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1.发明授权21910, 56634, 55053, 2504, 15977, 14760, 25501, 17903, 3700, 21529, 26176, 26343, 56638, 18610, 33217, 21967, H1983, M1983, 38555 or 593 molecules and uses therefor 失效21910,5563,4505,2504,15977,14760,25501,17903,3720,21529,26176,26343,5666,18610,33217,26967，H1983，M1983,38555或593分子及其用途公开(公告)号：US07696316B2
公开(公告)日：2010-04-13
申请号：US11583766
申请日：2006-10-19
申请人： Rosana Kapeller-Libermann , John Joseph Hunter , Rachel E. Meyers , Laura A. Rudolph-Owen , Rory A. J. Curtis , Peter J. Olandt , Fong-Ying Tsai , Katherine M. Galvin , Miyoung Chun , Mark J. Williamson , Inmaculada Silos-Santiago , Rajasekhar Bandaru
发明人： Rosana Kapeller-Libermann , John Joseph Hunter , Rachel E. Meyers , Laura A. Rudolph-Owen , Rory A. J. Curtis , Peter J. Olandt , Fong-Ying Tsai , Katherine M. Galvin , Miyoung Chun , Mark J. Williamson , Inmaculada Silos-Santiago , Rajasekhar Bandaru
CPC分类号： C07K14/47 , A01K2217/05 , C12N9/1235
摘要： The invention provides isolated nucleic acids molecules, designated 21910, 56634, 55053, 2504, 15977, 14760, 25501, 17903, 3700, 21529, 26176, 26343, 56638, 18610, 33217, 21967, h1983, m1983, 38555 and 593 nucleic acid molecules. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 21910, 56634, 55053, 2504, 15977, 14760, 25501, 17903, 3700, 21529, 26176, 26343, 56638, 18610, 33217, 21967, h1983, m1983, 38555 and 593 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a 21910, 56634, 55053, 2504, 15977, 14760, 25501, 17903, 3700, 21529, 26176, 26343, 56638, 18610, 33217, 21967, h1983, m1983, 38555 or 593 gene has been introduced or disrupted. The invention still further provides isolated 21910, 56634, 55053, 2504, 15977, 14760, 25501, 17903, 3700, 21529, 26176, 26343, 56638, 18610, 33217, 21967, h1983, m1983, 38555 or 593 proteins, fusion proteins, antigenic peptides and anti-21910, 56634, 55053, 2504, 15977, 14760, 25501, 17903, 3700, 21529, 26176, 26343, 56638, 18610, 33217, 21967, h1983, m1983, 38555 or 593 antibodies. Diagnostic and therapeutic methods utilizing compositions of the invention are also provided.
摘要翻译： 本发明提供分离的核酸分子，命名为21910,5663,55053,2504,15977,14760,25501,17903,3720,21529,26176,26343,5663,18610,33217,21967，h1983，m1983,38555和593核酸 分子。 本发明还提供反义核酸分子，含有21910,5663,55053,2504,15977,14760,25501,17903,3700,21529,26176,26343,5663,18610,33217,21967，h1983，m1983,3855的重组表达载体 和593个核酸分子，其中引入了表达载体的宿主细胞，以及非人类转基因动物，其中21910,5663,5553,2504,15977,14760,25501,17903,3720,21529,26176， 已经引入或破坏了18610,33217,21967，h1983，m1983,38555或593基因。 本发明还进一步提供分离的21910,5563,4560,25501,17903,3720,21529,26176,26343,5663,18610,33217,21967，h1983，m1983,38555或593蛋白，融合蛋白， 抗原肽和抗-19910,563634,55053,2504,15977,14760,25501,17903,3720,21529,26176,26343,56638,18610,33217,21967，h1983，m1983,38555或593抗体。 还提供了利用本发明组合物的诊断和治疗方法。
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2.发明申请Novel 13237, 18480, 2245, 16228, 7677, 26320, 46619, 33166, 16836, 46867, 21617, 55562, 39228, 62088, 46745, 23155, 21657, 42755, 32229, 22325, 46863 and 32252 molecules and uses therefor 失效小分子13237,18480,2245,16228,7677,26320,46169,36166,16836,46867,21617,55562,39228,62088,4675,23155,26657,42755,32229,22325,46863和32252分子及其用途公开(公告)号：US20090263860A1
公开(公告)日：2009-10-22
申请号：US11980299
申请日：2007-10-30
