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公开(公告)号：US11865191B2
公开(公告)日：2024-01-09
申请号：US16882271
申请日：2020-05-22
发明人： Surbhi Desai , Marie Christine Nlend , Kyle Gee , Matthew Baker , Robert Aggeler , Scott Sweeney , Aleksey Rukavishnikov , Shih-Jung Huang
CPC分类号： A61K49/0015 , A61K47/10 , A61K47/18 , A61K49/0058 , G01N33/533 , G01N33/582 , G01N33/68
摘要： This disclosure relates to the field of fluorescent dyes, and in particular, compositions and methods for increasing fluorescent signals and the reduction of fluorescent quenching.
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公开(公告)号：US11857643B2
公开(公告)日：2024-01-02
申请号：US16816015
申请日：2020-03-11
发明人： Surbhi Desai , Marie Christine Nlend , Kyle Gee , Matthew Baker , Robert Aggeler , Scott Sweeney , Aleksey Rukavishnikov , Shih-Jung Huang
CPC分类号： A61K49/0015 , A61K47/10 , A61K47/18 , A61K49/0058 , G01N33/533 , G01N33/582 , G01N33/68
摘要： This disclosure relates to the field of fluorescent dyes, and in particular, compositions and methods for increasing fluorescent signals and the reduction of fluorescent quenching.
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公开(公告)号：US20240042062A1
公开(公告)日：2024-02-08
申请号：US18380388
申请日：2023-10-16
发明人： Surbhi Desai , Marie Christine Nlend , Kyle Gee , Matthew Baker , Robert Aggeler , Scott Sweeney , Aleksey Rukavishnikov , Shih-Jung Huang
CPC分类号： A61K49/0015 , G01N33/582 , A61K47/10 , A61K47/18 , A61K49/0058 , G01N33/533 , G01N33/68
摘要： This disclosure relates to the field of fluorescent dyes, and in particular, compositions and methods for increasing fluorescent signals and the reduction of fluorescent quenching.
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公开(公告)号：US20180362766A1
公开(公告)日：2018-12-20
申请号：US15955332
申请日：2018-04-17
发明人： Kyle Gee , Upinder Singh , Aleksey Rukavishnikov , Daniel Beacham , Shih-Jung Huang , Michael Janes , Wenjun Zhou , Judith Berlier
摘要： Disclosed herein are compounds, compositions, methods and kits for detecting pH in samples using pH-sensitive fluorescent dyes. The compounds disclosed herein are novel xanthene-derivative dyes comprising an aniline moiety with one or more electron donating groups, which dyes are for detecting pH in samples either in vitro or in vivo. Also described herein are processes for preparing said dyes for use in the disclosed compositions, methods and kits.
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公开(公告)号：US10941435B2
公开(公告)日：2021-03-09
申请号：US16306609
申请日：2017-06-21
发明人： Kyle Gee , Wenjun Zhou , Shih-Jung Huang , Monica Tomaszewski
摘要： Provided herein are compounds, enzyme substrates, compositions, kits, uses, and methods for detecting the presence or absence of a caspase enzyme, measuring the activity of a caspase enzyme, or detecting the presence or absence of apoptosis. The detection or measurement can occur through intracellular cleavage of a compound or enzyme substrate, which can lead to an increase in fluorescence, e.g., in the violet or red channel, through liberation of a nucleic acid binding dye from a peptide, such as liberation of a DNA-binding dye from a negatively charged peptide comprising a sequence recognized and cleaved by a caspase.
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公开(公告)号：US10253185B2
公开(公告)日：2019-04-09
申请号：US15423890
申请日：2017-02-03
发明人： Kyle Gee , Upinder Singh , Aleksey Rukavishnikov , Daniel Beacham , Shih-Jung Huang , Michael Janes , Wenjun Zhou
摘要： Disclosed herein are compounds, compositions, methods and kits for detecting pH in samples using pH-sensitive fluorescent dyes. The compounds disclosed herein are novel xanthene-derivative dyes comprising an aniline moiety with one or more electron donating groups, which dyes are for detecting pH in samples either in vitro or in vivo. Also described herein are processes for preparing said dyes for use in the disclosed compositions, methods and kits.
