-
公开(公告)号：US20080065088A1
公开(公告)日：2008-03-13
申请号：US11846625
申请日：2007-08-29
申请人： Martin Hughes , Darren Seymour , Colin Turner , Paul Harmer , Richard Cornell , Howard Seeherman
发明人： Martin Hughes , Darren Seymour , Colin Turner , Paul Harmer , Richard Cornell , Howard Seeherman
CPC分类号： B01F15/00506 , A61F2002/2817 , A61F2002/30601 , B01F5/0685 , B01F5/0688 , B01F13/0023 , B01F15/0225
摘要： Bone cement mixing systems and related methods are disclosed. The bone cement mixing systems can include a first chamber, a second chamber, and a passage fluidly connecting the first and second chambers. A first piston can be disposed in the first chamber, and a second piston can be disposed in the second chamber.
摘要翻译： 公开了骨水泥混合系统及相关方法。 骨水泥混合系统可以包括第一室，第二室和流体连接第一和第二室的通道。 第一活塞可以设置在第一室中，第二活塞可以设置在第二室中。
-
公开(公告)号：US07413753B2
公开(公告)日：2008-08-19
申请号：US10160607
申请日：2002-05-31
申请人： Rebecca H. Li , Howard Seeherman
发明人： Rebecca H. Li , Howard Seeherman
CPC分类号： A61L27/227 , A61K38/02 , A61K38/1875 , A61L17/005 , A61L17/145 , A61L24/02 , A61L24/108 , A61L27/12 , A61L2430/02 , A61K2300/00
摘要： A composition for delivery of osteogenic proteins is disclosed. The composition comprises an osteogenic protein, a calcium phosphate material as a carrier, and an effective amount of an effervescent agent. Methods of making the compositions and methods of using the osteogenic compositions to treat osteoporotic and/or osteopenic bone are also disclosed.
摘要翻译： 公开了用于递送成骨蛋白的组合物。 组合物包含成骨蛋白，作为载体的磷酸钙材料和有效量的泡腾剂。 还公开了使组合物和使用成骨组合物治疗骨质疏松和/或骨质减少骨的方法。
-
3.发明授权Injectable calcium phosphate solid rods and pastes for delivery of osteogenic proteins 有权用于输送成骨蛋白的可注射磷酸钙固体棒和糊剂公开(公告)号：US07771755B2
公开(公告)日：2010-08-10
申请号：US10937364
申请日：2004-09-10
申请人： Rebecca Li , Howard Seeherman , Hyun Kim
发明人： Rebecca Li , Howard Seeherman , Hyun Kim
CPC分类号： A61L27/12 , A61K38/1875 , A61L27/227 , A61L27/425 , A61L27/46 , A61L27/50 , A61L2400/06
摘要： Osteogenic proteins are delivered via an injectable solid rod or hardenable paste. The formulation comprises a calcium phosphate material, an osteogenic protein, and optional additives and active ingredients such as a bone resorption inhibitor. Methods of making injectable pharmaceutical compositions and methods of using the osteogenic compositions to treat bone defects are also disclosed.
摘要翻译： 成骨蛋白通过可注射的固体棒或可硬化的糊剂递送。 该制剂包含磷酸钙材料，成骨蛋白质和任选的添加剂和活性成分如骨吸收抑制剂。 还公开了制备可注射药物组合物的方法和使用成骨组合物治疗骨缺损的方法。
-
公开(公告)号：US20090156462A1
公开(公告)日：2009-06-18
申请号：US12389171
申请日：2009-02-19
CPC分类号： A61L31/047 , A61K38/1875 , A61K38/36 , A61K38/363 , A61K38/37 , A61K38/39 , A61K38/4833 , A61K38/57 , A61L24/108 , A61L31/10
摘要： The present disclosure relates to hernia repair and methods for stimulating growth of fascia tissue employing compositions comprising fibrous tissue inducing proteins.
