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    NOVEL 18636, 2466, 43238, 1983, 52881, 2398, 45449, 50289, 52872 AND 26908 MOLECULES AND USES THEREFOR
    1.
    发明申请
    NOVEL 18636, 2466, 43238, 1983, 52881, 2398, 45449, 50289, 52872 AND 26908 MOLECULES AND USES THEREFOR 审中-公开
    NO 18636,2466,43238,1983,52881,29898,45449,50289,52872和26908分子及其用途

    公开(公告)号：US20110165147A1

    公开(公告)日：2011-07-07

    申请号：US13037699

    申请日：2011-03-01

    申请人： Maria A. Glucksmann ,  Inmaculada Silos-Santiago ,  Joseph M. Carroll ,  Katherine M. Galvin

    发明人： Maria A. Glucksmann ,  Inmaculada Silos-Santiago ,  Joseph M. Carroll ,  Katherine M. Galvin

    IPC分类号： A61K39/395 ,  C07H21/04 ,  C12N5/10 ,  C07K14/00 ,  C07K16/00 ,  C12P21/02 ,  C12Q1/68 ,  G01N33/00 ,  G01N33/53 ,  A61K38/00 ,  A61K38/16 ,  A61K31/711 ,  A61P43/00

    CPC分类号： C07K14/47 ,  C07K14/705 ,  Y10T436/143333

    摘要： The invention provides isolated nucleic acids molecules, designated 18636, 2466, 43238, 1983, 52881, 2398, 45449, 50289, 52872 and 26908 nucleic acid molecules. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 18636, 2466, 43238, 1983, 52881, 2398, 45449, 50289, 52872 and 26908 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a 18636, 2466, 43238, 1983, 52881, 2398, 45449, 50289, 52872 or 26908 gene has been introduced or disrupted. The invention still further provides isolated 18636, 2466, 43238, 1983, 52881, 2398, 45449, 50289, 52872 or 26908 proteins, fusion proteins, antigenic peptides and anti-18636, 2466, 43238, 1983, 52881, 2398, 45449, 50289, 52872 or 26908 antibodies. Diagnostic and therapeutic methods utilizing compositions of the invention are also provided.

    摘要翻译： 本发明提供分离的核酸分子，命名为18636,2466,43238,1983,52881,29898,45449,50289,52872和26908核酸分子。 本发明还提供反义核酸分子，含有18636,2466,43238,1983,52881,29898,45449,502892,5282和26908核酸分子的重组表达载体，已经引入表达载体的宿主细胞和非人转基因 引入或破坏18636,2466,43238,1983,52881,2398,45449,50289,52872或26908基因的动物。 本发明还进一步提供了分离的18636,2466,43238,1983,52881,2398,45449,50289,52872或26908蛋白，融合蛋白，抗原肽和抗-18636,2466,43238,1983,52881,29898,45449,50289 ，52872或26908抗体。 还提供了利用本发明组合物的诊断和治疗方法。

    Novel 18636, 2466, 43238, 1983, 52881, 2398, 45449, 50289, 52872 and 26908 molecules and uses therefor
    2.
    发明申请
    Novel 18636, 2466, 43238, 1983, 52881, 2398, 45449, 50289, 52872 and 26908 molecules and uses therefor 审中-公开
    小分子18636,2446,43238,1983,52881,29898,45449,50289,52872和26908分子及其用途

    公开(公告)号：US20090226451A1

    公开(公告)日：2009-09-10

    申请号：US12387287

    申请日：2009-04-28

    申请人： Maria A. Glucksmann ,  Inmaculada Silos-Santiago ,  Joseph M. Carroll ,  Katherine M. Galvin

    发明人： Maria A. Glucksmann ,  Inmaculada Silos-Santiago ,  Joseph M. Carroll ,  Katherine M. Galvin

    IPC分类号： A61K39/395 ,  C12N15/11 ,  C12N5/00 ,  C07K14/00 ,  C07K16/18 ,  C12P21/02 ,  G01N33/00 ,  G01N33/68 ,  G01N33/566 ,  C12Q1/68 ,  A61K38/02 ,  A61K38/16 ,  A61K31/7088

    CPC分类号： C07K14/47 ,  C07K14/705 ,  Y10T436/143333

    摘要： The invention provides isolated nucleic acids molecules, designated 18636, 2466, 43238, 1983, 52881, 2398, 45449, 50289, 52872 and 26908 nucleic acid molecules. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 18636, 2466, 43238, 1983, 52881, 2398, 45449, 50289, 52872 and 26908 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a 18636, 2466, 43238, 1983, 52881, 2398, 45449, 50289, 52872 or 26908 gene has been introduced or disrupted. The invention still further provides isolated 18636, 2466, 43238, 1983, 52881, 2398, 45449, 50289, 52872 or 26908 proteins, fusion proteins, antigenic peptides and anti-18636, 2466, 43238, 1983, 52881, 2398, 45449, 50289, 52872 or 26908 antibodies. Diagnostic and therapeutic methods utilizing compositions of the invention are also provided.

