公开(公告)号：US20240298932A1

公开(公告)日：2024-09-12

申请号：US18664947

申请日：2024-05-15

Applicant: Medtronic MiniMed, Inc.

Inventor： Ashwin K. Rao ,  Rebecca K. Gottlieb ,  Quyen B. Ong

IPC: A61B5/145 ,  A61B5/00 ,  A61B5/1477 ,  A61B5/1486 ,  C07K14/62 ,  C12Q1/00 ,  G01N33/52 ,  G01N33/66

CPC classification number: A61B5/14532 ,  A61B5/14517 ,  A61B5/1486 ,  G01N33/526 ,  G01N33/66 ,  A61B5/14539 ,  A61B5/14546 ,  A61B5/1477 ,  A61B5/6833 ,  C07K14/62 ,  C12Q1/006

Abstract: Described here are patches and methods for measuring glucose in sweat (and tears and the like). In general, the patches comprise an adhesive layer adapted to bond to skin of an individual, a substrate layer disposed over the adhesive layer and comprising a glucose sensing complex including a chromogen that changes color in the presence of certain concentrations of glucose, and a cover. In typical embodiments, the substrate layer has elements formed to direct and accumulate sweat that migrates from the skin of the individual to the glucose sensing complex. Methods of using the invention can comprise cleaning the skin surface, collecting sweat in a patch comprising this microfluidic constellation of elements, and observing concentrations of glucose collected in the sweat, for example either visually, or by using a smartphone or other computer processing device.

公开(公告)号：US20240023849A1

公开(公告)日：2024-01-25

申请号：US18344273

申请日：2023-06-29

Applicant: Medtronic MiniMed, Inc.

Inventor： Daniel E. Pesantez ,  Ashwin K. Rao ,  Inthirai Somasuntharam

IPC: A61B5/1486 ,  A61B5/145

CPC classification number: A61B5/14865 ,  A61B5/14532 ,  A61B5/14546

Abstract: Embodiments of the invention provide compositions useful in implantable devices such as analyte sensors as well as methods for making and using such compositions and devices. In typical embodiments of the invention, the device is a glucose sensor comprising an analyte modulating layer formed from acrylate hydrogel composition that modulates the diffusion of glucose through the analyte modulating layer and which further comprises a bioactive agent selected to enhance the biocompatibility of analyte sensors when implanted in vivo.

公开(公告)号：US20230404448A1

公开(公告)日：2023-12-21

申请号：US18136417

申请日：2023-04-19

Applicant: Medtronic MiniMed, Inc.

Inventor： Ellis Garai ,  Sarkis D. Aroyan ,  Anuj M. Patel ,  Ashwin K. Rao

IPC: A61B5/1495 ,  A61B5/145 ,  A61B5/1486 ,  A61B5/00

CPC classification number: A61B5/1495 ,  A61B5/14532 ,  A61B5/14865 ,  A61B2560/0276 ,  A61B5/7221 ,  A61B5/7203 ,  A61B5/4839

Abstract: A method for compensating for a life-lengthening agent for a glucose sensor includes accessing first and second electrochemical impedance spectroscopy (EIS) values of at least one parameter based on first and second EIS procedures performed on EIS signals from a working electrode of the glucose sensor, calculating a change in the at least one parameter between the first and second EIS values, estimating a concentration of the agent based on the change in the at least one parameter, and calculating a model effect in response to the concentration. In a case where the model effect is not greater than the threshold, the method further includes adjusting a sensor glucose value based on the concentration and sensor signals from the working electrode, and displaying the adjusted sensor glucose value.

公开(公告)号：US20140243634A1

公开(公告)日：2014-08-28

申请号：US13779584

申请日：2013-02-27

Applicant: MEDTRONIC MINIMED, INC.

Inventor： Ting Huang ,  Ashwin K. Rao ,  Rajiv Shah ,  Qingling Yang

IPC: A61B5/145 ,  A61B5/1477

CPC classification number: A61B5/14532 ,  A61B5/1477

Abstract: The invention disclosed herein includes amperometric glucose sensors having electrodes formed from processes that electrodeposit platinum black in a manner that produces relatively smooth three dimensional metal architectures, ones that contribute to sensor reliability and stability. Embodiments of the invention provide analyte sensors having such uniform electrode architectures as well as methods for making and using these sensor electrodes. A number of working embodiments of the invention are shown to be useful in amperometric glucose sensors worn by diabetic individuals.

Abstract translation: 本文公开的本发明包括电流葡萄糖传感器，其具有由以下方式形成的电极：电沉积铂黑以产生相对平滑的三维金属结构的方式，这些结构有助于传感器的可靠性和稳定性。 本发明的实施例提供具有这种均匀电极结构的分析物传感器以及用于制造和使用这些传感器电极的方法。 本发明的多个实施方案被证明可用于由糖尿病患者佩戴的电流葡萄糖传感器。

公开(公告)号：US20240335147A1

公开(公告)日：2024-10-10

申请号：US18602816

申请日：2024-03-12

Applicant: Medtronic MiniMed, Inc.

