公开(公告)号：US20090226448A1

公开(公告)日：2009-09-10

申请号：US12381747

申请日：2009-03-16

申请人： Maria A. Glucksmann ,  Rory A.J. Curtis ,  Jose M. Lora ,  Katherine M. Galvin ,  Inmaculada Silos-Santiago

发明人： Maria A. Glucksmann ,  Rory A.J. Curtis ,  Jose M. Lora ,  Katherine M. Galvin ,  Inmaculada Silos-Santiago

IPC分类号： A61K39/395 ,  C12N15/12 ,  C12N5/10 ,  C07K14/47 ,  C07K16/18 ,  C12P21/02 ,  C12Q1/68 ,  G01N33/566 ,  A61K31/7105 ,  A61K38/48 ,  A61K38/17 ,  A61P35/00 ,  A61P43/00

CPC分类号： C07K14/705 ,  A61K38/00

摘要： The invention provides isolated nucleic acids molecules, designated 18607, 15603, 69318, 12303, 48000, 52920, 5433, 38554, 57301, 58324, 55063, 52991, 59914, 59921 and 33751 nucleic acid molecules. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 18607, 15603, 69318, 12303, 48000, 52920, 5433, 38554, 57301, 58324, 55063, 52991, 59914, 59921 and 33751 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a 18607, 15603, 69318, 12303, 48000, 52920, 5433, 38554, 57301, 58324, 55063, 52991, 59914, 59921 or 33751 gene has been introduced or disrupted. The invention still further provides isolated 18607, 15603, 69318, 12303, 48000, 52920, 5433, 38554, 57301, 58324, 55063, 52991, 59914, 59921 or 33751 proteins, fusion proteins, antigenic peptides and anti-18607, 15603, 69318, 12303, 48000, 52920, 5433, 38554, 57301, 58324, 55063, 52991, 59914, 59921 or 33751 antibodies. Diagnostic and therapeutic methods utilizing compositions of the invention are also provided.

摘要翻译： 本发明提供分离的核酸分子，命名为18607,15603,69318,12303,48000,52920,5433,38554,57301,58324,55063,52991,59914,59921和33751核酸分子。 本发明还提供反义核酸分子，包含18607,15603,69318,12303,48000,52920,5433,38554,57301,58324,55063,52991,59914,59921和33751核酸分子的重组表达载体，其中宿主细胞 已经引入了表达载体，并且已导入或破坏其中18607,15603,69318,12303,48000,523020,5433,35554,57301,58324,55063,52991,59914,59921或33751基因的非人转基因动物。 本发明还进一步提供了分离的18607,15603,69318,12303,48000,5920,5433,38554,57301,58324,55063,52991,59914,59921或33751蛋白，融合蛋白，抗原肽和抗-18607,15603,69318 ，12303,48000,5920,5433,38554,57301,58324,55063,52991,59914,59921或33751抗体。 还提供了利用本发明组合物的诊断和治疗方法。

公开(公告)号：US20090226449A1

公开(公告)日：2009-09-10

申请号：US12381748

申请日：2009-03-16

申请人： Maria A. Glucksmann ,  Rory A.J. Curtis ,  Jose M. Lora ,  Katherine M. Galvin ,  Inmaculada Silos-Santiago

发明人： Maria A. Glucksmann ,  Rory A.J. Curtis ,  Jose M. Lora ,  Katherine M. Galvin ,  Inmaculada Silos-Santiago

IPC分类号： A61K39/395 ,  C12N15/12 ,  C12N5/10 ,  C07K14/47 ,  C07K16/18 ,  C12P21/02 ,  C12Q1/68 ,  G01N33/566 ,  A61K38/17 ,  A61K31/7105 ,  A61K38/48 ,  A61P35/00 ,  A61P43/00