申请人： Rachel E. Meyers , Mark J. Williamson , Rosana Kapeller-Libermann , Kyle J. MacBeth , John Joseph Hunter , Laura A. Rudolph-Owen , Rajasekhar Bandaru , Fong-Ying Tsai
发明人： Rachel E. Meyers , Mark J. Williamson , Rosana Kapeller-Libermann , Kyle J. MacBeth , John Joseph Hunter , Laura A. Rudolph-Owen , Rajasekhar Bandaru , Fong-Ying Tsai
CPC分类号： C12N9/1205 , A01K2217/05 , A61K48/00 , C07K2319/00
摘要： The invention provides isolated nucleic acids molecules, designated 13237, 18480, 2245, 16228, 7677, 26320, 46619, 33166, 16836, 46867, 21617, 55562, 39228, 62088, 46745, 23155, 21657, 42755, 32229, 22325, 46863 and 32252 nucleic acid molecules. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 13237, 18480, 2245, 16228, 7677, 26320, 46619, 33166, 16836, 46867, 21617, 55562, 39228, 62088, 46745, 23155, 21657, 42755, 32229, 22325, 46863 and 32252 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a 13237, 18480, 2245, 16228, 7677, 26320, 46619, 33166, 16836, 46867, 21617, 55562, 39228, 62088, 46745, 23155, 21657, 42755, 32229, 22325, 46863 or 32252 gene has been introduced or disrupted. The invention still further provides isolated 13237, 18480, 2245, 16228, 7677, 26320, 46619, 33166, 16836, 46867, 21617, 55562, 39228, 62088, 46745, 23155, 21657, 42755, 32229, 22325, 46863 or 32252 proteins, fusion proteins, antigenic peptides and anti-13237, 18480, 2245, 16228, 7677, 26320, 46619, 33166, 16836, 46867, 21617, 55562, 39228, 62088, 46745, 23155, 21657, 42755, 32229, 22325, 46863 or 32252 antibodies. Diagnostic and therapeutic methods utilizing compositions of the invention are also provided.
摘要翻译： 本发明提供分离的核酸分子，命名为13237,18480,2225,16228,7677,26320,4619,33166,16836,46867,21617,55562,39228,62088,46745,23155,21657,42755,32229,22325,46863 和32252个核酸分子。 本发明还提供反义核酸分子，重组表达载体，其含有13237,18480,2245,16228,7677,26320,4619,33166,16836,46867,21617,55562,39228,62088,46745,23155,216575,42755,32229 ，22325,46863和32252核酸分子，其中引入了表达载体的宿主细胞，以及非人类转基因动物，其中13237,18480,2362,46169,3677,26320,46869,38166,16836,46867,21617,26173,26169， 已经引入或破坏了55562,39228,62088,4675,23155,21657,42755,32229,22325,46863或32252基因。 本发明还进一步提供分离的13237,18480,2225,16228,7677,26320,4619,33166,16836,46867,21617,55562,39228,62088,46745,23155,21657,42755,32229,22325,46863或32252蛋白质 ，融合蛋白，抗原肽和抗-13237,18480,2225,16228,7677,26320,4619,33166,16836,46867,21617,55562,39228,62088,46745,23155,216547,42755,32229,22325,46863 或32252抗体。 还提供了利用本发明组合物的诊断和治疗方法。
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3.发明申请Novel 25869, 25934, 26335, 50365, 21117, 38692, 46508, 16816, 16839, 49937, 49931 and 49933 molecules and uses therefor 失效小分子25869,25934,26335,5049,21117,38692,46508,16816,16839,49937,49931和49933分子及其用途公开(公告)号：US20080241133A1
公开(公告)日：2008-10-02
申请号：US12150094
申请日：2008-04-24
申请人： Rory A. J. Curtis , Thomas Joseph Logan , Maria Alexandra Glucksmann , Rachel E. Meyers , Mark J. Williamson , Laura A. Rudolph-Owen , Miyoung Chun , Fong-Ying Tsai
发明人： Rory A. J. Curtis , Thomas Joseph Logan , Maria Alexandra Glucksmann , Rachel E. Meyers , Mark J. Williamson , Laura A. Rudolph-Owen , Miyoung Chun , Fong-Ying Tsai
IPC分类号： A61K39/395 , C12N15/11 , C12N5/06 , C07K14/00 , C07K16/18 , A61K31/70 , A61P43/00 , C12P21/04 , G01N33/566 , C12Q1/68 , A61K38/00
CPC分类号： C07K14/705 , A01K2217/05 , A61K38/00 , C07K14/395 , C07K14/43545 , C07K14/43581 , C07K14/43595 , C07K14/463 , C07K14/465 , C07K14/47 , C07K2319/00 , C12N9/00 , C12N9/0071 , C12N9/0083 , C12N9/1205 , C12N9/18 , C12N9/20 , C12N9/88 , C12N2310/3513 , C12Y207/01001 , C12Y301/04003
