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    Novel 18607, 15603, 69318, 12303, 48000, 52920, 5433, 38554, 57301, 58324, 55063, 52991, 59914, 59921 and 33751 molecules and uses therefor
    1.
    发明申请
    Novel 18607, 15603, 69318, 12303, 48000, 52920, 5433, 38554, 57301, 58324, 55063, 52991, 59914, 59921 and 33751 molecules and uses therefor 审中-公开
    小分子18607,15603,69318,12303,48000,52202,5333,38554,57301,58324,55063,52991,59914,59921和33751分子及其用途

    公开(公告)号：US20090226448A1

    公开(公告)日：2009-09-10

    申请号：US12381747

    申请日：2009-03-16

    申请人： Maria A. Glucksmann ,  Rory A.J. Curtis ,  Jose M. Lora ,  Katherine M. Galvin ,  Inmaculada Silos-Santiago

    发明人： Maria A. Glucksmann ,  Rory A.J. Curtis ,  Jose M. Lora ,  Katherine M. Galvin ,  Inmaculada Silos-Santiago

    IPC分类号： A61K39/395 ,  C12N15/12 ,  C12N5/10 ,  C07K14/47 ,  C07K16/18 ,  C12P21/02 ,  C12Q1/68 ,  G01N33/566 ,  A61K31/7105 ,  A61K38/48 ,  A61K38/17 ,  A61P35/00 ,  A61P43/00

    CPC分类号： C07K14/705 ,  A61K38/00

    摘要： The invention provides isolated nucleic acids molecules, designated 18607, 15603, 69318, 12303, 48000, 52920, 5433, 38554, 57301, 58324, 55063, 52991, 59914, 59921 and 33751 nucleic acid molecules. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 18607, 15603, 69318, 12303, 48000, 52920, 5433, 38554, 57301, 58324, 55063, 52991, 59914, 59921 and 33751 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a 18607, 15603, 69318, 12303, 48000, 52920, 5433, 38554, 57301, 58324, 55063, 52991, 59914, 59921 or 33751 gene has been introduced or disrupted. The invention still further provides isolated 18607, 15603, 69318, 12303, 48000, 52920, 5433, 38554, 57301, 58324, 55063, 52991, 59914, 59921 or 33751 proteins, fusion proteins, antigenic peptides and anti-18607, 15603, 69318, 12303, 48000, 52920, 5433, 38554, 57301, 58324, 55063, 52991, 59914, 59921 or 33751 antibodies. Diagnostic and therapeutic methods utilizing compositions of the invention are also provided.

    摘要翻译： 本发明提供分离的核酸分子，命名为18607,15603,69318,12303,48000,52920,5433,38554,57301,58324,55063,52991,59914,59921和33751核酸分子。 本发明还提供反义核酸分子，包含18607,15603,69318,12303,48000,52920,5433,38554,57301,58324,55063,52991,59914,59921和33751核酸分子的重组表达载体，其中宿主细胞 已经引入了表达载体，并且已导入或破坏其中18607,15603,69318,12303,48000,523020,5433,35554,57301,58324,55063,52991,59914,59921或33751基因的非人转基因动物。 本发明还进一步提供了分离的18607,15603,69318,12303,48000,5920,5433,38554,57301,58324,55063,52991,59914,59921或33751蛋白，融合蛋白，抗原肽和抗-18607,15603,69318 ，12303,48000,5920,5433,38554,57301,58324,55063,52991,59914,59921或33751抗体。 还提供了利用本发明组合物的诊断和治疗方法。

    Novel 18607, 15603, 69318, 12303, 48000, 52920, 5433, 38554, 57301, 58324, 55063, 52991, 59914, 59921, and 33751 molecules and uses therefor
    2.
    发明申请
    Novel 18607, 15603, 69318, 12303, 48000, 52920, 5433, 38554, 57301, 58324, 55063, 52991, 59914, 59921, and 33751 molecules and uses therefor 审中-公开
    小分子18607,15603,69318,12303,48000,52202,5333,35554,57301,58324,55063,52991,59914,59921和33751分子及其用途

    公开(公告)号：US20090226449A1

    公开(公告)日：2009-09-10

    申请号：US12381748

    申请日：2009-03-16

    申请人： Maria A. Glucksmann ,  Rory A.J. Curtis ,  Jose M. Lora ,  Katherine M. Galvin ,  Inmaculada Silos-Santiago

    发明人： Maria A. Glucksmann ,  Rory A.J. Curtis ,  Jose M. Lora ,  Katherine M. Galvin ,  Inmaculada Silos-Santiago

    IPC分类号： A61K39/395 ,  C12N15/12 ,  C12N5/10 ,  C07K14/47 ,  C07K16/18 ,  C12P21/02 ,  C12Q1/68 ,  G01N33/566 ,  A61K38/17 ,  A61K31/7105 ,  A61K38/48 ,  A61P35/00 ,  A61P43/00