摘要翻译： 本公开涉及疝修复和使用包含纤维组织诱导蛋白质的组合来刺激筋膜组织生长的方法。
-
公开(公告)号：US20080096797A1
公开(公告)日：2008-04-24
申请号：US11957691
申请日：2007-12-17
申请人： Rebecca Li , Howard Seeherman , Aliassghar Tofighi
发明人： Rebecca Li , Howard Seeherman , Aliassghar Tofighi
IPC分类号： A61K38/00
CPC分类号： A61L27/227 , A61K38/02 , A61K38/1875 , A61L17/005 , A61L17/145 , A61L24/02 , A61L24/108 , A61L27/12 , A61L2430/02 , A61K2300/00
摘要： A composition for delivery of osteogenic proteins is disclosed. The composition comprises an osteogenic protein, a calcium phosphate material as a carrier, and an effective amount of an effervescent agent. Methods of making the compositions and methods of using the osteogenic compositions to treat osteoporotic and/or osteopenic bone are also disclosed.
摘要翻译： 公开了用于递送成骨蛋白的组合物。 组合物包含成骨蛋白，作为载体的磷酸钙材料和有效量的泡腾剂。 还公开了使组合物和使用成骨组合物治疗骨质疏松和/或骨质减少骨的方法。
-
公开(公告)号：US20160082156A1
公开(公告)日：2016-03-24
申请号：US14839786
申请日：2015-08-28
申请人： Christopher G. WILSON , Eric J. Vanderploeg , Howard Seeherman , Zachary Decker , Eric Schmidt , Bethany Moore , Alexander Heubeck
发明人： Christopher G. WILSON , Eric J. Vanderploeg , Howard Seeherman , Zachary Decker , Eric Schmidt , Bethany Moore , Alexander Heubeck
CPC分类号： A61L27/44 , A61F2/28 , A61F2002/2817 , A61F2002/2835 , A61L27/46 , A61L27/54 , A61L27/56 , A61L2300/414 , A61L2400/06 , A61L2430/02 , A61L2430/24
摘要： Systems and methods for preparing osteoinductive synthetic bone grafts are provided in which a porous ceramic granule is loaded with an osteoinductive material, and then placed in contact with a biocompatible matrix material.
摘要翻译： 提供用于制备骨诱导性合成骨移植物的系统和方法，其中多孔陶瓷颗粒装载有骨诱导材料，然后与生物相容性基质材料接触。
-
7.发明申请Injectable Calcium Phosphate Solid Rods and Pastes for Delivery of Osteogenic Proteins 有权可注射的磷酸钙实心棒和用于输送成骨蛋白的浆料公开(公告)号：US20100273706A1
公开(公告)日：2010-10-28
申请号：US12829540
申请日：2010-07-02
申请人： Rebecca Li , Howard Seeherman , Hyun Kim
发明人： Rebecca Li , Howard Seeherman , Hyun Kim
CPC分类号： A61L27/12 , A61K38/1875 , A61L27/227 , A61L27/425 , A61L27/46 , A61L27/50 , A61L2400/06
摘要： Osteogenic proteins are delivered via an injectable solid rod or hardenable paste. The formulation comprises a calcium phosphate material, an osteogenic protein, and optional additives and active ingredients such as a bone resorption inhibitor. Methods of making injectable pharmaceutical compositions and methods of using the osteogenic compositions to treat bone defects are also disclosed.
摘要翻译： 成骨蛋白通过可注射的固体棒或可硬化的糊剂递送。 该制剂包含磷酸钙材料，成骨蛋白质和任选的添加剂和活性成分如骨吸收抑制剂。 还公开了制备可注射药物组合物的方法和使用成骨组合物治疗骨缺损的方法。
-
8.发明授权Injectable carrier formulations of hyaluronic acid derivatives for delivery of osteogenic proteins 失效用于输送成骨蛋白质的透明质酸衍生物的可注射载体制剂公开(公告)号：US07608580B2
公开(公告)日：2009-10-27
申请号：US11624463
申请日：2007-01-18
申请人： Hyun Kim , Rebecca Li , Alessandra Pavesio , Lanfranco Callegaro , Howard Seeherman , John Wozney
发明人： Hyun Kim , Rebecca Li , Alessandra Pavesio , Lanfranco Callegaro , Howard Seeherman , John Wozney
IPC分类号： A61K38/16
CPC分类号： A61K9/0024 , A61K9/0019 , A61K38/1875 , A61K47/26 , A61K47/36 , A61L27/20 , A61L27/227 , A61L27/46 , A61L2300/414 , A61L2400/06 , A61K2300/00 , C08L5/08
摘要： An injectable formulation is disclosed for delivery of osteogenic proteins. The formulation comprises a pharmaceutically acceptable admixture of an osteogenic protein; and formulations comprising osteogenic protein, hyaluronic acid derivatives and tricalcium phosphate are also disclosed. Methods for formulating porous injectable gels and pastes from hyaluronic acid are also disclosed.
