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1.发明授权Genes of cell wall-degrading enzymes derived from aspergillus, and method for the production the enzymes 失效源自曲霉的细胞壁降解酶的基因，以及生产酶的方法公开(公告)号：US07285407B2
公开(公告)日：2007-10-23
申请号：US11085185
申请日：2005-03-22
申请人： Masayuki Machida , Motoaki Sano , Misao Sunagawa , Tasuku Nakajima , Keietsu Abe , Katsuya Gomi , Kiyoshi Asai , Taishin Kin , Hideki Nagasaki , Akira Hosoyama , Osamu Akita , Naotake Ogasawara , Satoru Kuhara
发明人： Masayuki Machida , Motoaki Sano , Misao Sunagawa , Tasuku Nakajima , Keietsu Abe , Katsuya Gomi , Kiyoshi Asai , Taishin Kin , Hideki Nagasaki , Akira Hosoyama , Osamu Akita , Naotake Ogasawara , Satoru Kuhara
CPC分类号： C12P19/04 , C12N9/2405 , C12Y302/01039 , C12Y302/01058
摘要： The purpose of the present invention is to isolate a gene encoding novel exo-, or endo-β-1,3-glucanase, to obtain a microorganism having an enhanced expression of said gene and to degrade β-1,3-glucan to its low molecular weight form by means of said enzymes. The present invention relates to a gene or DNA encoding novel enzymes having β-1,3-glucanase activity (exo-, or endo-β-1,3-glucanase), a recombinant expression vector comprising them, a microorganism having the recombinant expression vector, the novel enzymes having β-1,3-glucanase activity, and a method for the production of said enzymes.
摘要翻译： 本发明的目的是分离编码新的外切或内切-β-1,3-葡聚糖酶的基因，以获得具有增强的所述基因表达的微生物，并将β-1,3-葡聚糖降解为其 低分子量形式通过所述酶。 本发明涉及编码具有β-1,3-葡聚糖酶活性的新型酶（外切-β-1,3-葡聚糖酶）的基因或DNA，包含它们的重组表达载体，具有重组表达的微生物 载体，具有β-1,3-葡聚糖酶活性的新型酶以及所述酶的生产方法。
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2.发明申请Novel genes of cell wall-degrading enzymes derived from aspergillus, and method for the production the enzymes 失效来自曲霉的细胞壁降解酶的新基因，以及生产酶的方法公开(公告)号：US20050287634A1
公开(公告)日：2005-12-29
申请号：US11085185
申请日：2005-03-22
申请人： Masayuki Machida , Motoaki Sano , Misao Sunagawa , Tasuku Nakajima , Keietsu Abe , Katsuya Gomi , Kiyoshi Asai , Taishin Kin , Hideki Nagasaki , Akira Hosoyama , Osamu Akita , Naotake Ogasawara , Satoru Kuhara
发明人： Masayuki Machida , Motoaki Sano , Misao Sunagawa , Tasuku Nakajima , Keietsu Abe , Katsuya Gomi , Kiyoshi Asai , Taishin Kin , Hideki Nagasaki , Akira Hosoyama , Osamu Akita , Naotake Ogasawara , Satoru Kuhara
CPC分类号： C12P19/04 , C12N9/2405 , C12Y302/01039 , C12Y302/01058
摘要： The purpose of the present invention is to isolate a gene encoding novel exo-, or endo-β-1,3-glucanase, to obtain a microorganism having an enhanced expression of said gene and to degrade β-1,3-glucan to its low molecular weight form by means of said enzymes. The present invention relates to a gene or DNA encoding novel enzymes having β-1,3-glucanase activity (exo-, or endo-β-1,3-glucanase), a recombinant expression vector comprising them, a microorganism having the recombinant expression vector, the novel enzymes having β-1,3-glucanase activity, and a method for the production of said enzymes.
