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公开(公告)号：US06325810B1
公开(公告)日：2001-12-04
申请号：US09345093
申请日：1999-06-30
申请人： Leslie Hamilton , Rao S. Bezwada , Mark B. Roller , Murty N. Vyakarnam , David A. Dalessandro , Joel S. Rosenblatt , Ram L. Kataria , Lowell G. Saferstein , James F. Martin
发明人： Leslie Hamilton , Rao S. Bezwada , Mark B. Roller , Murty N. Vyakarnam , David A. Dalessandro , Joel S. Rosenblatt , Ram L. Kataria , Lowell G. Saferstein , James F. Martin
IPC分类号： A61B1704
CPC分类号： A61B17/07207 , A61B17/07292 , A61B2017/00004 , A61B2017/07214
摘要： An apparatus for achieving hemostasis and pneumostasis along a staple line by utilizing a compliant bioabsorbable foam buttress which may be attached to one jaw of a surgical stapling apparatus by a biocompatible releasable adhesive.
摘要翻译： 一种用于通过使用柔性生物可吸收的泡沫支撑件，通过生物相容的可释放粘合剂附着到外科缝合装置的一个钳口上，沿着缝合线实现止血和肺静止的装置。
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公开(公告)号：US06273897B1
公开(公告)日：2001-08-14
申请号：US09515450
申请日：2000-02-29
IPC分类号： A61B1710
CPC分类号： A61L31/146 , A61B17/07207 , A61B17/07292 , A61B2017/00004 , A61B2017/07214 , A61L31/06 , C08L67/04
摘要： The present invention provides a surgical stapling apparatus and a buttress, i.e. pledget, for use in the surgical stapling apparatus, which buttress provides sealing for hemostasis and pneumostasis, and which buttress includes a continuous projection, or a plurality of projections, for cooperation with guide channels for thereby attaching the buttress to the staple cartridge or anvil in a releasable pressure fit relationship.
摘要翻译： 本发明提供了一种用于外科缝合装置的外科缝合装置和支撑物，即支架，所述支撑件用于外科缝合装置，所述支撑件提供用于止血和止血的密封，并且所述支撑件包括连续突出部或多个突出部，用于与引导件 通道，从而将支撑件以可释放的压力配合关系附接到钉仓或砧座。
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公开(公告)号：US06534084B1
公开(公告)日：2003-03-18
申请号：US09740289
申请日：2000-12-19
申请人： Murty N. Vyakarnam , Mark C. Zimmerman , Angelo George Scopelianos , Mark B. Roller , David V. Gorky
发明人： Murty N. Vyakarnam , Mark C. Zimmerman , Angelo George Scopelianos , Mark B. Roller , David V. Gorky
IPC分类号： A61F1300
CPC分类号： A61L27/3817 , A61F2/06 , A61F2/28 , A61F2/30756 , A61F2002/30004 , A61F2002/30011 , A61F2002/30014 , A61F2002/30018 , A61F2002/30032 , A61F2002/30062 , A61F2002/30677 , A61F2002/30766 , A61F2002/30784 , A61F2002/3092 , A61F2210/0004 , A61F2250/0014 , A61F2250/0018 , A61F2250/0023 , A61F2250/0029 , A61F2250/003 , A61F2250/0067 , A61L27/18 , A61L27/56 , A61L31/06 , A61L31/146 , Y10S514/945 , Y10S623/915 , C08L67/04
摘要： The present patent describes a three-dimensional inter-connected open cell porous foams that have a gradient in composition and/or microstructure through one or more directions. These foams can be made from a blend of absorbable and biocompatible polymers that are formed into foams having a compositional gradient transitioning from predominately one polymeric material to predominately a second polymeric material. These gradient foams are particularly well suited to tissue engineering applications and can be designed to mimic tissue transition or interface zones.
