公开(公告)号：US20210113117A1

公开(公告)日：2021-04-22

申请号：US16654353

申请日：2019-10-16

Applicant: Medtronic MiniMed, Inc.

Inventor： Akhil Srinivasan ,  Tyler Wong ,  Inthirai Somasuntharam

IPC: A61B5/1473 ,  A61B5/145 ,  C23C14/14 ,  C23C14/35

Abstract: Embodiments of the invention provide optimized sputtered metallic surfaces adapted for use with implantable medical devices as well as methods for making and using such polymeric surfaces. These sputtered metallic surfaces have features that function to inhibit or avoid an inflammatory immune response generated by implantable medical devices. Typical embodiments of the invention include an implantable glucose sensor used in the management of diabetes having a sputtered metallic surface adapted to contact an in vivo environment.

公开(公告)号：US20230123613A1

公开(公告)日：2023-04-20

申请号：US17501292

申请日：2021-10-14

Applicant: Medtronic MiniMed, Inc.

Inventor： Ashwin K. Rao ,  Quyen B. Ong ,  Michael E. Miller ,  Sarnath Chattaraj ,  Guangping Zhang ,  Poonam Gulati ,  Ariel Reider ,  Mohsen Askarinya ,  Michael N. Missaghi ,  Chi-En Lin ,  Xin Heng ,  Inthirai Somasuntharam ,  Melissa Tsang ,  Carlos E. Maldonado ,  Akhil Srinivasan

IPC: G01N27/327 ,  C12N9/04 ,  C12Q1/00 ,  G01N33/49

Abstract: The invention provides amperometric analyte sensor systems comprising one or more electrodes designed to monitor in vivo levels of 3-hydroxybutyrate (and optionally glucose as well) in order to facilitate the management of diabetic ketoacidosis. The invention further includes compositions, elements and methods useful with such amperometric analyte sensor systems.

公开(公告)号：US20240023849A1

公开(公告)日：2024-01-25

申请号：US18344273

申请日：2023-06-29

Applicant: Medtronic MiniMed, Inc.

Inventor： Daniel E. Pesantez ,  Ashwin K. Rao ,  Inthirai Somasuntharam

IPC: A61B5/1486 ,  A61B5/145

CPC classification number: A61B5/14865 ,  A61B5/14532 ,  A61B5/14546

Abstract: Embodiments of the invention provide compositions useful in implantable devices such as analyte sensors as well as methods for making and using such compositions and devices. In typical embodiments of the invention, the device is a glucose sensor comprising an analyte modulating layer formed from acrylate hydrogel composition that modulates the diffusion of glucose through the analyte modulating layer and which further comprises a bioactive agent selected to enhance the biocompatibility of analyte sensors when implanted in vivo.

公开(公告)号：US20230240569A1

公开(公告)日：2023-08-03

申请号：US18296198

申请日：2023-04-05

Applicant: Medtronic MiniMed, Inc.

Inventor： Akhil Srinivasan ,  Tyler R. Wong ,  Inthirai Somasuntharam

IPC: A61B5/1473 ,  A61B5/145 ,  C23C14/14 ,  C23C14/35

CPC classification number: A61B5/1473 ,  A61B5/1451 ,  C23C14/14 ,  C23C14/35 ,  A61B5/14532 ,  A61B2562/125

Abstract: Embodiments of the invention provide optimized sputtered metallic surfaces adapted for use with implantable medical devices as well as methods for making and using such polymeric surfaces. These sputtered metallic surfaces have features that function to inhibit or avoid an inflammatory immune response generated by implantable medical devices. Typical embodiments of the invention include an implantable glucose sensor used in the management of diabetes having a sputtered metallic surface adapted to contact an in vivo environment.

公开(公告)号：US11638545B2

公开(公告)日：2023-05-02

申请号：US16654353

申请日：2019-10-16

Applicant: Medtronic MiniMed, Inc.

Inventor： Akhil Srinivasan ,  Tyler Wong ,  Inthirai Somasuntharam

IPC: A61B5/1473 ,  C23C14/14 ,  C23C14/35 ,  A61B5/145

Abstract: Embodiments of the invention provide optimized sputtered metallic surfaces adapted for use with implantable medical devices as well as methods for making and using such polymeric surfaces. These sputtered metallic surfaces have features that function to inhibit or avoid an inflammatory immune response generated by implantable medical devices. Typical embodiments of the invention include an implantable glucose sensor used in the management of diabetes having a sputtered metallic surface adapted to contact an in vivo environment.

公开(公告)号：US20210076993A1

公开(公告)日：2021-03-18

申请号：US17025570

申请日：2020-09-18

Applicant: Medtronic MiniMed, Inc.

Inventor： Inthirai Somasuntharam ,  Jake Matteson ,  Matthew Jolly ,  Quyen Ong ,  Akhil Srinivasan ,  Poonam Gulati ,  Andrea Varsavsky ,  Sana Suhail

IPC: A61B5/145 ,  A61B5/1473 ,  A61K31/573

Abstract: Embodiments of the invention provide compositions useful in implantable devices such as analyte sensors as well as methods for making and using such compositions and devices. In typical embodiments of the invention, the device is a glucose sensor comprising a polymeric composition that includes amounts of one or more immunosuppressant agents so as to provide such membranes with improved material properties such as enhanced biocompatibility.