摘要翻译： 本发明的目的是分离编码新的外切或内切-β-1,3-葡聚糖酶的基因，以获得具有增强的所述基因表达的微生物，并将β-1,3-葡聚糖降解为其 低分子量形式通过所述酶。 本发明涉及编码具有β-1,3-葡聚糖酶活性的新型酶（外切-β-1,3-葡聚糖酶）的基因或DNA，包含它们的重组表达载体，具有重组表达的微生物 载体，具有β-1,3-葡聚糖酶活性的新型酶以及所述酶的生产方法。
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公开(公告)号：US07763444B2
公开(公告)日：2010-07-27
申请号：US12489827
申请日：2009-06-23
申请人： Katsuhiko Kitamoto , Manabu Arioka , Shotaro Yamaguchi , Masayuki Machida , Keietsu Abe , Katsuya Gomi , Kiyoshi Asai , Motoaki Sano , Taishin Kin , Hideki Nagasaki , Akira Hosoyama , Osamu Akita , Naotake Ogasawara , Satoru Kuhara
发明人： Katsuhiko Kitamoto , Manabu Arioka , Shotaro Yamaguchi , Masayuki Machida , Keietsu Abe , Katsuya Gomi , Kiyoshi Asai , Motoaki Sano , Taishin Kin , Hideki Nagasaki , Akira Hosoyama , Osamu Akita , Naotake Ogasawara , Satoru Kuhara
CPC分类号： C12N9/20 , C12Y301/01004
摘要： It is intended to provide koji mold-origin phospholipase A2 and a DNA encoding it. Namely, phospholipase A2 comprising the following protein (a) or (b): (a) a protein having an amino acid sequence represented by SEQ ID NO: 1 or 2; and (b) a protein having an amino acid sequence derived from an amino acid sequence represented by SEQ ID NO: 1 or 2 by a partial modification and serving as phospholipase A2.
摘要翻译： 旨在提供曲霉起源磷脂酶A2和编码它的DNA。 即，包含以下蛋白质（a）或（b）的磷脂酶A2：（a）具有SEQ ID NO：1或2所示的氨基酸序列的蛋白质; 和（b）通过部分修饰具有源自SEQ ID NO：1或2所示的氨基酸序列的氨基酸序列并作为磷脂酶A2的蛋白质。
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公开(公告)号：US20090263888A1
公开(公告)日：2009-10-22
申请号：US12489827
申请日：2009-06-23
申请人： Katsuhiko Kitamoto , Manabu Arioka , Shotaro Yamaguchi , Masayuki Machida , Keietsu Abe , Katsuya Gomi , Kiyoshi Asai , Motoaki Sano , Taishin Kin , Hideki Nagasaki , Akira Hosoyama , Osamu Akita , Naotake Ogasawara , Satoru Kuhara
发明人： Katsuhiko Kitamoto , Manabu Arioka , Shotaro Yamaguchi , Masayuki Machida , Keietsu Abe , Katsuya Gomi , Kiyoshi Asai , Motoaki Sano , Taishin Kin , Hideki Nagasaki , Akira Hosoyama , Osamu Akita , Naotake Ogasawara , Satoru Kuhara
CPC分类号： C12N9/20 , C12Y301/01004
摘要： It is intended to provide koji mold-origin phospholipase A2 and a DNA encoding it. Namely, phospholipase A2 comprising the following protein (a) or (b): (a) a protein having an amino acid sequence represented by SEQ ID NO: 1 or 2; and (b) a protein having an amino acid sequence derived from an amino acid sequence represented by SEQ ID NO: 1 or 2 by a partial modification and serving as phospholipase A2.
摘要翻译： 旨在提供曲霉起源磷脂酶A2和编码它的DNA。 即，包含以下蛋白质（a）或（b）的磷脂酶A2：（a）具有SEQ ID NO：1或2所示的氨基酸序列的蛋白质; 和（b）通过部分修饰具有源自SEQ ID NO：1或2所示的氨基酸序列的氨基酸序列并作为磷脂酶A2的蛋白质。
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公开(公告)号：US20060234320A1
公开(公告)日：2006-10-19
申请号：US10500251
申请日：2002-12-26
申请人： Masayuki Machida , Keietsu Abe , Katsuya Gomi , Kiyoshi Asai , Motoaki Sano , Taishin Kin , Hideki Nagasaki , Akira Hosoyama , Osamu Akita , Naotake Ogasawara , Satoru Kuhara , Chikara Tokunaga , Itaru Toda , Chiaki Saitoh , Akihiro Senoh
发明人： Masayuki Machida , Keietsu Abe , Katsuya Gomi , Kiyoshi Asai , Motoaki Sano , Taishin Kin , Hideki Nagasaki , Akira Hosoyama , Osamu Akita , Naotake Ogasawara , Satoru Kuhara , Chikara Tokunaga , Itaru Toda , Chiaki Saitoh , Akihiro Senoh
CPC分类号： C12N9/80 , C12N9/0022 , C12N9/48 , C12P21/06
摘要： The present invention provides DNA encoding novel pyroglutamyl peptidase derived from Aspergillus oryzae, pyroglutamyl peptidase which is produced by using the DNA, and a method for producing a protein lysate with a good flavor at a high hydrolysis rate.