摘要： The invention provides isolated nucleic acids molecules, designated 25869, 25934, 26335, 50365, 21117, 38692, 46508, 16816, 16839, 49937, 49931 and 49933 nucleic acid molecules. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 25869, 25934, 26335, 50365, 21117, 38692, 46508, 16816, 16839, 49937, 49931 or 49933 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a 25869, 25934, 26335, 50365, 21117, 38692, 46508, 16816, 16839, 49937, 49931 or 49933 gene has been introduced or disrupted. The invention still further provides isolated 25869, 25934, 26335, 50365, 21117, 38692, 46508, 16816, 16839, 49937, 49931 or 49933 proteins, fusion proteins, antigenic peptides and anti-25869, 25934, 26335, 50365, 21117, 38692, 46508, 16816, 16839, 49937, 49931 or 49933 antibodies. Diagnostic and therapeutic methods utilizing compositions of the invention are also provided.
摘要翻译： 本发明提供分离的核酸分子，命名为25869,25934,26335,50516,21117,38692,46508,16816,16839,49937,49931和49933核酸分子。 本发明还提供反义核酸分子，包含25869,25934,26335,50521,21117,38692,46508,16816,16839,4467,49931或49933核酸分子的重组表达载体，已经引入了表达载体的宿主细胞 ，以及引入或破坏25869,25934,26335,50365,21117,38692,46508,16816,16839,49937,49931或49933基因的非人转基因动物。 本发明还进一步提供了分离的25869,2593,26335,50365,21117,38692,46508,16816,16839,49937,49931或49933蛋白，融合蛋白，抗原肽和抗-25869,25934,26335,50365,211117,38692 ，46508,16816,16839,49937,49931或49933抗体。 还提供了利用本发明组合物的诊断和治疗方法。
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4.发明申请NOVEL 25869, 25934, 26335, 50365, 21117, 38692, 46508, 16816, 16839, 49937, 49931 AND 49933 MOLECULES AND USES THEREFOR 审中-公开新型25869,25934,26335,50365,211117,38692,46508,16816,16839,49937,49931和49933分子及其用途公开(公告)号：US20110150860A1
公开(公告)日：2011-06-23
申请号：US12755449
申请日：2010-04-07
申请人： Rory A.J. Curtis , Thomas Joseph Logan , Maria Alexandra Glucksmann , Rachel E. Meyers , Mark J. Williamson , Laura A. Rudolph-Owen , Miyoung Chun , Fong-Ying Tsai
发明人： Rory A.J. Curtis , Thomas Joseph Logan , Maria Alexandra Glucksmann , Rachel E. Meyers , Mark J. Williamson , Laura A. Rudolph-Owen , Miyoung Chun , Fong-Ying Tsai
IPC分类号： A61K39/395 , C07H21/04 , C07K14/00 , C07K16/00 , C12P21/06 , G01N33/53 , G01N33/48 , G01N33/50 , C12N5/10 , A61K31/711 , A61K38/16 , A61K31/7088 , A61P35/00 , A61P3/00 , A61P7/00 , A61P19/00 , A61P25/00 , A61P31/12
CPC分类号： C07K14/47 , A61K38/00 , G01N2500/00 , Y10T436/143333
摘要： The invention provides isolated nucleic acids molecules, designated 25869, 25934, 26335, 50365, 21117, 38692, 46508, 16816, 16839, 49937, 49931 and 49933 nucleic acid molecules. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 25869, 25934, 26335, 50365, 21117, 38692, 46508, 16816, 16839, 49937, 49931 or 49933 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a 25869, 25934, 26335, 50365, 21117, 38692, 46508, 16816, 16839, 49937, 49931 or 49933 gene has been introduced or disrupted. The invention still further provides isolated 25869, 25934, 26335, 50365, 21117, 38692, 46508, 16816, 16839, 49937, 49931 or 49933 proteins, fusion proteins, antigenic peptides and anti-25869, 25934, 26335, 50365, 21117, 38692, 46508, 16816, 16839, 49937, 49931 or 49933 antibodies. Diagnostic and therapeutic methods utilizing compositions of the invention are also provided.
