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公开(公告)号：US5536497A
公开(公告)日：1996-07-16
申请号：US994277
申请日：1992-12-21
IPC分类号： A61K39/00 , C07K14/195 , A61K39/02 , A61K38/00 , C07K14/00
CPC分类号： C07K14/195 , A61K39/00
摘要： Polypeptides related to fimbriae of Porphyromonas gingivalis are described and claimed which exhibit inhibition of bacterial adhesion to saliva-coated surfaces. The polypeptides are selected from the group consisting of fimbriae, fimbrillin, and fimbrial-related. peptides derived therefrom. The polypeptides are used as active ingredients in various oral formulations designed to prevent adhesion of P. gingivalis to host mucosal surfaces and thus interfering with the development of periodontitis. The polypeptides are also used in subunit vaccine formulations for use against pathogenic, fimbriated P. gingivalis in the prophylactic treatment of periodontitis. Use of the polypeptides for inducing protective immunity in serum and gingival crevicular fluid may prevent primary infection with P. gingivalis as well as the spread of the organism between intraoral reservoirs.
摘要翻译： 描述和要求保护与牙龈卟啉单胞菌菌毛有关的多肽，其表现出抑制对唾液涂覆的表面的细菌粘附。 多肽选自菌毛，芬布林林和菌毛相关。 衍生自其的肽。 多肽用作各种口服制剂中的活性成分，其旨在防止牙龈卟啉单胞菌粘附到宿主粘膜表面，从而干扰牙周炎的发展。 多肽还用于亚单位疫苗制剂中，用于在牙周炎的预防性治疗中用于抵抗致病性，流汗的牙龈卟啉菌。 使用多肽在血清和牙龈沟液中诱导保护性免疫可以预防牙龈卟啉单胞菌的原发感染以及生物体在口内储库之间的扩散。
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公开(公告)号：US5432055A
公开(公告)日：1995-07-11
申请号：US72067
申请日：1993-06-02
CPC分类号： C12Q1/689
摘要： The present invention relates to novel compositions comprising P. gingivalis specific oligonucleotides which are useful as primers to amplify particular regions of the genome of P. gingivalis during enzymatic nucleic acid amplification. The invention also provides a method for the detection of P. gingivalis, which may be present in a clinical specimen, using the P. gingivalis-specific primers and enzymatic nucleic acid amplification. The present invention also relates to P. gingivalis-specific oligonucleotides which are useful as probes to facilitate detection of the amplified regions of P. gingivalis DNA.
摘要翻译： 本发明涉及包含牙龈卟啉单胞菌特异性寡核苷酸的新型组合物，其可用作扩增酶核酸扩增期间牙龈卟啉单胞菌基因组的特定区域的引物。 本发明还提供了使用牙龈卟啉单胞菌特异性引物和酶促核酸扩增来检测牙龈卟啉单胞菌的方法，其可存在于临床标本中。 本发明还涉及牙龈卟啉单胞菌特异性寡核苷酸，其可用作促进牙龈卟啉单胞菌DNA扩增区域检测的探针。
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3.发明授权
公开(公告)号：US4287191A
公开(公告)日：1981-09-01
申请号：US140098
申请日：1980-04-14
IPC分类号： A61K31/60 , A01N37/36 , A61K8/42 , A61K8/69 , A61K31/165 , A61P1/02 , A61P31/04 , A61Q11/00 , C07C65/40 , C07C233/12 , C07C101/74 , C07C119/02
摘要： The composition comprises certain 5-acylsalicylanilides and more particularly comprises the compounds encompassed by the following generic formula: ##STR1## Where Z is a substituted phenyl ring of from 6 to 30 carbon atoms including substituents, R is a substituted or unsubstituted alkyl or phenyl group of from 2 to 30 carbon atoms including substituents and M is a radical selected from the group consisting of --C.dbd.N,--F,--NO.sub.2,--H, lower alkyl or lower haloalkyl.The preferred compositions of the invention have a partition coefficient greater than 4 and the substituted moieties in the phenyl ring of the Z group have a combined overall electron withdrawing effect on the phenyl ring of the Z group.The method of the invention comprises contacting the microorganism with a sufficient concentration of the above composition for a sufficient time to inhibit the growth of the microorganism.The above compositions are effective antiseptics against a wide range of microorganisms, especially bacteria, and the compositions surprisingly are especially effective against microorganisms prevalent in dental plaque.