CPC分类号： C07K14/705 ,  A61K38/00

摘要： The invention provides isolated nucleic acids molecules, designated 18607, 15603, 69318, 12303, 48000, 52920, 5433, 38554, 57301, 58324, 55063, 52991, 59914, 59921 and 33751 nucleic acid molecules. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 18607, 15603, 69318, 12303, 48000, 52920, 5433, 38554, 57301, 58324, 55063, 52991, 59914, 59921 and 33751 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a 18607, 15603, 69318, 12303, 48000, 52920, 5433, 38554, 57301, 58324, 55063, 52991, 59914, 59921 or 33751 gene has been introduced or disrupted. The invention still further provides isolated 18607, 15603, 69318, 12303, 48000, 52920, 5433, 38554, 57301, 58324, 55063, 52991, 59914, 59921 or 33751 proteins, fusion proteins, antigenic peptides and anti-18607, 15603, 69318, 12303, 48000, 52920, 5433, 38554, 57301, 58324, 55063, 52991, 59914, 59921 or 33751 antibodies. Diagnostic and therapeutic methods utilizing compositions of the invention are also provided.

摘要翻译： 本发明提供分离的核酸分子，命名为18607,15603,69318,12303,48000,52920,5433,38554,57301,58324,55063,52991,59914,59921和33751核酸分子。 本发明还提供反义核酸分子，包含18607,15603,69318,12303,48000,52920,5433,38554,57301,58324,55063,52991,59914,59921和33751核酸分子的重组表达载体，其中宿主细胞 已经引入了表达载体，并且已导入或破坏其中18607,15603,69318,12303,48000,523020,5433,35554,57301,58324,55063,52991,59914,59921或33751基因的非人转基因动物。 本发明还进一步提供了分离的18607,15603,69318,12303,48000,5920,5433,38554,57301,58324,55063,52991,59914,59921或33751蛋白，融合蛋白，抗原肽和抗-18607,15603,69318 ，12303,48000,5920,5433,38554,57301,58324,55063,52991,59914,59921或33751抗体。 还提供了利用本发明组合物的诊断和治疗方法。

公开(公告)号：US20110165147A1

公开(公告)日：2011-07-07

申请号：US13037699

申请日：2011-03-01

申请人： Maria A. Glucksmann ,  Inmaculada Silos-Santiago ,  Joseph M. Carroll ,  Katherine M. Galvin

发明人： Maria A. Glucksmann ,  Inmaculada Silos-Santiago ,  Joseph M. Carroll ,  Katherine M. Galvin

IPC分类号： A61K39/395 ,  C07H21/04 ,  C12N5/10 ,  C07K14/00 ,  C07K16/00 ,  C12P21/02 ,  C12Q1/68 ,  G01N33/00 ,  G01N33/53 ,  A61K38/00 ,  A61K38/16 ,  A61K31/711 ,  A61P43/00

CPC分类号： C07K14/47 ,  C07K14/705 ,  Y10T436/143333

摘要： The invention provides isolated nucleic acids molecules, designated 18636, 2466, 43238, 1983, 52881, 2398, 45449, 50289, 52872 and 26908 nucleic acid molecules. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 18636, 2466, 43238, 1983, 52881, 2398, 45449, 50289, 52872 and 26908 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a 18636, 2466, 43238, 1983, 52881, 2398, 45449, 50289, 52872 or 26908 gene has been introduced or disrupted. The invention still further provides isolated 18636, 2466, 43238, 1983, 52881, 2398, 45449, 50289, 52872 or 26908 proteins, fusion proteins, antigenic peptides and anti-18636, 2466, 43238, 1983, 52881, 2398, 45449, 50289, 52872 or 26908 antibodies. Diagnostic and therapeutic methods utilizing compositions of the invention are also provided.