摘要翻译： 本发明提供分离的核酸分子，命名为25869,25934,26335,50516,21117,38692,46508,16816,16839,49937,49931和49933核酸分子。 本发明还提供反义核酸分子，包含25869,25934,26335,50521,21117,38692,46508,16816,16839,4467,49931或49933核酸分子的重组表达载体，已经引入了表达载体的宿主细胞 ，以及引入或破坏25869,25934,26335,50365,21117,38692,46508,16816,16839,49937,49931或49933基因的非人类转基因动物。 本发明还进一步提供了分离的25869,2593,26335,50365,21117,38692,46508,16816,16839,49937,49931或49933蛋白，融合蛋白，抗原肽和抗-25869,25934,26335,50365,211117,38692 ，46508,16816,16839,49937,49931或49933抗体。 还提供了利用本发明组合物的诊断和治疗方法。
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5.发明申请NOVEL 27411, 23413, 22438, 23553, 25278, 26212, NARC SC1, NARC 10A, NARC 1, NARC 12, NARC 13, NARC17, NARC 25, NARC 3, NARC 4, NARC 7, NARC 8, NARC 11, NARC 14A, NARC 15, NARC 16, NARC 19, NARC 20, NARC 26, NARC 27, NARC 28, NARC 30, NARC 5, NARC 6, NARC 9, NARC 10C, NARC 8B, NARC 9, NARC2A, NARC 16B, NARC 1C, NARC 1A, NARC 25, 86604 AND 32222 MOLECULES AND USES THEREFOR 审中-公开新的27411,23413,22438,23553,25278,26212，NARC SC1，NARC 10A，NARC 1，NARC 12，NARC 13，NARC 17，NARC 25，NARC 3，NARC 4，NARC 7，NARC 8，NARC 11，NARC 14A ，NARC 15，NARC 16，NARC 19，NARC 20，NARC 26，NARC 27，NARC 28，NARC 30，NARC 5，NARC 6，NARC 9，NARC 10C，NARC 8B，NARC 9，NARC2A，NARC 16B，NARC 1C ，NARC 1A，NARC 25,86604和32222分子及其用途公开(公告)号：US20100291099A1
公开(公告)日：2010-11-18
申请号：US12817236
申请日：2010-06-17
申请人： Maria A. Glucksmann , Mark J. Williamson , Fong-Ying Tsai , Laura A. Rudolph-Owen , Rosanna Kapeller-Libermann , Rachel E. Meyers , Lillian Wei-Ming Chiang , John Joseph Hunter
发明人： Maria A. Glucksmann , Mark J. Williamson , Fong-Ying Tsai , Laura A. Rudolph-Owen , Rosanna Kapeller-Libermann , Rachel E. Meyers , Lillian Wei-Ming Chiang , John Joseph Hunter
IPC分类号： A61K39/395 , A61K38/45 , C12Q1/68 , G01N33/53 , C12P21/02 , C12N9/12 , C12N5/10 , C12N1/21 , G01N33/566 , A61K38/17 , A61K31/7088 , C07K14/47 , C07K16/18 , C07H21/04 , A61P35/00 , A61P11/00 , A61P13/08 , A61P1/16 , A61P9/04 , A61P9/10 , A61P25/28 , A61P25/16 , A61P17/00 , A61P35/02
CPC分类号： C12Q1/48 , C12N9/1288 , C12Q1/6883 , C12Q2600/112 , C12Q2600/136 , C12Q2600/158 , C12Y207/08005 , G01N2333/91 , G01N2500/00
摘要： The invention provides isolated nucleic acids molecules and proteins, designated 27411, 23413, 22438, 23553, 25278, 26212, NARC SC1, NARC 20A, NARC 1, NARC 12, NARC 13, NARC17, NARC 25, NARC 3, NARC 4, NARC 7, NARC 8, NARC 11, NARC 14A, NARC 15, NARC 16, NARC 19, NARC 20, NARC 26, NARC 27, NARC 28, NARC 30, NARC 5, NARC 6, NARC 9, NARC 10C, NARC 8B, NARC 9, NARC2A, NARC 16B, NARC 1C, NARC 1A, NARC 25, 86604 and 32222 nucleic acid molecules and proteins. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing said nucleic acid molecules, host cells into which the expression vectors have been introduced, nonhuman transgenic animals in which a said genes have been introduced or disrupted, fusion proteins, antigenic peptides and antibodies to said proteins. Diagnostic and therapeutic methods utilizing compositions of the invention are also provided.
