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公开(公告)号：US06368789B1
公开(公告)日：2002-04-09
申请号：US08464011
申请日：1995-06-05
IPC分类号： C12Q168
CPC分类号： C12N15/10 , A61K31/522 , A61K31/70 , A61K31/7076 , A61K31/711 , A61K38/00 , C12N5/0018 , C12N5/163 , C12N9/1241 , C12N15/113 , C12N15/1137 , C12N2501/70 , C12N2510/04 , C12Q1/48 , C12Q1/68 , C12Q1/6827 , C12Q1/686 , C12Q1/6876 , C12Q1/6886 , C12Q1/703 , C12Q2600/112 , C12Q2600/136 , C12Y207/07049 , G01N2333/91245 , Y02A50/409 , Y02A50/411 , Y10S977/773 , Y10S977/801 , Y10S977/918 , Y10S977/927 , Y10T436/10 , Y10T436/105831 , Y10T436/11 , Y10T436/115831 , C12Q2521/113
摘要： Method and compositions are provided for the determination of telomere length and telomerase activity, as well as the ability to inhibit telomerase activity in the treatment of proliferative diseases. Particularly, primers are elongated under conditions which minimize interference from other genomic sequences, so as to obtain accurate determinations of telomeric length or telomerase activity. In addition, compositions are provided for intracellular inhibition of telomerase activity and means are shown for slowing the loss of telomeric repeats in aging cells.
摘要翻译： 提供了测定端粒长度和端粒酶活性的方法和组合物，以及抑制端粒酶活性治疗增殖性疾病的能力。 特别地，引物在使来自其它基因组序列的干扰最小化的条件下伸长，以获得端粒长度或端粒酶活性的准确测定。 此外，提供组合物用于细胞内抑制端粒酶活性，并且显示了用于减缓衰老细胞中端粒重复的丧失的手段。
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公开(公告)号：US5695932A
公开(公告)日：1997-12-09
申请号：US60952
申请日：1993-05-13
IPC分类号： C12N15/09 , A61K31/70 , A61K31/7088 , A61K31/7105 , A61K38/00 , A61K38/43 , A61K38/45 , A61K38/55 , A61K45/00 , A61K48/00 , A61K49/00 , A61P35/00 , A61P43/00 , C12N5/00 , C12N5/16 , C12N9/12 , C12N15/10 , C12N15/113 , C12Q1/25 , C12Q1/48 , C12Q1/68 , C12Q1/70 , G01N33/573 , C12P19/34
CPC分类号： C12N15/10 , A61K31/522 , A61K31/70 , A61K31/7076 , A61K31/711 , C12N15/113 , C12N15/1137 , C12N5/0018 , C12N5/163 , C12N9/1241 , C12Q1/48 , C12Q1/68 , C12Q1/6827 , C12Q1/686 , C12Q1/6876 , C12Q1/6886 , C12Q1/703 , C12Y207/07049 , A61K38/00 , C12N2501/70 , C12N2510/04 , C12Q2600/112 , C12Q2600/136 , G01N2333/91245 , Y10S977/773 , Y10S977/801 , Y10S977/918 , Y10S977/927 , Y10T436/10 , Y10T436/105831 , Y10T436/11 , Y10T436/115831
摘要： Method and compositions are provided for the determination of telomere length and telomerase activity, as well as the ability to inhibit telomerase activity in the treatment of proliferative diseases. Particularly, primers are elongated under conditions which minimize interference from other genomic sequences, so as to obtain accurate determinations of telomeric length or telomerase activity. In addition, compositions are provided for intracellular inhibition of telomerase activity and means are shown for slowing the loss of telomeric repeats in aging cells.