摘要翻译： 该组合物包含某些5-酰基水杨酰苯胺，更具体地包括由以下通式所包括的化合物：其中Z是包含取代基的6至30个碳原子的取代苯环，R是取代或未取代的烷基或苯基 包括2至30个碳原子，包括取代基，M是选自-C = N，-F，-NO 2，-H，低级烷基或低级卤代烷基的基团。 本发明的优选组合物具有大于4的分配系数，并且Z基团的苯环中的取代部分在Z基团的苯环上具有组合的总吸电子效应。 本发明的方法包括使足够浓度的上述组合物的微生物接触足够的时间以抑制微生物的生长。 上述组合物是针对广泛的微生物，特别是细菌的有效的防腐剂，并且该组合物令人惊奇地对抗牙菌斑中普遍存在的微生物特别有效。
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公开(公告)号：US06407288B1
公开(公告)日：2002-06-18
申请号：US09969071
申请日：2001-10-02
IPC分类号： C07C23365
CPC分类号： C07C255/60 , C07C235/84
摘要： The present invention discloses novel naphthylsalicylanilides of the general formula wherein W is a substituted or unsubstituted naphthyl ring. The substitution on W includes replacing one or more —H with —OH, alkyl, O-alkyl, branched alkyl, or cycloalkyl, containing 1-6 carbon atoms or combinations thereof. Y is a substituted or unsubstituted phenyl ring or substituted or unsubstituted naphthyl ring. The substitution for Y includes replacement of one or more —H atoms with CN, CF3, NO2, methoxy, benzoyl, phenoxy, phenoxymethyl or combinations thereof. These compounds are useful as antibacterial against gram negative and gram positive bacteria and as antiinflammatory agents.
摘要翻译： 本发明公开了通式为W的取代或未取代的萘基萘基新的萘磺酰苯胺。 在W上的取代包括用含1-6个碳原子的-OH，烷基，O-烷基，支链烷基或环烷基取代一个或多个-H或其组合。 Y是取代或未取代的苯基环或取代或未取代的萘基环。 取代Y包括用CN，CF 3，NO 2，甲氧基，苯甲酰基，苯氧基，苯氧基甲基或其组合取代一个或多个-H原子。 这些化合物可用作抗革兰氏阴性和革兰氏阳性菌和抗炎剂的抗菌剂。
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5.发明授权Novel 5-alkylsulfonylsalicylanilides and microbiocidal compositions for controlling the growth of microorganisms 失效用于控制微生物生长的新型5-烷基磺酰基水杨酰胺和杀微生物组合物
公开(公告)号：US4939132A
公开(公告)日：1990-07-03
申请号：US723080
申请日：1985-04-15
IPC分类号： A61K31/60 , A61K8/46 , A61K8/69 , A61K31/165 , A61K31/18 , A61P1/02 , A61P31/04 , A61Q11/00 , C07C67/00 , C07C233/12 , C07C233/65 , C07C313/00 , C07C317/46 , C07C323/65
摘要： This invention relates to new 5-alkylsulfonylsalicylanilides and methods for their use. More particularly, the invention relates to compounds of the formula: ##STR1## Wherein Z is a substituted or unsubstituted phenyl ring of from 6 to 30 carbon atoms including substituents, R is a substituted or unsubstituted alkylsulfonyl group of from 1 to 20 carbon atoms including substitutents; and X is a radical selected from the group consisting of --CN, --NO.sub.2, --H, halogen, lower alkyl or lower haloalkyl.The above compounds and compositions containing them are effective antiseptics against a wide range of microorganisms, especially bacteria, and are surprisingly highly effective against microorganisms, particularly S. mutans, prevalent in dental plaque.