    摘要翻译： 本发明提供分离的核酸分子，命名为18636,2466,43238,1983,52881,29898,45449,50289,52872和26908核酸分子。 本发明还提供反义核酸分子，含有18636,2466,43238,1983,52881,29898,45449,502892,5282和26908核酸分子的重组表达载体，已经引入表达载体的宿主细胞和非人转基因 引入或破坏18636,2466,43238,1983,52881,2398,45449,50289,52872或26908基因的动物。 本发明还进一步提供了分离的18636,2466,43238,1983,52881,2398,45449,50289,52872或26908蛋白，融合蛋白，抗原肽和抗-18636,2466,43238,1983,52881,29898,45449,50289 ，52872或26908抗体。 还提供了利用本发明组合物的诊断和治疗方法。

    Novel 18607, 15603, 69318, 12303, 48000, 52920, 5433, 38554, 57301, 58324, 55063, 52991, 59914, 59921 and 33751 molecules and uses therefor
    3.
    发明申请
    Novel 18607, 15603, 69318, 12303, 48000, 52920, 5433, 38554, 57301, 58324, 55063, 52991, 59914, 59921 and 33751 molecules and uses therefor 审中-公开
    小分子18607,15603,69318,12303,48000,52202,5333,38554,57301,58324,55063,52991,59914,59921和33751分子及其用途

    公开(公告)号：US20090226448A1

    公开(公告)日：2009-09-10

    申请号：US12381747

    申请日：2009-03-16

    申请人： Maria A. Glucksmann ,  Rory A.J. Curtis ,  Jose M. Lora ,  Katherine M. Galvin ,  Inmaculada Silos-Santiago

    发明人： Maria A. Glucksmann ,  Rory A.J. Curtis ,  Jose M. Lora ,  Katherine M. Galvin ,  Inmaculada Silos-Santiago

    IPC分类号： A61K39/395 ,  C12N15/12 ,  C12N5/10 ,  C07K14/47 ,  C07K16/18 ,  C12P21/02 ,  C12Q1/68 ,  G01N33/566 ,  A61K31/7105 ,  A61K38/48 ,  A61K38/17 ,  A61P35/00 ,  A61P43/00

    CPC分类号： C07K14/705 ,  A61K38/00

    摘要： The invention provides isolated nucleic acids molecules, designated 18607, 15603, 69318, 12303, 48000, 52920, 5433, 38554, 57301, 58324, 55063, 52991, 59914, 59921 and 33751 nucleic acid molecules. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 18607, 15603, 69318, 12303, 48000, 52920, 5433, 38554, 57301, 58324, 55063, 52991, 59914, 59921 and 33751 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a 18607, 15603, 69318, 12303, 48000, 52920, 5433, 38554, 57301, 58324, 55063, 52991, 59914, 59921 or 33751 gene has been introduced or disrupted. The invention still further provides isolated 18607, 15603, 69318, 12303, 48000, 52920, 5433, 38554, 57301, 58324, 55063, 52991, 59914, 59921 or 33751 proteins, fusion proteins, antigenic peptides and anti-18607, 15603, 69318, 12303, 48000, 52920, 5433, 38554, 57301, 58324, 55063, 52991, 59914, 59921 or 33751 antibodies. Diagnostic and therapeutic methods utilizing compositions of the invention are also provided.

    摘要翻译： 本发明提供分离的核酸分子，命名为18607,15603,69318,12303,48000,52920,5433,38554,57301,58324,55063,52991,59914,59921和33751核酸分子。 本发明还提供反义核酸分子，包含18607,15603,69318,12303,48000,52920,5433,38554,57301,58324,55063,52991,59914,59921和33751核酸分子的重组表达载体，其中宿主细胞 已经引入了表达载体，并且已导入或破坏其中18607,15603,69318,12303,48000,523020,5433,35554,57301,58324,55063,52991,59914,59921或33751基因的非人转基因动物。 本发明还进一步提供了分离的18607,15603,69318,12303,48000,5920,5433,38554,57301,58324,55063,52991,59914,59921或33751蛋白，融合蛋白，抗原肽和抗-18607,15603,69318 ，12303,48000,5920,5433,38554,57301,58324,55063,52991,59914,59921或33751抗体。 还提供了利用本发明组合物的诊断和治疗方法。

    Novel 18607, 15603, 69318, 12303, 48000, 52920, 5433, 38554, 57301, 58324, 55063, 52991, 59914, 59921, and 33751 molecules and uses therefor
    4.
    发明申请
    Novel 18607, 15603, 69318, 12303, 48000, 52920, 5433, 38554, 57301, 58324, 55063, 52991, 59914, 59921, and 33751 molecules and uses therefor 审中-公开
    小分子18607,15603,69318,12303,48000,52202,5333,35554,57301,58324,55063,52991,59914,59921和33751分子及其用途

