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    Medication delivery device
    2.
    发明授权
    Medication delivery device 失效
    药物输送装置

    公开(公告)号：US06562011B1

    公开(公告)日：2003-05-13

    申请号：US09348536

    申请日：1999-07-07

    申请人： Thomas Buch-Rasmussen ,  Benny Munk ,  Jens Ulrik Poulsen ,  Henrik Ljungreen ,  Peter Møller Jensen ,  Jens Møller Jensen

    发明人： Thomas Buch-Rasmussen ,  Benny Munk ,  Jens Ulrik Poulsen ,  Henrik Ljungreen ,  Peter Møller Jensen ,  Jens Møller Jensen

    IPC分类号： A61M500

    CPC分类号： A61M5/24 ,  A61M5/31525 ,  A61M5/31535 ,  A61M5/31566 ,  A61M5/31578 ,  A61M2005/2407 ,  A61M2005/2488 ,  A61M2005/2492

    摘要： The present invention relates to a medication delivery device comprising a cartridge assembly, a dosing assembly and optionally a needle assembly. The cartridge assembly comprises a cartridge having a stopper adapted to receive a plunger means. Furthermore, the cartridge assembly has one end sealed with a pierceable sealing, said end comprising coupling means for engaging a needle assembly, and another end comprising coupling means for engaging the dosing assembly. At least one of the coupling means of the cartridge assembly is unitarily moulded with the cartridge. The dosing assembly comprises a plunger means and has coupling means for engaging the cartridge assembly. The cartridge assembly and the dosing assembly are coupled together for delivering selected doses of medication. The cartridge is preferably moulded from a plastic material, such as a transparent material, and may be housed in a cartridge housing for protection of the cartridge. The coupling means may be selected from threaded locks, snap locks, hinged locks, or bajonet locks. The medication delivery device is especially suitable for delivering insulin, growth hormone or other medicines.

    摘要翻译： 本发明涉及药物输送装置，其包括药筒组件，剂量组合件和任选的针组件。 盒组件包括具有适于容纳柱塞装置的止动件的盒。 此外，盒组件具有用可刺破密封件密封的一端，所述端部包括用于接合针组件的联接装置，以及包括用于接合给药组件的联接装置的另一端。 盒组件的联接装置中的至少一个与盒一体地模制。 配料组件包括柱塞装置并具有用于接合盒组件的联接装置。 药筒组件和剂量组合件联接在一起以递送选定剂量的药物。 盒优选地由诸如透明材料的塑料材料成型，并且可以容纳在盒壳体中以保护盒。 联接装置可以选自螺纹锁，卡扣锁，铰链锁或双面胶锁。 药物输送装置特别适用于输送胰岛素，生长激素或其他药物。

    Medicament transferring device
    3.
    发明授权
    Medicament transferring device 失效
    药物转运装置

    公开(公告)号：US06755810B1

    公开(公告)日：2004-06-29

    申请号：US09856258

    申请日：2001-09-20

    申请人： Thomas Buch-Rasmussen ,  Jens-Ulrik Poulsen ,  Henrik Ljunggreen

    发明人： Thomas Buch-Rasmussen ,  Jens-Ulrik Poulsen ,  Henrik Ljunggreen

    IPC分类号： A61M532

    CPC分类号： A61J1/2096 ,  A61J1/201 ,  A61M5/1782 ,  A61M5/31511

    摘要： The present invention relates to a transfer device for transferring medicament from a medicament container to a syringe with a needle. The transfer device is arranged for transferring accurate dosages of insulin, growth hormone or other medicaments. The accuracy is ensured by the device comprising means for mounting a syringe to the device, the needle piercing a sealing of the device. Opposite the sealing a piston is arranged, said piston being non-releasable engaged with the piston driver during transfer of the medicament. Thereby the piston is not erroneously drawn from the piston driver, which would otherwise lead to incorrect dosing. Furthermore, the device comprises dosing means including the piston driver.

    摘要翻译： 本发明涉及一种用于将药物从药物容器转移到具有针的注射器的转移装置。 转移装置被设置用于转移精确剂量的胰岛素，生长激素或其他药物。 通过装置确保精度，该装置包括用于将注射器安装到装置的装置，针刺穿装置的密封。 在密封件相对的位置布置有活塞，所述活塞在药物转移期间不可释放地与活塞驱动器接合。 因此，活塞不会从活塞驱动器错误地抽出，否则会导致不正确的配量。 此外，该装置包括包括活塞驱动器的计量装置。

    Medical article with coated surfaces exhibiting low friction and protein adsorption
    4.
    发明授权
    Medical article with coated surfaces exhibiting low friction and protein adsorption 失效
    具有低摩擦和蛋白质吸附的涂层表面的医疗制品

    公开(公告)号：US06461334B1

    公开(公告)日：2002-10-08

    申请号：US09260758

    申请日：1999-03-02

    申请人： Thomas Buch-Rasmussen ,  Patric Jannasch ,  Erling Bonne Jørgensen ,  Ib Johannesen ,  Sokol Ndoni

