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公开(公告)号：US20050014151A1
公开(公告)日：2005-01-20
申请号：US10489688
申请日：2001-09-12
申请人： Marcus Textor , Roger MIchel , Janos Voros , Jeffrey Hubbell , Jost Lussi
发明人： Marcus Textor , Roger MIchel , Janos Voros , Jeffrey Hubbell , Jost Lussi
CPC分类号： B82Y30/00 , A61L27/34 , A61L29/085 , A61L31/10 , B82Y15/00 , G01N33/54353 , G01N33/54366 , G01N33/54373 , C08L71/02
摘要： A device with chemical surface patterns (defined surface areas of at least two different chemical compositions) with biochemical or biological relevance on substrates with prefabricated patterns of at least two different types of regions (α, β, . . . ), whereas at least two different, consecutively applied molecular self-assembly systems (A, B, . . . ) are used in a way that at least one of the applied assembly systems (A or B or . . . ) is specific to one type of the prefabricated patterns (α or β or . . . ).
摘要翻译： 具有至少两种不同类型区域（α，β，...）的预制图案的具有生化或生物相关性的具有化学表面图案（至少两种不同化学组成的限定表面积）的装置，而至少两种 使用不同的连续应用的分子自组装系统（A，B ...），其方法是至少一个所应用的组装系统（A或B或...）特定于一种类型的预制模式 （alpha或beta或...）。
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公开(公告)号：US20080199371A1
公开(公告)日：2008-08-21
申请号：US11667204
申请日：2004-11-12
IPC分类号： B01J10/00
CPC分类号： B01L3/502776 , B01J19/0046 , B01J2219/00286 , B01J2219/00432 , B01J2219/00527 , B01J2219/00576 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/00612 , B01J2219/0063 , B01J2219/00637 , B01J2219/00659 , B01J2219/00677 , B01J2219/00711 , B01J2219/00722 , B01J2219/00725 , B01J2219/00743 , B01L3/502707 , B01L2200/0636 , B01L2300/0636 , B01L2300/0816 , B01L2400/0487 , B82Y30/00 , Y10T156/10
摘要： A microfluidic device and its use for the production of micro-arrays, in particular for the detection of protein interactions, is described. Said microfluidic device comprises a flow cell part (1) and a chip part (2) together forming at least two crossing, preferably perpendicular, closed channels (3, 4), said flow cell part forming open channels providing the bottom wall and at least part of the side walls, in particular three walls of said closed channels (3, 4), said closed channels (3, 4) being connected to at least three fluid providing means for generating at least three fluid flows (7) and said closed channels (3, 4) being designed and dimensioned such that the flow of at least three aqueous fluids streaming through each of said channels (3, 4) is laminar at least until after said crossing of said channels (6), said chip part (2) forming the top wall and optionally part of said side walls, in particular the fourth wall, of said closed channels (3, 4) and having a surface that is activatable by reaction with an activating molecule.