    公开(公告)号：US20090226449A1

    公开(公告)日：2009-09-10

    申请号：US12381748

    申请日：2009-03-16

    申请人： Maria A. Glucksmann ,  Rory A.J. Curtis ,  Jose M. Lora ,  Katherine M. Galvin ,  Inmaculada Silos-Santiago

    发明人： Maria A. Glucksmann ,  Rory A.J. Curtis ,  Jose M. Lora ,  Katherine M. Galvin ,  Inmaculada Silos-Santiago

    IPC分类号： A61K39/395 ,  C12N15/12 ,  C12N5/10 ,  C07K14/47 ,  C07K16/18 ,  C12P21/02 ,  C12Q1/68 ,  G01N33/566 ,  A61K38/17 ,  A61K31/7105 ,  A61K38/48 ,  A61P35/00 ,  A61P43/00

    CPC分类号： C07K14/705 ,  A61K38/00

    摘要： The invention provides isolated nucleic acids molecules, designated 18607, 15603, 69318, 12303, 48000, 52920, 5433, 38554, 57301, 58324, 55063, 52991, 59914, 59921 and 33751 nucleic acid molecules. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 18607, 15603, 69318, 12303, 48000, 52920, 5433, 38554, 57301, 58324, 55063, 52991, 59914, 59921 and 33751 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a 18607, 15603, 69318, 12303, 48000, 52920, 5433, 38554, 57301, 58324, 55063, 52991, 59914, 59921 or 33751 gene has been introduced or disrupted. The invention still further provides isolated 18607, 15603, 69318, 12303, 48000, 52920, 5433, 38554, 57301, 58324, 55063, 52991, 59914, 59921 or 33751 proteins, fusion proteins, antigenic peptides and anti-18607, 15603, 69318, 12303, 48000, 52920, 5433, 38554, 57301, 58324, 55063, 52991, 59914, 59921 or 33751 antibodies. Diagnostic and therapeutic methods utilizing compositions of the invention are also provided.

    摘要翻译： 本发明提供分离的核酸分子，命名为18607,15603,69318,12303,48000,52920,5433,38554,57301,58324,55063,52991,59914,59921和33751核酸分子。 本发明还提供反义核酸分子，包含18607,15603,69318,12303,48000,52920,5433,38554,57301,58324,55063,52991,59914,59921和33751核酸分子的重组表达载体，其中宿主细胞 已经引入了表达载体，并且已导入或破坏其中18607,15603,69318,12303,48000,523020,5433,35554,57301,58324,55063,52991,59914,59921或33751基因的非人转基因动物。 本发明还进一步提供了分离的18607,15603,69318,12303,48000,5920,5433,38554,57301,58324,55063,52991,59914,59921或33751蛋白，融合蛋白，抗原肽和抗-18607,15603,69318 ，12303,48000,5920,5433,38554,57301,58324,55063,52991,59914,59921或33751抗体。 还提供了利用本发明组合物的诊断和治疗方法。

    Methods and compositions for treating urological disorders using 1435, 559, 34021, 44099, 25278, 641, 260, 55089, 21407, 42032, 46656, 62553, 302, 323, 12303, 985, 13237, 13601, 18926, 318, 2058 or 6351 molecules
    8.
    发明申请
    Methods and compositions for treating urological disorders using 1435, 559, 34021, 44099, 25278, 641, 260, 55089, 21407, 42032, 46656, 62553, 302, 323, 12303, 985, 13237, 13601, 18926, 318, 2058 or 6351 molecules 审中-公开
    使用1435,549,34021,44099,25278,641,260,55089,21407,42032,4656,52553,302,323,12303,985,13237,13601,18926,318,2058或用于治疗泌尿系统疾病的方法和组合物或 6351分子

    公开(公告)号：US20060088881A1

    公开(公告)日：2006-04-27

    申请号：US11302678

    申请日：2005-12-14

    申请人： Inmaculada Silos-Santiago ,  Venkateswarlu Karicheti

    发明人： Inmaculada Silos-Santiago ,  Venkateswarlu Karicheti

    IPC分类号： C12Q1/68 ,  G01N33/53

    CPC分类号： C12Q1/6883 ,  C12Q2600/158

    摘要： The present invention relates to methods for the diagnosis and treatment of a urological disorder or urological disorders. Specifically, the present invention identifies the differential expression of 1435, 559, 34021, 44099, 25278, 641, 260, 55089, 21407, 42032, 46656, 62553, 302, 323, 12303, 985, 13237, 13601, 18926, 318, 2058 and 6351 genes in tissues relating to urological disorders, relative to their expression in normal, or non-urological disorders, and/or in response to manipulations relevant to a urological disorder. The present invention describes methods for the diagnostic evaluation and prognosis of various urological disorders, and for the identification of subjects exhibiting a predisposition to such conditions. The invention also provides methods for identifying a compound capable of modulating a urological disorder or urological disorders. The present invention also provides methods for the identification and therapeutic use of compounds as treatments of urological disorders.

