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    Spectroscopic analysis apparatus and method with excitation system and focus monitoring system
    1.
    发明授权
    Spectroscopic analysis apparatus and method with excitation system and focus monitoring system 失效
    光谱分析装置及方法与激励系统和焦点监测系统

    公开(公告)号：US07583380B2

    公开(公告)日：2009-09-01

    申请号：US10547971

    申请日：2004-03-01

    申请人： Michael Cornelis Van Beek ,  Peter Ferdinand Greve

    发明人： Michael Cornelis Van Beek ,  Peter Ferdinand Greve

    IPC分类号： G01J3/30

    CPC分类号： A61B5/0059 ,  A61B5/0068 ,  G01J3/44 ,  G01N21/65 ,  G02B21/241

    摘要： The present invention relates to an analysis apparatus, in particular a spectroscopic analysis apparatus, for analyzing an object, such as blood of a patient, and a corresponding analysis method. To aim the confocal detection volume inside a blood vessel orthogonal polarized spectral imaging (OPSI) is used to locate blood capillaries in the skin. An imaging system (img) with slightly shifted imaging planes (i1, i2) for OPS imaging of blood vessels is proposed to provide auto-focusing. The confocal Raman detection plane (dp) is located in between these two imaging planes (i1, i2). Based on measured amount of defocus for the imaging planes (i1, i2), the focusing of the imaging system (img), the excitation system (exs) for exciting the target region and the detection plane (dp) is located inside the blood vessel (V). Thus, continuous auto-focusing with high accuracy can be achieved. The invention relates also to an optical tracking system for continuously tracking a point of a moving object (obj).

    摘要翻译： 本发明涉及用于分析患者血液等物体的分析装置，特别是光谱分析装置以及相应的分析方法。 为了瞄准血管内的共焦检测体积，使用正交偏振光谱成像（OPSI）来定位皮肤中的毛细血管。 提出了一种具有稍微偏移的成像平面（i1，i2）用于血管的OPS成像的成像系统（img），以提供自动聚焦。 共焦拉曼检测平面（dp）位于这两个成像平面（i1，i2）之间。 基于测量的成像平面（i1，i2）的散焦量，成像系统（img）的聚焦，用于激发目标区域的激发系统（exs）和检测平面（dp）位于血管内 （V）。 因此，可以实现高精度的连续自动聚焦。 本发明还涉及用于连续跟踪移动物体（obj）的点的光学跟踪系统。

    Method of, System For, and Medical Image Acquisition System For Imaging an Interior of a Turbid Medium Taking Into Account the Geometry of the Turbid Medium
    2.
    发明申请
    Method of, System For, and Medical Image Acquisition System For Imaging an Interior of a Turbid Medium Taking Into Account the Geometry of the Turbid Medium 审中-公开

    公开(公告)号：US20080309940A1

    公开(公告)日：2008-12-18

    申请号：US12094698

    申请日：2006-11-20

    申请人： Martinus Bernardus Van Der Mark ,  Michael Cornelis Van Beek ,  Levinus Pieter Bakker

    发明人： Martinus Bernardus Van Der Mark ,  Michael Cornelis Van Beek ,  Levinus Pieter Bakker