Inventor： Dmitri A. Kossakovski ,  Ashwin K. Rao ,  Suryakiran Vadrevu

IPC: A61B5/1486 ,  A61B5/145

CPC classification number: A61B5/14865 ,  A61B5/14532

Abstract: Embodiments of the invention provide amperometric analyte sensors having membranes made from materials selected to transport analytes such as glucose to an enzyme within the sensor while simultaneously inhibiting the movement of interfering species such as acetaminophen to the electrode within the sensor. While embodiments of the invention can be used in a variety of contexts, typical embodiments of the invention include glucose or ketone sensors used in the management of diabetes.

公开(公告)号：US20230310341A1

公开(公告)日：2023-10-05

申请号：US18192479

申请日：2023-03-29

Applicant: Medtronic MiniMed, Inc.

Inventor： Ellis Garai ,  Ashwin K. Rao ,  Margaret R. Miller ,  Sarkis D. Aroyan

IPC: A61K9/70 ,  A61B5/145 ,  A61B5/00

CPC classification number: A61K9/7092 ,  A61B5/14532 ,  A61B5/6833 ,  A61B2560/0412

Abstract: The invention provides a skin adhesive patch that inhibits skin irritation by releasing an anti-inflammatory agent such as a corticosteroid topically on the skin surface. Embodiments of the invention can be adapted for use with a wide variety of adhesive patches that are used to couple medical components to the skin of patients such as the devices that diabetic patients use including insulin infusion sets, patch pumps, and all-in-one patch sets.

公开(公告)号：US11642454B2

公开(公告)日：2023-05-09

申请号：US16893145

申请日：2020-06-04

Applicant: MEDTRONIC MINIMED, INC.

Inventor： Chia-Hung Chiu ,  Rebecca K. Gottlieb ,  Ellis Garai ,  Akhil Srinivasan ,  Andrea Varsavsky ,  Adam S. Trock ,  Ashwin K. Rao ,  Hsifu Wang ,  Daniel E. Pesantez ,  Isabella Ella Miya ,  Xinrui Zhang ,  Guruguhan Meenakshisundaram

IPC: A61M5/172 ,  A61M5/142 ,  A61M39/10 ,  A61M5/162 ,  A61M37/00 ,  A61M5/168

CPC classification number: A61M5/14248 ,  A61M5/162 ,  A61M5/16831 ,  A61M5/1723 ,  A61M37/0015 ,  A61M39/10 ,  A61M2005/14252 ,  A61M2037/0023 ,  A61M2205/50 ,  A61M2205/8206 ,  A61M2205/8243 ,  A61M2230/201

Abstract: A fluid infusion system includes a housing configured to be adhesively coupled to an anatomy of the user. The housing comprises a communication device configured to wirelessly communicate a physiological characteristic to a communication component of a fluid infusion device. The fluid infusion system includes a fluid flow path from the fluid infusion device into the anatomy of the user, and the fluid flow path is configured to extend from the housing for insertion into the anatomy of the user.

公开(公告)号：US20230140353A1

公开(公告)日：2023-05-04

申请号：US17517616

申请日：2021-11-02

Applicant: Medtronic MiniMed, Inc.

Inventor： Ellis Garai ,  Ashwin K. Rao ,  Lawrence S. Ring

IPC: A61B17/34 ,  A61M39/00

Abstract: A medical device includes a base having a needle channel and a first surface configured to be secured to a patient's skin. An insertable member is configured to be secured to the base with a length portion of the insertable member extending out of the needle channel at the first surface, for insertion through the patient's skin at an insertion site. A septum extends across the needle channel. The septum has a body through which an insertion needle may be selectively extended to facilitate the subcutaneous insertion of the length portion of the insertable member. The septum provides a liquid seal across the needle channel. The needle channel and the septum provide a sealed volume in which a limited amount of blood or other fluid from the insertion site may be held.

公开(公告)号：US20230113175A1

公开(公告)日：2023-04-13

申请号：US17497441

申请日：2021-10-08

Applicant: Medtronic MiniMed, Inc.

Inventor： Ellis Garai ,  Jenn-Hann L. Wang ,  Ashwin K. Rao

IPC: A61B5/1486 ,  A61B5/145 ,  A61K31/573

Abstract: Embodiments of the invention provide compositions useful in implantable devices such as analyte sensors as well as methods for making and using such compositions and devices. In typical embodiments of the invention, the device is a glucose sensor comprising a polymeric composition disposed on a flexible assembly within the sensor that includes amounts of one or more immunosuppressant agents designed to provide such sensors with improved material properties such as enhanced biocompatibility.

公开(公告)号：US20210024972A1

公开(公告)日：2021-01-28

申请号：US16523882

申请日：2019-07-26

Applicant: Medtronic MiniMed, Inc.

Inventor： Daniel E. Pesantez ,  Ashwin K. Rao ,  Ellis Garai ,  Rui Kong ,  Michael E. Miller

IPC: C12Q1/00 ,  A61B5/145 ,  A61B5/1486 ,  G01N27/327

Abstract: Embodiments of the invention provide multilayer analyte sensors having elements and/or architectures that function to improve oxygen delivery to sensor enzymes in manner that enhances sensor function, as well as methods for making and using such sensors. Typical embodiments of the invention include glucose sensors used in the management of diabetes.