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公开(公告)号：US5783428A
公开(公告)日：1998-07-21
申请号：US804144
申请日：1997-02-20
申请人： Makoto Goto , Terukazu Nara , Izuru Tokumaru , Nobutake Fugono , Yasukazu Uchida , Masato Terasawa , Hideaki Yukawa
发明人： Makoto Goto , Terukazu Nara , Izuru Tokumaru , Nobutake Fugono , Yasukazu Uchida , Masato Terasawa , Hideaki Yukawa
CPC分类号： C12P7/46 , C12P13/20 , Y10S435/832 , Y10S435/833
摘要： Fumaric acid is produced by reacting a culture of a microorganism which produces maleate isomerase that exhibits a maximum activity at not less than 50.degree. C. or a treated product thereof with maleic acid in an aqueous solution, and isomerizing maleic acid to produce fumaric acid. L-aspartic acid is produced by reacting both of a culture of a microorganism which produces maleate isomerase or a treated product thereof and a culture of a microorganism which produces aspartase or a treated product thereof with maleic acid and ammonia in an aqueous solution, producing L-aspartic acid from maleic acid and ammonia by enzyme reactions, and recovering L-aspartic acid from the reaction mixture.
摘要翻译： 富马酸是通过使生成马来酸异构酶的微生物培养物（其在50℃以上表现出最大活性）或其处理产物与马来酸在水溶液中反应，并使马来酸异构化以产生富马酸而制备的。 L-天冬氨酸通过使水解产生马来酸异构酶的微生物培养物或其处理产物和产生天冬氨酰胺的微生物培养物或其处理产物与马来酸和氨反应，生成L - 天冬氨酸通过酶反应从马来酸和氨中回收，并从反应混合物中回收L-天冬氨酸。
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2.发明授权Process for culturing microorganisms of the genus Pseudomonas and process for producing L-Alanine using said microorganisms 失效培养基因组培养微生物的方法和使用微生物生产L-赖氨酸的方法
公开(公告)号：US5149651A
公开(公告)日：1992-09-22
申请号：US691880
申请日：1991-04-26
申请人： Makoto Goto , Terukazu Nara , Yasukazu Uchida , Masato Terasawa , Hideaki Yukawa , Hisashi Yamagata
发明人： Makoto Goto , Terukazu Nara , Yasukazu Uchida , Masato Terasawa , Hideaki Yukawa , Hisashi Yamagata
CPC分类号： C12P13/06 , Y10S435/874 , Y10S435/876 , Y10S435/877
摘要： Microorganisms of the genus Pseudomonas containing aspartate beta-decarboxylase at a high level are produced by culturing said microorganism in a medium supplemented with a chelating agent. L-Alanine can be efficiently produced from L-aspartic acid said microorganisms or the treated product thereof.
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公开(公告)号：US5677156A
公开(公告)日：1997-10-14
申请号：US623001
申请日：1996-03-28
申请人： Makoto Goto , Izuru Tokumaru , Masato Terasawa , Hideaki Yukawa
发明人： Makoto Goto , Izuru Tokumaru , Masato Terasawa , Hideaki Yukawa
CPC分类号： C12P7/46 , C12P13/20 , Y10S435/829 , Y10S435/84
摘要： Fumaric acid is produced by reacting maleic acid in an aqueous solution with a microorganism which has maleate isomerase activity or with a preparation from the microorganism having the maleate isomerase activity, and producing fumaric acid in a reaction solution by enzymatic isomerization of maleic acid carried out under the condition that the dissolved oxygen concentration in the reaction solution is substantially maintained at 4 ppm or less, for example, by sealing the reaction solution with one or more gases selected from N.sub.2, Ar, and He.
