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公开(公告)号：US11339425B2
公开(公告)日：2022-05-24
申请号：US16382294
申请日：2019-04-12
Applicant: LIFE TECHNOLOGIES CORPORATION
Inventor： Jacob K. Freudenthal , Geoffrey Dahlhoff , Kevin Maher , Ming Song Chen , Gary Lim , Ronald Danehy , David Fortescue , Ming Shen , Woon Liang Soh , Francis T. Cheng , Ruoyun Wu , Thiam Chye Lee , Gary A. Chappell , Chee Kiong Lim , Jeff Dere , Ted Straub , Jorge Fonseca , Kuan Moon Boo , Soo Yong Lau
Abstract: A biological analysis system is provided. The system comprises an interchangeable assembly configured to accommodate any one of a plurality of sample holders, each respective sample holder configured to receive a plurality of samples. The system also includes a control system configured to cycle the plurality of samples through a series of temperatures. The system further includes an optical system configured to detect fluorescent signals emitted from the plurality of samples. The optical system, in particular, can comprise a single field lens, an excitation source, an optical sensor, and a plurality of filter components. The excitation source can be one or more light emitting diodes. The field lends can be a bi-convex lens.
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公开(公告)号：US10323274B2
公开(公告)日：2019-06-18
申请号：US14348504
申请日：2012-09-28
Applicant: LIFE TECHNOLOGIES CORPORATION
Inventor： Jacob K. Freudenthal , Kevin Maher , Ming Song Chen , Theodore E. Straub , Kuan Moon Boo , Soo Yong Lau
Abstract: A biological analysis system is provided. The system comprises an interchangeable assembly configured to accommodate any one of a plurality of sample holders, each respective sample holder configured to receive a plurality of samples. The system also includes a control system configured to cycle the plurality of samples through a series of temperatures. The system further includes an optical system configured to detect fluorescent signals emitted from the plurality of samples. The optical system, in particular, can comprise a single field lens, an excitation source, an optical sensor, and a plurality of filter components. The excitation source can be one or more light emitting diodes. The field lens can be a bi-convex lens.
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公开(公告)号：USD774206S1
公开(公告)日：2016-12-13
申请号：US29552491
申请日：2016-01-22
Applicant: LIFE TECHNOLOGIES CORPORATION
Designer： Kuan Moon Boo , Way Xuang Lee , Wuh Ken Loh , Zeqi Tan , Sandro Klein
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公开(公告)号：US20140213487A1
公开(公告)日：2014-07-31
申请号：US14348504
申请日：2012-09-28
Applicant: LIFE TECHNOLOGIES CORPORATION
Inventor： Jacob K. Freudenthal , Geoffrey Dahlhoff , Kevin Maher , Ming Song Chen , Gary Lim , Ronald Danehy , David Fortescue , Ming Shen , Woon Liang Soh , Francis T. Cheng , Ruoyun Wu , Thiam Chye Lee , Gary A. Chappell , Chee Kiong Lim , Jeff Dere , Theodore E. Straub , Jorge Fonseca , Kuan Moon Boo , Soo Yong Lau
CPC classification number: C12Q1/686 , B01L3/50855 , B01L3/50857 , B01L7/52 , B01L2200/023 , B01L2200/025 , B01L2200/028 , B01L2200/143 , B01L2300/021 , B01L2300/046 , B01L2300/0654 , B01L2300/0829 , B01L2300/1827 , B01L2300/1844
Abstract: A biological analysis system is provided. The system comprises an interchangeable assembly configured to accommodate any one of a plurality of sample holders, each respective sample holder configured to receive a plurality of samples. The system also includes a control system configured to cycle the plurality of samples through a series of temperatures. The system further includes an optical system configured to detect fluorescent signals emitted from the plurality of samples. The optical system, in particular, can comprise a single field lens, an excitation source, an optical sensor, and a plurality of filter components. The excitation source can be one or more light emitting diodes. The field lens can be a bi-convex lens.
Abstract translation: 提供生物分析系统。 该系统包括被配置为容纳多个样品保持器中的任何一个的可互换组件，每个样品保持器被配置为接收多个样品。 该系统还包括被配置为使多个样品循环通过一系列温度的控制系统。 该系统还包括被配置为检测从多个样本发射的荧光信号的光学系统。 特别地，光学系统可以包括单个场透镜，激发源，光学传感器和多个滤光器组件。 激发源可以是一个或多个发光二极管。 场透镜可以是双凸透镜。
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公开(公告)号：US20240416335A1
公开(公告)日：2024-12-19
申请号：US18739087
申请日：2024-06-10
Inventor： Wui Khen Kevin LIAW , Kuan Moon Boo , Huei Steven YEO , Wern Yuh FOO , Joshua Mathew MEAD , Justina Linkai BONG , Mikko MAKINEN , Mio Xiu Lu LING , Way Xuang LEE , Wen Lun CHAN , Yunxiang LIU
IPC: B01L3/02
Abstract: Multichannel pipettes, electroporation systems utilizing the multichannel pipettes and methods for electroporating a cell. The electroporation system includes a multichannel pipette, a pipette tip(s), a pipette docking assembly, and a pulse generator. The pipette docking assembly includes a pipette station, a pipette station guard, and a reservoir.
