公开(公告)号：US20080045817A1

公开(公告)日：2008-02-21

申请号：US10596562

申请日：2004-12-20

申请人： Michael Cornelis Van Beek ,  Egbert Lenderink ,  Robert Frans Maria Hendriks

发明人： Michael Cornelis Van Beek ,  Egbert Lenderink ,  Robert Frans Maria Hendriks

IPC分类号： A61B5/00

CPC分类号： A61B5/0059

摘要： Provided is a method and an apparatus for detection of objects below the surface of diffuse scattering media, in particular blood capillaries in organs such as the skin of human beings, using Orthogonal Polarized Spectral Imaging (OPSI), according to the invention comprising the steps of: imaging the object in question at at least two different angles so as to obtain a shift of position in the imaging plane; and subsequently comparing relative shifts of objects in the two images so as to obtain coordinates of the imaged objects with respect to the organ surface.

摘要翻译： 提供了一种用于根据本发明使用正交偏振光谱成像（OPSI）检测漫射散射介质，特别是诸如人皮肤的器官中的毛细血管表面下方的物体的方法和装置，包括以下步骤： ：以至少两个不同的角度对所讨论的物体进行成像，以获得成像平面中位置的偏移; 并且随后比较两个图像中的对象的相对偏移，以获得相对于器官表面的成像对象的坐标。

公开(公告)号：US07405825B2

公开(公告)日：2008-07-29

申请号：US10539540

申请日：2003-12-19

申请人： Frank Jeroen Pieter Schuurmans ,  Michael Cornelis Van Beek ,  Levinus Pieter Bakker ,  Wouter Harry Jacinth Rensen ,  Bernardus Hendrikus Wilhelmus Hendriks ,  Robert Frans Maria Hendriks ,  Thomas Steffen

发明人： Frank Jeroen Pieter Schuurmans ,  Michael Cornelis Van Beek ,  Levinus Pieter Bakker ,  Wouter Harry Jacinth Rensen ,  Bernardus Hendrikus Wilhelmus Hendriks ,  Robert Frans Maria Hendriks ,  Thomas Steffen

IPC分类号： G01J3/32 ,  G01J3/457 ,  G02B26/02

CPC分类号： G01J3/02 ,  G01J3/0205 ,  G01J3/021 ,  G01J3/10 ,  G01J3/28 ,  G01J3/36 ,  G01N21/274 ,  G01N21/31 ,  G01N2021/3196 ,  G01N2201/129

摘要： The optical analysis system (20) for determining an amplitude of a principal component of an optical signal comprises a multivariate optical element (10) for reflecting the optical signal and thereby weighing the optical signal by a spectral weighing function, and a detector (9, 9P, 9N) for detecting the weighed optical signal. The optical analysis system (20) may further comprise a dispersive element (2) for spectrally dispersing the optical signal, the multivariate optical element being arranged to receive the dispersed optical signal. The blood analysis system (40) comprises the optical analysis system (20) according to the invention.

摘要翻译： 用于确定光信号的主分量的幅度的光学分析系统（20）包括用于反射光信号并由此通过光谱称重功能称重光信号的多元光学元件（10） 9 P，9 N），用于检测加权的光信号。 光学分析系统（20）还可以包括用于光谱分散光学信号的色散元件（2），所述多元光学元件被布置成接收分散的光信号。 血液分析系统（40）包括根据本发明的光学分析系统（20）。

公开(公告)号：US20080285812A1

公开(公告)日：2008-11-20

申请号：US11568719

申请日：2005-04-28

申请人： Wouter Harry Jacinth Rensen ,  Robert Frans Maria Hendriks ,  Michael Cornelis Van Beek ,  Antonius Hermanus Maria Akkermans

发明人： Wouter Harry Jacinth Rensen ,  Robert Frans Maria Hendriks ,  Michael Cornelis Van Beek ,  Antonius Hermanus Maria Akkermans

IPC分类号： G06K9/00

CPC分类号： G06K9/00033 ,  G06K2009/00932

摘要： The invention relates to a personal identification method and to a corresponding apparatus. Their elements are mainly a light source emitting a beam of light towards a target, a first imaging module receiving a return beam coming back from said target and displaying an image of the target of a first type, and a second imaging module also receiving said return beam and displaying an image of the target of a second type. An identification module allows to combine the information given by said image of a first type and said image of a second type and to identify, or not, a person according to a similarity criterion.

