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    Methods and moulds for use in fabricating side-ported microneedles
    2.
    发明申请
    Methods and moulds for use in fabricating side-ported microneedles 失效
    用于制造侧端微针的方法和模具

    公开(公告)号：US20100305516A1

    公开(公告)日：2010-12-02

    申请号：US10592559

    申请日：2004-03-12

    申请人： Yuan Xu ,  Minghua Wang ,  Mei Ma Chen ,  Zhongli Li ,  Chee Yen Lim ,  Pei Ying Joyce Tan

    发明人： Yuan Xu ,  Minghua Wang ,  Mei Ma Chen ,  Zhongli Li ,  Chee Yen Lim ,  Pei Ying Joyce Tan

    IPC分类号： A61M5/00 ,  B22C9/22 ,  B29C33/42 ,  C25D1/00

    CPC分类号： B29C33/0061 ,  A61M37/0015 ,  A61M2037/003 ,  A61M2037/0053 ,  B29C33/301 ,  B29C33/3857 ,  B29C33/40 ,  B29C33/424 ,  B29C33/56 ,  B29C59/026 ,  B29C2791/001 ,  B29C2793/0009 ,  B29L2031/756 ,  B29L2031/759 ,  B81B2201/055 ,  B81C99/009 ,  C25D1/02 ,  Y10T29/49885 ,  Y10T29/4998 ,  Y10T29/49982 ,  Y10T29/49984 ,  Y10T29/49986 ,  Y10T29/49988

    摘要： Side-ported microneedles are produced from a suitably shaped microneedle mould (40). A microneedle mould base (32) is made with a number of microneedle mould recesses (30) in it. One surface of the microneedle mould base (32) is coated with a seed layer (34). The microneedle mould base (32) contains two microneedle mould sheets (24, 26), which are separated to gain access to an internal surface of one of the microneedle mould sheets (24, 26). Side-port forming channels (38) are formed on one of the internal surfaces, intersecting with the recesses (30) within the relevant microneedle mould sheet (24). The two microneedle mould sheets (24, 26) are placed back together and joined together as a unitary microneedle mould (40). The microneedles are formed in the recesses (30) by depositing a microneedle layer (44) therein and on the surface with the seed layer (34). The microneedle layer (44) fails to deposit at side-port forming holes (42) where the side-port forming channels (38) intersect the recesses (30), which result in side-ports (46) in the moulded microneedles (52).

    摘要翻译： 由适当形状的微针模具（40）制造侧端微针。 微针模具基座（32）在其中形成有许多微针模具凹槽（30）。 微针模具基座（32）的一个表面涂覆有种子层（34）。 微针模具基座（32）包含两个微针模具片（24,26），它们分开以进入其中一个微针模板（24,26）的内表面。 侧孔形成通道（38）形成在与相关微针模板（24）内的凹部（30）相交的一个内表面上。 将两个微针模具片（24,26）放置在一起并作为整体式微针模具（40）连接在一起。 通过在其中放置微针层（44）并在种子层（34）的表面上，在凹部（30）中形成微针。 该微针层（44）不能沉积在侧孔形成通道（42）处，其中侧孔形成通道（38）与凹槽（30）相交，这导致模制微针（52）中的侧端口（46） ）。

    Plastic blood Lancet
    4.
    发明授权
    Plastic blood Lancet 有权

    公开(公告)号：US10271781B2

    公开(公告)日：2019-04-30

    申请号：US14437283

    申请日：2012-11-05

    申请人： Chee Yen Lim

    发明人： Chee Yen Lim

    IPC分类号： A61B5/00 ,  A61B5/151 ,  A61B5/15

    摘要： The present invention provides a surgically invasive pointed article for skin penetration and capillary whole blood extraction whose penetration ability can be disabled after use by deforming the tips. The present invention is made by injection molding a plastic needle 35 having an anchoring means 45 using a first material, followed by another injection molding process to over-mold a first body segment 20 and second body segment 30 using a second material to encase the plastic needle 35 thereby anchoring the plastic needle 35 to prevent further movement of the plastic needle 35. The encasing of the second material provide a barrier isolating the plastic needle 35 from the ambient to protect the tips 50 from damage and once sterilized, to conserve the sterile conditions till point of use. The barrier formed by a second over-molding process comprises a detachable cap 20 and a body 30. The present invention is normally used for blood sampling applications but can also be used for applications such as vaccination or skin allergy testing, and transdermal/intradermal drug delivery.