摘要翻译： 本发明提供分离的核酸分子和蛋白质，命名为27411,23413,22438,23553,25278,26212，NARC SC1，NARC 20A，NARC 1，NARC 12，NARC 13，NARC 17，NARC 25，NARC 3，NARC 4，NARC 7，NARC 8，NARC 11，NARC 14A，NARC 15，NARC 16，NARC 19，NARC 20，NARC 26，NARC 27，NARC 28，NARC 30，NARC 5，NARC 6，NARC 9，NARC 10C，NARC 8B， NARC 9，NARC2A，NARC 16B，NARC 1C，NARC 1A，NARC 25，86604和32222核酸分子和蛋白质。 本发明还提供了反义核酸分子，含有所述核酸分子的重组表达载体，其中引入了表达载体的宿主细胞，其中所述基因已导入或破坏的非人类转基因动物，融合蛋白，抗原肽和抗体 到蛋白质。 还提供了利用本发明组合物的诊断和治疗方法。
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公开(公告)号：US07029895B2
公开(公告)日：2006-04-18
申请号：US10426776
申请日：2003-04-30
申请人： Maria A. Glucksmann , Mark J. Williamson , Fong-Ying Tsai , Laura A. Rudolph-Owen , Rosanna Kapeller-Libermann , Rachel E. Meyers , Lillian Wei-Ming Chiang , John Joseph Hunter
发明人： Maria A. Glucksmann , Mark J. Williamson , Fong-Ying Tsai , Laura A. Rudolph-Owen , Rosanna Kapeller-Libermann , Rachel E. Meyers , Lillian Wei-Ming Chiang , John Joseph Hunter
CPC分类号： C12N9/1288 , A01K2217/05 , A61K38/00 , A61K47/6805 , A61K47/6809 , A61K47/6821 , A61K48/00 , A61K2039/505 , C07K14/4747 , C07K2319/00 , C12N9/14 , C12N9/16 , C12N9/6472 , G01N33/5011 , G01N33/57407 , G01N33/57484 , G01N2500/10
摘要： The invention provides isolated nucleic acids molecules and proteins, designated 27411, 23413, 22438, 23553, 25278, 26212, NARC SC1, NARC 10A, NARC 1, NARC 12, NARC 13, NARC 17, NARC 25, NARC 3, NARC 4, NARC 7, NARC 8, NARC 11, NARC 14A, NARC 15, NARC 16, NARC 19, NARC 20, NARC 26, NARC 27, NARC 28, NARC 30, NARC 5, NARC 6, NARC 9, NARC 10C, NARC 8B, NARC 9, NARC2A, NARC 16B, NARC 1C, NARC 1A, NARC 25, 86604 and 32222 nucleic acid molecules and proteins. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing said nucleic acid molecules, host cells into which the expression vectors have been introduced, nonhuman transgenic animals in which a said genes have been introduced or disrupted, fusion proteins, antigenic peptides and antibodies to said proteins. Diagnostic and therapeutic methods utilizing compositions of the invention are also provided.
