公开(公告)号：US20060211955A1

公开(公告)日：2006-09-21

申请号：US11438717

申请日：2006-05-22

申请人： Michael Horzewski ,  Alan Kaganov ,  Veijo Suorsa ,  Todd Thompson

发明人： Michael Horzewski ,  Alan Kaganov ,  Veijo Suorsa ,  Todd Thompson

IPC分类号： A61H1/00 ,  A61H1/02

CPC分类号： A61H23/0236 ,  A61B90/50 ,  A61B2017/00725 ,  A61B2017/00734 ,  A61B2018/00023 ,  A61N7/00 ,  A61N2007/0073

摘要： Systems and methods stimulate circulatory activity in a targeted body region of an individual by applying ultrasound energy. Before, during or after the application of ultrasound energy, the systems and methods administer an agent to individual that results, e.g., in an angiogenic effect, or in a reduction of blood perfusion, or a chemotherapy effect. The application of ultrasound energy selectively increases blood perfusion or uptake of the agent in the targeted body region.

公开(公告)号：US20070244415A1

公开(公告)日：2007-10-18

申请号：US11811373

申请日：2007-06-08

申请人： Michael Horzewski ,  Veijo Suorsa ,  Todd Thompson

发明人： Michael Horzewski ,  Veijo Suorsa ,  Todd Thompson

IPC分类号： A61H1/00

CPC分类号： A61H23/0236 ,  A61H2205/08 ,  A61N7/00

摘要： Systems and methods apply audible acoustic energy to cause vasodilation and/or to increase tissue perfusion.

摘要翻译： 系统和方法应用声音能量引起血管舒张和/或增加组织灌注。

公开(公告)号：US20080064991A1

公开(公告)日：2008-03-13

申请号：US11804858

申请日：2007-05-21

申请人： Veijo Suorsa ,  Todd Thompson ,  Michael Horzewski

发明人： Veijo Suorsa ,  Todd Thompson ,  Michael Horzewski

IPC分类号： A61N7/00

CPC分类号： A61N7/00 ,  A61B8/4427 ,  A61B8/4444 ,  A61B90/50 ,  A61B2017/00725 ,  A61B2017/00734 ,  A61B2018/00023 ,  A61N2007/0073

摘要： Systems and methods deliver ultrasound energy to an ultrasound transducer. In one arrangement, the ultrasound energy is delivered at an output frequency that varies over time within a range of output frequencies. The systems and methods select from within the range an operating output frequency for the ultrasound transducer based upon preprogrammed selection rules. The systems and methods can deliver ultrasound energy to the ultrasound transducer at or near the operating output frequency selected, to perform a therapeutic or diagnostic function. In another arrangement, the systems and methods deliver ultrasound energy to the ultrasound transducer at or near a first output power condition to perform a first function, as well as at or near a second output power condition that differs from the first output power condition to perform a second function that differs from the first function. In this arrangement, the systems and methods deliver ultrasound energy to the ultrasound transducer at a power condition that transitions, according to a ramping function, from a condition at or near the first output power condition, for execution of the first function, toward a condition at or near the second output power condition, for execution of the second function. The ramping function may, e.g., be linear or non-linear.

摘要翻译： 系统和方法向超声波传感器提供超声能量。 在一种布置中，超声能量以在输出频率范围内随时间变化的输出频率传送。 系统和方法根据预编程的选择规则从范围内选择超声换能器的工作输出频率。 所述系统和方法可以在所选择的操作输出频率处或附近向超声换能器递送超声波能量，以执行治疗或诊断功能。 在另一种布置中，系统和方法在第一输出功率条件处或接近第一输出功率条件下向超声波换能器传送超声能量，以执行第一功能，以及在与第一输出功率条件不同的第二输出功率条件或附近，以执行 与第一功能不同的第二功能。 在这种布置中，系统和方法在超声换能器的功率条件下，向超声波换能器输送超声波能量，该功率状态根据斜坡函数从第一输出功率状态或接近第一输出功率状态的状态转移到第一功能的状态 在第二输出功率条件或其附近，用于执行第二功能。 斜坡函数可以例如是线性的或非线性的。

公开(公告)号：US20070265601A1

公开(公告)日：2007-11-15

申请号：US11825873

申请日：2007-07-10

申请人： Michael Horzewski ,  Veijo Suorsa ,  Todd Thompson

发明人： Michael Horzewski ,  Veijo Suorsa ,  Todd Thompson

IPC分类号： A61B17/00

CPC分类号： A61N7/00 ,  A61B90/50 ,  A61B2017/00725 ,  A61B2017/00734 ,  A61B2018/00023 ,  A61N2007/0073

摘要： Systems and methods monitor and enable the use of a medical instrument that is configured to be operated in a prescribed manner. The systems and methods employ a use register sized and configured to be carried by the medical instrument, which comprises a memory field for recording a start date and time at an instance of first operation of the medical instrument. The systems and methods also employ a use monitoring controller, which is adapted and configured to be coupled to the use register. The use monitoring controller includes a start validation function that compares the start date and time to a present real date and time and provides a start validation output based upon the comparison. The use monitoring controller also includes an enablement function that enables operation of the medical instrument only if the start validation output meets prescribed criteria.

