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    Polyalkylene oxide-modified single chain polypeptides
    4.
    发明授权
    Polyalkylene oxide-modified single chain polypeptides 有权
    聚环氧烷改性单链多肽

    公开(公告)号：US06824782B2

    公开(公告)日：2004-11-30

    申请号：US09791540

    申请日：2001-02-26

    申请人： Marc Whitlow ,  Robert G. L. Shorr ,  David R. Filpula ,  Lihsyng Stanford Lee

    发明人： Marc Whitlow ,  Robert G. L. Shorr ,  David R. Filpula ,  Lihsyng Stanford Lee

    IPC分类号： A61K39395

    CPC分类号： G01N33/6857 ,  A61K47/60 ,  A61K2039/505 ,  C07K16/30 ,  C07K19/00 ,  C07K2317/41 ,  C07K2317/622 ,  C07K2319/00

    摘要： The present invention relates to the chemical modification of single chain polypeptides by means of covalent attachment of strands of poly(ethylene glycol) PEG and similar poly(alkylene oxides) to single chain polypeptide binding molecules that have the three dimensional folding and, thus, the binding ability and specificity, of the variable region of an antibody. Such preparations of modified single chain polypeptide binding molecules have reduced immugenicity and antigenicity as well as having a longer halflife in the bloodstream as compared to the parent polypeptide. These beneficial properties of the modified single chain polypeptide binding molecules make them very useful in a variety of therapeutic applications. The invention also relates to multivalent antigen-binding molecules capable of PEGylation. Compositions of, genetic constructions for, methods of use, and methods for producing PEGylated antigen-binding proteins are disclosed.

    摘要翻译： 本发明涉及通过将聚（乙二醇）PEG和类似的聚（环氧烷）的链共价连接到具有三维折叠的单链多肽结合分子的单链多肽的化学修饰，因此涉及 抗体的可变区的结合能力和特异性。 与亲本多肽相比，修饰的单链多肽结合分子的这种制剂具有降低的免疫性和抗原性，并且在血流中具有更长的半衰期。 修饰的单链多肽结合分子的这些有益性质使得它们在各种治疗应用中非常有用。 本发明还涉及能够进行PEG化的多价抗原结合分子。 公开了用于生产聚乙二醇化抗原结合蛋白的遗传构建，使用方法和方法的组合物。

    Single-chain antigen-binding proteins capable of glycosylation, production and uses thereof
    5.
    发明授权
    Single-chain antigen-binding proteins capable of glycosylation, production and uses thereof 失效
    能够进行糖基化，生产和使用的单链抗原结合蛋白

    公开(公告)号：US06323322B1

    公开(公告)日：2001-11-27

    申请号：US09069821

    申请日：1998-04-30

    申请人： David Filpula ,  Maoliang Wang ,  Robert Shorr ,  Marc Whitlow ,  Lihsyng S. Lee

    发明人： David Filpula ,  Maoliang Wang ,  Robert Shorr ,  Marc Whitlow ,  Lihsyng S. Lee

    IPC分类号： C07K1600

    CPC分类号： G01N33/6857 ,  A61K47/60 ,  A61K2039/505 ,  C07K16/30 ,  C07K19/00 ,  C07K2317/41 ,  C07K2317/622 ,  C07K2319/00

    摘要： The present invention relates to single-chain antigen-binding molecules capable of glycosylation. Compositions of, genetic constructions coding for, and methods for producing monovalent and multivalent single-chain antigen-binding molecules capable of glycosylation are described and claimed. Composition of, genetic constructions coding for, and methods for producing glycosylated monovalent and multivalent single-chain antigen-binding molecules capable of polyalkylene oxide conjugation are described and claimed. The invention also relates to methods for producing a polypeptide having increased glycosylation and the polypeptide produced by the described method. Uses resulting from the multifunctionality of a glycosylated/polyalkylene oxide conjugated antigen-binding protein are also described and claimed.

    摘要翻译： 本发明涉及能够进行糖基化的单链抗原结合分子。 描述和要求保护编码的组成，以及产生能够糖基化的单价和多价单链抗原结合分子的方法。 描述和要求保护编码的遗传结构的组成，以及能够产生聚环氧烷共轭的糖基化单价和多价单链抗原结合分子的方法。 本发明还涉及生产具有增加的糖基化的多肽的方法和通过所述方法产生的多肽。 还描述和要求保护由糖基化/聚环氧烷结合的抗原结合蛋白的多功能性产生的用途。