摘要:
The present invention relates to fusion peptides which exhibit potent anti-retroviral activity. The fusion peptides of the invention comprise a macromolecular carrier group fused to a gp41-derived DP178 (SEQ ID NO:1) peptide corresponding to amino acids 638 to 673 of the HIV-1LA1 gp41 protein, or fragments, analogs or homologs of DP178. The invention further relates to the uses of such fusion peptides as inhibitory of human and non-human retroviral, especially HIV, transmission to uninfected cells.
摘要翻译:本发明涉及显示出有力的抗逆转录病毒活性的融合肽。 本发明的融合肽包含与gp41衍生的DP178(SEQ ID NO:1)肽融合的大分子载体基团,其对应于HIV-1 LA1Gp41蛋白的氨基酸638至673,或 DP178的片段,类似物或同系物。 本发明还涉及这种融合肽如抑制人和非人类逆转录病毒,特别是HIV,向未感染细胞的传播的用途。
摘要:
A system and method for wireless communication with and among nodes of a welding cell are provided. The system includes a communications device adapted for wireless communication with a welding node provided with a wireless communications interface. The system further includes welding nodes of one welding cell communicating wirelessly with welding nodes of the same welding cell, welding nodes of another welding cell, a customer specific LAN and global factory controls. The invention further comprises methodologies for facilitating wireless communication with and among nodes of a welding cell.
摘要:
Disclosed herein are a vehicle console and a latching system for a vehicle console with dual latch differentiation. The latching system comprises at least one lid pivotally attached to the console to move between a closed position and an open position relative to the opening. First and second latches are mounted to the lid. The first latch is configured to detach the lid from the first coupling to permit the lid to move to the open position while still attached to the secondary compartment, thereby exposing the primary compartment. The second latch is configured to detach the lid from both the first coupling and second coupling to permit the lid to move to the open position, detached from the secondary compartment. The first and second latches each comprise a hand engageable contact surface and the contact surface of one of the first and second latches comprises a tactile differentiator.
摘要:
A method for providing network management using a remote device. The method may include receiving an end-user message from an end-user device configured to communicate with a network management tool and processing the received message to perform a network management function on at least one network component. The end-user device may include one of a plurality of wireless devices, and the network management tool is configurable to communicate with any of the plurality of wireless devices.
摘要:
An electronic game including at least one display exhibiting a plurality of windows or segments each displaying a different subject matter is disclosed. The different subject matter in each of the plurality of windows preferably includes a real time promotional points total, an awards display, a sponsor advertising material display, an Internet display and an electronic game. The electronic game, which may include a wagering game, may be played by tendering money or tendering promotional points instead of money. Promotional points may be awarded instead of a portion of a money award, or supplemental to it. Promotional points may be accumulated by players through both gaming and non-gaming activities, including activities not involving a commercial transaction. An electronic gaining apparatus is described which also serves as an Internet portal.
摘要:
The present invention relates to peptides which exhibit potent anti-retroviral activity. The peptides of the invention comprise DP178 (SEQ ID:1) peptide corresponding to amino acids 638 to 673 of the HIV-1LAI gp41 protein, and fragments, analogs and homologs of DP178. The invention further relates to the uses of such peptides as inhibitory of human and non-human retroviral, especially HIV, transmission to uninfected cells.
摘要:
Systems and methods for awarding bonuses associated with gaming machines are disclosed. A bonus system host generates and transmits bonus event information to a gaming machine for display. The bonus system can be associated with a player tracking network including a remote player tracking host and a player tracking device at a gaming machine, which can include a controller and display. Alternatively, no player tracking device exists at the gaming machine, and bonus information is sent to a display on the gaming machine itself. A bonus can be awarded independent of the outcome of play on the gaming machine, and can be a themed bonus. Bonus event results for a specific player can be carried over to a following instance of a game played by that specific player. One form of bonus can be improved pay tables, with odds calculated as a function of player play within the bonus system.
摘要:
Disclosed herein are a vehicle console and a latching system for a vehicle console with dual latch differentiation. The latching system comprises at least one lid pivotally attached to the console to move between a closed position and an open position relative to the opening. First and second latches are mounted to the lid. The first latch is configured to detach the lid from the first coupling to permit the lid to move to the open position while still attached to the secondary compartment, thereby exposing the primary compartment. The second latch is configured to detach the lid from both the first coupling and second coupling to permit the lid to move to the open position, detached from the secondary compartment. The first and second latches each comprise a hand engageable contact surface and the contact surface of one of the first and second latches comprises a tactile differentiator.
摘要:
A controller includes a first input that receives a signal indicating an energy consumption value of a compressor, a second input that receives a signal indicating an energy consumption value of a variable speed condenser fan, a third input that receives a signal indicating an ambient temperature, a fourth input that receives a signal indicating a condenser temperature, an output that provides a control signal to the variable speed condenser fan, a memory that stores a temperature difference set-point, and a processor in communication with the inputs, the output and the memory. The processor calculates a difference between the ambient temperature and the condenser temperature, compares the difference with the temperature difference set-point, controls the variable speed condenser fan based on the comparison, monitors the energy consumption values, and modulates the temperature difference set-point to minimize energy consumption.
摘要:
Isoxazoles of formula (A) or (B) are inhibitors of HSP90 activity, and useful for treatment of, for example cancers: (A), (B) wherein R1, is a group of formula (IA): —Ar1-(Alk1)p-(Z)r-(Alk2)s-Q, wherein in any compatible combination Ar1 is an optionally substituted aryl or heteroaryl radical, Alk1 and Alk2 are optionally substituted divalent C1-C6 alkylene or C2-C6 alkenylene radicals, p, r and s are independently 0 or 1, Z is -0-, —S—, —(C═O)—, —(C═S)—, —SO2—, —C(═O)O—, —C(═O)NRA—, —C(═S)NRA—, —SO2NRA—, —NRAC(═O)—, —NRASO2— or —NRA— wherein RA is hydrogen or C1-C6 alkyl, and Q is hydrogen or an optionally substituted carbocyclic or heterocyclic radical; R2 is (i) a group of formula (IA) above or (ii) a carboxamide radical; or (iii) a non aromatic carbocyclic or heterocyclic ring wherein a ring carbon is optionally substituted, and/or a ring nitrogen is optionally substituted by a group of formula -(Alk1)p-(Z)r-(Alk2)s-Q wherein Q, Alk1, Alk2, Z, p, r and s are as defined above in relation to group (IA); and R3 is hydrogen, optionally substituted cycloalkyl, cycloalkenyl, C1-C6 alkyl, C1-C6 alkenyl, or C1-C6 alkynyl; or a carboxyl, carboxamide, or carboxyl ester group.