摘要翻译： 本发明提供分离的核酸分子，命名为18636,2466,43238,1983,52881,29898,45449,50289,52872和26908核酸分子。 本发明还提供反义核酸分子，含有18636,2466,43238,1983,52881,29898,45449,502892,5282和26908核酸分子的重组表达载体，已经引入表达载体的宿主细胞和非人转基因 引入或破坏18636,2466,43238,1983,52881,2398,45449,50289,52872或26908基因的动物。 本发明还进一步提供了分离的18636,2466,43238,1983,52881,2398,45449,50289,52872或26908蛋白，融合蛋白，抗原肽和抗-18636,2466,43238,1983,52881,29898,45449,50289 ，52872或26908抗体。 还提供了利用本发明组合物的诊断和治疗方法。

公开(公告)号：US20090226451A1

公开(公告)日：2009-09-10

申请号：US12387287

申请日：2009-04-28

申请人： Maria A. Glucksmann ,  Inmaculada Silos-Santiago ,  Joseph M. Carroll ,  Katherine M. Galvin

发明人： Maria A. Glucksmann ,  Inmaculada Silos-Santiago ,  Joseph M. Carroll ,  Katherine M. Galvin

IPC分类号： A61K39/395 ,  C12N15/11 ,  C12N5/00 ,  C07K14/00 ,  C07K16/18 ,  C12P21/02 ,  G01N33/00 ,  G01N33/68 ,  G01N33/566 ,  C12Q1/68 ,  A61K38/02 ,  A61K38/16 ,  A61K31/7088

CPC分类号： C07K14/47 ,  C07K14/705 ,  Y10T436/143333

摘要： The invention provides isolated nucleic acids molecules, designated 18636, 2466, 43238, 1983, 52881, 2398, 45449, 50289, 52872 and 26908 nucleic acid molecules. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 18636, 2466, 43238, 1983, 52881, 2398, 45449, 50289, 52872 and 26908 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a 18636, 2466, 43238, 1983, 52881, 2398, 45449, 50289, 52872 or 26908 gene has been introduced or disrupted. The invention still further provides isolated 18636, 2466, 43238, 1983, 52881, 2398, 45449, 50289, 52872 or 26908 proteins, fusion proteins, antigenic peptides and anti-18636, 2466, 43238, 1983, 52881, 2398, 45449, 50289, 52872 or 26908 antibodies. Diagnostic and therapeutic methods utilizing compositions of the invention are also provided.

摘要翻译： 本发明提供分离的核酸分子，命名为18636,2466,43238,1983,52881,29898,45449,50289,52872和26908核酸分子。 本发明还提供反义核酸分子，含有18636,2466,43238,1983,52881,29898,45449,502892,5282和26908核酸分子的重组表达载体，已经引入表达载体的宿主细胞和非人转基因 引入或破坏18636,2466,43238,1983,52881,2398,45449,50289,52872或26908基因的动物。 本发明还进一步提供了分离的18636,2466,43238,1983,52881,2398,45449,50289,52872或26908蛋白，融合蛋白，抗原肽和抗-18636,2466,43238,1983,52881,29898,45449,50289 ，52872或26908抗体。 还提供了利用本发明组合物的诊断和治疗方法。

公开(公告)号：US07696316B2

公开(公告)日：2010-04-13

申请号：US11583766

申请日：2006-10-19

申请人： Rosana Kapeller-Libermann ,  John Joseph Hunter ,  Rachel E. Meyers ,  Laura A. Rudolph-Owen ,  Rory A. J. Curtis ,  Peter J. Olandt ,  Fong-Ying Tsai ,  Katherine M. Galvin ,  Miyoung Chun ,  Mark J. Williamson ,  Inmaculada Silos-Santiago ,  Rajasekhar Bandaru

发明人： Rosana Kapeller-Libermann ,  John Joseph Hunter ,  Rachel E. Meyers ,  Laura A. Rudolph-Owen ,  Rory A. J. Curtis ,  Peter J. Olandt ,  Fong-Ying Tsai ,  Katherine M. Galvin ,  Miyoung Chun ,  Mark J. Williamson ,  Inmaculada Silos-Santiago ,  Rajasekhar Bandaru