摘要翻译： 本专利描述了通过一个或多个方向具有组成和/或微结构的梯度的三维相互连接的开孔多孔泡沫。 这些泡沫可以由可吸收和生物相容的聚合物的混合物制成，其形成为具有从主要是一种聚合物材料到主要是第二聚合物材料的组成梯度转变的泡沫体。 这些梯度泡沫特别适用于组织工程应用，并且可以设计成模拟组织转变或界面区域。
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公开(公告)号：US07012106B2
公开(公告)日：2006-03-14
申请号：US10401469
申请日：2003-03-28
申请人： Jenny J. Yuan , Joseph H. Contiliano , Yufu Li , Zhigang Li , Mark B. Roller , Murty N. Vyakarnam
发明人： Jenny J. Yuan , Joseph H. Contiliano , Yufu Li , Zhigang Li , Mark B. Roller , Murty N. Vyakarnam
CPC分类号： A61L31/127 , A61L31/125 , A61L31/148 , Y10S525/937
摘要： The present invention is directed to reinforced, biocompatible, biodegradable compositions suitable for use in implantable medical devices and medical devices made at least in part from such compositions, where the compositions include a biocompatible, biodegradable polymer; a biocompatible, biodegradable wax; and greater than about 30 weight percent of an inorganic filler material.
摘要翻译： 本发明涉及适用于至少部分由这样的组合物制备的可植入医疗装置和医疗装置的增强的，生物相容的，可生物降解的组合物，其中组合物包括生物相容的可生物降解的聚合物; 生物相容的，可生物降解的蜡; 和大于约30重量％的无机填料。
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公开(公告)号：US06365149B2
公开(公告)日：2002-04-02
申请号：US09740086
申请日：2000-12-19
申请人： Murty N. Vyakarnam , Mark C. Zimmerman , Angelo George Scopelianos , Mark B. Roller , David V. Gorky
发明人： Murty N. Vyakarnam , Mark C. Zimmerman , Angelo George Scopelianos , Mark B. Roller , David V. Gorky
IPC分类号： A01N6300
CPC分类号： A61L27/3817 , A61F2/06 , A61F2/28 , A61F2/30756 , A61F2002/30004 , A61F2002/30011 , A61F2002/30014 , A61F2002/30018 , A61F2002/30032 , A61F2002/30062 , A61F2002/30677 , A61F2002/30766 , A61F2002/30784 , A61F2002/3092 , A61F2210/0004 , A61F2250/0014 , A61F2250/0018 , A61F2250/0023 , A61F2250/0029 , A61F2250/003 , A61F2250/0067 , A61L27/18 , A61L27/56 , A61L31/06 , A61L31/146 , Y10S514/945 , Y10S623/915 , C08L67/04
摘要： The present patent describes a three-dimensional interconnected open cell porous foams that have a gradient in composition and/or microstructure through one or more directions. These foams can be made from a blend of absorbable and biocompatible polymers that are formed into foams having a compositional gradient transitioning from predominately one polymeric material to predominately a second polymeric material. These gradient foams are particularly well suited to tissue engineering applications and can be designed to mimic tissue transition or interface zones.
