公开(公告)号：US11458230B2

公开(公告)日：2022-10-04

申请号：US17097901

申请日：2020-11-13

Applicant: Massachusetts Institute of Technology

Inventor： Christopher J. Bettinger ,  Joost P. Bruggeman ,  Lino Da Silva Ferreira ,  Jeffrey M. Karp ,  Robert S. Langer ,  Christiaan Nijst ,  Andreas Zumbuehl ,  Jason Burdick ,  Sonia J. Kim

IPC: C08G63/685 ,  C08J3/24 ,  C08K5/00 ,  A61L31/06 ,  A61L27/18 ,  A61L27/38 ,  A61L27/58 ,  C12N11/096 ,  C12N11/087 ,  A61K35/12 ,  A61K35/48 ,  A61K45/06 ,  A61L31/14

Abstract: The present inventions in various aspects provide elastic biodegradable polymers. In various embodiments, the polymers are formed by the reaction of a multifunctional alcohol or ether and a difunctional or higher order acid to form a pre-polymer, which is cross-linked to form the elastic biodegradable polymer. In preferred embodiments, the cross-linking is performed by functionalization of one or more OR groups on the pre-polymer backbone with vinyl, followed by photopolymerization to form the elastic biodegradable polymer composition or material. Preferably, acrylate is used to add one or more vinyls to the backbone of the pre-polymer to form an acrylated pre-polymer. In various embodiments, acrylated pre-polymers are co-polymerized with one or more acrylated co-polymers.

公开(公告)号：US20190091377A1

公开(公告)日：2019-03-28

申请号：US16206937

申请日：2018-11-30

Applicant: Massachusetts Institute of Technology

Inventor： Christopher J. Bettinger ,  Joost P. Bruggeman ,  Lino da Silva Ferreira ,  Jeffrey M. Karp ,  Robert S. Langer ,  Christiaan Nijst ,  Andreas Zumbuehl ,  Jason Burdick ,  Sonia J. Kim

IPC: A61L31/06 ,  A61L31/14 ,  A61L27/18 ,  A61K45/06 ,  A61K35/48 ,  A61K35/12 ,  A61L27/38 ,  A61L27/58 ,  C08G63/685 ,  C12N11/08 ,  C08K5/00 ,  C08J3/24 ,  C08L67/00 ,  C08L67/07

Abstract: The present inventions in various aspects provide elastic biodegradable polymers. In various embodiments, the polymers are formed by the reaction of a multifunctional alcohol or ether and a difunctional or higher order acid to form a pre-polymer, which is cross-linked to form the elastic biodegradable polymer. In preferred embodiments, the cross-linking is performed by functionalization of one or more OR groups on the pre-polymer backbone with vinyl, followed by photopolymerization to form the elastic biodegradable polymer composition or material. Preferably, acrylate is used to add one or more vinyls to the backbone of the pre-polymer to form an acrylated pre-polymer. In various embodiments, acrylated pre-polymers are co-polymerized with one or more acrylated co-polymers.

公开(公告)号：US10179195B2

公开(公告)日：2019-01-15

申请号：US14182095

申请日：2014-02-17

Applicant: Massachusetts Institute of Technology

Inventor： Christopher J. Bettinger ,  Joost P. Bruggeman ,  Lino da Silva Ferreira ,  Jeffrey M. Karp ,  Robert S. Langer ,  Christiaan Nijst ,  Andreas Zumbuehl ,  Jason Burdick ,  Sonia J. Kim

IPC: C12N11/08 ,  C08J3/24 ,  C08K5/00 ,  C08L67/02 ,  A61L31/06 ,  A61L27/18 ,  A61L27/38 ,  A61L27/58 ,  C08G63/685 ,  A61K35/12 ,  A61K35/48 ,  A61K45/06 ,  A61L31/14

Abstract: The present inventions in various aspects provide elastic biodegradable polymers. In various embodiments, the polymers are formed by the reaction of a multifunctional alcohol or ether and a difunctional or higher order acid to form a pre-polymer, which is cross-linked to form the elastic biodegradable polymer. In preferred embodiments, the cross-linking is performed by functionalization of one or more OR groups on the pre-polymer backbone with vinyl, followed by photopolymerization to form the elastic biodegradable polymer composition or material. Preferably, acrylate is used to add one or more vinyls to the backbone of the pre-polymer to form an acrylated pre-polymer. In various embodiments, acrylated pre-polymers are co-polymerized with one or more acrylated co-polymers.

公开(公告)号：US20140186312A1

公开(公告)日：2014-07-03

申请号：US14182095

申请日：2014-02-17

Applicant: Massachusetts Institute of Technology

Inventor： Christopher J. Bettinger ,  Joost P. Bruggeman ,  Lino da Silva Ferreira ,  Jeffrey M. Karp ,  Robert S. Langer ,  Christiaan Nijst ,  Andreas Zumbuehl ,  Jason Burdick ,  Sonia J. Kim

IPC: A61L31/06 ,  A61L31/14 ,  A61K45/06 ,  A61K35/12 ,  A61K35/48

CPC classification number: A61L31/06 ,  A61K35/12 ,  A61K35/48 ,  A61K45/06 ,  A61L27/18 ,  A61L27/38 ,  A61L27/58 ,  A61L31/148 ,  C08G63/6854 ,  C08J3/24 ,  C08J3/246 ,  C08J2367/00 ,  C08J2367/07 ,  C08K5/0025 ,  C12N11/08 ,  C08L67/00 ,  C08L67/07

Abstract: The present inventions in various aspects provide elastic biodegradable polymers. In various embodiments, the polymers are formed by the reaction of a multifunctional alcohol or ether and a difunctional or higher order acid to form a pre-polymer, which is cross-linked to form the elastic biodegradable polymer. In preferred embodiments, the cross-linking is performed by functionalization of one or more OR groups on the pre-polymer backbone with vinyl, followed by photopolymerization to form the elastic biodegradable polymer composition or material. Preferably, acrylate is used to add one or more vinyls to the backbone of the pre-polymer to form an acrylated pre-polymer. In various embodiments, acrylated pre-polymers are co-polymerized with one or more acrylated co-polymers.