摘要翻译： 提供了测定端粒长度和端粒酶活性的方法和组合物，以及抑制端粒酶活性治疗增殖性疾病的能力。 特别地，引物在使来自其它基因组序列的干扰最小化的条件下伸长，以获得端粒长度或端粒酶活性的准确测定。 此外，提供组合物用于细胞内抑制端粒酶活性，并且显示了用于减缓衰老细胞中端粒重复的丧失的手段。
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公开(公告)号：US6007989A
公开(公告)日：1999-12-28
申请号：US819867
申请日：1997-03-14
申请人： Michael D. West , Calvin B. Harley , Scott L. Weinrich , Catherine M. Strahl , Michael J. McEachern , Jerry Shay , Woodring E. Wright , Elizabeth H. Blackburn , Nam Woo Kim , Homayoun Vaziri
发明人： Michael D. West , Calvin B. Harley , Scott L. Weinrich , Catherine M. Strahl , Michael J. McEachern , Jerry Shay , Woodring E. Wright , Elizabeth H. Blackburn , Nam Woo Kim , Homayoun Vaziri
IPC分类号： A61K38/00 , C12N5/00 , C12N5/16 , C12N9/12 , C12N15/10 , C12N15/113 , C12Q1/68 , C12Q1/70 , C12P19/34
CPC分类号： C12N15/1137 , A61K31/70 , C12N15/10 , C12N15/113 , C12N5/0018 , C12N5/163 , C12N9/1241 , C12Q1/686 , C12Q1/6886 , C12Q1/703 , C12Y207/07049 , A61K38/00 , C12N2501/70 , C12N2510/04 , C12Q2600/136 , C12Q2600/156
摘要： Method and compositions are provided for the determination of telomere length and telomerase activity, as well as the ability to increase or decrease telomerase activity in the treatment of proliferative diseases. Particularly, primers are elongated under conditions which minimize interference from other genomic sequences, so as to obtain accurate determinations of telomeric length or telomerase activity. In addition, compositions are provided for intracellular inhibition of telomerase activity and means are shown for slowing or reversing the loss of telomeric repeats in aging cells.
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4.发明授权Diagnostic methods for conditions associated with elevated cellular levels of telomerase activity 失效与端粒酶活性升高的细胞水平相关的病症的诊断方法公开(公告)号：US06551774B1
公开(公告)日：2003-04-22
申请号：US09378535
申请日：1999-08-20
申请人： Michael D. West , Calvin B. Harley , Scott L. Weinrich , Catherine M. Strahl , Michael J. McEachern , Jerry Shay , Woodring E. Wright , Elizabeth H. Blackburn , Nam Woo Kim , Homayoun Vaziri
发明人： Michael D. West , Calvin B. Harley , Scott L. Weinrich , Catherine M. Strahl , Michael J. McEachern , Jerry Shay , Woodring E. Wright , Elizabeth H. Blackburn , Nam Woo Kim , Homayoun Vaziri
IPC分类号： C12Q168
CPC分类号： C12N15/1137 , A61K31/70 , A61K38/00 , C12N5/0018 , C12N5/163 , C12N9/1241 , C12N15/10 , C12N15/113 , C12N2501/70 , C12N2510/04 , C12Q1/686 , C12Q1/6886 , C12Q1/703 , C12Q2600/136 , C12Q2600/156 , C12Y207/07049 , C12Q2525/151 , C12Q2521/113
摘要： Method and compositions are provided for the determination of telomere length and telomerase activity, as well as the ability to increase or decrease telomerase activity in the treatment of proliferative diseases. Particularly, primers are elongated under conditions which minimize interference from other genomic sequences, so as to obtain accurate determinations of telomeric length or telomerase activity. In addition, compositions are provided for intracellular inhibition of telomerase activity and means are shown for slowing or reversing the loss of telomeric repeats in aging cells.