摘要翻译： 描述了微流体装置及其用于生产微阵列的用途，特别是用于蛋白质相互作用的检测。 所述微流体装置包括流动池部分（1）和芯片部分（2），一起形成至少两个交叉的，优选垂直的封闭通道（3,4），所述流动池部分形成开放通道，提供底壁并且至少 侧壁的一部分，特别是所述封闭通道（3,4）的三个壁，所述封闭通道（3,4）连接至少三个流体供应装置，用于产生至少三个流体流（7）和所述封闭通道 通道（3,4）的设计和尺寸使得流过每个所述通道（3,4）的至少三种含水流体的流动至少在所述通道（6），所述芯片部分 2）形成所述封闭通道（3,4）的顶壁和任选部分所述侧壁，特别是第四壁，并具有可通过与活化分子反应而激活的表面。
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3.发明申请Electrochemical Patterning on Multi-Channel Microelectrode Array for Biosensing Applications 审中-公开用于生物传感应用的多通道微电极阵列上的电化学图案公开(公告)号：US20080113352A1
公开(公告)日：2008-05-15
申请号：US11663310
申请日：2005-09-20
申请人： Janos Voros , Marcus Textor , Clarence Tang , Beat Keller
发明人： Janos Voros , Marcus Textor , Clarence Tang , Beat Keller
CPC分类号： B01J19/0046 , B01J2219/00286 , B01J2219/00495 , B01J2219/00531 , B01J2219/00596 , B01J2219/00608 , B01J2219/00612 , B01J2219/00617 , B01J2219/00635 , B01J2219/00659 , B01J2219/00713 , B01J2219/00722 , B01J2219/00725 , B01J2219/0074
摘要： Described is a method for electrochemically patterning a microelectrode array (MEA) with at least two different kinds of macromolecules. Said method comprising the steps of: providing a platform with a surface that comprises individually addressable conductive microelectrode surfaces; covering said platform surface with an adlayer of resistant polymer; desorbing said adlayer from a first kind of conductive microelectrodes intended for the selective adsorption of a first kind of macromolecules, in particular proteins, by applying a potential; subjecting the desorbed surfaces to the first macromolecule under conditions such that said first macromolecule adsorbs to said desorbed surfaces, and repeating the desorption/adsorption steps with a second or further kind of macromolecules until all kinds of desired macromolecules are adsorbed. A microchip array produced by the inventive method is also described. Such chip arrays can be used to study a large diversity of biological interactions, e.g. protein-protein interactions, protein-cell interactions, protein-nucleic acid interactions, etc.
摘要翻译： 描述了用至少两种不同种类的大分子电化学构图微电极阵列（MEA）的方法。 所述方法包括以下步骤：提供具有包括单独可寻址的导电微电极表面的表面的平台; 用抗性聚合物的覆层覆盖所述平台表面; 从用于通过施加电位选择性吸附第一种大分子，特别是蛋白质的第一种导电微电极解吸附子; 在使所述第一高分子吸附到所述解吸附表面的条件下将解吸附的表面经受脱附的表面，并且用第二种或其它类型的大分子重复解吸附/吸附步骤，直到吸附所有种类的所需大分子。 还描述了通过本发明方法制造的微芯片阵列。 这种芯片阵列可用于研究大量生物相互作用，例如， 蛋白质 - 蛋白质相互作用，蛋白质 - 细胞相互作用，蛋白质 - 核酸相互作用等。
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公开(公告)号：US10130274B2
公开(公告)日：2018-11-20
申请号：US13704420
申请日：2011-06-14
IPC分类号： A61B5/04 , A61N1/05 , H05K1/02 , A61N1/30 , B05D7/00 , A61B5/00 , H05K1/09 , H05K3/12 , H05K3/24 , H05K3/46
摘要： An implantable device for the electrical and/or pharmaceutical stimulation of the central nervous system, especially the spinal cord, is suggested. The device comprises a conformable substrate which is primarily composed of a flexible and stretchable polymer, and a plurality of flexible electrodes and conductive leads embedded in the conformable substrate. Not only the substrate, but also the leads are stretchable. The substrate may consist of PDMS, and the leads may consist of a conductive PDMS, in particular, PDMS with an electrically conductive filler material, and may optionally be metal-coated. The device defines a multi-electrode array which may be employed for neurostimulation in the epidural or subdural space of an animal or human.
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公开(公告)号：US08951241B2
公开(公告)日：2015-02-10
申请号：US13810221
申请日：2011-07-06
CPC分类号： A61F2/04 , A61F2/82 , A61F2002/047 , A61F2002/048 , A61F2250/0001 , A61M25/0017 , A61M27/008 , A61N1/20 , A61N1/36007 , A61N1/3787
摘要： A medical device is disclosed, which comprises a functional unit (C) for permanent or temporary placement in the urogenital tract of a human or animal body. The functional unit has at least one electrically conducting portion. A power source (G) supplies a current to the electrically conducting portion after placement of the functional unit in the urogenital tract. In this manner, the growth of bacteria on the functional unit can be reduced.
