公开(公告)号：US20160228876A1

公开(公告)日：2016-08-11

申请号：US15017393

申请日：2016-02-05

Applicant: LIFE TECHNOLOGIES CORPORATION

Inventor： Yong Chu ,  Jeffrey Marks ,  Jacob Freudenthal ,  Mingsong Chen ,  Tiong Han Toh ,  Mauro Aguanno ,  Lik Seng Lau ,  Lian Seng Loh ,  Kok Siong Teo ,  Zeng Wei Chu ,  Xin Mathers ,  Michael Uy ,  Huei Yeo ,  Kuan Moon Boo ,  Way Xuang Lee ,  Chin Yong Koo ,  Wei Fuh Teo ,  Soo Yong Lau ,  Hon Siu Shin ,  Zeqi Tan ,  Thomas Wessel ,  Woo David

IPC: B01L7/00 ,  C12Q1/68 ,  G01N21/64

CPC classification number: B01L7/52 ,  B01L2200/145 ,  B01L2300/18 ,  B01L2300/1822 ,  C12Q1/6806 ,  G01N21/274 ,  G01N21/6452 ,  G01N21/6486 ,  G01N35/026 ,  G01N2021/6439 ,  G01N2035/00316 ,  G01N2035/00366 ,  G01N2201/061 ,  G01N2201/12

Abstract: A biological analysis system is provided. The system comprises a sample block assembly. The sample block assembly comprises a sample block configured to accommodate a sample holder, the sample holder configured to receive a plurality of samples. The system also comprises a control system configured to cycle the plurality of samples through a series of temperatures. The system further comprises an automated tray comprising a slide assembly, the tray configured to reversibly slide the sample block assembly from a closed to an open position to allow user access to the plurality of sample holders.

Abstract translation: 提供生物分析系统。 该系统包括样品块组件。 样品块组件包括被配置为容纳样品架的样品块，样品保持器被配置为接收多个样品。 该系统还包括配置成使多个样品循环通过一系列温度的控制系统。 所述系统还包括自动盘，其包括滑动组件，所述托盘被配置为可将所述样品块组件从关闭位置可逆地滑动至打开位置，以允许使用者接近所述多个样品保持器。

公开(公告)号：US20250027881A1

公开(公告)日：2025-01-23

申请号：US18766173

申请日：2024-07-08

Applicant: LIFE TECHNOLOGIES CORPORATION

Inventor： Mingsong Chen ,  Jeffrey A. Marks ,  Jacob K. Freudenthal ,  Mauro Aguanno ,  Woon Liang Terence Soh ,  Kuan Moon Boo

IPC: G01N21/64 ,  G01N21/03 ,  G01N21/27

Abstract: An instrument for processing and/or measuring a biological process comprises a sample processing system and an excitation source exhibiting a spectral function of output power or intensity verses wavelength of output power or intensity. The spectral function has a minima wavelength corresponding to a local minima value of the output power or intensity; a first maxima wavelength corresponding to a first local maxima of output power or intensity, the output power or intensity at the first local maxima being greater than the output power or intensity at any wavelength less than the minima wavelength; a second maxima wavelength corresponding to a second local maxima of output power or intensity, the output power or intensity at the second local maxima being greater than the output at any wavelength greater than the minima wavelength; the minima wavelength is between the first maxima wavelength and the second maxima wavelength.

公开(公告)号：US11920191B2

公开(公告)日：2024-03-05

申请号：US17151657

申请日：2021-01-18

Applicant: Life TECHNOLOGIES CORPORATION

Inventor： Mingsong Chen ,  Kuan Moon Boo ,  Tiong Han Toh ,  Mauro Aguanno ,  Soo Yong Lau ,  Huei Yeo ,  Wei Fuh Teo

IPC: B01L7/00 ,  B01L99/00 ,  C12Q1/686 ,  G01N21/64 ,  G02B21/24

CPC classification number: C12Q1/686 ,  B01L7/52 ,  G01N21/6428 ,  G01N21/6452 ,  G01N21/6456 ,  G01N21/6458 ,  G02B21/244 ,  B01L2200/10 ,  B01L2300/0654 ,  B01L2300/0829 ,  B01L2300/168 ,  B01L2300/18 ,  G01N2021/6463

Abstract: An instrument for biological analysis includes a base, an excitation source, an optical sensor, an excitation optical system, and an emission optical system. The base is configured to receive a sample holder comprising a plurality of biological samples. The optical sensor is configured to receive emissions from the biological samples in response to the excitation source. The instrument may additionally include a sensor lens enclosed by a lens case and a focusing mechanism including a gear that engages the lens case, the focusing mechanism being accessible outside the enclosure for adjusting a focus. The may instrument further include a sensor aperture dispose along an emission optical path and a blocking structure disposed to cooperate with the sensor aperture such that none of the reflected radiation from an illuminated surface near the sample holder is received by the optical sensor that does not also reflect off another surface of the instrument.