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Patent Agency Ranking
公开(公告)号：US11583862B2
公开(公告)日：2023-02-21
申请号：US15266943
申请日：2016-09-15
Applicant: LIFE TECHNOLOGIES CORPORATION
Inventor： Kuan Moon Boo , Wei Fuh Teo , Wuh Ken Loh , Zeqi Tan , Siew Yin Lee
Abstract: A thermal block assembly for use in a biological analysis system includes a sample block, a heating and cooling element, a heat sink including a surface, the surface including a plurality of projections for engaging the heating and cooling element to hold the heating and cooling element on the heat sink. A thermal block assembly for use in a biological analysis system includes a heating and cooling element, a sample block including a lower surface configured to be thermally coupled to the heating and cooling element, one or more temperature sensors configured to extend through the one or more slots of the lower surface of the sample block, and one or more thermal pads between the one or more temperature sensors and heating and cooling element.
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公开(公告)号：US10591416B2
公开(公告)日：2020-03-17
申请号：US14766725
申请日：2014-02-24
Applicant: LIFE TECHNOLOGIES CORPORATION
Inventor： Mingsong Chen , Mauro Aguanno , Kuan Moon Boo , Woon Liang Terence Soh , Jacob K. Freudenthal , Jeffrey A. Marks
Abstract: An instrument for processing and/or measuring a biological process contains a sample processing system, an excitation source, an excitation optical system, an optical sensor, and an emission optical system. The sample processing system is configured to retain a first sample holder and a second sample holder, wherein the number of sample cells is different for each sample holder or a characteristic dimension for the first sample cells is different from that of the second sample holder. The instrument also includes an excitation source temperature controller comprising a temperature sensor that is coupled to the excitation source. The temperature controller is configured to produce a first target temperature when the first sample holder is retained by the instrument and to produce a second target temperature when the second sample holder is retained by the instrument.
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公开(公告)号：US10239059B2
公开(公告)日：2019-03-26
申请号：US14778106
申请日：2014-02-14
Applicant: LIFE TECHNOLOGIES CORPORATION
Inventor： Tiong Han Toh , Wuh Ken Loh , Kuan Moon Boo , Sandro Klein , Daniel Welsh
IPC: B01L7/00
Abstract: In one aspect, a thermal cycler system is disclosed. The thermal cycler can be comprised of a device housing and a cover that is operably connected to the device housing. The cover can include a handle portion, a device lid portion, a sample block platen, and a link bar. The device lid portion is attached to the proximal side of the handle portion with a first pin. The sample block platen is operably connected to the handle portion such that the sample block platen is positioned against the sample block when the handle portion is flush with the device lid portion and the cover is in a closed position. The link bar is pivotably connected to the device housing at a first terminal end portion and a second pin at an opposite second terminal end portion, wherein the handle portion is elevated away from the device lid portion before the cover is moved to an open position.
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公开(公告)号：US20250027881A1
公开(公告)日：2025-01-23
申请号：US18766173
申请日：2024-07-08
Applicant: LIFE TECHNOLOGIES CORPORATION
Inventor： Mingsong Chen , Jeffrey A. Marks , Jacob K. Freudenthal , Mauro Aguanno , Woon Liang Terence Soh , Kuan Moon Boo
Abstract: An instrument for processing and/or measuring a biological process comprises a sample processing system and an excitation source exhibiting a spectral function of output power or intensity verses wavelength of output power or intensity. The spectral function has a minima wavelength corresponding to a local minima value of the output power or intensity; a first maxima wavelength corresponding to a first local maxima of output power or intensity, the output power or intensity at the first local maxima being greater than the output power or intensity at any wavelength less than the minima wavelength; a second maxima wavelength corresponding to a second local maxima of output power or intensity, the output power or intensity at the second local maxima being greater than the output at any wavelength greater than the minima wavelength; the minima wavelength is between the first maxima wavelength and the second maxima wavelength.
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公开(公告)号：US11920191B2
公开(公告)日：2024-03-05
申请号：US17151657
申请日：2021-01-18
Applicant: Life TECHNOLOGIES CORPORATION
Inventor： Mingsong Chen , Kuan Moon Boo , Tiong Han Toh , Mauro Aguanno , Soo Yong Lau , Huei Yeo , Wei Fuh Teo
CPC classification number: C12Q1/686 , B01L7/52 , G01N21/6428 , G01N21/6452 , G01N21/6456 , G01N21/6458 , G02B21/244 , B01L2200/10 , B01L2300/0654 , B01L2300/0829 , B01L2300/168 , B01L2300/18 , G01N2021/6463
Abstract: An instrument for biological analysis includes a base, an excitation source, an optical sensor, an excitation optical system, and an emission optical system. The base is configured to receive a sample holder comprising a plurality of biological samples. The optical sensor is configured to receive emissions from the biological samples in response to the excitation source. The instrument may additionally include a sensor lens enclosed by a lens case and a focusing mechanism including a gear that engages the lens case, the focusing mechanism being accessible outside the enclosure for adjusting a focus. The may instrument further include a sensor aperture dispose along an emission optical path and a blocking structure disposed to cooperate with the sensor aperture such that none of the reflected radiation from an illuminated surface near the sample holder is received by the optical sensor that does not also reflect off another surface of the instrument.
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