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1.发明申请Proteins capable of binding to female sex hormones and process for producing the same 审中-公开能够结合女性性激素的蛋白质及其制备方法公开(公告)号：US20060110771A1
公开(公告)日：2006-05-25
申请号：US10506063
申请日：2003-02-28
CPC分类号： C07K14/575 , C07K14/47 , C07K16/26 , C07K2317/565 , C07K2317/567 , C07K2317/622 , G01N33/74 , G01N33/743
摘要： The present invention provides a protein capable of binding to a female sex hormone, which protein is supplemented with useful properties for measuring, quantifying and concentrating female sex hormones, such as high sensitivity, low cross-reactivity, unlikelihood of being influenced by interfering substances, and unlikelihood of being influenced by solvents. Specifically, the present invention provides a recombinant protein prepared by obtaining various genes for various antibodies against female sex hormones, and modifying, by gene recombination technology, various properties of the original antibody, such as affinity, avidity, cross-reactivity, resistance for interfering substance on antigen-antibody reaction, resistance for interfering substance on enzymatic color developing reaction, resistance for solvent and the like.
摘要翻译： 本发明提供能够结合雌性激素的蛋白质，该蛋白质补充有用于测量，定量和浓缩女性性激素的有用性质，例如高灵敏度，低交叉反应性，受干扰物质影响的不可靠性， 并且不受溶剂影响。 具体地说，本发明提供了通过获得针对女性性激素的各种抗体的各种基因而制备的重组蛋白质，并且通过基因重组技术修饰原始抗体的各种性质，例如亲和力，亲合力，交叉反应性，抗干扰性 抗原抗体反应的物质，干燥物质对酶显色反应的抵抗性，溶剂性等。
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2.发明申请Proteins capable of binding to environmental hormones and process for producing the same 审中-公开能够结合环境激素的蛋白质及其制备方法公开(公告)号：US20050019833A1
公开(公告)日：2005-01-27
申请号：US10929543
申请日：2004-08-31
申请人： Hideo Ohkawa , Shigeru Fujimoto , Yasuhiro Goda
发明人： Hideo Ohkawa , Shigeru Fujimoto , Yasuhiro Goda
IPC分类号： C07K14/47 , C07K16/26 , C07K16/44 , C12N1/15 , C12N1/19 , C12N1/21 , C12N15/13 , G01N33/53 , A61K39/395
CPC分类号： C07K16/44 , C07K14/47 , C07K16/26 , C07K2317/31 , C07K2317/565 , C07K2317/622 , C07K2319/00
摘要： The present invention provides a protein capable of binding to an environmental hormone, which protein is supplemented with useful properties for measuring, quantifying and concentrating environmental hormones, such as high sensitivity, low cross-reactivity, unlikelihood of being influenced by interfering substances, and unlikelihood of being influenced by solvents. Specifically, the present invention provides a modified protein prepared by obtaining various genes for various antibodies with environmental hormones, and modifying, by gene recombination technology, various properties of the original antibody, such as affinity, avidity, cross-reactivity, resistance for interfering substance on antigen-antibody reaction, resistance for interfering substance on enzymatic color developing reaction, resistance for solvent and the like.