    IPC分类号： G01N21/00

    CPC分类号： G01N21/4795 ,  G01N2021/1787 ,  G01N2021/4766 ,  G01N2021/6439

    摘要： The invention relates to a method of imaging an interior of a turbid medium (45) comprising the following steps: accommodation of the turbid medium (45) inside a receiving volume (20); coupling transmission input light (65) from a transmission light source into the receiving volume (12), with said transmission input light (65) being chosen such that it is capable of propagating through the turbid medium (45) and with at least a part of said transmission input light (65) passing through a matching medium (50) in the receiving volume (12), said matching medium (50) being chosen to reduce optical boundary effects at an interface between the turbid medium (45) and its surroundings; detection of transmission output light emanating from the receiving volume as a result of coupling transmission input light (65) from the transmission light source into the receiving volume (12) through use of a transmission photodetector unit. The invention also relates to a system for imaging an interior of a turbid medium (45) and a medical image acquisition system both using the method. According to the invention, the method, system for imaging an interior of a turbid medium (45), and medical image acquisition system are adapted such that data relating to the exterior of the turbid medium (45) can be obtained. This object is realized in that the method further comprises the following additional steps: coupling geometry input light (70, 75, 80) from a geometry light source into the receiving volume (12), with the receiving volume comprising the turbid medium (45), with the receiving volume (12) further comprising a geometry medium (60) for surrounding the turbid medium (45) during coupling of geometry input light (70, 75, 80) into the receiving volume (12), and with the combination of the geometry input light (70, 75, 80), the geometry medium (60), and the interface being chosen for creating a contrast between the turbid medium and its surroundings; —detection of the contrast between the turbid medium (45) and its surroundings; reconstructing an image of an interior of the turbid medium (45) using the detected contrast.

    OPTICAL DETECTION METHOD AND DEVICE FOR OPTICAL DETECTION OF THE CONDITION OF JOINTS
    6.
    发明申请
    OPTICAL DETECTION METHOD AND DEVICE FOR OPTICAL DETECTION OF THE CONDITION OF JOINTS 审中-公开
    光学检测方法和用于光学检测接头状态的装置

    公开(公告)号：US20110066034A1

    公开(公告)日：2011-03-17

    申请号：US12992609

    申请日：2009-05-20

    申请人： Wouter Harry Jacinth Rensen ,  Michael Cornelis Van Beek ,  Rik Harbers

    发明人： Wouter Harry Jacinth Rensen ,  Michael Cornelis Van Beek ,  Rik Harbers

    IPC分类号： A61B6/00

    摘要： An optical detection method is provided, wherein a body part (5) comprising at least one joint is irradiated with light. Local attenuation of the light by the body part (5) is detected as attenuation measurements (2) at the position of the at least one joint and at the position of at least one other portion of the body part (5); and wherein blood flow to and/or from the body part (5) is temporarily at least partially blocked and thereafter enabled again (3). Distinct local attenuation measurements for the at least one joint and for at least one other portion of the body part (5) are performed for at least two of the times before (I), during (II), and after (III) the blocking of blood flow.

    摘要翻译： 提供了一种光学检测方法，其中包括至少一个接头的主体部分（5）被照射光。 在身体部分（5）的光的局部衰减被检测为在至少一个关节的位置处和身体部分（5）的至少另一部分的位置处的衰减测量（2）。 并且其中进入和/或离开身体部分（5）的血液流动暂时至少部分被阻止，然后再次启动（3）。 对于至少一个关节和身体部分（5）的至少一个其他部分的不同局部衰减测量在（I）之前，（II）期间和（III）之后的至少两次中进行， 的血流。

    Optical analysis system using multivariate optical elements
    7.
    发明授权
    Optical analysis system using multivariate optical elements 失效
    光学分析系统采用多元光学元件

    公开(公告)号：US07671973B2

    公开(公告)日：2010-03-02

    申请号：US10596564

    申请日：2004-12-16

    申请人： Michael Cornelis Van Beek ,  Frank Jeroen Pieter Schuurmans ,  Levinus Pieter Bakker

    发明人： Michael Cornelis Van Beek ,  Frank Jeroen Pieter Schuurmans ,  Levinus Pieter Bakker

    IPC分类号： G01N33/48

    CPC分类号： A61B5/1455 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/14552 ,  G01J3/36 ,  G01N21/65 ,  G01N33/49

    摘要： The present invention provides an optical analysis system for determining an amplitude of a principal component of an optical signal. The principal component is indicative of the concentration of a particular compound or various compounds of a substance that is subject to spectroscopic analysis. The optical signal is subject to wavelength selective weighting and wavelength selective spatial separation specified by a weighting function. The optical signal is preferably separated into two parts that corresponding to a positive and negative spectral band of the weighting function, respectively. The separation provides separate detection of the separated parts of the optical signal without significant loss of intensity, thereby providing an improved signal to noise ratio of the determined principal component. Separation and weighting of the optical signal is realized by two multivariate optical elements.

