摘要:
The present invention concerns a compound having the formula (I) a N-oxide form, a stereochemical isomer, racemic mixture, salt, prodrug, ester or metabolite thereof. It further relates to processes for their preparation as well as pharmaceutical compositions, their use as medicines, and diagnostic kits comprising them. The present invention also concerns combinations of the present entry inhibitors with anti-retroviral agents. It further relates to their use in assays as reference compounds or as reagents. The compounds of the present invention are useful for preventing or treating infection by HIV and for treating AIDS.
摘要:
The present invention concerns a compound having the formula (I) a N-oxide form, a stereochemical isomer, racemic mixture, salt, prodrug, ester or metabolite thereof. It further relates to processes for their preparation as well as pharmaceutical compositions, their use as medicines, and diagnostic kits comprising them. The present invention also concerns combinations of the present entry inhibitors with anti-retroviral agents. It further relates to their use in assays as reference compounds or as reagents. The compounds of the present invention are useful for preventing or treating infection by HIV and for treating AIDS.
摘要:
The present invention is concerned with This invention relates to C34 peptide derivatives that are inhibitors of viral infection and/or exhibit antifusogenic properties. In particular, this invention relates to C34 derivatives having inhibiting activity against human immunodeficiency virus (HIV), respiratory syncytial virus (RSV), human parainfluenza virus (HPV), measles virus (MeV), and simian immunodeficiency virus (SIV) with long duration of action for the treatment of the respective viral infections.
摘要:
The claimed invention is directed toward modified HIV-1 gp41 C-terminal heptad repeat fusion inhibitors. In particular, peptide derivatives of C-34 were prepared (e.g., FB006M) and modified with 3-maleimidoproionic acid (MPA), which allows rapid and irreversible conjugation to serum albumin at a 1:1 molar ratio. These polypeptides have an extended half-life in vivo and display potent antiviral activity against HIV-1.
摘要:
Multi-key content processing systems and methods, for processing content with at least one distribution target position. Each of the distribution target positions corresponds to an authorization key. An example method includes the steps of: encrypting said content with a content key; forming a key link based on said content key and the authorization key of said at least one distribution target position; and attaching said key link to the encrypted content.
摘要:
Biodegradable oligomeric polyesters based upon hydroxy acids, such as glycolic acid (GA), lactic acid (LLA), and copolymers thereof are described. Composites that include biodegradable polyesters and bioabsorbable fillers are also described. The described polymers and composites are injectable and in situ curable.
摘要:
A channel merging method for a VOD system, said method comprises the steps of: in response to requests from a plurality of clients for a video program, establishing a root channel (S1) and at least one sub-channel (S11), said root channel (S1) being established according to a request from a client that makes the earliest request, each of said sub-channels (S11) being established in response to a request from a client that makes a later request; and monitoring variation of the number of the clients that are using each of said established channels, and maintaining the channel if the number of the clients using the monitored channel is not zero, and closing the channel if the number of the clients using the monitored channel becomes zero.
摘要:
A hypervideo player for playing hypervideos containing both video and hypervideo hyperlinks provides user selectable run-time options for the form of hypervideo hyperlink emphasis region display attributes displayed at the time of viewing. The hypervideo player may reside on a host system. The hypervideo player integrates video file(s) and hypervideo hyperlink data file(s) to form a hypervideo. The hypervideo player decodes a video file, encodes the decoded video file with a corresponding hypervideo hyperlink data file at key frames of the video file to form a hypervideo, displays the hypervideo on a display device and provides the user, at the time of viewing, with at least one user selectable option for the form of hypervideo hyperlink emphasis region display attributes. The hypervideo player preferably employs interpolation between key frames to determine the display position of the hypervideo hyperlink emphasis region(s) in non-key frames of the hypervideo. The use of key frame encoding and interpolation to determine the display position between key frames, enable the hypervideo hyperlink emphasis region(s) to be displayed at all desired locations of the hypervideo even though the hypervideo hyperlink data is encoded only at key frames.
摘要:
A method and system is disclosed for configuring a queue profile based on an input values received from a user. According to an exemplary embodiment, a series of threshold queue sizes are generated based in part on the input values and a corresponding series of drop priority values. A lookup table may be provided to categories the threshold queue sizes within predetermined queue size blocks.
摘要:
The present invention provides methods, systems and apparatus for encrypting and for decrypting a data stream, for securely sending a data stream and for securely receiving a data stream, and for secure transmission of a data stream. The data stream, after at least a part of it being encrypted, is transmitted from a sender to a receiver via a channel. An exemplary method for encrypting comprises: adjusting encryption attributes during transmission; encrypting the data stream according to the adjusted encryption attributes; and transmitting the encrypted data stream and information of the encryption attributes to the receiver.