摘要翻译： 本专利描述了通过一个或多个方向具有组成和/或微结构的梯度的三维相互连接的开孔多孔泡沫。 这些泡沫可以由可吸收和生物相容的聚合物的混合物制成，其形成为具有从主要是一种聚合物材料到主要是第二聚合物材料的组成梯度转变的泡沫体。 这些梯度泡沫特别适用于组织工程应用，并且可以设计成模拟组织转变或界面区域。
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公开(公告)号：US07112417B2
公开(公告)日：2006-09-26
申请号：US09938364
申请日：2001-08-24
申请人： Murty N. Vyakarnam , Mark C. Zimmerman , Angelo George Scopelianos , Iksoo Chun , Mora C. Melican , Clairene A. Bazilio , Mark B. Roller , David V. Gorky
发明人： Murty N. Vyakarnam , Mark C. Zimmerman , Angelo George Scopelianos , Iksoo Chun , Mora C. Melican , Clairene A. Bazilio , Mark B. Roller , David V. Gorky
CPC分类号： A61L27/3852 , A61F2/06 , A61F2/28 , A61F2/30756 , A61F2002/30004 , A61F2002/30011 , A61F2002/30014 , A61F2002/30018 , A61F2002/30032 , A61F2002/30062 , A61F2002/30677 , A61F2002/30766 , A61F2002/30784 , A61F2002/3092 , A61F2210/0004 , A61F2250/0014 , A61F2250/0018 , A61F2250/0023 , A61F2250/0029 , A61F2250/003 , A61F2250/0067 , A61L27/18 , A61L27/3817 , A61L27/3843 , A61L27/56 , A61L31/06 , A61L31/146 , Y10S514/945 , Y10T428/24132 , Y10T428/24149 , Y10T428/24165 , Y10T428/24322 , Y10T428/24793 , Y10T428/249953 , Y10T428/249955 , Y10T428/249958 , Y10T428/249986 , Y10T428/268 , Y10T428/31786 , C08L67/04
摘要： The present patent describes a biocompatible composite made of a first fibrous layer attached to a three-dimensional inter-connected open cell porous foams that have a gradient in composition and/or microstructure through one or more directions. These composites can be made from blends of absorbable and biocompatible polymers. These biocompatible composites are particularly well suited to tissue engineering applications and can be designed to mimic tissue transition or interface zones.
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公开(公告)号：US06333029B1
公开(公告)日：2001-12-25
申请号：US09345096
申请日：1999-06-30
申请人： Murty N. Vyakarnam , Mark C. Zimmerman , Angelo George Scopelianos , Mark B. Roller , David V. Gorky
发明人： Murty N. Vyakarnam , Mark C. Zimmerman , Angelo George Scopelianos , Mark B. Roller , David V. Gorky
IPC分类号： A01N6300
CPC分类号： A61L27/3817 , A61F2/06 , A61F2/28 , A61F2/30756 , A61F2002/30004 , A61F2002/30011 , A61F2002/30014 , A61F2002/30018 , A61F2002/30032 , A61F2002/30062 , A61F2002/30677 , A61F2002/30766 , A61F2002/30784 , A61F2002/3092 , A61F2210/0004 , A61F2250/0014 , A61F2250/0018 , A61F2250/0023 , A61F2250/0029 , A61F2250/003 , A61F2250/0067 , A61L27/18 , A61L27/56 , A61L31/06 , A61L31/146 , Y10S514/945 , Y10S623/915 , C08L67/04
摘要： The present patent describes a three-dimensional inter-connected open cell porous foams that have a gradient in composition and/or microstructure through one or more directions. These foams can be made from a blend of absorbable and biocompatible polymers that are formed into foams having a compositional gradient transitioning from predominately one polymeric material to predominately a second polymeric material. These gradient foams are particularly well suited to tissue engineering applications and can be designed to mimic tissue transition or interface zones.