IPC分类号： C07K14/00 ,  C07H21/04 ,  C12P21/04 ,  C12P21/06

CPC分类号： C07K14/47 ,  A01K2217/05 ,  C12N9/1235

摘要： The invention provides isolated nucleic acids molecules, designated 21910, 56634, 55053, 2504, 15977, 14760, 25501, 17903, 3700, 21529, 26176, 26343, 56638, 18610, 33217, 21967, h1983, m1983, 38555 and 593 nucleic acid molecules. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 21910, 56634, 55053, 2504, 15977, 14760, 25501, 17903, 3700, 21529, 26176, 26343, 56638, 18610, 33217, 21967, h1983, m1983, 38555 and 593 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a 21910, 56634, 55053, 2504, 15977, 14760, 25501, 17903, 3700, 21529, 26176, 26343, 56638, 18610, 33217, 21967, h1983, m1983, 38555 or 593 gene has been introduced or disrupted. The invention still further provides isolated 21910, 56634, 55053, 2504, 15977, 14760, 25501, 17903, 3700, 21529, 26176, 26343, 56638, 18610, 33217, 21967, h1983, m1983, 38555 or 593 proteins, fusion proteins, antigenic peptides and anti-21910, 56634, 55053, 2504, 15977, 14760, 25501, 17903, 3700, 21529, 26176, 26343, 56638, 18610, 33217, 21967, h1983, m1983, 38555 or 593 antibodies. Diagnostic and therapeutic methods utilizing compositions of the invention are also provided.

摘要翻译： 本发明提供分离的核酸分子，命名为21910,5663,55053,2504,15977,14760,25501,17903,3720,21529,26176,26343,5663,18610,33217,21967，h1983，m1983,38555和593核酸 分子。 本发明还提供反义核酸分子，含有21910,5663,55053,2504,15977,14760,25501,17903,3700,21529,26176,26343,5663,18610,33217,21967，h1983，m1983,3855的重组表达载体 和593个核酸分子，其中引入了表达载体的宿主细胞，以及非人类转基因动物，其中21910,5663,5553,2504,15977,14760,25501,17903,3720,21529,26176， 已经引入或破坏了18610,33217,21967，h1983，m1983,38555或593基因。 本发明还进一步提供分离的21910,5563,4560,25501,17903,3720,21529,26176,26343,5663,18610,33217,21967，h1983，m1983,38555或593蛋白，融合蛋白， 抗原肽和抗-19910,563634,55053,2504,15977,14760,25501,17903,3720,21529,26176,26343,56638,18610,33217,21967，h1983，m1983,38555或593抗体。 还提供了利用本发明组合物的诊断和治疗方法。

公开(公告)号：US06939698B2

公开(公告)日：2005-09-06

申请号：US10074527

申请日：2002-02-12

申请人： Peter J. Olandt ,  Rachel E. Meyers ,  Katherine M. Galvin

发明人： Peter J. Olandt ,  Rachel E. Meyers ,  Katherine M. Galvin

IPC分类号： C12N9/10 ,  C12Q1/48 ,  G01N33/573 ,  C12P21/06 ,  C07H21/04 ,  C12N9/00

CPC分类号： G01N33/573 ,  C12N9/1048 ,  C12Q1/48 ,  G01N2333/91091 ,  G01N2500/00 ,  G01N2500/04 ,  G01N2500/20

摘要： The invention provides isolated nucleic acids molecules, designated 33945 nucleic acid molecules, which encode novel glycosyltransferase family members. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 33945 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a 33945 gene has been introduced or disrupted. The invention still further provides isolated 33945 proteins, fusion proteins, antigenic peptides and anti-33945 antibodies. Diagnostic and therapeutic methods utilizing compositions of the invention are also provided.

摘要翻译： 本发明提供编码新的糖基转移酶家族成员的分离的核酸分子，命名为33945核酸分子。 本发明还提供了反义核酸分子，含有33945个核酸分子的重组表达载体，其中引入了表达载体的宿主细胞，以及引入或破坏了33945基因的非人转基因动物。 本发明还进一步提供了分离的33945蛋白，融合蛋白，抗原肽和抗33945抗体。 还提供了利用本发明组合物的诊断和治疗方法。