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公开(公告)号：US07314739B2
公开(公告)日：2008-01-01
申请号：US10493210
申请日：2002-10-17
CPC分类号： C12N9/20
摘要： The invention relates to a lipase variant which can be prepared by carrying out, on the amino acid sequence of a starting lipase selected from the lipase homologous family I.1 or I.2, at least one amino acid substitution in those positions which correspond to the positions 17, 29, 30, 52, 86, 117, 122, 160, 163, 167, 265, 266, 286, 289 in the prototype lipase sequence SEQ ID NO: 1.
摘要翻译： 本发明涉及脂酶变体，其可通过在选自脂肪酶同源家族I.1或I.2的起始脂肪酶的氨基酸序列上进行至少一个氨基酸取代而制备， 原型脂肪酶序列SEQ ID NO：1中的位置17,29,30,25,66,117,122,160,163,167,265,266,286,289。
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公开(公告)号：US20050255571A1
公开(公告)日：2005-11-17
申请号：US10493210
申请日：2002-10-17
IPC分类号： C12N15/09 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N9/20 , C12N15/55 , C12P41/00 , C12P7/62 , C12P7/40
CPC分类号： C12N9/20
摘要： The invention relates to a lipase variant which can be prepared by carrying out, on the amino acid sequence of a starting lipase selected from the lipase homologous family I.1 or I.2, at least one amino acid substitution in those positions which correspond to the positions 17, 29, 30, 52, 86, 117, 122, 160, 163, 167, 265, 266, 286, 289 in the prototype lipase sequence SEQ ID NO: 1.
摘要翻译： 本发明涉及脂酶变体，其可通过在选自脂肪酶同源家族I.1或I.2的起始脂肪酶的氨基酸序列上进行至少一个氨基酸取代而制备， 原型脂肪酶序列SEQ ID NO：1中的位置17,29,30,25,66,117,122,160,163,167,265,266,286,289。
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公开(公告)号：US08153408B2
公开(公告)日：2012-04-10
申请号：US12278464
申请日：2007-01-31
IPC分类号： C12P7/26
CPC分类号： C12P41/004 , C12P7/36
摘要： A process for the racemization of an optically active alpha-hydroxyketone by incubating said alpha-hydroxyketone in the presence of an acetoin racemase of Lactobacillus.
摘要翻译： 通过在乳杆菌的乙偶姻消旋酶存在下温育所述α-羟基酮来使光学活性α-羟基酮外消旋化的方法。
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公开(公告)号：US08012725B2
公开(公告)日：2011-09-06
申请号：US11667721
申请日：2005-11-15
IPC分类号： C12P7/16 , C12P7/02 , C12P7/04 , C12Q1/26 , C12Q1/32 , C12N1/00 , C12N1/20 , C12N9/02 , C07H21/04
摘要： The present invention relates to enzymic processes for preparing S-butan-2-ol; and to enzymes for carrying out said processes; to nucleic acid sequences coding for said enzymes, to expression cassettes, vectors and recombinant hosts containing said nucleic acid sequences.
摘要翻译： 本发明涉及制备S-丁-2-醇的酶法; 和用于进行所述方法的酶; 编码所述酶的核酸序列，含有所述核酸序列的表达盒，载体和重组宿主。
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公开(公告)号：US20100009421A1
公开(公告)日：2010-01-14
申请号：US12439427
申请日：2007-08-30
申请人： Rainer Stürmer , Bernhard Hauer , Bettina Rosche , André Mueller
发明人： Rainer Stürmer , Bernhard Hauer , Bettina Rosche , André Mueller
IPC分类号： C12P7/26
CPC分类号： C12P7/26 , C12N9/0036
摘要： The invention relates to a method for the enzymatic reduction of alkyne derivatives of the formula (1), wherein R1 represents H, C1-C6-alkyl, C2-C6-alkenyl, or an optionally substituted carbocyclic or heterocyclic, aromatic or non-aromatic group, R2 represents H, C1-C6-alkyl, C2-C6-alkenyl, by reaction in the presence of special reductases.
摘要翻译： 本发明涉及一种用于酶还原式（1）的炔衍生物的方法，其中R 1表示H，C 1 -C 6 - 烷基，C 2 -C 6 - 烯基或任选取代的碳环或杂环，芳族或非芳族 基团，R2表示H，C1-C6-烷基，C2-C6-烯基，通过在特殊的还原酶存在下反应。
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6.发明授权Process for the reduction of cinnamaldehyde derivative employing enoate reductases 有权用烯酸还原酶还原肉桂醛衍生物的方法公开(公告)号：US08597915B2
公开(公告)日：2013-12-03
申请号：US13576280
申请日：2011-02-01
申请人： Bernhard Hauer , Rainer Stürmer , Clemens Stückler , Kurt Faber
发明人： Bernhard Hauer , Rainer Stürmer , Clemens Stückler , Kurt Faber
CPC分类号： C12P7/24 , C12P41/002
摘要： The present invention relates to a novel enzymatically catalyzed method for the production of asymmetric aromatic aldehydes in an aqueous reaction medium containing certain organic co-solvents.