摘要翻译： 提供了用于测定端粒长度和端粒酶活性的方法和组合物，以及在增殖性疾病的治疗中增加或减少端粒酶活性的能力。 特别地，引物在使来自其它基因组序列的干扰最小化的条件下伸长，以获得端粒长度或端粒酶活性的准确测定。 此外，提供组合物用于细胞内抑制端粒酶活性，并且显示了用于减缓或逆转衰老细胞中端粒重复的丧失的手段。
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5.发明授权Therapy and diagnosis of conditions related to telomere length and/or telomerase activity 失效治疗和诊断与端粒长度和/或端粒酶活性有关的病症
公开(公告)号：US5645986A
公开(公告)日：1997-07-08
申请号：US153051
申请日：1993-11-12
申请人： Michael D. West , Calvin B. Harley , Catherine M. Strahl , Michael J. McEachern , Jerry Shay , Woodring E. Wright , Elizabeth H. Blackburn , Homayoun Vaziri
发明人： Michael D. West , Calvin B. Harley , Catherine M. Strahl , Michael J. McEachern , Jerry Shay , Woodring E. Wright , Elizabeth H. Blackburn , Homayoun Vaziri
IPC分类号： A61K38/00 , C12N5/00 , C12N5/16 , C12N9/12 , C12N15/10 , C12N15/113 , C12Q1/68 , C12Q1/70 , C12P19/34
CPC分类号： A61K31/70 , C12N15/10 , C12N15/113 , C12N15/1137 , C12N5/0018 , C12N5/163 , C12N9/1241 , C12Q1/6827 , C12Q1/686 , C12Q1/6876 , C12Q1/6886 , C12Q1/703 , C12Y207/07049 , A61K38/00 , C12N2501/70 , C12N2510/04 , C12Q2600/136
摘要： Method and compositions are provided for the determination of telomere length and telomerase activity, as well as the ability to increase or decrease telomerase activity in the treatment of proliferative diseases. Particularly, primers are elongated under conditions which minimize interference from other genomic sequences, so as to obtain accurate determinations of telomeric length or telomerase activity. In addition, compositions are provided for intracellular inhibition of telomerase activity and means are shown for slowing or reversing the loss of telomeric repeats in aging cells.
摘要翻译： 提供了用于测定端粒长度和端粒酶活性的方法和组合物，以及在增殖性疾病的治疗中增加或减少端粒酶活性的能力。 特别地，引物在使来自其它基因组序列的干扰最小化的条件下伸长，以获得端粒长度或端粒酶活性的准确测定。 此外，提供组合物用于细胞内抑制端粒酶活性，并且显示了用于减缓或逆转衰老细胞中端粒重复的丧失的手段。
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6.发明授权Methods for diagnosis of conditions associated with elevated levels of telomerase activity 失效用于诊断与端粒酶活性水平升高相关的病症的方法
公开(公告)号：US5840495A
公开(公告)日：1998-11-24
申请号：US480037
申请日：1995-06-07
申请人： Michael D. West , Jerry Shay , Woodring Wright
发明人： Michael D. West , Jerry Shay , Woodring Wright
IPC分类号： C12N15/09 , A61K31/70 , A61K31/7088 , A61K31/7105 , A61K38/00 , A61K38/43 , A61K38/45 , A61K38/55 , A61K45/00 , A61K48/00 , A61K49/00 , A61P35/00 , A61P43/00 , C12N5/00 , C12N5/16 , C12N9/12 , C12N15/10 , C12N15/113 , C12Q1/25 , C12Q1/48 , C12Q1/68 , C12Q1/70 , G01N33/573 , G01N33/53
CPC分类号： C12N15/10 , A61K31/522 , A61K31/70 , A61K31/7076 , A61K31/711 , C12N15/113 , C12N15/1137 , C12N5/0018 , C12N5/163 , C12N9/1241 , C12Q1/48 , C12Q1/68 , C12Q1/6827 , C12Q1/686 , C12Q1/6876 , C12Q1/6886 , C12Q1/703 , C12Y207/07049 , A61K38/00 , C12N2501/70 , C12N2510/04 , C12Q2600/112 , C12Q2600/136 , G01N2333/91245 , Y10S977/773 , Y10S977/801 , Y10S977/918 , Y10S977/927 , Y10T436/10 , Y10T436/105831 , Y10T436/11 , Y10T436/115831
摘要： Method and compositions are provided for the determination of telomere length and telomerase activity, as well as the ability to inhibit telomerase activity in the treatment of proliferative diseases. Particularly, primers are elongated under conditions which minimize interference from other genomic sequences, so as to obtain accurate determinations of telomeric length or telomerase activity. In addition, compositions are provided for intracellular inhibition of telomerase activity.