摘要翻译： 通过马来酸在水溶液中与具有马来酸异构酶活性的微生物或具有马来酸异构酶活性的微生物的制剂反应制备富马酸，并通过在下面进行的马来酸的酶促异构化在反应溶液中产生富马酸 反应溶液中的溶解氧浓度基本上保持在4ppm以下的条件，例如通过用一种或多种选自N 2，Ar和He的气体密封反应溶液。
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4.发明授权L-alanine production with two microorganisms having fumarase inactivity in a single reaction tank 失效在单反应罐中具有两种具有不饱和脂肪酸的微生物的L-阿兰生产
公开(公告)号：US5116743A
公开(公告)日：1992-05-26
申请号：US790063
申请日：1991-11-12
申请人： Makoto Goto , Terukazu Nara , Masato Terasawa , Hideaki Yukawa
发明人： Makoto Goto , Terukazu Nara , Masato Terasawa , Hideaki Yukawa
IPC分类号： C12P13/06
CPC分类号： C12P13/06 , Y10S435/874 , Y10S435/876 , Y10S435/877
摘要： There is disclosed a process for producing L-alanine by reacting in a single reaction tank, in an aqueous reaction mixture having a pH of 6 to 10 and containing at least one .alpha.-keto acid, fumaric acid or a salt thereof with ammonia or ammonium ions in the presence of two microorganisms having fumarase inactivity.
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公开(公告)号：US5496715A
公开(公告)日：1996-03-05
申请号：US293969
申请日：1994-08-24
申请人： Makoto Goto , Terukazu Nara , Masato Terasawa , Hideaki Yukawa
发明人： Makoto Goto , Terukazu Nara , Masato Terasawa , Hideaki Yukawa
CPC分类号： C12R1/01 , C12P17/165 , Y10S435/822
摘要： There is disclosed a process for preparing indigo which comprises bringing an indigo-producing bacteria belonging to genus Acinetobacter or treated products thereof into contact with an aqueous solution containing at least indole to have indigo formed and accumulated in the aqueous solution; and collecting indigo from the aqueous solution.
摘要翻译： 公开了制备靛蓝的方法，其包括将属于不动杆菌属的靛蓝生产细菌或其处理产物与至少含有吲哚的水溶液接触以形成并积聚在水溶液中的靛蓝; 并从水溶液中收集靛蓝。
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公开(公告)号：US5776740A
公开(公告)日：1998-07-07
申请号：US682193
申请日：1996-07-17
CPC分类号： C12P13/22
摘要： The present invention relates to a process for producing L-tryptophan in a single-stage reaction, comprising carrying out an L-tryptophan producing reaction with glycine, formaldehyde and indole as raw materials in an aqueous solution in the presence of microbial cells having serine transhydroxymethylase or a treated products thereof and microbial cells having tryptophan synthase or tryptophanase, or a treated products thereof; and collecting produced L-tryptophan from the reaction solution.
摘要翻译： 本发明涉及在单阶段反应中生产L-色氨酸的方法，包括在具有丝氨酸转羟甲基化酶的微生物细胞存在下，在水溶液中以甘氨酸，甲醛和吲哚为原料进行产生L-色氨酸的反应 或其处理产物和具有色氨酸合酶或色氨酸酶的微生物细胞或其处理产物; 并从反应溶液中收集产生的L-色氨酸。
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公开(公告)号：US11490900B2
公开(公告)日：2022-11-08
申请号：US16490327
申请日：2017-03-03
申请人： Makoto Goto , Tsuyoshi Murase
发明人： Makoto Goto , Tsuyoshi Murase
摘要： An osteotomy assistance kit includes a bone treatment assistance device and an attaching position confirmation device. The attaching position confirmation device includes a feature point indication rod to be applied via a tip portion to a feature point of the bone, a rod support unit that removably supports the feature point indication rod such that the tip portion is indicating the feature point of the bone, and a second support member that movably supports the rod support unit and indicates one of scales on the rod support unit. The bone treatment assistance device includes cutting slits, and first guide holes that guides first rods set to a predetermined positional relation. The second support member of the attaching position confirmation device is attached to the protrusion of the bone treatment assistance device.