公开(公告)号：US10591416B2

公开(公告)日：2020-03-17

申请号：US14766725

申请日：2014-02-24

Applicant: LIFE TECHNOLOGIES CORPORATION

Inventor： Mingsong Chen ,  Mauro Aguanno ,  Kuan Moon Boo ,  Woon Liang Terence Soh ,  Jacob K. Freudenthal ,  Jeffrey A. Marks

IPC: G01N21/64 ,  G01N21/27 ,  G01N21/03

Abstract: An instrument for processing and/or measuring a biological process contains a sample processing system, an excitation source, an excitation optical system, an optical sensor, and an emission optical system. The sample processing system is configured to retain a first sample holder and a second sample holder, wherein the number of sample cells is different for each sample holder or a characteristic dimension for the first sample cells is different from that of the second sample holder. The instrument also includes an excitation source temperature controller comprising a temperature sensor that is coupled to the excitation source. The temperature controller is configured to produce a first target temperature when the first sample holder is retained by the instrument and to produce a second target temperature when the second sample holder is retained by the instrument.

公开(公告)号：US20240309441A1

公开(公告)日：2024-09-19

申请号：US18583747

申请日：2024-02-21

Applicant: Life Technologies Corporation

Inventor： Mingsong Chen ,  Soo Yong Lau ,  Kuan Moon Boo ,  Mauro Aguanno ,  Huei Yeo ,  Tiong Han Toh ,  Wei Fuh Teo

IPC: C12Q1/686 ,  B01L7/00 ,  G01N21/64 ,  G02B21/24

CPC classification number: C12Q1/686 ,  B01L7/52 ,  G01N21/6428 ,  G01N21/6452 ,  G01N21/6456 ,  G01N21/6458 ,  G02B21/244 ,  B01L2200/10 ,  B01L2300/0654 ,  B01L2300/0829 ,  B01L2300/168 ,  B01L2300/18 ,  G01N2021/6463

Abstract: An instrument for biological analysis includes a base, an excitation source, an optical sensor, an excitation optical system, and an emission optical system. The base is configured to receive a sample holder comprising a plurality of biological samples. The optical sensor is configured to receive emissions from the biological samples in response to the excitation source. The instrument may additionally include a sensor lens enclosed by a lens case and a focusing mechanism including a gear that engages the lens case, the focusing mechanism being accessible outside the enclosure for adjusting a focus. The instrument may further include a sensor aperture dispose along an emission optical path and a blocking structure disposed to cooperate with the sensor aperture such that none of the reflected radiation from an illuminated surface near the sample holder is received by the optical sensor that does not also reflect off another surface of the instrument.

公开(公告)号：US12031916B2

公开(公告)日：2024-07-09

申请号：US17962123

申请日：2022-10-07

Applicant: LIFE TECHNOLOGIES CORPORATION

Inventor： Mingsong Chen ,  Mauro Aguanno ,  Kuan Moon Boo ,  Woon Liang Terence Soh ,  Jacob K. Freudenthal ,  Jeffrey A. Marks

IPC: G01N21/64 ,  G01N21/03 ,  G01N21/27

CPC classification number: G01N21/6486 ,  G01N21/0332 ,  G01N21/274 ,  G01N21/645 ,  G01N21/6452 ,  G01N2201/061 ,  G01N2201/0624 ,  G01N2201/0627 ,  G01N2201/121

Abstract: An instrument for processing and/or measuring a biological process comprises a sample processing system and an excitation source exhibiting a spectral function of output power or intensity verses wavelength of output power or intensity. The spectral function has a minima wavelength corresponding to a local minima value of the output power or intensity; a first maxima wavelength corresponding to a first local maxima of output power or intensity, the output power or intensity at the first local maxima being greater than the output power or intensity at any wavelength less than the minima wavelength; a second maxima wavelength corresponding to a second local maxima of output power or intensity, the output power or intensity at the second local maxima being greater than the output at any wavelength greater than the minima wavelength; the minima wavelength is between the first maxima wavelength and the second maxima wavelength.

公开(公告)号：US11467092B2

公开(公告)日：2022-10-11

申请号：US16797561

申请日：2020-02-21

Applicant: LIFE TECHNOLOGIES CORPORATION

Inventor： Mingsong Chen ,  Mauro Aguanno ,  Kuan Moon Boo ,  Woon Liang Terence Soh ,  Jacob K. Freudenthal ,  Jeffrey A. Marks

IPC: G01N21/64 ,  G01N21/27 ,  G01N21/03

Abstract: An instrument for processing and/or measuring a biological process contains a sample processing system, an excitation source, an excitation optical system, an optical sensor, and an emission optical system. The sample processing system is configured to retain a first sample holder and a second sample holder, wherein the number of sample cells is different for each sample holder or a characteristic dimension for the first sample cells is different from that of the second sample holder. The instrument also includes an excitation source temperature controller comprising a temperature sensor that is coupled to the excitation source. The temperature controller is configured to produce a first target temperature when the first sample holder is retained by the instrument and to produce a second target temperature when the second sample holder is retained by the instrument.