摘要翻译： 提供了测定端粒长度和端粒酶活性的方法和组合物，以及抑制端粒酶活性治疗增殖性疾病的能力。 特别地，引物在使来自其它基因组序列的干扰最小化的条件下伸长，以获得端粒长度或端粒酶活性的准确测定。 此外，提供组合物用于细胞内抑制端粒酶活性。
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7.发明授权
公开(公告)号：US5707795A
公开(公告)日：1998-01-13
申请号：US487290
申请日：1995-06-07
申请人： Michael D. West , Jerry Shay , Woodring Wright
发明人： Michael D. West , Jerry Shay , Woodring Wright
IPC分类号： C12N15/09 , A61K31/70 , A61K31/7088 , A61K31/7105 , A61K38/00 , A61K38/43 , A61K38/45 , A61K38/55 , A61K45/00 , A61K48/00 , A61K49/00 , A61P35/00 , A61P43/00 , C12N5/00 , C12N5/16 , C12N9/12 , C12N15/10 , C12N15/113 , C12Q1/25 , C12Q1/48 , C12Q1/68 , C12Q1/70 , G01N33/573 , C12P19/34 , C07H21/04
CPC分类号： C12N15/10 , A61K31/522 , A61K31/70 , A61K31/7076 , A61K31/711 , C12N15/113 , C12N15/1137 , C12N5/0018 , C12N5/163 , C12N9/1241 , C12Q1/48 , C12Q1/68 , C12Q1/6827 , C12Q1/686 , C12Q1/6876 , C12Q1/6886 , C12Q1/703 , C12Y207/07049 , A61K38/00 , C12N2501/70 , C12N2510/04 , C12Q2600/112 , C12Q2600/136 , G01N2333/91245 , Y10S977/773 , Y10S977/801 , Y10S977/918 , Y10S977/927 , Y10T436/10 , Y10T436/105831 , Y10T436/11 , Y10T436/115831
摘要： Method and compositions are provided for the determination of telomere length and telomerase activity, as well as the ability to inhibit telomerase activity in the treatment of proliferative diseases. Particularly, primers are elongated under conditions which minimize interference from other genomic sequences, so as to obtain accurate determinations of telomeric length or telomerase activity. In addition, compositions are provided for intracellular inhibition of telomerase activity.
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公开(公告)号：US5686245A
公开(公告)日：1997-11-11
申请号：US475778
申请日：1995-06-07
申请人： Michael D. West , Jerry Shay , Woodring Wright
发明人： Michael D. West , Jerry Shay , Woodring Wright
IPC分类号： C12N15/09 , A61K31/70 , A61K31/7088 , A61K31/7105 , A61K38/00 , A61K38/43 , A61K38/45 , A61K38/55 , A61K45/00 , A61K48/00 , A61K49/00 , A61P35/00 , A61P43/00 , C12N5/00 , C12N5/16 , C12N9/12 , C12N15/10 , C12N15/113 , C12Q1/25 , C12Q1/48 , C12Q1/68 , C12Q1/70 , G01N33/573 , C12P19/34
CPC分类号： C12N15/10 , A61K31/522 , A61K31/70 , A61K31/7076 , A61K31/711 , C12N15/113 , C12N15/1137 , C12N5/0018 , C12N5/163 , C12N9/1241 , C12Q1/48 , C12Q1/68 , C12Q1/6827 , C12Q1/686 , C12Q1/6876 , C12Q1/6886 , C12Q1/703 , C12Y207/07049 , A61K38/00 , C12N2501/70 , C12N2510/04 , C12Q2600/112 , C12Q2600/136 , G01N2333/91245 , Y10S977/773 , Y10S977/801 , Y10S977/918 , Y10S977/927 , Y10T436/10 , Y10T436/105831 , Y10T436/11 , Y10T436/115831
摘要： Method and compositions are provided for the determination of telomere length and telomerase activity, as well as the ability to inhibit telomerase activity in the treatment of proliferative diseases. Particularly, primers are elongated under conditions which minimize interference from other genomic sequences, so as to obtain accurate determinations of telomeric length or telomerase activity. In addition, compositions are provided for intracellular inhibition of telomerase activity.