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公开(公告)号：US10398510B2
公开(公告)日：2019-09-03
申请号：US15035915
申请日：2014-08-01
申请人： Makoto Goto
发明人： Makoto Goto
IPC分类号： A61B17/15 , A61B17/17 , A61B34/10 , B33Y10/00 , B33Y50/02 , B33Y80/00 , A61B17/80 , G05B19/4099 , A61B17/00
摘要： A manufacturing method of a bone cutting assist device includes generating a bone cutting assist device model representing the bone cutting assist device including a fitting surface that fits a surface of a bone model, a cutting slit that guides a cutting jig, a first guide hole for inserting a first rod model, and second guide holes for inserting second rod models. The manufacturing method also includes outputting three-dimensional manufacturing data representing the generated bone cutting assist device model, and manufacturing the bone cutting assist device according to the outputted three-dimensional manufacturing data.
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公开(公告)号：US20090156856A1
公开(公告)日：2009-06-18
申请号：US12066300
申请日：2006-09-13
申请人： Suguru Ohara , Satoshi Hiyoshi , Yukihiro Isogai , Makoto Goto
发明人： Suguru Ohara , Satoshi Hiyoshi , Yukihiro Isogai , Makoto Goto
CPC分类号： C07C69/75 , C07C29/141 , C07C31/27 , C07C45/50 , C07C45/69 , C07C67/08 , C07C2601/14 , C07C2602/42 , C10M105/38 , C10M2207/2835 , C10N2230/02 , C10N2230/06 , C10N2230/08 , C10N2230/10 , C07C47/445 , C07C31/278
摘要： The present invention provides a lubricating oil comprising an alicyclic compound represented by a general formula (I): wherein n is an integer of 0 or 1; one of R1 and R2 represents —CH2OR4 (wherein R4 represents a carboxylic acid residue) while the other one represents alkyl, lower alkyl-substituted or unsubstituted cycloalkyl, aryl, or aralkyl; and R3 represents —CH2OR5 (wherein R5 represents a carboxylic residue) and the like. The lubricating oil of the present invention has an excellent traction coefficient, excellent heat resistance, or the like. For the lubricating oil of the present invention, the alicyclic compound represented by the general formula (I) can be directly used as it is, and other base oils such as ester oil, poly-α-olefin, mineral oil, or silicone oil may be included therein, if necessary.
摘要翻译： 本发明提供一种润滑油，其含有通式（I）表示的脂环族化合物：其中n为0或1的整数; R 1和R 2之一表示-CH 2 OR 4（其中R 4表示羧酸残基），而另一个表示烷基，低级烷基取代或未取代的环烷基，芳基或芳烷基; 和R 3表示-CH 2 OR 5（其中R 5表示羧基残基）等。 本发明的润滑油具有优异的牵引系数，优异的耐热性等。 对于本发明的润滑油，可以直接使用由通式（I）表示的脂环族化合物，其它基油如酯油，聚-α-烯烃，矿物油或硅油可以 如果有必要的话。
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公开(公告)号：US06979146B2
公开(公告)日：2005-12-27
申请号：US10923800
申请日：2004-08-24
申请人： Tadayuki Yamada , Kouji Yamamoto , Makoto Goto
发明人： Tadayuki Yamada , Kouji Yamamoto , Makoto Goto
摘要： In order to melt snow and prevent freezing without consuming energy wastefully and to monitor a road surface state remotely, a road surface sensor includes: a rotating stand provided so as to be reciprocatingly rotatable upward on the road surface; a snow-melting/freezing heat quantity measurement dummy road surface having an electric heater buried therein and to use as a reference road surface for heat quantity measurement to derive a melting heat quantity for snow falling on the surface and a heat quantity required for freezing prevention; a reference light irradiating/reflected light receiving device that is attached so as to be rotatable with the rotating stand; a space reflected light receiving device; a non-contact road temperature measuring device; a non-contact snow cover depth measuring device; a road surface image pickup device; and a moisture sensor. The reference light irradiating/reflected light receiving device includes a reference light irradiating device for irradiating reference light and a reflected light receiving device for receiving reflected light of the reference light from the road surface, and the reflected light receiving device separates and receives only reflected light of the reference light out of the reflected light from the road surface.
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