Abstract translation: 本发明在各方面提供弹性可生物降解的聚合物。 在各种实施方案中，聚合物通过多官能醇或醚和双官能或更高级酸的反应形成以形成预聚物，其被交联以形成弹性可生物降解的聚合物。 在优选的实施方案中，通过用乙烯基官能化预聚物主链上的一个或多个OR基团进行交联，然后进行光聚合以形成弹性可生物降解的聚合物组合物或材料。 优选地，使用丙烯酸酯将一种或多种乙烯基加成到预聚物的主链上以形成丙烯酸酯化的预聚物。 在各种实施方案中，丙烯酸酯化的预聚物与一种或多种丙烯酸酯化共聚物共聚。

公开(公告)号：US20210128794A1

公开(公告)日：2021-05-06

申请号：US17097901

申请日：2020-11-13

Applicant: Massachusetts Institute of Technology

Inventor： Christopher J. Bettinger ,  Joost P. Bruggeman ,  Lino da Silva Ferreira ,  Jeffrey M. Karp ,  Robert S. Langer ,  Christiaan Nijst ,  Andreas Zumbuehl ,  Jason Burdick ,  Sonia J. Kim

IPC: A61L31/06 ,  A61L27/18 ,  A61L27/38 ,  A61L27/58 ,  C08G63/685 ,  C08J3/24 ,  C08K5/00 ,  C12N11/08 ,  A61K35/12 ,  A61K35/48 ,  A61K45/06 ,  A61L31/14

Abstract: The present inventions in various aspects provide elastic biodegradable polymers. In various embodiments, the polymers are formed by the reaction of a multifunctional alcohol or ether and a difunctional or higher order acid to form a pre-polymer, which is cross-linked to form the elastic biodegradable polymer. In preferred embodiments, the cross-linking is performed by functionalization of one or more OR groups on the pre-polymer backbone with vinyl, followed by photopolymerization to form the elastic biodegradable polymer composition or material. Preferably, acrylate is used to add one or more vinyls to the backbone of the pre-polymer to form an acrylated pre-polymer. In various embodiments, acrylated pre-polymers are co-polymerized with one or more acrylated co-polymers.

公开(公告)号：US20160009657A1

公开(公告)日：2016-01-14

申请号：US14643845

申请日：2015-03-10

Applicant: Massachusetts Institute of Technology

Inventor： Daniel Griffith Anderson ,  Andreas Zumbuehl ,  Elizaveta S. Leshchiner ,  Robert S. Langer ,  Michael Solomon Goldberg

IPC: C07D233/61 ,  C07C229/12 ,  A61K47/22 ,  C07C231/12 ,  C07C227/10 ,  A61K47/18 ,  C07C229/16 ,  C07C237/06

CPC classification number: C07D233/61 ,  A61K9/1617 ,  A61K47/18 ,  A61K47/22 ,  A61K48/00 ,  A61K48/0033 ,  C07C227/10 ,  C07C229/12 ,  C07C229/14 ,  C07C229/16 ,  C07C229/18 ,  C07C231/12 ,  C07C237/06 ,  C07D211/26 ,  C07D243/08 ,  C07D295/12 ,  C07D307/14 ,  C07D317/28 ,  C12N15/88

Abstract: Nitrogen-containing lipids prepared from the conjugate addition of amines to acrylates, acrylamides, or other carbon-carbon double bonds conjugated to electron-withdrawing groups are described. Methods of preparing these lipids from commercially available starting materials are also provided. These amine-containing lipids or salts forms of these lipids are preferably biodegradable and biocompatible and may be used in a variety of drug delivery systems. Given the amino moiety of these lipids, they are particularly suited for the delivery of polynucleotides. Complexes or nanoparticles containing the inventive lipid and polynucleotide have been prepared. The inventive lipids may also be used to in preparing microparticle for drug delivery. They are particularly useful in delivering labile agents given their ability to buffer the pH of their surroundings.

Abstract translation: 描述了从共轭加成胺到丙烯酸酯，丙烯酰胺或与吸电子基团共轭的其它碳 - 碳双键制备的含氮脂质。 还提供了从市售的起始原料制备这些脂质的方法。 这些含脂质的脂质或这些脂质的盐形式优选是可生物降解的和生物相容的，并可用于各种药物递送系统。 鉴于这些脂质的氨基部分，它们特别适用于递送多核苷酸。 已经制备了含有本发明的脂质和多核苷酸的复合物或纳米颗粒。 本发明的脂质也可用于制备用于药物递送的微粒。 考虑到缓冲其周围环境的pH值，它们特别适用于提供不稳定剂。