    摘要翻译： 本发明涉及诊断和治疗泌尿系统疾病或泌尿系统疾病的方法。 具体而言，本发明鉴别1435,549,34021,44099,25278,641,260,55089,21407,42032,4656,65353,302,232,12303,985,13237,13601,18926,318的差异表达， 相对于其在正常或非泌尿系统疾病中的表达和/或响应于与泌尿系统疾病相关的操作，与泌尿系统疾病相关的组织中的2058和6351个基因。 本发明描述了各种泌尿系统疾病的诊断评估和预后的方法，以及用于鉴定表现出这种病症倾向的受试者。 本发明还提供了鉴定能够调节泌尿系统疾病或泌尿系统疾病的化合物的方法。 本发明还提供了用于鉴定和治疗性使用化合物作为泌尿系统疾病治疗的方法。

    53010, a human carboxylesterase family member and uses thereof
    9.
    发明授权
    53010, a human carboxylesterase family member and uses thereof 失效
    53010，人羧酸酯酶家族成员及其用途

    公开(公告)号：US06664091B2

    公开(公告)日：2003-12-16

    申请号：US10023515

    申请日：2001-12-18

    申请人： Rory A. J. Curtis ,  Inmaculada Silos-Santiago

    发明人： Rory A. J. Curtis ,  Inmaculada Silos-Santiago

    IPC分类号： C12N918

    CPC分类号： C12N9/18

    摘要： The invention provides isolated nucleic acids molecules, designated 53010 nucleic acid molecules, which encode novel carboxylesterase members. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 53010 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a 53010 gene has been introduced or disrupted. The invention still further provides isolated 53010 proteins, fusion proteins, antigenic peptides and anti-53010 antibodies. Diagnostic methods utilizing compositions of the invention are also provided.

    摘要翻译： 本发明提供分离的核酸分子，命名为53010核酸分子，其编码新的羧酸酯酶成员。 本发明还提供了反义核酸分子，含有53010个核酸分子的重组表达载体，其中引入了表达载体的宿主细胞，以及53010基因被引入或破坏的非人转基因动物。 本发明还进一步提供了分离的53010蛋白，融合蛋白，抗原肽和抗-53010抗体。 还提供了利用本发明组合物的诊断方法。

    Methods and compositions for treating urological disorders using carboxypeptidase Z identified as 8263
    10.
    发明授权
    Methods and compositions for treating urological disorders using carboxypeptidase Z identified as 8263 有权
    使用羧肽酶Z鉴定为8263的泌尿系统疾病的方法和组合物

    公开(公告)号：US07258971B2

    公开(公告)日：2007-08-21

    申请号：US10757262

    申请日：2004-01-14

    申请人： Venkateswarlu Karicheti ,  Inmaculada Silos-Santiago ,  Scott D. Eliasof

    发明人： Venkateswarlu Karicheti ,  Inmaculada Silos-Santiago ,  Scott D. Eliasof

    IPC分类号： C12Q1/00 ,  A61K39/00

    CPC分类号： C07K14/47

    摘要： The present invention relates to methods for the diagnosis and treatment of a urological disorder or urological disorders. Specifically, the present invention identifies the differential expression of Carboxypeptidase Z, identified as “8263” gene in tissues relating to urological disorder, relative to their expression in normal, or non-urological disorder disease states, and/or in response to manipulations relevant to a urological disorder. The present invention describes methods for the diagnostic evaluation and prognosis of various urological diseases, and for the identification of subjects exhibiting a predisposition to such conditions. The invention also provides methods for identifying a compound capable of modulating a urological disorder or urological disorders. The present invention also provides methods for the identification and therapeutic use of compounds as treatments of urological disorders.

    摘要翻译： 本发明涉及诊断和治疗泌尿系统疾病或泌尿系统疾病的方法。 具体而言，本发明鉴定了相对于在正常或非泌尿疾病疾病状态下的表达，和/或响应于与泌尿系疾病相关的操作相关的与泌尿系疾病相关的组织中鉴定为“8263”基因的羧肽酶Z的差异表达 泌尿系统疾病 本发明描述了各种泌尿疾病的诊断评估和预后的方法，以及用于鉴定表现出这种病症倾向的受试者。 本发明还提供了鉴定能够调节泌尿系统疾病或泌尿系统疾病的化合物的方法。 本发明还提供了用于鉴定和治疗性使用化合物作为泌尿系统疾病治疗的方法。