摘要翻译： 本发明提供能够结合环境激素的蛋白质，该蛋白质补充有用于测量，定量和浓缩环境激素的有用性质，例如高灵敏度，低交叉反应性，受干扰物质影响的不可能性和不可能性 受到溶剂的影响。 具体地说，本发明提供了通过获得具有环境激素的各种抗体的各种基因制备的修饰蛋白质，并且通过基因重组技术修饰了原始抗体的各种性质，例如亲和力，亲合力，交叉反应性，抗干扰物质的抗性 抗原抗体反应，对酶促显色反应的干扰物质的抗性，溶剂性等。
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3.发明授权Monoclonal antibody for immunoassay of detergents and their degradation products and its use 失效用于免疫测定洗涤剂及其降解产物的单克隆抗体及其用途公开(公告)号：US06251612B1
公开(公告)日：2001-06-26
申请号：US08942915
申请日：1997-10-02
IPC分类号： G01N3353
CPC分类号： C07K16/44 , G01N33/5308
摘要： A hybridoma obtainable by fusing a spleen cell or lymphocyte of an animal immunized by a complex of a surfactant compound for synthetic detergent and protein with a myeloma cell, which produces a monoclonal antibody against the compound or its degradation product. A monoclonal antibody against a surfactant compound for synthetic detergent or its degradation product which is produced by the hybridoma, a kit for immunoassay of detergent, its degradation product or a mixture thereof containing as an essential constitutional component the monoclonal antibody, and an immunoassay method, in particular, ELISA of detergent, its degradation product or a mixture thereof in a specimen by reacting the specimen with the monoclonal antibody supported on a carrier and the detergent, its degradation product or the mixture thereof labeled with a labeling agent are also disclosed.
摘要翻译： 通过将由合成洗涤剂和蛋白质的表面活性剂化合物的复合物免疫的动物的脾细胞或淋巴细胞与骨髓瘤细胞融合而获得的杂交瘤，其产生针对该化合物或其降解产物的单克隆抗体。 针对合成洗涤剂或其降解产物的表面活性剂化合物的单克隆抗体，其由杂交瘤产生，用于免疫测定洗涤剂的试剂盒，其降解产物或其含有作为单克隆抗体的必需组成成分的混合物，以及免疫测定法， 特别地，还公开了通过使样品与负载在载体上的单克隆抗体以及用标记试剂标记的洗涤剂，其降解产物或其混合物使样品中的洗涤剂，其降解产物或其混合物的ELISA。
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公开(公告)号：US5816559A
公开(公告)日：1998-10-06
申请号：US816647
申请日：1997-03-13
申请人： Shigeru Fujimoto
发明人： Shigeru Fujimoto
CPC分类号： E04H9/021 , E04H2009/026
摘要： A seismic isolation device comprises a floor body which is arranged on a structural floor and to which an object of seismic isolation is mounted, a first restoring member disposed on the structural floor and adapted to impart a horizontal restoring force to the floor body when the floor body is horizontally displaced with respect to the structural floor, a first damping member arranged in association with the first restoring member and adapted to impart a horizontal damping force when the floor body is horizontally displaced with respect to the structural floor, a first engaging member projecting from the floor body towards the structural floor, a second engaging member provided on the first restoring member and sliding while coming into contact with the first engaging member, a second restoring member disposed to a lower portion of the floor body and adapted to impart a vertical restoring force when the floor body is vertically displaced with respect to the structural floor, a second damping member arranged in association with the second restoring member and adapted to impart a vertical damping force when the floor body is vertically displaced with respect to the structural floor, and a support mechanism for supporting the floor body to be movable in a horizontal direction.
摘要翻译： 隔震装置包括布置在结构地板上并且安装有隔震物体的地板本体，设置在结构地板上的第一恢复构件，并且适于在地面上施加水平恢复力到地板本体 主体相对于结构地板水平移位，第一阻尼构件与第一恢复构件相关联地布置并且适于当地板本体相对于结构地板水平移位时施加水平阻尼力;第一接合构件突出 从所述地板本体向结构地板施加第二接合构件，所述第二接合构件设置在所述第一恢复构件上并在与所述第一接合构件接触的同时滑动;第二恢复构件，设置在所述地板本体的下部， 当地板体相对于结构地板垂直移位时的恢复力，第二 阻尼构件，其与所述第二恢复构件相关联地布置并且适于在所述地板主体相对于所述结构地板垂直移位时施加垂直阻尼力;以及支撑机构，用于支撑所述地板本体以在水平方向上可移动。
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5.发明授权
公开(公告)号：US5017755A
公开(公告)日：1991-05-21
申请号：US424695
申请日：1989-10-20
申请人： Susumu Yahagi , Shuichi Ishida , Shigeru Fujimoto
发明人： Susumu Yahagi , Shuichi Ishida , Shigeru Fujimoto
IPC分类号： G02F1/13 , G02F1/1343
CPC分类号： G02F1/13439 , G02F1/1309
摘要： An apparatus for repairing a liquid crystal display comprises a common electrode, pixel electrodes facing the common electrode, and a liquid crystal sealed between the common and pixel electrodes. If the liquid crystal contains foreign matter which short-circuits the common and pixel electrodes to each other, a pixel electrode is irradiated with a laser beam such that at least a ring line region completely surrounding a portion touching the foreign matter is burnt away, whereby a region inside of the ring line region and a region outside of the ring line region are electrically insulated from each other.