摘要翻译： 本专利描述了通过一个或多个方向具有组成和/或微结构的梯度的三维相互连接的开孔多孔泡沫。 这些泡沫可以由可吸收和生物相容的聚合物的混合物制成，其形成为具有从主要是一种聚合物材料到主要是第二聚合物材料的组成梯度转变的泡沫体。 这些梯度泡沫特别适用于组织工程应用，并且可以设计成模拟组织转变或界面区域。
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公开(公告)号：US06355699B1
公开(公告)日：2002-03-12
申请号：US09345095
申请日：1999-06-30
IPC分类号： C08J926
CPC分类号： C08J9/26 , A61L15/26 , A61L15/425 , A61L27/18 , A61L27/56 , A61L31/06 , A61L31/146 , C08J9/28 , C08J2367/02 , C08L67/04
摘要： The present invention provides an improved lyophilization process for forming biocompatible foam structures. The process allows the foam structures to be tailored for specific end uses. The foams formed by this process are well suited to be used in medical applications such as tissue engineering. The foam structures may also contain pharmaceutically active substances
摘要翻译： 本发明提供了用于形成生物相容性泡沫结构的改进的冻干方法。 该方法允许为特定的最终用途定制泡沫结构。 由该方法形成的泡沫非常适用于医疗应用如组织工程。 泡沫结构还可以含有药物活性物质
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公开(公告)号：US06306424B1
公开(公告)日：2001-10-23
申请号：US09469118
申请日：1999-12-21
申请人： Murty N. Vyakarnam , Mark C. Zimmerman , Angelo George Scopelianos , Iksoo Chun , Mora C. Melican , Clairene A. Bazilio , Mark B. Roller , David V. Gorky
发明人： Murty N. Vyakarnam , Mark C. Zimmerman , Angelo George Scopelianos , Iksoo Chun , Mora C. Melican , Clairene A. Bazilio , Mark B. Roller , David V. Gorky
IPC分类号： A61F200
CPC分类号： A61L27/3852 , A61F2/06 , A61F2/28 , A61F2/30756 , A61F2002/30004 , A61F2002/30011 , A61F2002/30014 , A61F2002/30018 , A61F2002/30032 , A61F2002/30062 , A61F2002/30677 , A61F2002/30766 , A61F2002/30784 , A61F2002/3092 , A61F2210/0004 , A61F2250/0014 , A61F2250/0018 , A61F2250/0023 , A61F2250/0029 , A61F2250/003 , A61F2250/0067 , A61L27/18 , A61L27/3817 , A61L27/3843 , A61L27/56 , A61L31/06 , A61L31/146 , Y10S514/945 , Y10T428/24132 , Y10T428/24149 , Y10T428/24165 , Y10T428/24322 , Y10T428/24793 , Y10T428/249953 , Y10T428/249955 , Y10T428/249958 , Y10T428/249986 , Y10T428/268 , Y10T428/31786 , C08L67/04
摘要： The present patent describes a biocompatible composite made of a first fibrous layer attached to a three-dimensional inter-connected open cell porous foams that have a gradient in composition and/or microstructure through one or more directions. These composites can be made from blends of absorbable and biocompatible polymers. These biocompatible composites are particularly well suited to tissue engineering applications and can be designed to mimic tissue transition or interface zones.
摘要翻译： 本专利描述了一种生物相容性复合材料，其由连接到通过一个或多个方向具有组成和/或微结构的梯度的三维相互连接的开孔多孔泡沫的第一纤维层制成。 这些复合材料可以由可吸收和生物相容性聚合物的混合物制成。 这些生物相容性复合材料特别适用于组织工程应用，可以设计为模拟组织转变或界面区域。
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公开(公告)号：US09492952B2
公开(公告)日：2016-11-15
申请号：US13435544
申请日：2012-03-30
申请人： Emma Kim Luong-Van , Isabel Rodriguez , Hong Yee Low , Noha Elmouelhi , Kevin Cooper , Sriram Natarajan , Murty N. Vyakarnam , Chee Tiong Lim
发明人： Emma Kim Luong-Van , Isabel Rodriguez , Hong Yee Low , Noha Elmouelhi , Kevin Cooper , Sriram Natarajan , Murty N. Vyakarnam , Chee Tiong Lim
CPC分类号： B29C33/52 , A61B2017/00871 , A61B2017/00938 , A61B2017/00942 , A61B2017/00951 , A61L27/18 , A61L31/06 , Y10T428/24355 , C08L67/04
摘要： A polydioxanone film comprising substantially cylindrical polydioxanone pillars on at least one side thereof, said pillars having diameters from about 0.2 μm to about 3 μm, and heights from about 2 μm to about 20 μm from the surface of the film, a process for adsorbing proteins using the film and medical devices incorporating the film.
摘要翻译： 一种聚二恶烷酮薄膜，其至少在其一面上包括基本上圆柱形的聚二恶烷酮柱，所述柱具有约0.2μm至约3μm的直径，以及距膜的约2μm至约20μm的高度，用于吸附蛋白质的方法 使用包含该膜的胶片和医疗装置。
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