公开(公告)号：US20110034964A1

公开(公告)日：2011-02-10

申请号：US12920086

申请日：2009-02-27

申请人： Yafei Bi ,  Haifeng Li ,  Mark Zdeblick ,  Todd Thompson ,  Robert Leichner

发明人： Yafei Bi ,  Haifeng Li ,  Mark Zdeblick ,  Todd Thompson ,  Robert Leichner

IPC分类号： A61N1/08 ,  A61N1/362 ,  A61N1/05 ,  A61N1/39

CPC分类号： A61N1/05 ,  A61N1/025 ,  A61N1/37 ,  A61N1/378

摘要： Apparatus and methods enable robust, reliable control for implantable medical devices, including cardiac pacemakers, defibrillators and cardiac resynchronization devices. Integrated circuits in the devices have minimized interfaces, can derive power from the interface signals, and have high voltage and latch-up protection. A device lead has a power generation circuit and a switching circuit using cascaded PMOS transistors for operating with a stable voltage despite fluctuations in the supplied voltage. The lead has control electronics that provide a very low impedance between an electrode and a lead conductor during most of the duration of a pacing pulse, but during a brief initial portion of the pacing pulse, provide a very high impedance to permit charging up a power supply that is local to the control electronics. A method of stabilizing the external impedance and a system for fault detection and fault recovery for an implantable device are also provided.

摘要翻译： 装置和方法能够对可植入医疗装置（包括心脏起搏器，除颤器和心脏再同步装置）进行可靠的，可靠的控制。 器件中的集成电路具有最小化的接口，可以从接口信号中获取功率，并具有高电压和闭锁保护。 器件引线具有发电电路和使用级联PMOS晶体管的开关电路，用于尽管工作电压的波动以稳定的电压工作。 引线具有控制电子学，其在起搏脉冲的大部分持续时间期间在电极和引线导体之间提供非常低的阻抗，但是在起搏脉冲的短暂初始部分期间，提供非常高的阻抗以允许充电电力 供应是本地控制电子产品。 还提供了一种稳定外部阻抗的方法和用于可植入装置的故障检测和故障恢复系统。

公开(公告)号：US07862608B2

公开(公告)日：2011-01-04

申请号：US10746668

申请日：2003-12-23

申请人： Michael Hogendijk ,  Todd Thompson

发明人： Michael Hogendijk ,  Todd Thompson

IPC分类号： A61F2/06 ,  A61M29/00

CPC分类号： A61F2/966 ,  A61F2/88 ,  A61F2/885 ,  A61F2/91 ,  A61F2/95 ,  A61F2002/068 ,  A61F2002/828 ,  A61F2220/0016 ,  A61F2230/0054 ,  A61F2250/0068

摘要： The present invention is directed to an implantable vascular prosthesis configured for use in a wide range of applications, such as treating aneurysms, maintaining patency in a vessel, and allowing for the controlled delivery of therapeutic agents to a vessel wall. The prosthesis comprises one or more helical sections coupled to one or more anchoring sections having a generally zig-zag or cell-like configuration. The prosthesis is configured to conform to a vessel wall without substantially remodeling the vessel, and further is configured to be precisely deployed in a vessel without shifting or foreshortening during deployment.

摘要翻译： 本发明涉及一种可植入血管假体，其被配置用于广泛的应用中，例如治疗动脉瘤，维持血管中的开放性，并允许将治疗剂控制递送到血管壁。 假体包括一个或多个螺旋部分，其联接到具有大致Z字形或细胞样构造的一个或多个锚定部分。 假体被配置成符合血管壁而不会基本上重塑血管，并且进一步构造成在展开期间精确地展开在容器中而不会移动或缩短。

公开(公告)号：US20100204766A1

公开(公告)日：2010-08-12

申请号：US12097959

申请日：2006-12-22

申请人： Mark Zdeblick ,  Robert Leichner ,  Behrad Aria ,  Nilay Jani ,  Haifeng Li ,  Todd Thompson ,  Lawrence Arne ,  Timothy Robertson ,  Yafei Bi ,  Vladimier Gelfandbein

发明人： Mark Zdeblick ,  Robert Leichner ,  Behrad Aria ,  Nilay Jani ,  Haifeng Li ,  Todd Thompson ,  Lawrence Arne ,  Timothy Robertson ,  Yafei Bi ,  Vladimier Gelfandbein

IPC分类号： A61N1/05

CPC分类号： A61N1/056 ,  A61B5/0422 ,  A61N1/025 ,  A61N1/362 ,  A61N1/3686 ,  A61N1/372 ,  A61N1/37205 ,  A61N1/37276 ,  A61N1/37288 ,  A61N1/3756

摘要： Embodiments of the present invention enable robust, reliable control functionality for effectors present on intraluminal, e.g., vascular leads, as well as other types of implantable devices. Embodiments of the invention enable the required functionality for accurate long term control of effectors units, even ones present on multiplex carrier configurations, while provide for low power consumption. Aspects of the invention include implantable integrated circuits that have power extraction; energy storage; communication; and device configuration functional blocks, where these functional blocks are all present in a single integrated circuit on an intraluminal-sized support. Also provided by the invention are effector assemblies that include the integrated circuits, as well as implantable medical devices, e.g., pulse generators that include the same, as well as systems and kits thereof and methods of using the same, e.g., in pacing applications, including cardiac resynchronization therapy (CRT) applications.