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公开(公告)号：US4656131A
公开(公告)日：1987-04-07
申请号：US674598
申请日：1984-11-26
申请人： Kazuaki Kitano , Shigeru Fujimoto
发明人： Kazuaki Kitano , Shigeru Fujimoto
IPC分类号： C12N15/09 , A61K38/00 , A61K38/21 , C07K14/56 , C07K14/57 , C12N1/21 , C12P21/02 , C12R1/19 , C12P21/00
摘要： A method for producing high yields of interferons which comprises cultivating a microorganism carrying an expression vector with a structural gene of interferon inserted therein in a chemically defined medium containing L-glutamic acid and an iron ion source and preferably further containing an zinc ion source or zinc and copper ion sources, and recovering interferon from the culture.
摘要翻译： 一种生产高产量干扰素的方法，其包括在含有L-谷氨酸和铁离子源的化学定义培养基中培养携带具有插入其中的干扰素结构基因的表达载体的微生物，并且优选进一步含有锌离子源或锌 和铜离子源，并从培养物中回收干扰素。
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公开(公告)号：US07232974B2
公开(公告)日：2007-06-19
申请号：US11192174
申请日：2005-07-29
申请人： Hiroshi Watanabe , Toshiharu Myoga , Masahiro Kanatani , Koichi Mitsuhata , Keiji Ueda , Seiji Kikuhara , Toshiharu Nagashima , Shigeru Fujimoto
发明人： Hiroshi Watanabe , Toshiharu Myoga , Masahiro Kanatani , Koichi Mitsuhata , Keiji Ueda , Seiji Kikuhara , Toshiharu Nagashima , Shigeru Fujimoto
IPC分类号： B23K9/12
CPC分类号： B23K37/0276 , B23K9/0286 , B23K9/127 , B23K9/167 , B23K9/173 , B23K37/0533 , B23K2101/06
摘要： A welding head which can easily move the torch portion of the welding head in the circumferential direction and the vertical moving direction of the outer circumference of the to-be-welded tubes even in a narrow gap, includes a torch rotating ring that rotates on the outer circumferences of the tubes by matching with the central axis of the to-be-welded tubes and a torch vertical moving ring disposed concentrically with the ring inside the ring, provided with a torch base for supporting a torch on the front ends, a first gear group for driving and rotating the ring around the tubes, a second gear group that is disposed in parallel to the first gear group and drives and rotates the ring around the tubes, a drive shaft for driving the two gear groups, and a torch rotating motor for driving the drive shaft, and a third gear group that can drive the ring while rotating it in the same direction as or in reverse to that of the ring at a speed equal to or higher or lower than that of the first gear group for rotating the ring around the tubes and vertically moving the torch, and a torch vertical moving motor for driving this third gear group.