    发明人： Thomas Buch-Rasmussen ,  Patric Jannasch ,  Erling Bonne Jørgensen ,  Ib Johannesen ,  Sokol Ndoni

    IPC分类号： A61M5315

    CPC分类号： A61M5/31513 ,  A61J1/062 ,  A61M5/2448 ,  A61M2005/3131

    摘要： The present invention relates to a medical article for containing a pharmaceutical protein preparation comprising at least a first component and a second component, having at least one surface coated with a coating to reduce the friction between the two components and to reduce the protein adsorption to the coating. The coating is a hydrophilic coating whereby the hydrophilicity of the surface of the coating as measured by the water contact angle is below 90°, and the long term static friction forces between the first and the second component are below 14 N. The coatings according to the present invention are especially suited for permanently coating in ternal surfaces of containers equipped with stoppers for storage and administration of liquid protein preparations, such as insulin preparations. The coating is preferably a silicon-containing coating, such as a poly(dialkyl siloxane) oil or copolymer. The invention further relates to a process of producing a component of a medical article coated as described above, comprising adding the coating material to the component material prior to molding and subsequently molding the component from the mixture, or molding the component from the component material and subsequently applying the coating material to the at least one surface of the component, and hydrophilizing the coating material prior to the molding or after the molding. Also the invention relates to a coating as defined above for articles having at least a first component and a second component.

    摘要翻译： 本发明涉及一种用于容纳含有至少第一组分和第二组分的药物蛋白质制剂的医疗制品，其具有至少一个涂覆有涂层的表面以减少两种组分之间的摩擦并减少蛋白质吸附至 涂层。 涂层是一种亲水性涂层，其中通过水接触角测量的涂层表面的亲水性低于90°，​​第一和第二组分之间的长期静摩擦力低于14N。根据 本发明特别适用于在装有用于贮存和给药液体蛋白制剂例如胰岛素制剂的塞子的容器的三元表面中永久地涂覆。 涂层优选为含硅涂层，例如聚（二烷基硅氧烷）油或共聚物。 本发明还涉及如上所述涂敷的医疗用品的成分的制造方法，其特征在于，在成型前将所述涂料添加到所述成分材料中，从所述混合物中随后成型所述成分，或者从所述成分材料成型所述成分， 随后将涂层材料施加到部件的至少一个表面，并且在模制之前或模制之后使涂层材料亲水化。 本发明还涉及如上所述的具有至少第一组分和第二组分的制品的涂层。

    Working cylinder
    5.
    发明授权
    Working cylinder 失效
    工作缸

    公开(公告)号：US6010485A

    公开(公告)日：2000-01-04

    申请号：US932354

    申请日：1997-09-17

    申请人： Thomas Buch-Rasmussen ,  Jens Ulrik Poulsen ,  Henrik Ljunggreen ,  Jens M.o slashed.ller Jensen

    发明人： Thomas Buch-Rasmussen ,  Jens Ulrik Poulsen ,  Henrik Ljunggreen ,  Jens M.o slashed.ller Jensen

    IPC分类号： A61M5/31 ,  A61M5/178 ,  A61M5/20 ,  A61M5/315 ,  A61M39/00 ,  A61M5/00

    CPC分类号： A61M5/31525 ,  A61M5/204 ,  A61M5/31595 ,  A61M5/31555 ,  A61M5/31561 ,  A61M5/3158

    摘要： The present invention relates to a drug delivery system, comprising a reservoir from which set doses are apportioned, a dose setting mechanism by which the relative position of two elements is changed by a distance proportional to a set dose, and a push button by activation of which an element is moved a distance corresponding to the distance proportional to the set dose, further comprises a working cylinder having an open end into which a plunger fits, and a closed end at which an inlet and an outlet port connect the space beneath the plunger with an inlet communicating with the reservoir and an outlet communicating with a drug delivery member, respectively. Valves means at the inlet and outlet control the passages from the reservoir to the working cylinder and from the working cylinder to the drug delivery member, respectively. The cylinder with the plunger, and the injection member are independently exchangeable, disposable parts.

    摘要翻译： 本发明涉及一种药物递送系统，其包括分配设定剂量的储存器，剂量设定机构，通过该剂量设定机构将两个元件的相对位置改变与设定剂量成比例的距离，以及按钮，通过激活 元件被移动到与设定剂量成比例的距离处的距离，还包括具有开口端的柱塞配合的工作缸和入口和出口连接柱塞下方的空间的封闭端 其中入口与储存器连通并且分别与药物递送构件连通。 阀门在入口和出口处分别控制从储存器到工作缸以及从工作缸到药物传送构件的通道。 具有柱塞的气缸和注射构件可独立地更换，一次性部件。

    Medicament container of polymer of linear olefin for storing a liquid medicament
    6.
    发明授权
    Medicament container of polymer of linear olefin for storing a liquid medicament 失效
    用于储存液体药物的线性烯烃聚合物的药物容器