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7.发明授权Fluorescent chemical compounds having high selectivity for double stranded DNA, and methods for their use 有权对双链DNA具有高选择性的荧光化合物及其使用方法公开(公告)号：US08865904B2
公开(公告)日：2014-10-21
申请号：US13861123
申请日：2013-04-11
IPC分类号： C07D215/00 , C07D417/04 , C07D215/10 , C07D277/72 , C07D277/74 , G01N21/64 , C07D417/14 , C07D417/06 , C07D215/227
CPC分类号： G01N33/582 , C07D215/10 , C07D215/227 , C07D277/72 , C07D277/74 , C07D417/04 , C07D417/06 , C07D417/14 , C12Q1/6876 , G01N21/6428 , G01N21/6486 , G01N2021/6439 , G01N2201/06113 , Y10T436/143333
摘要： Chemical compounds having a high selectivity for double stranded DNA over RNA and single stranded DNA are disclosed. The chemical compounds are stains that become fluorescent upon illumination and interaction with double stranded DNA, but exhibit reduced or no fluorescence in the absence of double stranded DNA. The compounds can be used in a variety of biological applications to qualitatively or quantitatively assay DNA, even in the presence of RNA.
摘要翻译： 公开了对RNA和单链DNA具有对双链DNA的高选择性的化合物。 化学化合物是在照射时变成荧光并与双链DNA相互作用的污渍，但在不存在双链DNA的情况下表现出减少的或没有荧光。 该化合物可用于各种生物学应用中，以定性或定量测定DNA，即使在RNA的存在下。
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公开(公告)号：US09599622B2
公开(公告)日：2017-03-21
申请号：US14402358
申请日：2013-03-14
发明人： Kyle Gee , Upinder Singh , Aleksey Rukavishnikov , Daniel Beacham , Shih-Jung Huang , Michael Janes , Wenjun Zhou
CPC分类号： C09B11/24 , A61K49/0041 , C07D311/90 , G01N33/5005 , G01N33/582 , G01N33/84
摘要： Disclosed herein are compounds, compositions, methods and kits for detecting pH in samples using pH-sensitive fluorescent dyes. The compounds disclosed herein are novel xanthene-derivative dyes comprising an aniline moiety with one or more electron donating groups, which dyes are for detecting pH in samples either in vitro or in vivo. Also described herein are processes for preparing said dyes for use in the disclosed compositions, methods and kits.
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公开(公告)号：US09366676B2
公开(公告)日：2016-06-14
申请号：US14797415
申请日：2015-07-13
IPC分类号： C07D215/00 , G01N33/58 , G01N21/64 , C07D215/10 , C07D215/227 , C07D277/72 , C07D277/74 , C07D417/04 , C07D417/06 , C07D417/14 , C12Q1/68
CPC分类号： G01N33/582 , C07D215/10 , C07D215/227 , C07D277/72 , C07D277/74 , C07D417/04 , C07D417/06 , C07D417/14 , C12Q1/6876 , G01N21/6428 , G01N21/6486 , G01N2021/6439 , G01N2201/06113 , Y10T436/143333
摘要： Chemical compounds having a high selectivity for double stranded DNA over RNA and single stranded DNA are disclosed. The chemical compounds are stains that become fluorescent upon illumination and interaction with double stranded DNA, but exhibit reduced or no fluorescence in the absence of double stranded DNA. The compounds can be used in a variety of biological applications to qualitatively or quantitatively assay DNA, even in the presence of RNA.
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公开(公告)号：US20150241438A1
公开(公告)日：2015-08-27
申请号：US14402375
申请日：2013-03-14
发明人： Kyle Gee , Upinder Singh , Aleksey Rukavishnikov , Daniel Beacham , Shih-Jung Huang , Michael Janes , Wenjun Zhou , Judith Berlier
IPC分类号： G01N33/58 , C07D311/90
CPC分类号： C09B11/24 , A61K49/0041 , C07D311/90 , G01N33/5005 , G01N33/582 , G01N33/84
摘要： Disclosed herein are compounds, compositions, methods and kits for detecting pH in samples using pH-sensitive fluorescent dyes. The compounds disclosed herein are novel xanthene-derivative dyes comprising an aniline moiety with one or more electron donating groups, which dyes are for detecting pH in samples either in vitro or in vivo. Also described herein are processes for preparing said dyes for use in the disclosed compositions, methods and kits.
摘要翻译： 本文公开了使用pH敏感荧光染料检测样品中的pH的化合物，组合物，方法和试剂盒。 本文公开的化合物是包含具有一个或多个给电子基团的苯胺部分的新型呫吨衍生物染料，该染料用于在体外或体内检测样品中的pH。 本文还描述了用于制备用于所公开的组合物，方法和试剂盒的所述染料的方法。
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