摘要翻译： 即使在狭窄的间隙中也能够容易地使待焊接管的外周的圆周方向和外周的移动方向移动焊接头的焊接头包括： 通过与待焊接管的中心轴线匹配的管的外周和与环内环内同心设置的割炬垂直移动环，设置有用于在前端支撑割炬的焊炬底座，第一 齿轮组，用于围绕管驱动和旋转环;第二齿轮组，其平行于第一齿轮组设置并驱动并围绕管旋转环;驱动轴，用于驱动两个齿轮组;以及手电筒旋转 用于驱动驱动轴的马达，以及第三齿轮组，其能够以等于或高于或低于所述涡卷的速度在与所述环的相同方向旋转的同时驱动所述环 t齿轮组，用于围绕管旋转环并垂直移动割炬，以及用于驱动该第三齿轮组的割炬垂直运动电机。
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公开(公告)号：US20070026455A1
公开(公告)日：2007-02-01
申请号：US10547810
申请日：2004-03-05
申请人： Masahiro Tomita , Shigeru Fujimoto
发明人： Masahiro Tomita , Shigeru Fujimoto
CPC分类号： C07K16/00 , C07K2317/10 , C12N5/163
摘要： The present invention provides a method of producing an antibody-producing hybridoma, which includes fusing a B cell immunized in vitro and a myeloma cell, and which is more efficient and practical than the conventional methods, more specifically a method of producing an antibody-producing hybridoma, which includes fusing a B cell immunized with an antigenic substance in the coexistence of a cytokine and a glycolipid in vitro, and a myeloma cell, and use thereof.
摘要翻译： 本发明提供一种产生产生抗体的杂交瘤的方法，其包括使体外免疫的B细胞和骨髓瘤细胞融合，其比常规方法更有效和更实用，更具体地说是产生抗体的方法 杂交瘤，其包括在细胞因子和糖脂在体外共存时融合抗原性物质免疫的B细胞和骨髓瘤细胞及其用途。
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公开(公告)号：US4599834A
公开(公告)日：1986-07-15
申请号：US665159
申请日：1984-10-26
CPC分类号： E02D27/34
摘要： A seismic isolator has a sliding plate fixed on the lower surface of a building, a connecting plate underlying the sliding plate, an elastic first support disposed between the connecting plate and a foundation of the building to support the building, a second support disposed between the connecting plate and the foundation and urged by a biasing force of a spring member such that its upper end is brought into tight contact with the lower surface of the connecting plate, and a jack for adjusting the biasing force of the spring member. A frictional force acting between the sliding plate and the connecting plate is larger than that between the connecting plate and the upper end of the second support.
摘要翻译： 地震隔离器具有固定在建筑物的下表面上的滑板，滑板下面的连接板，设置在连接板和建筑物的基座之间以支撑建筑物的弹性第一支撑件， 连接板和基座，并且通过弹簧构件的偏置力而被推压，使得其上端与连接板的下表面紧密接触，以及用于调节弹簧构件的偏置力的千斤顶。 作用在滑板和连接板之间的摩擦力大于连接板和第二支撑件的上端之间的摩擦力。
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公开(公告)号：US06336296B1
公开(公告)日：2002-01-08
申请号：US09472810
申请日：1999-12-28
IPC分类号： E04C252
CPC分类号： E04F15/02476 , E04F15/02405 , E04F15/02411
摘要： A floor system includes a plurality of panels placed on a base floor. A space is formed between the panels and the base floor for laying cables. A plurality of sliding plates are arranged on the base floor. A plurality of supports are provided and each support of the plurality of supports is arranged on each of the sliding plates so as to freely slide. The plurality of panels are supported by the plurality of supports by being fixed on a pedestal of the each support of the plurality of supports. The plurality of panels are hence connected to each other to form a single floor surface. The dynamic coefficient of friction between the bottom of the supports and the sliding plates is selected to be a value within a range of 0.09 to 0.25.
摘要翻译： 地板系统包括放置在底座上的多个面板。 在面板和基座之间形成用于铺设电缆的空间。 多个滑板布置在底座上。 提供多个支撑件，并且每个支撑件的每个支撑件布置在每个滑板上以便自由滑动。 多个面板通过固定在多个支撑件的每个支撑件的基座上由多个支撑件支撑。 因此，多个面板彼此连接以形成单个地板表面。 支撑体底部和滑板之间的动态摩擦系数选择为0.09〜0.25的范围内的值。
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