摘要翻译： 公开了用于递送成骨蛋白质的可注射制剂。 该制剂包含成骨蛋白的药学上可接受的混合物; 并且还公开了包含成骨蛋白，透明质酸衍生物和磷酸三钙的制剂。 还公开了从透明质酸配制多孔可注射凝胶和糊剂的方法。
-
9.发明申请INJECTABLE CARRIER FORMULATIONS OF HYALURONIC ACID DERIVATIVES FOR DELIVERY OF OSTEOGENIC PROTEINS 失效用于递送蛋白质的羟丙酸衍生物的可手动载体配方公开(公告)号：US20070134342A1
公开(公告)日：2007-06-14
申请号：US11624463
申请日：2007-01-18
申请人： Hyun Kim , Rebecca Li , Alessandra Pavesio , Lanfranco Callegaro , Howard Seeherman , John Wozney
发明人： Hyun Kim , Rebecca Li , Alessandra Pavesio , Lanfranco Callegaro , Howard Seeherman , John Wozney
IPC分类号： A61K38/18 , A61K31/728 , A61K9/14
CPC分类号： A61K9/0024 , A61K9/0019 , A61K38/1875 , A61K47/26 , A61K47/36 , A61L27/20 , A61L27/227 , A61L27/46 , A61L2300/414 , A61L2400/06 , A61K2300/00 , C08L5/08
摘要： An injectable formulation is disclosed for delivery of osteogenic proteins. The formulation comprises a pharmaceutically acceptable admixture of an osteogenic protein; and formulations comprising osteogenic protein, hyaluronic acid derivatives and tricalcium phosphate are also disclosed. Methods for formulating porous injectable gels and pastes from hyaluronic acid are also disclosed.
摘要翻译： 公开了用于递送成骨蛋白质的可注射制剂。 该制剂包含成骨蛋白的药学上可接受的混合物; 并且还公开了包含成骨蛋白，透明质酸衍生物和磷酸三钙的制剂。 还公开了从透明质酸配制多孔可注射凝胶和糊剂的方法。
-
公开(公告)号：US08952131B2
公开(公告)日：2015-02-10
申请号：US13211755
申请日：2011-08-17
申请人： Stephen Berasi , Robert Vincent Martinez , Michael John Cain , John Wozney , Howard Seeherman , Z. Sean Juo , Valerie P. Calabro , Christopher Todd Brown
发明人： Stephen Berasi , Robert Vincent Martinez , Michael John Cain , John Wozney , Howard Seeherman , Z. Sean Juo , Valerie P. Calabro , Christopher Todd Brown
摘要： The invention relates to novel designer osteogenic proteins having altered affinity for a cognate receptor, nucleic acids encoding the same, and methods of use therefor. More preferably, the novel designer osteogenic proteins are designer BMPs and have altered affinity for a cognate BMP receptor. The designer BMPs demonstrate altered biological characteristics and provide potential useful novel therapeutics.
摘要翻译： 本发明涉及对同型受体具有改变的亲和力的新型设计者成骨蛋白质，及其编码的核酸及其使用方法。 更优选地，新设计的成骨蛋白是设计者BMP并且对同源BMP受体具有改变的亲和力。 设计者BMPs展示了改变的生物学特征，并提供潜在的有用的新型治疗。
-
-
-
-
-
-
-
-
-
搜索结果
24 条记录 (耗时 0.032 秒)