摘要翻译： 本发明提供分离的核酸分子和蛋白质，命名为27411,23413,22438,23553,25278,26212，NARC SC1，NARC 10A，NARC 1，NARC 12，NARC 13，NARC 17，NARC 25，NARC 3，NARC 4， NARC 7，NARC 8，NARC 11，NARC 14A，NARC 15，NARC 16，NARC 19，NARC 20，NARC 26，NARC 27，NARC 28，NARC 30，NARC 5，NARC 6，NARC 9，NARC 10C，NARC 8B ，NARC 9，NARC2A，NARC 16B，NARC 1C，NARC 1A，NARC 25，86604和32222核酸分子和蛋白质。 本发明还提供了反义核酸分子，含有所述核酸分子的重组表达载体，其中引入了表达载体的宿主细胞，其中所述基因已导入或破坏的非人类转基因动物，融合蛋白，抗原肽和抗体 到蛋白质。 还提供了利用本发明组合物的诊断和治疗方法。
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7.发明申请Novel 27411, 23413, 22438, 23553, 25278, 26212, NARC SC1, NARC 10A, NARC 1, NARC 12, NARC 13, NARC17, NARC 25, NARC 3, NARC 4, NARC 7, NARC 8, NARC 11, NARC 14A, NARC 15, NARC 16, NARC 19, NARC 20, NARC 26, NARC 27, NARC 28, NARC 30, NARC 5, NARC 6, NARC 9, NARC 10C, NARC 8B, NARC 9, NARC2A, NARC 16B, NARC1C, NARC 1A, NARC 25, 86604 and 32222 molecules and uses therefor 失效新的27411,23413,22438,23553,25278,26212，NARC SC1，NARC 10A，NARC 1，NARC 12，NARC 13，NARC 17，NARC 25，NARC 3，NARC 4，NARC 7，NARC 8，NARC 11，NARC 14A ，NARC 15，NARC 16，NARC 19，NARC 20，NARC 26，NARC 27，NARC 28，NARC 30，NARC 5，NARC 6，NARC 9，NARC 10C，NARC 8B，NARC 9，NARC2A，NARC 16B，NARC1C， NARC 1A，NARC 25,86604和32222分子及其用途公开(公告)号：US20090269350A1
公开(公告)日：2009-10-29
申请号：US12316681
申请日：2008-12-16
申请人： Maria A. Glucksmann , Mark J. Williamson , Fong-Ying Tsai , Laura A. Rudolph-Owen , Rosanna Kapeller-Libermann , Rachel E. Meyers , Lillian Wei-Ming Chiang , John Joseph Hunter
发明人： Maria A. Glucksmann , Mark J. Williamson , Fong-Ying Tsai , Laura A. Rudolph-Owen , Rosanna Kapeller-Libermann , Rachel E. Meyers , Lillian Wei-Ming Chiang , John Joseph Hunter
IPC分类号： A61K39/395 , C07H21/04 , C12N5/00 , C07K14/00 , C07K16/00 , C12P21/06 , C12Q1/68 , G01N33/53 , A61K31/7088 , A61K38/16
CPC分类号： C12N9/1288 , A01K2217/05 , A61K38/00 , A61K47/6805 , A61K47/6809 , A61K47/6821 , A61K48/00 , A61K2039/505 , C07K14/4747 , C07K2319/00 , C12N9/14 , C12N9/16 , C12N9/6472 , G01N33/5011 , G01N33/57407 , G01N33/57484 , G01N2500/10
摘要： The invention provides isolated nucleic acids molecules and proteins, designated 27411, 23413, 22438, 23553, 25278, 26212, NARC SC1, NARC 20A, NARC 1, NARC 12, NARC 13, NARC17, NARC 25, NARC 3, NARC 4, NARC 7, NARC 8, NARC 11, NARC 14A, NARC 15, NARC 16, NARC 19, NARC 20, NARC 26, NARC 27, NARC 28, NARC 30, NARC 5, NARC 6, NARC 9, NARC 10C, NARC 8B, NARC 9, NARC2A, NARC 16B, NARC 1C, NARC 1A, NARC 25, 86604 and 32222 nucleic acid molecules and proteins. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing said nucleic acid molecules, host cells into which the expression vectors have been introduced, nonhuman transgenic animals in which a said genes have been introduced or disrupted, fusion proteins, antigenic peptides and antibodies to said proteins. Diagnostic and therapeutic methods utilizing compositions of the invention are also provided.