摘要翻译： 提供了测定端粒长度和端粒酶活性的方法和组合物，以及抑制端粒酶活性治疗增殖性疾病的能力。 特别地，引物在使来自其它基因组序列的干扰最小化的条件下伸长，以获得端粒长度或端粒酶活性的准确测定。 此外，提供组合物用于细胞内抑制端粒酶活性。
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9.发明授权公开(公告)号：US06194206B1
公开(公告)日：2001-02-27
申请号：US08998876
申请日：1997-12-24
申请人： Michael D. West , Jerry Shay , Woodring Wright
发明人： Michael D. West , Jerry Shay , Woodring Wright
IPC分类号： A61K3170
CPC分类号： C12N15/10 , A61K31/522 , A61K31/70 , A61K31/7076 , A61K31/711 , A61K38/00 , C12N5/0018 , C12N5/163 , C12N9/1241 , C12N15/113 , C12N15/1137 , C12N2501/70 , C12N2510/04 , C12Q1/48 , C12Q1/68 , C12Q1/6827 , C12Q1/686 , C12Q1/6876 , C12Q1/6886 , C12Q1/703 , C12Q2600/112 , C12Q2600/136 , C12Y207/07049 , G01N2333/91245 , Y02A50/409 , Y02A50/411 , Y10S977/773 , Y10S977/801 , Y10S977/918 , Y10S977/927 , Y10T436/10 , Y10T436/105831 , Y10T436/11 , Y10T436/115831 , C12Q2521/113
摘要： Method and compositions are provided for the determination of telomere length and telomerase activity, as well as the ability to inhibit telomerase activity in the treatment of proliferative diseases. Particularly, primers are elongated under conditions which minimize interference from other genomic sequences, so as to obtain accurate determinations of telomeric length or telomerase activity. In addition, compositions are provided for intracellular inhibition of telomerase activity.
摘要翻译： 提供了测定端粒长度和端粒酶活性的方法和组合物，以及抑制端粒酶活性治疗增殖性疾病的能力。 特别地，引物在使来自其它基因组序列的干扰最小化的条件下伸长，以获得端粒长度或端粒酶活性的准确测定。 此外，提供组合物用于细胞内抑制端粒酶活性。
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10.发明授权
公开(公告)号：US5489508A
公开(公告)日：1996-02-06
申请号：US38766
申请日：1993-03-24
申请人： Michael D. West , Jerry Shay , Woodring Wright
发明人： Michael D. West , Jerry Shay , Woodring Wright
IPC分类号： C12N15/09 , A61K31/70 , A61K31/7088 , A61K31/7105 , A61K38/00 , A61K38/43 , A61K38/45 , A61K38/55 , A61K45/00 , A61K48/00 , A61K49/00 , A61P35/00 , A61P43/00 , C12N5/00 , C12N5/16 , C12N9/12 , C12N15/10 , C12N15/113 , C12Q1/25 , C12Q1/48 , C12Q1/68 , C12Q1/70 , G01N33/573 , C12P19/34 , C07H21/04
CPC分类号： C12N15/10 , A61K31/522 , A61K31/70 , A61K31/7076 , A61K31/711 , C12N15/113 , C12N15/1137 , C12N5/0018 , C12N5/163 , C12N9/1241 , C12Q1/48 , C12Q1/68 , C12Q1/6827 , C12Q1/686 , C12Q1/6876 , C12Q1/6886 , C12Q1/703 , C12Y207/07049 , A61K38/00 , C12N2501/70 , C12N2510/04 , C12Q2600/112 , C12Q2600/136 , G01N2333/91245 , Y10S977/773 , Y10S977/801 , Y10S977/918 , Y10S977/927 , Y10T436/10 , Y10T436/105831 , Y10T436/11 , Y10T436/115831
摘要： Method and compositions are provided for the determination of telomere length and telomerase activity, as well as the ability to inhibit telomerase activity in the treatment of proliferative diseases. Particularly, primers are elongated under conditions which minimize interference from other genomic sequences, so as to obtain accurate determinations of telomeric length or telomerase activity. In addition, compositions are provided for intracellular inhibition of telomerase activity.
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