摘要翻译： 本发明涉及新的5-烷基磺酰基水杨酰胺及其使用方法。 更具体地说，本发明涉及下式的化合物：其中Z是取代或未取代的6至30个碳原子的苯环，包括取代基，R是1至20个碳原子的取代或未取代的烷基磺酰基，包括 替代品 X为选自-CN，-NO 2，-H，卤素，低级烷基或低级卤代烷基的基团。 上述含有它们的化合物和组合物是广泛的微生物，特别是细菌的有效的防腐剂，并且对于在牙菌斑中普遍存在的微生物，特别是变形链球菌，令人惊奇地高度有效。
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公开(公告)号：US4358443A
公开(公告)日：1982-11-09
申请号：US176419
申请日：1980-08-08
IPC分类号： A01N37/40 , A61K8/42 , A61K8/69 , A61Q11/00 , C07C65/40 , C07C233/12 , A01N37/36 , C07C103/29
摘要： The composition comprises certain 5-alkylsalicylanilides and more particularly comprises the compounds encompassed by the following generic formula: ##STR1## Where Z is a substituted phenyl ring of from 6 to 30 carbon atoms including substituents, and R is a substituted or unsubstituted n-alkyl or phenyl group of from 4 to 30 carbon atoms including substituents.The preferred compositions of the invention have a partition coefficient greater than 4 and the substituted moieties in the phenyl ring of the Z group have a combined overall electron withdrawing effect on the phenyl ring of the Z group.The method of the invention comprises contacting a microorganism affected by the above composition with a sufficient concentration of the above composition for a sufficient time to inhibit the growth of the microorganism.The above compositions are effective antiseptics against a wide range of microorganisms, especially bacteria, and the compositions surprisingly are effective against microorganisms prevalent in dental plaque.
摘要翻译： 该组合物包含某些5-烷基水杨酰胺，更具体地包括由以下通式所包括的化合物：其中Z是含有6至30个碳原子的取代苯环，包括取代基，R是取代或未取代的正烷基 或含有4-30个碳原子的苯基，包括取代基。 本发明的优选组合物具有大于4的分配系数，并且Z基团的苯环中的取代部分在Z基团的苯环上具有组合的总吸电子效应。 本发明的方法包括使受上述组合物影响的微生物与足够浓度的上述组合物接触足够的时间以抑制微生物的生长。 上述组合物是针对广泛的微生物，特别是细菌的有效的防腐剂，并且该组合物令人惊奇地对于牙菌斑中普遍存在的微生物是有效的。
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7.发明授权Method of relieving chronic inflammation by using 5-alkylsulfonylsalicylanilides 失效使用5-烷基磺酰基水杨酰胺缓解慢性炎症的方法
公开(公告)号：US6117859A
公开(公告)日：2000-09-12
申请号：US407244
申请日：1999-09-28
IPC分类号： A61K9/107 , A61K31/167 , A61K31/63
CPC分类号： A61K31/609 , A61K31/167 , A61K9/1075
摘要： A method of treating chronic inflammation in a mammal is disclosed which comprises contacting the affected area with an amount sufficient to ameliorate the inflammatory condition, of a compound of the following formula: ##STR1## wherein Z is a substituted phenyl ring, R is an alkylsulfonyl group of 1-20 carbon atoms, and X is selected from the group consisting of --CN, --NO.sub.2, --H, halogen, lower alkyl and lower haloalkyl.
摘要翻译： 公开了一种治疗哺乳动物慢性炎症的方法，其包括使受影响的区域与足以改善炎性病症的量接触下式的化合物：其中Z是取代的苯环，R是1的烷基磺酰基 -20个碳原子，X选自-CN，-NO 2，-H，卤素，低级烷基和低级卤代烷基。
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公开(公告)号：US5455041A
公开(公告)日：1995-10-03
申请号：US121041
申请日：1993-09-13
申请人： Robert J. Genco , Moon-Il Cho
发明人： Robert J. Genco , Moon-Il Cho
CPC分类号： A61K9/0063 , A61C8/0006 , A61K6/0032
摘要： A method for inducing periodontal regeneration including soft tissue, cementum, and bone regeneration, resulting in a type of healing characteristic of the anatomy and architecture of the undiseased tissue, comprising treating the surface of the damaged root with a demineralizing agent, and then applying a growth factor directly to the treated bone surface.