摘要翻译： 本发明提供分离的核酸分子和蛋白质，命名为27411,23413,22438,23553,25278,26212，NARC SC1，NARC 20A，NARC 1，NARC 12，NARC 13，NARC 17，NARC 25，NARC 3，NARC 4，NARC 7，NARC 8，NARC 11，NARC 14A，NARC 15，NARC 16，NARC 19，NARC 20，NARC 26，NARC 27，NARC 28，NARC 30，NARC 5，NARC 6，NARC 9，NARC 10C，NARC 8B， NARC 9，NARC2A，NARC 16B，NARC 1C，NARC 1A，NARC 25，86604和32222核酸分子和蛋白质。 本发明还提供了反义核酸分子，含有所述核酸分子的重组表达载体，其中引入了表达载体的宿主细胞，其中所述基因已导入或破坏的非人类转基因动物，融合蛋白，抗原肽和抗体 到蛋白质。 还提供了利用本发明组合物的诊断和治疗方法。
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公开(公告)号：US07482147B2
公开(公告)日：2009-01-27
申请号：US11313836
申请日：2005-12-21
申请人： Maria A. Glucksmann , Mark J. Williamson , Fong-Ying Tsai , Laura A. Rudolph-Owen , Rosanna Kapeller-Libermann , Rachel E. Meyers , Lillian Wei-Ming Chiang , John J. Hunter
发明人： Maria A. Glucksmann , Mark J. Williamson , Fong-Ying Tsai , Laura A. Rudolph-Owen , Rosanna Kapeller-Libermann , Rachel E. Meyers , Lillian Wei-Ming Chiang , John J. Hunter
CPC分类号： C12N9/1288 , A01K2217/05 , A61K38/00 , A61K47/6805 , A61K47/6809 , A61K47/6821 , A61K48/00 , A61K2039/505 , C07K14/4747 , C07K2319/00 , C12N9/14 , C12N9/16 , C12N9/6472 , G01N33/5011 , G01N33/57407 , G01N33/57484 , G01N2500/10
摘要： The invention provides isolated nucleic acids molecules and proteins, designated 27411, 23413, 22438, 23553, 25278, 26212, NARC SC1, NARC 10A, NARC 1, NARC 12, NARC 13, NARC17, NARC 25, NARC 3, NARC 4, NARC 7, NARC 8, NARC 11, NARC 14A, NARC 15, NARC 16, NARC 19, NARC 20, NARC 26, NARC 27, NARC 28, NARC 30, NARC 5, NARC 6, NARC 9, NARC 10C, NARC 8B, NARC 9, NARC2A, NARC 16B, NARC 1C, NARC 1A, NARC 25, 86604 and 32222 nucleic acid molecules and proteins. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing said nucleic acid molecules, host cells into which the expression vectors have been introduced, nonhuman transgenic animals in which a said genes have been introduced or disrupted, fusion proteins, antigenic peptides and antibodies to said proteins. Diagnostic and therapeutic methods utilizing compositions of the invention are also provided.
摘要翻译： 本发明提供分离的核酸分子和蛋白质，命名为27411,23413,22438,23553,25278,26212，NARC SC1，NARC 10A，NARC 1，NARC 12，NARC 13，NARC 17，NARC 25，NARC 3，NARC 4，NARC 7，NARC 8，NARC 11，NARC 14A，NARC 15，NARC 16，NARC 19，NARC 20，NARC 26，NARC 27，NARC 28，NARC 30，NARC 5，NARC 6，NARC 9，NARC 10C，NARC 8B， NARC 9，NARC2A，NARC 16B，NARC 1C，NARC 1A，NARC 25，86604和32222核酸分子和蛋白质。 本发明还提供了反义核酸分子，含有所述核酸分子的重组表达载体，其中引入了表达载体的宿主细胞，其中所述基因已导入或破坏的非人类转基因动物，融合蛋白，抗原肽和抗体 到蛋白质。 还提供了利用本发明组合物的诊断和治疗方法。
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9.发明申请Novel 27875, 22025, 27420, 17906, 16319, 55092 and 10218 molecules and uses therefor 审中-公开小分子27875,22025,27420,17906,16319,55092和10218分子及其用途公开(公告)号：US20100136010A1
公开(公告)日：2010-06-03
申请号：US12288465
申请日：2008-10-21
申请人： Rosana Kappeller-Libermann , David White , Keith E. Robison , Kyle J. MacBeth , Joseph M. Carroll , William James Cook , Rachel E. Meyers , Miyoung Chun , Mark J. Williamson
发明人： Rosana Kappeller-Libermann , David White , Keith E. Robison , Kyle J. MacBeth , Joseph M. Carroll , William James Cook , Rachel E. Meyers , Miyoung Chun , Mark J. Williamson
IPC分类号： A61K39/395 , A61K38/45 , A61K38/46 , A61K38/48 , C12Q1/68 , G01N33/53 , C12Q1/34 , C12P21/00 , C12N5/10 , C12N5/00 , A61K38/00 , A61K38/17 , A61K31/713 , A61K31/7088 , C07K14/435 , C07K16/40 , C07H21/04 , A61P31/12 , A61P9/00 , A61P35/00 , A61P19/08 , A61P7/00