摘要翻译： 本发明提供了编码来自米曲霉的新型焦谷氨酰肽酶的DNA，通过使用该DNA产生的焦谷氨酰肽酶，以及以高水解速率生产具有良好风味的蛋白质裂解物的方法。
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公开(公告)号：US07186540B2
公开(公告)日：2007-03-06
申请号：US10327388
申请日：2002-12-24
申请人： Masayuki Machida , Keietsu Abe , Katsuya Gomi , Kiyoshi Asai , Motoaki Sano , Taishin Kin , Hideki Nagasaki , Akira Hosoyama , Osamu Akita , Naotake Ogasawara , Satoru Kuhara , Kotaro Ito , Kenichiro Matsushima , Yasuji Koyama
发明人： Masayuki Machida , Keietsu Abe , Katsuya Gomi , Kiyoshi Asai , Motoaki Sano , Taishin Kin , Hideki Nagasaki , Akira Hosoyama , Osamu Akita , Naotake Ogasawara , Satoru Kuhara , Kotaro Ito , Kenichiro Matsushima , Yasuji Koyama
IPC分类号： C12N9/80 , C12N5/00 , C12N15/00 , C12N1/20 , C12N1/00 , C07H21/04 , C12P21/06 , C07K14/00 , C12N9/78
CPC分类号： C12N9/80 , C12N9/0022 , C12N9/48 , C12P21/06
摘要： A completely novel glutaminase is provided: (a) a protein consisting of an amino acid sequence represented by SEQ ID NO: 2, or (b) a protein consisting of an amino acid sequence derived from the amino acid sequence represented by SEQ ID NO: 2 by deletion, substitution or addition of one or more amino acids, and possessing glutaminase activity. This protein is a novel glutaminase possessing excellent thermostability and the like.
摘要翻译： 提供了一种全新的谷氨酰胺酶：（a）由SEQ ID NO：2所示的氨基酸序列组成的蛋白质，或（b）由SEQ ID NO：2所示的氨基酸序列衍生的氨基酸序列组成的蛋白质， 2通过缺失，取代或添加一个或多个氨基酸，并且具有谷氨酰胺酶活性。 该蛋白质是具有优异的热稳定性等的新型谷氨酰胺酶。
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公开(公告)号：US20050142650A1
公开(公告)日：2005-06-30
申请号：US10498517
申请日：2002-12-25
申请人： Kensuke Yuuki , Atsuki Toumoto , Masayuki Machida , Katsuya Gomi , Kiyoshi Asai , Motoaki Sano , Taishin Kin , Hideki Nagasaki , Akira Hosoyama , Osamu Akita , Naotake Ogasawara , Satoru Kuhara
发明人： Kensuke Yuuki , Atsuki Toumoto , Masayuki Machida , Katsuya Gomi , Kiyoshi Asai , Motoaki Sano , Taishin Kin , Hideki Nagasaki , Akira Hosoyama , Osamu Akita , Naotake Ogasawara , Satoru Kuhara
IPC分类号： C12N1/15 , C12N1/19 , C12N1/21 , C12N9/06 , C12N9/48 , C12N9/62 , C12N9/80 , C12N15/52 , C12N15/53 , C12N15/57 , C12P21/06 , C07H21/04 , C12N1/16 , C12N1/18 , C12N15/74
CPC分类号： C12N9/80 , C12N9/0022 , C12N9/48 , C12P21/06
摘要： Lysyl oxidase derived from filamentous fungi and a DNA encoding thereof are provided. Lysyl oxidase including a protein described in of the following (a) or (b): (a) a protein having an amino acid sequence set forth in SEQ ID NO: 2; or (b) a protein having an amino acid sequence obtained by modifying a part of the amino acid sequence set forth in SEQ ID NO: 2, and functioning as lysyl oxidase.
