents, and one or more solvents to stimulate the flow of oil from a formation.
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公开(公告)号：US11788054B2
公开(公告)日：2023-10-17
申请号：US17429773
申请日：2020-02-21
发明人： Sean Farmer , Ken Alibek , Blake Ott
摘要： The subject invention provides improved methods for producing mannosylerythritol lipids (MEL) using yeasts not previously known to produce MEL. In particular, Meyerozyma guilliermondii (Pichia guilliermondii) is cultivated in a specially-tailored nutrient medium and under cultivation conditions such that the yeast unnaturally produces MEL and/or MEL-like molecules in greater amounts and at increased rates than when using standard MEL production with, for example, Pseudozyma aphidis. Yeast culture compositions are also provided, comprising yeast cells, growth medium, and high concentrations of MEL.
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公开(公告)号：US12060541B2
公开(公告)日：2024-08-13
申请号：US17349223
申请日：2021-06-16
发明人： Sean Farmer , Ken Alibek
CPC分类号： C11D3/381 , B08B1/12 , B08B1/143 , B08B3/026 , B08B3/04 , B08B3/08 , B08B9/027 , C11D17/0043 , C11D2111/20
摘要： The subject invention provides yeast-based products, as well as their use to improve industrial production and performance by, for example, efficiently cleaning contaminating and/or fouling substances such as FOG, biofilm, paraffin, and/or asphaltenes from industrial equipment.
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公开(公告)号：US11760969B2
公开(公告)日：2023-09-19
申请号：US16331438
申请日：2017-09-08
发明人： Sean Farmer , Paul S. Zorner , Ken Alibek , Kent Adams , Tyler Dixon
CPC分类号： C12M41/26 , C12M23/44 , C12M23/52 , C12M23/58 , C12M41/12 , C12N1/14 , C12N1/16 , C12N1/20 , C12P7/64 , C12P19/44 , Y02A40/10
摘要： The invention relates to systems and methods for effective production and use of microorganisms and/or the fermentation broth in which they are produced. Advantageously, the system is cost-effective, scalable, quick, versatile, efficacious, and helpful in reducing resistance to chemical compounds and residue that concerns consumers.
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公开(公告)号：US11759544B2
公开(公告)日：2023-09-19
申请号：US16965353
申请日：2019-05-24
发明人： Sean Farmer , Ken Alibek , Albina Tskhay
IPC分类号： A61L15/36 , A61P17/02 , A61K31/6615 , A61K35/66 , A61K36/064 , A61K36/886 , A61K45/06 , A61L15/26 , A61L15/38 , A61L15/40 , A61L15/44
CPC分类号： A61L15/36 , A61K31/6615 , A61K35/66 , A61K36/064 , A61K36/886 , A61K45/06 , A61L15/26 , A61L15/38 , A61L15/40 , A61L15/44 , A61P17/02
摘要： The subject invention provides topical therapeutic compositions and methods of their use for enhanced healing of wounds, including burns, and scars of the skin. Specifically, in one embodiment, the subject invention provides materials and methods for reducing the healing time of skin wounds and for reducing the appearance of scars. The subject invention utilizes topical compositions comprising microbial growth by-products and, optionally, a topically-acceptable carrier. In specific embodiments, the microbial growth by-products are biosurfactants.
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公开(公告)号：US12063935B2
公开(公告)日：2024-08-20
申请号：US17514391
申请日：2021-10-29
发明人： Karthik N. Karathur , Sean Farmer
IPC分类号： A01N63/38 , A01C23/04 , A01N63/22 , C05G3/80 , C08L101/00 , C12N1/14 , C12N1/20 , C12R1/07 , C12R1/885
CPC分类号： A01N63/38 , A01C23/047 , A01N63/22 , C08L101/00 , C12N1/14 , C12N1/20 , C05G3/80 , C12R2001/07 , C12R2001/885
摘要： The subject invention provides materials and methods for reducing deleterious atmospheric gases, such as greenhouse gases (GHGs) by enhancing utilization and storage of carbon in plants, as well as increasing the sequestration of carbon in plant and soil matter in the form of degradation-resistant organic polymers.
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