摘要:
An imidazole compound of the formula: wherein Ring A is benzene or a heterocyclic ring; G is alkylthio, alkylsulfonyl, optionally substituted phenyl, or optionally substituted heterocyclic ring group, etc.; Ring C is imidazole; R1 is carbamoyl, etc.; R2 is cyano, nitro, hydroxyl, an alkoxy, a halogen, carboxy, an alkoxycarbonyl, carbamoyl, amino, an alkyl, etc.; m is 0 to 2; and R4 is hydrogen, an alkyl, etc., or a pharmaceutically acceptable salt thereof, is a large conductance calcium-activated K channel opener useful for treatment of pollakiuria, urinary incontinence, etc.
摘要翻译:下式的咪唑化合物:其中环A是苯或杂环; G是烷硫基,烷基磺酰基,任选取代的苯基或任选取代的杂环基团等; 环C是咪唑; R 1是氨基甲酰基等; R 2是氰基,硝基,羟基,烷氧基,卤素,羧基,烷氧基羰基,氨基甲酰基,氨基,烷基等; m为0〜2; R 4是氢,烷基等或其药学上可接受的盐,是用于治疗尿频,尿失禁等的大电导钙激活K通道开放剂。
摘要:
The present invention provides a novel variant androgen receptor (ARaiv) lacking ligand binding domain, a nucleic acid encoding the same and use thereof. That is, the present invention provides a method of screening for a substance for the prophylaxis or treatment of cancer, which includes contacting an ARaiv protein or ARaiv-producing cell with a test compound, measuring the activity of ARaiv (e.g., transcription regulating action of androgen responsive gene) or expression level thereof, and selecting a compound that suppresses the activity or expression level.
摘要:
A color filter preventing the occurrence of cross-talk between colors while improving light extraction efficiency, a method of manufacturing the color filter, and a light-emitting device are provided. The color filter includes: a plurality of color filter layers for a plurality of colors arranged on a substrate, a plurality of projections arranged in contact with the color filter layers, the projections of which parts on a side closer to the color filter layers are connected to one another; and a reflecting mirror film formed so as to be laid over a side surface of each of the plurality of projections.
摘要:
An electronic device includes an electronic circuit section, a case, and a connector housing. The electronic circuit section includes a connector terminal. The case seals the electronic circuit section in such a manner that the connector terminal protrudes to an outside of the case. The connector housing is integrated with the case and has an approximately cylindrical shape to surround an outer circumference of the connector terminal. The case and the connector housing are made of resin with a molding tool by filling resin into a case cavity and a connector-housing cavity of the molding tool in a state where the electronic circuit section is held by a holding portion of the molding tool.
摘要:
The present invention provides a condensed furan compound of the formula (I): wherein Ring X is benzene, pyridine, or the like; Y is an optionally substituted amino, an optionally substituted cycloalkyl, an optionally substituted aryl, an optionally substituted saturated heterocyclic group, an optionally substituted unsaturated heterocyclic group; A is a single bond, lower alkylene, lower alkenylidene, lower alkenylene or an oxygen atom; R3 is hydrogen or the like; and, R4 is hydrogen, or the like, or pharmaceutically acceptable salts thereof, which is useful as a medicament, particularly, as an activated blood coagulation factor X inhibitor.
摘要翻译:本发明提供式(I)的缩合呋喃化合物:其中环X为苯,吡啶等; Y是任选取代的氨基,任选取代的环烷基,任选取代的芳基,任选取代的饱和杂环基,任选取代的不饱和杂环基; A是单键,低级亚烷基,低级亚烯基,低级亚烯基或氧原子; R 3是氢等; 和R 4是氢等,或其药学上可接受的盐,其可用作药物,特别是作为活化凝血因子X抑制剂。
摘要:
A system and method for controlling a video display blanking signal so as to maintain a full display screen while minimizing interference with the displayed picture. To control the blanking signal one or more photosensors are placed at the periphery of the display screen. When a CRT overscans the screen at a sensor's location, the light from the CRT is incident on the sensor and the sensor generates a signal proportional to the amount of incident light. The sensor signal is used to adjust the CRT scan such that the CRT scan covers the screen but does not degrade the displayed picture.
摘要:
A skin-whitening agent offering an excellent whitening effect and being effective in preventing and treating age spots, freckles, etc., where such skin-whitening agent contains as its effective ingredient a whey protein hydrolyzate characterized by a molecular weight distribution of 10 kDa or less, main peak of 200 Da to 3 kDa, APL (average peptide-chain length) of 2 to 8, free amino acid content of 20% or less, and antigenicity of one-ten thousandth of β-lactoglobulin or less, as well as a cosmetic, drink or food, feed, pharmaceutical preparation or other skin-whitening product containing such skin-whitening agent.
摘要:
Disclosed are: a sense-improving agent which comprises, as an active ingredient, a phospholipid or a sphingosine-containing phospholipid and/or a derivative thereof, particularly a sphingomyelin, and which has an effect of improving the dulling of senses at a periphery when ingested orally or directly applied to the skin; and a sense-improving food, beverage, feed or cosmetic comprising the sense-improving agent. The phospholipid to be used may be a chemically synthesized phospholipid or a naturally occurring phospholipid, preferably a phospholipid derived from an edible material such as soybean and egg yolk, particularly preferably a phospholipid derived from milk.
摘要:
Disclosed are: a skin whitening agent including, as an active ingredient, a complex of carbonic acid and/or bicarbonic acid, a metal and an LF, a decomposition product of the complex, or a complex of carbonic acid and/or bicarbonic acid, a metal and a decomposition product of an LF; and a food, beverage, feed or cosmetic including the skin whitening agent. The skin whitening agent can be ingested safely on a daily basis, and exhibits an excellent skin whitening effect.
摘要:
A semiconductor device includes: a semiconductor chip; a package for accommodating the chip, wherein the package has a box shape with an opening and a bottom; and a cover for sealing the opening of the package. The semiconductor chip is disposed on the bottom of the package. The cover has a plate shape. The cover includes a protrusion, which is disposed at a center of the plate shape. The protrusion protrudes toward an outside of the package.