    摘要翻译： 本发明提供了一种用于确定光信号的主分量的幅度的光学分析系统。 主要成分指示特定化合物或受光谱分析的物质的各种化合物的浓度。 光信号经受由加权函数指定的波长选择加权和波长选择性空间分离。 光信号优选分为对应于加权函数的正和负光谱带的两部分。 分离提供对光信号的分离部分的单独检测，而没有明显的强度损失，从而提供确定的主要分量的改善的信噪比。 光信号的分离和加权由两个多元光学元件实现。

    Method of, System for, and Medical Image Acquisition System for Imaging an Interior of a Turbid Medium Taking Into Account the Geometry of the Turbid Medium
    8.
    发明申请
    Method of, System for, and Medical Image Acquisition System for Imaging an Interior of a Turbid Medium Taking Into Account the Geometry of the Turbid Medium 审中-公开

    公开(公告)号：US20080309941A1

    公开(公告)日：2008-12-18

    申请号：US12094802

    申请日：2006-11-20

    申请人： Martinus Bernardus Van Der Mark ,  Michael Cornelis Van Beek ,  Levinus Pieter Bakker

    发明人： Martinus Bernardus Van Der Mark ,  Michael Cornelis Van Beek ,  Levinus Pieter Bakker

    IPC分类号： G01N21/00

    CPC分类号： G01N21/4795 ,  G01N2021/1787 ,  G01N2021/4766 ,  G01N2021/6439

    摘要： The invention relates to a method of imaging an interior of a turbid medium (45) comprising the following steps: accommodation of the turbid medium (45) inside a receiving volume; coupling transmission input light (65) from a transmission light source into the receiving volume, with said transmission input light (65) being chosen such that it is capable of propagating through the turbid medium (45); detection of transmission output light emanating from the receiving volume as a result of coupling transmission input light from the light source into the receiving volume through use of a transmission photodetector unit. The invention also relates to a system for imaging an interior of a turbid medium (45) and to a medical image acquisition system both using the method. The method, system, and medical image acquisition system are adapted such that an improved way of obtaining data relating to the exterior of the turbid medium (45) is realized. The object of the invention is realized in that the method further comprises the following steps:—coupling geometry input light (70, 75, 80) from a geometry light source into the receiving volume, with the receiving volume comprising the turbid medium (45) and with the combination of the geometry input light (70, 75, 80) and the interface (60) being chosen for creating a contrast between the turbid medium (45) and its surroundings; detection of the contrast (60) between the turbid medium (45) and its surroundings through use of a contrast photodetector unit; reconstructing an image of an interior of the turbid medium (45) using a the detected contrast (60). The system for imaging an interior of a turbid medium (45) and the medical image acquisition device are adapted to further comprise a geometry light source and a contrast photodetector unit.

    Measurement Head For Non-Invasive Blood Analysis
    9.
    发明申请
    Measurement Head For Non-Invasive Blood Analysis 失效
    非侵入性血液分析测量头

    公开(公告)号：US20080262324A1

    公开(公告)日：2008-10-23

    申请号：US11568743

    申请日：2005-05-03

    申请人： Marjolein Van Der Voort ,  Bernardus Leonardus Gerardus Bakker ,  Gerald Lucassen ,  Hendrikus Antonius Cornelus Maria Compen ,  Michael Cornelis Van Beek ,  Wouter Harry Jacinth Rensen

    发明人： Marjolein Van Der Voort ,  Bernardus Leonardus Gerardus Bakker ,  Gerald Lucassen ,  Hendrikus Antonius Cornelus Maria Compen ,  Michael Cornelis Van Beek ,  Wouter Harry Jacinth Rensen