摘要翻译： 提供衍生自丝状真菌的赖氨酰氧化酶及其编码的DNA。 包含以下（a）或（b）所述的蛋白质的赖氨酰氧化酶：（a）具有SEQ ID NO：2所示的氨基酸序列的蛋白质; 或（b）具有通过修饰SEQ ID NO：2所示氨基酸序列的一部分而作为赖氨酰氧化酶起作用的氨基酸序列的蛋白质。
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公开(公告)号：US20070004003A1
公开(公告)日：2007-01-04
申请号：US10547708
申请日：2004-03-02
申请人： Katsuhiko Kitamoto , Manabu Arioka , Shotaro Yamaguchi , Masayuki Machida , Keletsu Abe , Katsuya Gomi , Kiyoshi Asai , Motoaki Sano , Taishin Kin , Hideki Nagasaki , Akira Hosoyama , Osamu Akita , Naotake Ogasawara , Satoru Kuhara
发明人： Katsuhiko Kitamoto , Manabu Arioka , Shotaro Yamaguchi , Masayuki Machida , Keletsu Abe , Katsuya Gomi , Kiyoshi Asai , Motoaki Sano , Taishin Kin , Hideki Nagasaki , Akira Hosoyama , Osamu Akita , Naotake Ogasawara , Satoru Kuhara
CPC分类号： C12N9/20 , C12Y301/01004
摘要： It is intended to provide koji mold-origin phospholipase A2 and a DNA encoding it. Namely, phospholipase A2 comprising the following protein (a) or (b): (a) a protein having an amino acid sequence represented by SEQ ID NO: 1 or 2; and (b) a protein having an amino acid sequence derived from an amino acid sequence represented by SEQ ID NO: 1 or 2 by a partial modification and serving as phospholipase A2.
摘要翻译： 旨在提供曲霉起源磷脂酶A 2 N 2和编码它的DNA。 即，包含以下蛋白质（a）或（b）的磷脂酶A 2 ：（a）具有SEQ ID NO：1或2所示的氨基酸序列的蛋白质; 和（b）通过部分修饰具有源自SEQ ID NO：1或2所示的氨基酸序列的氨基酸序列并用作磷脂酶A 2的蛋白质。
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公开(公告)号：US08354073B2
公开(公告)日：2013-01-15
申请号：US11628306
申请日：2005-05-23
申请人： Yuji Oki , Satoru Kuhara
发明人： Yuji Oki , Satoru Kuhara
CPC分类号： G01N21/0303 , B01L3/502715 , B01L2300/0654 , B01L2300/0803 , B01L2300/0816 , B01L2300/0867 , B01L2400/0409 , G01N21/645 , Y10T436/11
摘要： The present invention provides an inspection chip using light, which is able to provide an irradiation of light at a high precision. The present invention further provides an inspection chip capable of carrying out the inspection of a sample in a simple manner by using a plurality of lights.The inspection chip of the present invention comprises a light amplifier element and a sample holding section for holding a sample, in which the light amplifier element is oriented so as to face to the sample holding section, so that the light emitted from the light amplifier element can irradiate the sample held in the sample holding section.
摘要翻译： 本发明提供一种使用光的检查芯片，其能够以高精度提供光的照射。 本发明还提供一种能够通过使用多个灯以简单的方式进行样品检查的检查芯片。 本发明的检查芯片包括光放大器元件和用于保持样品的样品保持部分，其中光放大器元件被定向成面向样品保持部分，使得从光放大器元件发射的光 可以照射保持在样品保持部中的样品。
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公开(公告)号：US20070161556A1
公开(公告)日：2007-07-12
申请号：US11516396
申请日：2006-09-05
摘要： The present invention provides therapeutic targets for antifungal treatment, especially CIK1.
摘要翻译： 本发明提供抗真菌治疗的治疗靶点，特别是CIK1。
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