摘要翻译： 本发明涉及个人识别方法和相应的装置。 它们的元件主要是朝向目标发射光束的光源，第一成像模块接收从所述目标回来的返回光束并显示第一类型的目标的图像，以及第二成像模块，还接收所述返回 并显示第二类型的目标的图像。 识别模块允许组合由所述第一类型的图像和所述第二类型的图像给出的信息，并且根据相似性标准来识别或不识别人。

公开(公告)号：US07583380B2

公开(公告)日：2009-09-01

申请号：US10547971

申请日：2004-03-01

申请人： Michael Cornelis Van Beek ,  Peter Ferdinand Greve

发明人： Michael Cornelis Van Beek ,  Peter Ferdinand Greve

IPC分类号： G01J3/30

CPC分类号： A61B5/0059 ,  A61B5/0068 ,  G01J3/44 ,  G01N21/65 ,  G02B21/241

摘要： The present invention relates to an analysis apparatus, in particular a spectroscopic analysis apparatus, for analyzing an object, such as blood of a patient, and a corresponding analysis method. To aim the confocal detection volume inside a blood vessel orthogonal polarized spectral imaging (OPSI) is used to locate blood capillaries in the skin. An imaging system (img) with slightly shifted imaging planes (i1, i2) for OPS imaging of blood vessels is proposed to provide auto-focusing. The confocal Raman detection plane (dp) is located in between these two imaging planes (i1, i2). Based on measured amount of defocus for the imaging planes (i1, i2), the focusing of the imaging system (img), the excitation system (exs) for exciting the target region and the detection plane (dp) is located inside the blood vessel (V). Thus, continuous auto-focusing with high accuracy can be achieved. The invention relates also to an optical tracking system for continuously tracking a point of a moving object (obj).

摘要翻译： 本发明涉及用于分析患者血液等物体的分析装置，特别是光谱分析装置以及相应的分析方法。 为了瞄准血管内的共焦检测体积，使用正交偏振光谱成像（OPSI）来定位皮肤中的毛细血管。 提出了一种具有稍微偏移的成像平面（i1，i2）用于血管的OPS成像的成像系统（img），以提供自动聚焦。 共焦拉曼检测平面（dp）位于这两个成像平面（i1，i2）之间。 基于测量的成像平面（i1，i2）的散焦量，成像系统（img）的聚焦，用于激发目标区域的激发系统（exs）和检测平面（dp）位于血管内 （V）。 因此，可以实现高精度的连续自动聚焦。 本发明还涉及用于连续跟踪移动物体（obj）的点的光学跟踪系统。

公开(公告)号：US20080309940A1

公开(公告)日：2008-12-18

申请号：US12094698

申请日：2006-11-20

申请人： Martinus Bernardus Van Der Mark ,  Michael Cornelis Van Beek ,  Levinus Pieter Bakker

发明人： Martinus Bernardus Van Der Mark ,  Michael Cornelis Van Beek ,  Levinus Pieter Bakker

IPC分类号： G01N21/00

CPC分类号： G01N21/4795 ,  G01N2021/1787 ,  G01N2021/4766 ,  G01N2021/6439

摘要： The invention relates to a method of imaging an interior of a turbid medium (45) comprising the following steps: accommodation of the turbid medium (45) inside a receiving volume (20); coupling transmission input light (65) from a transmission light source into the receiving volume (12), with said transmission input light (65) being chosen such that it is capable of propagating through the turbid medium (45) and with at least a part of said transmission input light (65) passing through a matching medium (50) in the receiving volume (12), said matching medium (50) being chosen to reduce optical boundary effects at an interface between the turbid medium (45) and its surroundings; detection of transmission output light emanating from the receiving volume as a result of coupling transmission input light (65) from the transmission light source into the receiving volume (12) through use of a transmission photodetector unit. The invention also relates to a system for imaging an interior of a turbid medium (45) and a medical image acquisition system both using the method. According to the invention, the method, system for imaging an interior of a turbid medium (45), and medical image acquisition system are adapted such that data relating to the exterior of the turbid medium (45) can be obtained. This object is realized in that the method further comprises the following additional steps: coupling geometry input light (70, 75, 80) from a geometry light source into the receiving volume (12), with the receiving volume comprising the turbid medium (45), with the receiving volume (12) further comprising a geometry medium (60) for surrounding the turbid medium (45) during coupling of geometry input light (70, 75, 80) into the receiving volume (12), and with the combination of the geometry input light (70, 75, 80), the geometry medium (60), and the interface being chosen for creating a contrast between the turbid medium and its surroundings; —detection of the contrast between the turbid medium (45) and its surroundings; reconstructing an image of an interior of the turbid medium (45) using the detected contrast.