摘要翻译： 公开了一种医疗装置，其包括用于在人体或动物体的泌尿生殖道中永久或临时放置的功能单元（C）。 功能单元具有至少一个导电部分。 在将功能单元放置在泌尿生殖道中之后，电源（G）向导电部分提供电流。 以这种方式，可以减少功能单元上细菌的生长。
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公开(公告)号：US20130123756A1
公开(公告)日：2013-05-16
申请号：US13810221
申请日：2011-07-06
CPC分类号： A61F2/04 , A61F2/82 , A61F2002/047 , A61F2002/048 , A61F2250/0001 , A61M25/0017 , A61M27/008 , A61N1/20 , A61N1/36007 , A61N1/3787
摘要： A medical device is disclosed, which comprises a functional unit (C) for permanent or temporary placement in the urogenital tract of a human or animal body. The functional unit has at least one electrically conducting portion. A power source (G) supplies a current to the electrically conducting portion after placement of the functional unit in the urogenital tract. In this manner, the growth of bacteria on the functional unit can be reduced.
摘要翻译： 公开了一种医疗装置，其包括用于在人体或动物体的泌尿生殖道中永久或临时放置的功能单元（C）。 功能单元具有至少一个导电部分。 在将功能单元放置在泌尿生殖道中之后，电源（G）向导电部分提供电流。 以这种方式，可以减少功能单元上细菌的生长。
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公开(公告)号：US20090325171A1
公开(公告)日：2009-12-31
申请号：US12454067
申请日：2009-05-12
申请人： Thomas Hirt , Zhihua Lu , Janos Voros , Dorothea Niederberger
发明人： Thomas Hirt , Zhihua Lu , Janos Voros , Dorothea Niederberger
CPC分类号： C07H19/00
摘要： Vesicles for use in biosensors that have both high specificity and high sensitivity, where the vesicles include a receptor specific for the intended analyte and a signal generating component.
摘要翻译： 用于具有高特异性和高灵敏度的生物传感器中的囊泡，其中囊泡包括对于预期分析物特异性的受体和信号产生组分。
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公开(公告)号：US20080302960A1
公开(公告)日：2008-12-11
申请号：US12117801
申请日：2008-05-09
IPC分类号： G12B21/08
CPC分类号： G01Q30/14 , G01N33/48707 , G01N33/48728 , G01Q60/02 , G01Q60/38 , G01Q60/44 , G01Q70/06
摘要： A probe arrangement with a probe for local electrophysiological analysis of cells (4) such as patch-clamp techniques for use with atomic force microscopy, has a probe with a cantilever arm (2) connected to a probe holder (3). The probe has a probe tip (4) at a probing end (5) of the cantilever arm (2) and a fluid channel (6) in the cantilever arm (2) connecting a probe tip aperture (7) with a fluid reservoir (8) via a duct (9). The fluid channel (6), the duct (9) and the fluid reservoir (8) are adapted to be filled with a fluid solution (10) enabling ion transport for electrophysiological analysis. A first electrode (15) for electrophysiological analysis is placed in the fluid reservoir (8) and/or in the duct (9) and/or in the fluid channel (6).
摘要翻译： 具有用于细胞局部电生理分析的探针的探针装置（4），例如用原子力显微镜使用的膜片钳技术，具有连接到探针支架（3）的悬臂（2）的探针。 探针在悬臂（2）的探测端（5）处具有探针尖端（4）以及悬臂（2）中的流体通道（6），其将探针尖端孔（7）与流体储存器 8）通过管道（9）。 流体通道（6），管道（9）和流体储存器（8）适于填充有能够进行电生理分析的离子输送的流体溶液（10）。 用于电生理分析的第一电极（15）放置在流体储存器（8）和/或管道（9）和/或流体通道（6）中。
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