    CPC分类号： C07K14/705 ,  A61K38/00

    摘要： The invention provides isolated nucleic acids molecules, designated 18607, 15603, 69318, 12303, 48000, 52920, 5433, 38554, 57301, 58324, 55063, 52991, 59914, 59921 and 33751 nucleic acid molecules. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 18607, 15603, 69318, 12303, 48000, 52920, 5433, 38554, 57301, 58324, 55063, 52991, 59914, 59921 and 33751 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a 18607, 15603, 69318, 12303, 48000, 52920, 5433, 38554, 57301, 58324, 55063, 52991, 59914, 59921 or 33751 gene has been introduced or disrupted. The invention still further provides isolated 18607, 15603, 69318, 12303, 48000, 52920, 5433, 38554, 57301, 58324, 55063, 52991, 59914, 59921 or 33751 proteins, fusion proteins, antigenic peptides and anti-18607, 15603, 69318, 12303, 48000, 52920, 5433, 38554, 57301, 58324, 55063, 52991, 59914, 59921 or 33751 antibodies. Diagnostic and therapeutic methods utilizing compositions of the invention are also provided.

    摘要翻译： 本发明提供分离的核酸分子，命名为18607,15603,69318,12303,48000,52920,5433,38554,57301,58324,55063,52991,59914,59921和33751核酸分子。 本发明还提供反义核酸分子，包含18607,15603,69318,12303,48000,52920,5433,38554,57301,58324,55063,52991,59914,59921和33751核酸分子的重组表达载体，其中宿主细胞 已经引入了表达载体，并且已导入或破坏其中18607,15603,69318,12303,48000,523020,5433,35554,57301,58324,55063,52991,59914,59921或33751基因的非人转基因动物。 本发明还进一步提供了分离的18607,15603,69318,12303,48000,5920,5433,38554,57301,58324,55063,52991,59914,59921或33751蛋白，融合蛋白，抗原肽和抗-18607,15603,69318 ，12303,48000,5920,5433,38554,57301,58324,55063,52991,59914,59921或33751抗体。 还提供了利用本发明组合物的诊断和治疗方法。

    Novel TWIK-6, TWIK-7, IC23927, TWIK-8, IC47611, IC47615, HNMDA-1, TWIK-9, alpha2delta-4, 8099, 46455, 54414, 53763, 97076, 97102, 44181, 67084Fl and 67084alt molecules and uses therefor
    5.
    发明申请
    Novel TWIK-6, TWIK-7, IC23927, TWIK-8, IC47611, IC47615, HNMDA-1, TWIK-9, alpha2delta-4, 8099, 46455, 54414, 53763, 97076, 97102, 44181, 67084Fl and 67084alt molecules and uses therefor 审中-公开
    新颖的TWIK-6，TWIK-7，IC23927，TWIK-8，IC47611，IC47615，HNMDA-1，TWIK-9，α2delta-4,8099,46455,5414,53763,97076,97102,44181,67084F1和67084altalt分子， 用它

    公开(公告)号：US20080032289A1

    公开(公告)日：2008-02-07

    申请号：US11050947

    申请日：2005-02-04

    申请人： Rory A.J. Curtis ,  Maria Alexandra Glucksmann ,  Inmaculada Silos-Santiago

    发明人： Rory A.J. Curtis ,  Maria Alexandra Glucksmann ,  Inmaculada Silos-Santiago

    IPC分类号： C07K14/435 ,  C07K16/18 ,  C12N1/00 ,  C12N15/12 ,  C12N15/63 ,  C12N5/00 ,  C12P21/02 ,  C12Q1/68 ,  G01N33/53 ,  G01N33/68

    CPC分类号： G01N33/57415 ,  A01K2217/05 ,  A01K2217/075 ,  A61K38/00 ,  C07K14/705 ,  C07K16/18 ,  C07K2319/00 ,  G01N33/57419 ,  G01N33/57423 ,  G01N33/57434 ,  G01N33/6872 ,  G01N2800/32 ,  G01N2800/325 ,  Y10T436/143333