公开(公告)号：US07453564B2

公开(公告)日：2008-11-18

申请号：US10595358

申请日：2004-10-15

申请人： Wouter Harry Rensen ,  Michael Cornelis Van Beek ,  Marjolein Van Der Voort ,  Bernardus Leonardus Bakker ,  Gerhardus Wilhelmus Lucassen ,  Teunis Willem Tukker

发明人： Wouter Harry Rensen ,  Michael Cornelis Van Beek ,  Marjolein Van Der Voort ,  Bernardus Leonardus Bakker ,  Gerhardus Wilhelmus Lucassen ,  Teunis Willem Tukker

IPC分类号： G01J3/00

CPC分类号： A61B5/0059 ,  A61B5/0068 ,  A61B5/489

摘要： A property of a fluid is determined spectroscopically, such as for the purposes of in vivo blood analysis. First the position of a volume of interest through which the fluid flows is determined by an optical detection step by making use of an objective. Preferably the optical detection step is an imaging step. Next the objective is moved to bring the focal point of the objective into coincidence with the volume of interest. In this position an optical spectroscopic step is performed. This has the advantage that the measurement beam for performing the optical spectroscopy travels along the optical axis for optimum efficiency.

摘要翻译： 光谱性质确定流体的性质，例如用于体内血液分析的目的。 首先，通过利用目标的光学检测步骤来确定流体流过的感兴趣体积的位置。 优选地，光学检测步骤是成像步骤。 接下来的目标是使目标的焦点与感兴趣的数量相吻合。 在该位置，进行光学分光步骤。 这具有以下优点：用于执行光学光谱的测量光束沿着光轴行进以获得最佳效率。

公开(公告)号：US20120170824A1

公开(公告)日：2012-07-05

申请号：US13320358

申请日：2010-05-10

申请人： Bernardus Hendrikus Wilhelmus Hendriks ,  Michael Cornelis Van Beek ,  Peter-Andre Redert ,  Frederik Jan De Bruijn ,  Drazenko Babic ,  Robert Johannes Frederik Homan ,  Ralph Braspenning ,  Wei Pien Lee ,  Karl Catharina Van Bree ,  Caifeng Shan

发明人： Bernardus Hendrikus Wilhelmus Hendriks ,  Michael Cornelis Van Beek ,  Peter-Andre Redert ,  Frederik Jan De Bruijn ,  Drazenko Babic ,  Robert Johannes Frederik Homan ,  Ralph Braspenning ,  Wei Pien Lee ,  Karl Catharina Van Bree ,  Caifeng Shan

IPC分类号： G06K9/00

CPC分类号： A61B6/025 ,  A61B6/4423 ,  A61B6/4441 ,  A61B6/5247 ,  A61B90/361 ,  A61B90/39 ,  A61B2090/376

摘要： The invention provides a system (102) for accurately detecting a patient's (114) movement during imaging procedures. The system comprises a camera (126) for providing a stream of camera images of a part of a patient's exterior (206). The system (102) furthermore comprises a fiducial element (116), which fiducial element (116) is mountable on said part of the patient's exterior (206), and which fiducial element (116) is detectable in the stream of camera images, and an image processor (128) for detecting a displacement of the fiducial element based on consecutive camera images comprised in at least the stream of camera images and for generating an output signal (129) indicative for said displacement. Herein, the fiducial element (116) has an in-plane stiffness which is substantially larger than an in-plane stiffness of said part of the patient's exterior. In addition, the fiducial element (116) and said part of the patient's exterior are provided with substantially equal outer in-plane dimensions.

摘要翻译： 本发明提供一种用于在成像过程期间准确地检测患者（114）运动的系统（102）。 该系统包括用于提供患者外部（206）的一部分的相机图像流的照相机（126）。 所述系统（102）还包括基准元件（116），所述基准元件（116）可安装在所述患者外部部分（206）的所述部分上，并且所述基准元件（116）在相机图像流中是可检测的，以及 图像处理器（128），用于基于包括在至少相机图像流中的连续相机图像来检测基准元素的位移，并且用于生成指示所述位移的输出信号（129）。 这里，基准元件（116）具有的面内刚度基本上大于患者外部部分的平面内刚度。 此外，基准元件（116）和患者外部的所述部分设置有基本上相等的外部平面外尺寸。

公开(公告)号：US20110066034A1

公开(公告)日：2011-03-17

申请号：US12992609

申请日：2009-05-20

申请人： Wouter Harry Jacinth Rensen ,  Michael Cornelis Van Beek ,  Rik Harbers

发明人： Wouter Harry Jacinth Rensen ,  Michael Cornelis Van Beek ,  Rik Harbers

IPC分类号： A61B6/00

摘要： An optical detection method is provided, wherein a body part (5) comprising at least one joint is irradiated with light. Local attenuation of the light by the body part (5) is detected as attenuation measurements (2) at the position of the at least one joint and at the position of at least one other portion of the body part (5); and wherein blood flow to and/or from the body part (5) is temporarily at least partially blocked and thereafter enabled again (3). Distinct local attenuation measurements for the at least one joint and for at least one other portion of the body part (5) are performed for at least two of the times before (I), during (II), and after (III) the blocking of blood flow.