    公开(公告)号：US5945187A

    公开(公告)日：1999-08-31

    申请号：US991518

    申请日：1997-12-16

    申请人： Thomas Buch-Rasmussen ,  Patric Jannasch ,  Erling Bonne J.o slashed.rgensen

    发明人： Thomas Buch-Rasmussen ,  Patric Jannasch ,  Erling Bonne J.o slashed.rgensen

    IPC分类号： A61J1/00 ,  A61J1/05 ,  A61J1/06 ,  C08K3/40 ,  C08L23/04 ,  C08L23/10 ,  C08L23/12 ,  C08L45/00 ,  C08L23/00

    CPC分类号： A61J1/062 ,  A61J1/10 ,  C08L23/04 ,  C08L23/10 ,  C08L23/12 ,  Y10T428/1352 ,  Y10T428/1397

    摘要： A medicaments, container for storing a liquid medicament comprising one or more active medicaments, water and at least one preservative has a preferably cylindrical wall defining an interior space for such liquid medicament. The wall includes at least two opposed portions composed of a polymer material with a thickness of between 0.3 mm and 3 mm, a light transmission at 400 nm of 25% or more measured through the opposed container wall portions when the container is filled with water, using a standard spectrophotometer and air as reference. The polymer wall portions are of a material comprising at least 70% by weight of a linear optionally branched polyolefin material, the olefin monomer being selected from ethylene, propylene, butylene or a mixture thereof The polyolefin material has a crystallinity above 35% by weight, measured by differential scanning calorimetry, by cutting pieces from the container walls and heating them in an aluminum pan from 10.degree. C. to 270.degree. C. at the scanning rate of 10.degree. C./min, recording and integrating the melting endotherms, and using the value of 209 J/g for 100% crystalline polypropylene as a reference.

    摘要翻译： 药物，用于储存包含一种或多种活性药物，水和至少一种防腐剂的液体药物的容器具有限定用于这种液体药物的内部空间的优选圆柱形壁。 所述壁包括至少两个相对部分，所述至少两个相对部分由厚度在0.3mm至3mm之间的聚合物材料组成，当容器充满水时通过相对的容器壁部分测量的400nm的透光率为25％或更高， 使用标准分光光度计和空气作为参考。 聚合物壁部分是包含至少70重量％的线性任意支化聚烯烃材料的材料，烯烃单体选自乙烯，丙烯，丁烯或其混合物。聚烯烃材料的结晶度高于35重量％ 通过差示扫描量热法测量，通过从容器壁切割并将其在10℃至270℃的铝盘中以10℃/分钟的扫描速率加热，记录并整合熔融吸热温度， 使用209J / g的值作为100％结晶聚丙烯的参考。

    Medicament container of polymer of cyclic hydrocarbon for storing a liquid medicament
    10.
    发明授权
    Medicament container of polymer of cyclic hydrocarbon for storing a liquid medicament 失效
    用于储存液体药物的环状烃聚合物的药物容器

    公开(公告)号：US06680091B2

    公开(公告)日：2004-01-20

    申请号：US08991519

    申请日：1997-12-16

    申请人： Thomas Buch-Rasmussen ,  Patric Jannasch ,  Erling Bonne Jørgensen

    发明人： Thomas Buch-Rasmussen ,  Patric Jannasch ,  Erling Bonne Jørgensen

    IPC分类号： B29D2200

    CPC分类号： A61J1/062 ,  A61J1/10 ,  C08L23/04 ,  C08L23/10 ,  C08L23/12 ,  Y10T428/1352 ,  Y10T428/1397

    摘要： A medicament container for storing a liquid medicament, such as insulin, comprises a wall with at least two opposite portions made of a polymer material having a light transmission at 400 nm of at least 25%, a glass transition temperature above 50° C., and a density of 0.95 g/cm3 or more. The polymer material comprises at least 70% by weight of a copolymer material composed of aliphatic cyclic or bicyclic hydrocarbons with 5 to 7 membered ring or rings and ethylene or propylene. The container is substantially inert to the medicament and, because it is either transparent or at least includes at least two opposed transparent portions, it is possible visually to inspect the contents of the container to make sure that the medicament has not crystalized or polymerized. The walls of the container provide a good barrier against m-cresol/phenol/benzyl alcohol preservatives and water.

    摘要翻译： 用于储存诸如胰岛素的液体药物的药物容器包括具有至少两个相对部分的壁，所述至少两个相对部分由聚合物材料制成，所述聚合物材料在400nm处的透光率至少为25％，玻璃化转变温度高于50℃， 且密度为0.95g / cm 3以上。 聚合物材料包含至少70重量％的由具有5至7元环或环的脂族环或双环烃和乙烯或丙烯组成的共聚物材料。 容器对药物基本上是惰性的，并且由于其是透明的或至少包括至少两个相对的透明部分，所以可以在目视上检查容器的内容物以确保药物未结晶化或聚合。 容器壁提供了对间甲酚/苯酚/苯甲醇防腐剂和水的良好屏障。