摘要翻译： 一种用于诱导包括软组织，牙骨质和骨再生的牙周再生的方法，导致未破裂组织的解剖结构和结构的愈合特征，包括用脱盐剂处理受损根的表面，然后施加 生长因子直接处理骨表面。
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公开(公告)号：US4997830A
公开(公告)日：1991-03-05
申请号：US476299
申请日：1990-02-07
申请人： Arie J. van Winkelhoff , Edwin G. Winkel , Ronald J. Goene , Lars A. Christersson , Joseph J. Zambon , Robert J. Genco
发明人： Arie J. van Winkelhoff , Edwin G. Winkel , Ronald J. Goene , Lars A. Christersson , Joseph J. Zambon , Robert J. Genco
IPC分类号： A61K31/43
CPC分类号： A61K31/43 , Y10S514/90 , Y10S514/902
摘要： A pharmaceutical combination of Metronidazole and Amoxicillin for the treatment of periodontitis. Conventional therapeutic doses of both the Metronidazole and Amoxicillin given as a combination therapy has been unexpectedly found to effectively treat periodontitis.
摘要翻译： 甲硝唑和阿莫西林的药物组合治疗牙周炎。 作为组合治疗给予甲硝唑和阿莫西林的常规治疗剂量已被意外地发现有效治疗牙周炎。
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10.发明授权
公开(公告)号：US4741999A
公开(公告)日：1988-05-03
申请号：US833856
申请日：1986-02-26
IPC分类号： C12N15/02 , C07K14/005 , C07K14/195 , C07K14/41 , C07K16/00 , C07K19/00 , C12P21/00 , C12P21/08 , C12Q1/02 , C12R1/01 , G01N33/569 , G01N33/577 , C12N5/00 , C12N15/00
CPC分类号： C12Q1/02 , G01N33/56955 , Y10S435/948 , Y10S435/968 , Y10S530/808
摘要： Actinobacillus actinomycetemcomitans has frequently been implicated in juvenile periodontitis. The present monoclonal antibodies are specific to Actinobacillus actinomycetemcomitans. The present monoclonal antibodies are typically employed as reagents which include an inert carrier, preferably a liquid, such as buffered saline solution and a preservative. The carrier compositions are suitably selected to provide for the proper dispersal of bacteria, and to preserve the integrity of antigens and supplemental structures. The selection of the proper carrier is especially important in the detection in mixtures which include bacteria which produce large amounts of autolyltic enzymes such as B. gingivalis. The monoclonal antibodies of the present invention are useful in clinical testing and differentiating antigens in the gingival or subgingival sera. The method of testing and differentiating involves the steps of contacting a sample of the bacterial flora from a lesion or other site with a measured amount of monoclonal antibody specific to a single antigen site on Actinobacillus actinomycetemcomitans and subsequently measuring the number of antibody-antigen complexes formed.
摘要翻译： 放线杆菌放线杆菌通常涉及青少年牙周炎。 本发明的单克隆抗体对放线杆菌放线杆菌具有特异性。 本单克隆抗体通常用作试剂，其包括惰性载体，优选液体，例如缓冲盐溶液和防腐剂。 适当地选择载体组合物以提供细菌的适当分散，并保持抗原和补充结构的完整性。 适当载体的选择在包括产生大量内膜蛋白酶如牙龈卟啉菌的细菌的混合物中的检测中是特别重要的。 本发明的单克隆抗体可用于牙龈或龈下血清中的抗原的临床检测和鉴别。 测试和鉴别的方法包括将病原体或其他部位的细菌菌群样品与放线杆菌放线菌素单个抗原位点特异的测量量的单克隆抗体接触并随后测量形成的抗体 - 抗原复合物的数量 。
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