    SURGICALLY INVASIVE POINTED ARTICLES FOR SKIN PENETRATION AND METHODS FOR THEIR PREPARATION
    5.
    发明申请
    SURGICALLY INVASIVE POINTED ARTICLES FOR SKIN PENETRATION AND METHODS FOR THEIR PREPARATION 审中-公开
    用于皮肤渗透的有意义的入侵物品及其制备方法

    公开(公告)号：US20140243867A1

    公开(公告)日：2014-08-28

    申请号：US14351894

    申请日：2011-11-02

    申请人： Chee Yen Lim

    发明人： Chee Yen Lim

    IPC分类号： A61B5/151 ,  B29C45/14

    CPC分类号： A61B5/15134 ,  A61B5/150022 ,  A61B5/150282 ,  A61B5/150427 ,  A61B5/150511 ,  A61B5/150587 ,  A61B5/150618 ,  A61B5/150717 ,  A61B5/150923 ,  A61B5/15117 ,  A61B5/15186 ,  A61M5/3202 ,  B29C45/14

    摘要： A surgically invasive pointed article for skin penetration and its fabrication method are presented. The present invention comprises a protruding sharp end portion and a body portion, the protruding sharp end portion comprising at least one penetration tip that can be disabled after use. The tip disablement after use is an effective safety measure in eradicating accidental injuries and re-use. The tip disablement can be carried out manually by the user or automatically if the article is used with a custom-made tip-disabling applicator. The skin penetration device can be used as a lancet for blood sampling, a needle for immunization and skin allergy testing, or a skin breaching device for transdermal drug delivery. The second aspect of the invention is a method for preparing the surgically invasive pointed article for skin penetration. The preparation method includes injection mould the articles into at least two body segments, the first body segment comprising at least one protruding end for skin penetration, and the second body segment being hollow forming a handle for handling purpose or an adaptor for fitting into an applicator. The third aspect of the invention is an over-moulding process for packaging purposes, wherein the articles moulded with a first material mentioned above are over-moulded with a second softer and cheaper material to form various additional functional parts.

    摘要翻译： 介绍了一种用于皮肤穿透的手术侵入性尖端物品及其制造方法。 本发明包括突出的尖端部分和主体部分，突出的尖端部分包括至少一个穿透尖端，该穿透尖端在使用后可被禁用。 使用后的提示禁用是消除意外伤害和重复使用的有效安全措施。 尖端禁用可以由用户手动执行，或者如果物品与定制的尖头禁用施放器一起使用，则可自动进行。 皮肤穿透装置可以用作血液取样的刺血针，用于免疫的针和皮肤过敏测试，或用于透皮药物递送的皮肤破裂装置。 本发明的第二方面是用于制备用于皮肤穿透的外科手术侵入性尖端物品的方法。 该制备方法包括将制品注射成至少两个主体部分，第一主体部分包括用于皮肤穿透的至少一个突出端，并且第二主体部分是中空的，形成用于处理目的的手柄或用于装配到施加器中的适配器 。 本发明的第三方面是用于包装目的的过度成型方法，其中用上述第一种材料模制的制品用第二较软和便宜的材料进行超模塑以形成各种附加的功能部件。

    PLASTIC BLOOD LANCET
    6.
    发明申请
    PLASTIC BLOOD LANCET 审中-公开
    塑料血液网

    公开(公告)号：US20150265198A1

    公开(公告)日：2015-09-24

    申请号：US14437283

    申请日：2012-11-05

    申请人： Chee Yen LIM

    发明人： Chee Yen Lim

    IPC分类号： A61B5/151 ,  A61B5/15

    CPC分类号： A61B5/15101 ,  A61B5/150022 ,  A61B5/150282 ,  A61B5/150297 ,  A61B5/150312 ,  A61B5/150412 ,  A61B5/150503 ,  A61B5/150564 ,  A61B5/150618 ,  A61B5/150717 ,  A61B5/15105 ,  A61B5/15142

    摘要： The present invention provides a surgically invasive pointed article for skin penetration and capillary whole blood extraction whose penetration ability can be disabled after use by deforming the tips. The present invention is made by injection moulding a plastic needle 35 having an anchoring means 45 using a first material, followed by another injection moulding process to over-mould a first body segment 20 and second body segment 30 using a second material to encase the plastic needle 35 thereby anchoring the plastic needle 35 to prevent further movement of the plastic needle 35. The encasing of the second material provide a barrier isolating the plastic needle 35 from the ambient to protect the tips 50 from damage and once sterilized, to conserve the sterile conditions till point of use. The barrier formed by a second over-moulding process comprises a detachable cap 20 and a body 30. The present invention is normally used for blood sampling applications but can also be used for applications such as vaccination or skin allergy testing, and transdermal/intradermal drug delivery.