摘要翻译： 提供了一种光学检测方法，其中包括至少一个接头的主体部分（5）被照射光。 在身体部分（5）的光的局部衰减被检测为在至少一个关节的位置处和身体部分（5）的至少另一部分的位置处的衰减测量（2）。 并且其中进入和/或离开身体部分（5）的血液流动暂时至少部分被阻止，然后再次启动（3）。 对于至少一个关节和身体部分（5）的至少一个其他部分的不同局部衰减测量在（I）之前，（II）期间和（III）之后的至少两次中进行， 的血流。

公开(公告)号：US07671973B2

公开(公告)日：2010-03-02

申请号：US10596564

申请日：2004-12-16

申请人： Michael Cornelis Van Beek ,  Frank Jeroen Pieter Schuurmans ,  Levinus Pieter Bakker

发明人： Michael Cornelis Van Beek ,  Frank Jeroen Pieter Schuurmans ,  Levinus Pieter Bakker

IPC分类号： G01N33/48

CPC分类号： A61B5/1455 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/14552 ,  G01J3/36 ,  G01N21/65 ,  G01N33/49

摘要： The present invention provides an optical analysis system for determining an amplitude of a principal component of an optical signal. The principal component is indicative of the concentration of a particular compound or various compounds of a substance that is subject to spectroscopic analysis. The optical signal is subject to wavelength selective weighting and wavelength selective spatial separation specified by a weighting function. The optical signal is preferably separated into two parts that corresponding to a positive and negative spectral band of the weighting function, respectively. The separation provides separate detection of the separated parts of the optical signal without significant loss of intensity, thereby providing an improved signal to noise ratio of the determined principal component. Separation and weighting of the optical signal is realized by two multivariate optical elements.

摘要翻译： 本发明提供了一种用于确定光信号的主分量的幅度的光学分析系统。 主要成分指示特定化合物或受光谱分析的物质的各种化合物的浓度。 光信号经受由加权函数指定的波长选择加权和波长选择性空间分离。 光信号优选分为对应于加权函数的正和负光谱带的两部分。 分离提供对光信号的分离部分的单独检测，而没有明显的强度损失，从而提供确定的主要分量的改善的信噪比。 光信号的分离和加权由两个多元光学元件实现。

公开(公告)号：US20080309941A1

公开(公告)日：2008-12-18

申请号：US12094802

申请日：2006-11-20

申请人： Martinus Bernardus Van Der Mark ,  Michael Cornelis Van Beek ,  Levinus Pieter Bakker

发明人： Martinus Bernardus Van Der Mark ,  Michael Cornelis Van Beek ,  Levinus Pieter Bakker

IPC分类号： G01N21/00

CPC分类号： G01N21/4795 ,  G01N2021/1787 ,  G01N2021/4766 ,  G01N2021/6439

摘要： The invention relates to a method of imaging an interior of a turbid medium (45) comprising the following steps: accommodation of the turbid medium (45) inside a receiving volume; coupling transmission input light (65) from a transmission light source into the receiving volume, with said transmission input light (65) being chosen such that it is capable of propagating through the turbid medium (45); detection of transmission output light emanating from the receiving volume as a result of coupling transmission input light from the light source into the receiving volume through use of a transmission photodetector unit. The invention also relates to a system for imaging an interior of a turbid medium (45) and to a medical image acquisition system both using the method. The method, system, and medical image acquisition system are adapted such that an improved way of obtaining data relating to the exterior of the turbid medium (45) is realized. The object of the invention is realized in that the method further comprises the following steps:—coupling geometry input light (70, 75, 80) from a geometry light source into the receiving volume, with the receiving volume comprising the turbid medium (45) and with the combination of the geometry input light (70, 75, 80) and the interface (60) being chosen for creating a contrast between the turbid medium (45) and its surroundings; detection of the contrast (60) between the turbid medium (45) and its surroundings through use of a contrast photodetector unit; reconstructing an image of an interior of the turbid medium (45) using a the detected contrast (60). The system for imaging an interior of a turbid medium (45) and the medical image acquisition device are adapted to further comprise a geometry light source and a contrast photodetector unit.