摘要翻译： 本发明涉及一种在含有某些有机助溶剂的含水反应介质中生产不对称芳族醛的新的酶促催化方法。
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公开(公告)号：US20100035315A1
公开(公告)日：2010-02-11
申请号：US12514215
申请日：2007-11-13
申请人： Rainer Stürmer , Bernhard Hauer , Thomas Friedrich , Kurt Faber , Melanie Hall
发明人： Rainer Stürmer , Bernhard Hauer , Thomas Friedrich , Kurt Faber , Melanie Hall
IPC分类号： C12P7/26
CPC分类号： C12P7/24 , C12P7/26 , C12P7/40 , C12P7/46 , C12P7/62 , C12P13/008 , C12P17/10 , C12P41/002
摘要： A method for enzymatic preparation of compounds of the general formula (2) from unsaturated alkene derivatives of the general formula (1) by reducing a compound of the formula (1) in the presence of a reductase, comprising at least one of the polypeptide sequences SEQ ID NO: 1, 2 or 3 or having a functionally equivalent polypeptide sequence which is at least 80% identical to SEQ ID NO: 1, 2 or 3.
摘要翻译： 一种通过在还原酶的存在下还原式（1）的化合物，从通式（1）的不饱和烯烃衍生物中酶制备通式（2）的化合物的方法，所述方法包括至少一种多肽序列 具有与SEQ ID NO：1,2或3至少80％相同的功能等同多肽序列的SEQ ID NO：1,2或3。
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公开(公告)号：US08313923B2
公开(公告)日：2012-11-20
申请号：US12514215
申请日：2007-11-13
申请人： Rainer Stürmer , Bernhard Hauer , Thomas Friedrich , Kurt Faber , Melanie Hall
发明人： Rainer Stürmer , Bernhard Hauer , Thomas Friedrich , Kurt Faber , Melanie Hall
IPC分类号： C12P7/26
CPC分类号： C12P7/24 , C12P7/26 , C12P7/40 , C12P7/46 , C12P7/62 , C12P13/008 , C12P17/10 , C12P41/002
摘要： A method for enzymatic preparation of compounds of the general formula (2) from unsaturated alkene derivatives of the general formula (1) by reducing a compound of the formula (1) in the presence of a reductase, comprising at least one of the polypeptide sequences SEQ ID NO: 1, 2 or 3 or having a functionally equivalent polypeptide sequence which is at least 80% identical to SEQ ID NO: 1, 2 or 3.
摘要翻译： 一种通过在还原酶的存在下还原式（1）的化合物，从通式（1）的不饱和烯烃衍生物中酶制备通式（2）的化合物的方法，所述方法包括至少一种多肽序列 具有与SEQ ID NO：1,2或3至少80％相同的功能等同多肽序列的SEQ ID NO：1,2或3。
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公开(公告)号：US20090221046A1
公开(公告)日：2009-09-03
申请号：US12278464
申请日：2007-01-31
IPC分类号： C12P7/26
CPC分类号： C12P41/004 , C12P7/36
摘要： A process for the racemisation of an optically active alpha-hydroxyketone by incubating said alpha-hydroxyketone in the presence of an acetoin racemase of Lactobacillus.
摘要翻译： 通过在乳杆菌的乙酰丁酰消旋酶存在下温育所述α-羟基酮来使光学活性的α-羟基酮消旋化的方法。
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公开(公告)号：US07531331B2
公开(公告)日：2009-05-12
申请号：US10362530
申请日：2001-08-30
摘要： The invention relates to novel proteins from Pseudomonas glumae, having esterase activity, in particular butynol I esterase activity, to nucleic acid sequences coding therefor, to expression cassettes, vectors and recombinant microorganisms; to methods for preparing said proteins and to the use thereof for enzymic, in particular enantioselective enzymic, ester hydrolysis or transesterification of organic esters.
摘要翻译： 本发明涉及具有酯酶活性，特别是丁酸酯酶活性的编码的核酸序列，表达盒，载体和重组微生物的新型蛋白质， 涉及用于制备所述蛋白质的方法及其用于酶，特别是对映选择性酶，酯水解或酯交换有机酯的用途。
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