    摘要翻译： 本发明提供了一种用于皮肤渗透和毛细血管全血提取的外科手术侵入性尖端物品，其使用后的穿透能力可通过使尖端变形而被禁用。 本发明通过使用第一材料注射成型具有锚定装置45的塑料针35，然后通过另一种注射成型工艺来模制第一主体部分20和第二主体部分30，使用第二材料来包住塑料 针35，从而锚定塑料针35以防止塑料针35的进一步移动。第二材料的包封提供了将塑料针35与环境隔离的障碍物，以保护尖端50不被损坏并一旦被灭菌，以保存无菌 使用条件。 通过第二过度成型方法形成的阻挡层包括可拆卸盖20和主体30.本发明通常用于血液取样应用，但也可用于例如疫苗接种或皮肤过敏测试，以及透皮/皮内药物 交货。

    CONTACTLESS CONDUCTIVITY DETECTOR
    7.
    发明申请
    CONTACTLESS CONDUCTIVITY DETECTOR 审中-公开
    无连接电导率检测器

    公开(公告)号：US20120160691A1

    公开(公告)日：2012-06-28

    申请号：US13311315

    申请日：2011-12-05

    申请人： Kambiz Ansari Mahabadi ,  Isabel Rodriguez Fernandez ,  Chee Yen Lim ,  Jasmine Shu Ying Yuen

    发明人： Kambiz Ansari Mahabadi ,  Isabel Rodriguez Fernandez ,  Chee Yen Lim ,  Jasmine Shu Ying Yuen

    IPC分类号： G01N27/447 ,  B81B1/00

    CPC分类号： G01N27/4473 ,  G01N27/44791

    摘要： A portable electrophoretic contactless conductivity detection (C4D) system for analysis on a microfluidic chip houses in one embodiment a fluidic compartment for receiving the microfluidic chip, and four detection electrodes: first and second emitting electrodes, and first and second receiving electrodes. The first emitting electrode and the first receiving electrode are adjacent to a first channel wall of the microfluidic chip, and the second emitting electrode and the second receiving electrode are adjacent to a second channel wall, where the second channel wall is opposite to the first channel wall. In an embodiment, the electrodes are provided as portions of a removable cartridge cell.

    摘要翻译： 在一个实施例中，用于在微流体芯片上分析的便携式电泳非接触电导检测系统（C4D）用于接收微流体芯片的流体隔室和四个检测电极：第一和第二发射电极以及第一和第二接收电极。 第一发射电极和第一接收电极与微流体芯片的第一通道壁相邻，并且第二发射电极和第二接收电极邻近第二通道壁，其中第二通道壁与第一通道相对 壁。 在一个实施例中，电极被提供为可移除盒式电池的部分。

    CONTACTLESS CONDUCTIVITY DETECTOR
    8.
    发明申请
    CONTACTLESS CONDUCTIVITY DETECTOR 有权
    无连接电导率检测器

    公开(公告)号：US20110140721A1

    公开(公告)日：2011-06-16

    申请号：US13057922

    申请日：2009-08-07

    申请人： Kambiz Ansari Mahabadi ,  Isabel Rodriguez Fernandez ,  Chee Yen Lim

    发明人： Kambiz Ansari Mahabadi ,  Isabel Rodriguez Fernandez ,  Chee Yen Lim

    IPC分类号： G01R27/26

    CPC分类号： G01N27/4473 ,  G01N27/44791

    摘要： The contactless conductivity detector in one embodiment includes a microfluidic chip having a channel (102) thereon and four detection electrodes: first and second emitting electrodes (100a, 101a), and first and second receiving electrodes (100b, 101b). The channel (102) is defined by channel walls. The first emitting electrode (100a) and the first receiving electrode (100b) are adjacent a first channel wall, and the second emitting electrode (101a) and the second receiving electrode (101b) are adjacent a second channel wall, the second channel wall being opposite the first channel wall.

    摘要翻译： 一个实施例中的非接触电导检测器包括其上具有通道（102）的微流体芯片和四个检测电极：第一和第二发射电极（100a，101a）以及第一和第二接收电极（100b，101b）。 通道（102）由通道壁限定。 第一发光电极（100a）和第一接收电极（100b）与第一通道壁相邻，第二发光电极（101a）和第二接收电极（101b）相邻于第二通道壁，第二通道壁为 在第一个通道墙对面。

    Method of fabricating microneedle patches
    10.
    发明授权
    Method of fabricating microneedle patches 有权

    公开(公告)号：US11504512B2

    公开(公告)日：2022-11-22

    申请号：US16491462

    申请日：2017-05-10

    申请人： Chee Yen Lim

    发明人： Chee Yen Lim

    IPC分类号： A61M37/00 ,  B29C39/02 ,  B29C39/42 ,  B29K105/00 ,  B29L31/00

    摘要： In the preferred embodiment, a method of making microneedles comprises i) providing a microneedle template (300) having a plurality of microneedles cavities (360) on one surface, ii) preparing a casting solution (320) comprising at least one matrix material and its solvent, iii) subjecting said microneedle template (300) to a vacuum pressure for a length of time to deprive it of air, iv) dispensing the casting solution (320) over the air-deprived microneedle template, v) allowing the casting solution (320) to be drawn into the air-deprived microneedle cavities (360) completely, and vi) allowing the dissolving microneedles to solidify or dry in a controlled environment.