    摘要： The invention provides isolated nucleic acids molecules, designated TWIK-6, TWIK-7, IC23927, TWIK-8, IC47611, IC47615, HNMDA-1, TWIK-9, α2δ-4, 8099, 46455, 54414, 53763, 97076, 97102, 44181, 67084FL and 67084alt nucleic acid molecules, which encode novel ion channel family molecules, including calcium channels, potassium channels, and NMDA receptors. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing TWIK-6, TWIK-7, IC23927, TWIK-8, IC47611, IC47615, HNMDA-1, TWIK-9, α2δ-4, 8099, 46455, 54414, 53763, 97076, 97102, 44181, 67084FL and 67084alt nucleic acid molecules, host cells into which the expression vectors have been introduced, and non-human transgenic animals in which a TWIK-6, TWIK-7, IC23927, TWIK-8, IC47611, IC47615, HNMDA-1, TWIK-9, α2δ-4, 8099, 46455, 54414, 53763, 97076, 97102, 44181, 67084FL and 67084alt gene has been introduced or disrupted. The invention still further provides isolated TWIK-6, TWIK-7, IC23927, TWIK-8, IC47611, IC47615, HNMDA-1, TWIK-9, α2δ-4, 8099, 46455, 54414, 53763, 97076, 97102, 44181, 67084FL and 67084alt polypeptides, fusion polypeptides, antigenic peptides and anti-TWIK-6, TWIK-7, IC23927, TWIK-8, IC47611, IC47615, HNMDA-1, TWIK-9, α2δ-4, 8099, 46455, 54414, 53763, 97076, 97102, 44181, 67084FL and 67084alt antibodies. Diagnostic and therapeutic methods utilizing compositions of the invention are also provided.

    摘要翻译： 本发明提供分离的核酸分子，称为TWIK-6，TWIK-7，IC23927，TWIK-8，IC47611，IC47615，HNMDA-1，TWIK-9，α2Δ-4,8099， 46455,55414,53763,97076,97102,44181,67084FL和67084alt核酸分子，其编码新的离子通道家族分子，包括钙通道，钾通道和NMDA受体。 本发明还提供反义核酸分子，含有TWIK-6，TWIK-7，IC23927，TWIK-8，IC47611，IC47615，HNMDA-1，TWIK-9，α2Δ- 4,8099,46455,54144,53763,97076,97102,44181,67084FL和67084alt核酸分子，其中引入了表达载体的宿主细胞，以及非人转基因动物，其中TWIK-6，TWIK-7 ，IC23927，TWIK-8，IC47611，IC47615，HNMDA-1，TWIK-9，α2Δ-4,8099,46455,5414,53763,97076,97102,44181,67084FL和67084alt基因 已被引入或中断。 本发明还进一步提供了分离的TWIK-6，TWIK-7，IC23927，TWIK-8，IC47611，IC47615，HNMDA-1，TWIK-9，α2ΔΔ4,8099,46455,5444 ，53763,97076,97102,44181,67084FL和67084alt多肽，融合多肽，抗原肽和抗TWIK-6，TWIK-7，IC23927，TWIK-8，IC47611，IC47615，HNMDA-1，TWIK-9， 3Δ-4，8099,46455,5414,53763,97076,97102,44181,67084FL和67084alt抗体。 还提供了利用本发明组合物的诊断和治疗方法。

    NOVEL MEMBERS OF THE CAPSAICIN/VANILLOID RECEPTOR FAMILY OF PROTEINS AND USES THEREOF
    8.
    发明申请
    NOVEL MEMBERS OF THE CAPSAICIN/VANILLOID RECEPTOR FAMILY OF PROTEINS AND USES THEREOF 失效
    CAPSAICIN / VANILLOID受体家族蛋白质的新成员及其用途

    公开(公告)号：US20080171339A1

    公开(公告)日：2008-07-17

    申请号：US11967558

    申请日：2007-12-31

    申请人： Rory A.J. Curtis

    发明人： Rory A.J. Curtis

    IPC分类号： G01N33/53 ,  C07H21/00 ,  C12N15/63 ,  C12N1/00 ,  C12P21/00 ,  G01N33/68 ,  C07K7/00 ,  C07K14/00 ,  C07K16/00

    CPC分类号： C07K14/705 ,  Y10T436/143333

    摘要： The invention provides isolated nucleic acids molecules, designated hVR-1, hVR-2, and rVR-2 nucleic acid molecules, which encode novel members of the Capsaicin/Vanilloid receptor family. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing hVR-1, hVR-2, and rVR-2 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which an hVR-1, hVR-2, and rVR-2 gene has been introduced or disrupted. The invention still further provides isolated hVR-1, hVR-2, and rVR-2 proteins, fusion proteins, antigenic peptides and anti-hVR-1, anti-hVR-2, and anti-rVR-2 antibodies. Diagnostic methods utilizing compositions of the invention are also provided.

    摘要翻译： 本发明提供编码辣椒素/香草素受体家族的新成员的分离的核酸分子，命名为hVR-1，hVR-2和rVR-2核酸分子。 本发明还提供反义核酸分子，含有hVR-1，hVR-2和rVR-2核酸分子的重组表达载体，其中引入了表达载体的宿主细胞，以及非人类转基因动物，其中hVR-1 ，hVR-2和rVR-2基因已被引入或破坏。 本发明还进一步提供了分离的hVR-1，hVR-2和rVR-2蛋白，融合蛋白，抗原肽和抗hVR-1，抗hVR-2和抗rVR-2抗体。 还提供了利用本发明组合物的诊断方法。