    IPC分类号： A61B5/00

    CPC分类号： A61B5/0059 ,  A61B5/0062 ,  A61B5/68 ,  A61B5/6843

    摘要： The present invention provides an efficient approach of attaching and fixing a measurement head for a spectroscopic system to a variety of different parts of the skin of a patient. The measurement head preferably features a compact design providing a flexible handling and offering a huge variety of application areas taking into account the plurality of properties of various portions of the skin. Furthermore, the measurement head features a robust and uncomplicated optical design not requiring a lateral shifting of the optical axis of the objective. Such transverse relative movements between the objective and a capillary vessel in the skin are preferably performed by mechanically shifting the skin with respect to the objective of the measurement head. Moreover, the measurement head is adapted to host one or more pressure sensors measuring the contact pressure between the measurement head and the skin. This pressure information can further be exploited in order to calibrate the spectroscopic analysis means, to regulate the contact pressure within predefined margins specifying an optimum range of contact pressure for spectroscopic examination of capillary vessels.

    摘要翻译： 本发明提供了将用于分光系统的测量头附接和固定到患者皮肤的各种不同部分的有效方法。 测量头优选地具有紧凑的设计，提供灵活的处理，并且考虑到皮肤的各个部分的多个性质，提供了各种各样的应用领域。 此外，测量头具有坚固且不复杂的光学设计，不需要物镜的光轴的横向偏移。 物体和皮肤中的毛细血管之间的这种横向相对移动优选通过相对于测量头的目标机械地移动皮肤来执行。 此外，测量头适于承载测量测量头与皮肤之间的接触压力的一个或多个压力传感器。 可以进一步利用该压力信息来校准光谱分析装置，以调节预定余量内的接触压力，从而规定用于毛细血管的光谱检查的最佳接触压力范围。

    Protection Mechanism for Spectroscopic Analysis of Biological Tissue
    10.
    发明申请
    Protection Mechanism for Spectroscopic Analysis of Biological Tissue 审中-公开
    生物组织光谱分析保护机制

    公开(公告)号：US20080249380A1

    公开(公告)日：2008-10-09

    申请号：US11568549

    申请日：2005-04-19

    申请人： Michael Cornelis Van Beek ,  Wouter Harry Jacinth Rensen ,  Marjolein Van Der Voort

    发明人： Michael Cornelis Van Beek ,  Wouter Harry Jacinth Rensen ,  Marjolein Van Der Voort

    IPC分类号： A61B5/145

    CPC分类号： A61B5/0059 ,  A61B5/0531 ,  A61B2090/065

    摘要： The present invention provides a protection mechanism for a spectroscopic analysis system being adapted to determine a property of a biological structure in a volume of interest of a patient. The spectroscopic system preferably makes use of high power radiation, and provides a protection mechanism for preventing an accidental exposure of light sensitive tissue of a body. The invention provides a variety of approaches to detect whether a measurement head of the spectroscopic system is in a measurement position. The measurement position of the measurement head can effectively be determined by making use of e.g. a pressure sensor, a sensor measuring the electric resistance of the skin of the patient, or even by optical means analyzing the intensity or the spatial structure of a monitoring beam providing a visual image of the volume of interest.

    摘要翻译： 本发明提供了一种用于光谱分析系统的保护机制，其适于确定患者感兴趣体积的生物结构的性质。 光谱系统优选利用高功率辐射，并且提供用于防止身体的感光组织的意外暴露的保护机构。 本发明提供了多种方法来检测分光系统的测量头是否处于测量位置。 测量头的测量位置可以有效地通过使用例如测量头来确定。 压力传感器，测量患者皮肤电阻的传感器，或者甚至通过分析提供感兴趣体积的视觉图像的监测光束的强度或空间结构的光学装置来测量。