摘要翻译： 本发明的实施例对存在于管腔内（例如血管引线）以及其它类型的可植入装置的效果器提供了鲁棒，可靠的控制功能。 本发明的实施例能够实现对效果器单元的准确的长期控制所需的功能，即使存在于多路载波配置上的单元也能提供低功耗。 本发明的方面包括具有功率提取的可植入集成电路; 储能; 通讯; 以及器件配置功能块，其中这些功能块都存在于腔内尺寸支持体上的单个集成电路中。 本发明还提供了包括集成电路的效应器组件以及可植入的医疗装置，例如包括其的脉冲发生器，以及其系统和套件，以及使用该装置的方法，例如在起搏应用中， 包括心脏再同步治疗（CRT）应用。

公开(公告)号：US20080183072A1

公开(公告)日：2008-07-31

申请号：US11664340

申请日：2007-03-30

申请人： Timothy L. Robertson ,  George M. Savage ,  Todd Thompson ,  Mark J. Zdeblick ,  Olivier Colliou ,  Benedict J. Costello

发明人： Timothy L. Robertson ,  George M. Savage ,  Todd Thompson ,  Mark J. Zdeblick ,  Olivier Colliou ,  Benedict J. Costello

IPC分类号： A61B5/05

CPC分类号： A61B5/1107 ,  A61B5/0031 ,  A61B5/686 ,  A61B8/12 ,  A61B8/488 ,  A61B8/56 ,  A61B2562/046 ,  A61N1/3627 ,  A61N1/365

摘要： Methods for evaluating motion of a tissue, such as of a cardiac location, e.g., heart wall, via continuous field tomography are provided. In the subject methods, a continuous field (e.g., an electrical, mechanical, electro-mechanical, or other field) sensing element is stably associated with the tissue location. A property of the applied continuous field is detected with the sensing element to evaluate movement of the tissue location. Also provided are systems, devices and related compositions for practicing the subject methods. The subject methods and devices find use in a variety of different applications, including cardiac resynchronization therapy.

摘要翻译： 提供了通过连续场断层摄影评估诸如心脏位置（例如心脏壁）的组织运动的方法。 在主题方法中，连续场（例如，电，机械，机电或其他场）感测元件与组织位置稳定地相关联。 使用感测元件检测所施加的连续场的属性，以评估组织位置的运动。 还提供了用于实践主题方法的系统，装置和相关组合物。 主题方法和设备可用于各种不同的应用，包括心脏再同步治疗。

公开(公告)号：US20050246010A1

公开(公告)日：2005-11-03

申请号：US10836909

申请日：2004-04-30

申请人： Miles Alexander ,  Todd Thompson ,  Tim Huynh ,  Ray Betelia

发明人： Miles Alexander ,  Todd Thompson ,  Tim Huynh ,  Ray Betelia

IPC分类号： A61F2/06 ,  A61F2/84 ,  A61F2/88 ,  A61F2/90

CPC分类号： A61F2/95 ,  A61F2/88 ,  A61F2/91

摘要： The present invention is directed to a delivery catheter for use in deploying a vascular prosthesis having a self-expanding helical section for use in a wide range of interventional applications. The delivery catheter comprises an elongated member having a helical ledge with a pitch selected to impose a predetermined amount of foreshortening on the vascular prosthesis during deployment. Methods of making and using the delivery catheter of the present invention also are provided.

摘要翻译： 本发明涉及用于部署具有自扩张螺旋段的血管假体的输送导管，用于广泛的介入应用。 递送导管包括细长构件，该细长构件具有螺旋凸缘，所述螺旋凸缘具有间距，其在展开期间在血管假体上施加预定量的缩短。 还提供了制造和使用本发明的输送导管的方法。

公开(公告)号：US20050192342A1

公开(公告)日：2005-09-01

申请号：US10789835

申请日：2004-02-27

申请人： Todd Thompson ,  George Wilding

发明人： Todd Thompson ,  George Wilding

IPC分类号： A61K31/353

CPC分类号： C07D311/72 ,  A61K31/353

摘要： Methods for the prevention and/or alleviation of androgen-mediated disorders treatable by administering a chroman-derived anti-androgen compound are provided by the present invention. The invention further provides pharmaceutical and nutraceutical compositions containing chroman-derived anti-androgen compounds useful in the prevention and/or alleviation of androgen-mediated disorders, particularly prostate cancer.

摘要翻译： 通过本发明提供了通过施用苯并二氢吡喃衍生的抗雄激素化合物可治疗的雄激素介导的疾病的预防和/或缓解方法。 本发明进一步提供了含有色氨酸衍生的抗雄激素化合物的药物和营养组合物，其用于预防和/或减轻雄激素介导的病症，特别是前列腺癌。