CPC分类号： G01N33/5008 , A61K38/00 , C12N9/1007 , C12N9/16 , C12N9/6489 , C12Q1/37 , C12Q1/6883 , C12Q2600/158 , C12Y301/04017 , G01N33/5011 , G01N33/502 , G01N33/56983 , G01N33/56994 , G01N33/57426 , G01N33/5761 , G01N33/5767 , G01N33/68 , G01N2333/916 , G01N2333/96486 , G01N2500/04
摘要： The invention provides isolated nucleic acids molecules, designated 27875, 22025, 27420, 16319, 55092 and 10218 nucleic acid molecules. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 27875, 22025, 27420, 16319, 55092 and 10218 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a 27875, 22025, 27420, 16319, 55092 and 10218 gene has been introduced or disrupted. The invention still further provides isolated 27875, 22025, 27420, 17906, 16319, 55092 or 10218 proteins, fusion proteins, antigenic peptides and anti-27875, 22025, 27420, 17906, 16319, 55092 or 10218 antibodies. Diagnostic and therapeutic methods utilizing compositions of the invention are also provided.
摘要翻译： 本发明提供分离的核酸分子，命名为27875,22025,27420,16319,55092和10218核酸分子。 本发明还提供反义核酸分子，含有27875,22025,27420,16319,55092和10218核酸分子的重组表达载体，已经引入表达载体的宿主细胞，以及非人类转基因动物，其中27875,22025， 27420,16319,55092和10218基因已被引入或破坏。 本发明还进一步提供了分离的27875,22025,27420,17906,16319,55092或10218蛋白，融合蛋白，抗原肽和抗27875,22025,27420,17906,16319,55092或10218抗体。 还提供了利用本发明组合物的诊断和治疗方法。
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10.发明授权27875, 22025, 27420, 17906, 16319, 55092 and 10218 molecules and uses therefor 有权27875,22025,27420,17906,16319,55092和10218分子及其用途公开(公告)号：US07098015B2
公开(公告)日：2006-08-29
申请号：US10386414
申请日：2003-03-11
申请人： Kyle J. MacBeth , Joseph M. Carroll , William James Cook , Rachel E. Meyers , Miyoung Chun , Mark J. Williamson
发明人： Kyle J. MacBeth , Joseph M. Carroll , William James Cook , Rachel E. Meyers , Miyoung Chun , Mark J. Williamson
CPC分类号： G01N33/5008 , A61K38/00 , C12N9/1007 , C12N9/16 , C12N9/6489 , C12Q1/37 , C12Q1/6883 , C12Q2600/158 , C12Y301/04017 , G01N33/5011 , G01N33/502 , G01N33/56983 , G01N33/56994 , G01N33/57426 , G01N33/5761 , G01N33/5767 , G01N33/68 , G01N2333/916 , G01N2333/96486 , G01N2500/04
摘要： The invention provides isolated nucleic acids molecules, designated 27875, 22025, 27420, 16319, 55092 and 10218 nucleic acid molecules. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 27875, 22025, 27420, 16319, 55092 and 10218 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a 27875, 22025, 27420, 16319, 55092 and 10218 gene has been introduced or disrupted. The invention still further provides isolated 27875, 22025, 27420, 17906, 16319, 55092 or 10218 proteins, fusion proteins, antigenic peptides and anti-27875, 22025, 27420, 17906, 16319, 55092 or 10218 antibodies. Diagnostic and therapeutic methods utilizing compositions of the invention are also provided.
摘要翻译： 本发明提供分离的核酸分子，命名为27875,22025,27420,16319,55092和10218核酸分子。 本发明还提供反义核酸分子，含有27875,22025,27420,16319,55092和10218核酸分子的重组表达载体，已经引入表达载体的宿主细胞，以及非人类转基因动物，其中27875,22025， 27420,16319,55092和10218基因已被引入或破坏。 本发明还进一步提供了分离的27875,22025,27420,17906,16319,55092或10218蛋白，融合蛋白，抗原肽和抗27875,22025,27420,17906,16319,55092或10218抗体。 还提供了利用本发明组合物的诊断和治疗方法。
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