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    Integrated Circuit Implementation and Fault Control System, Device, and Method
    1.
    发明申请
    Integrated Circuit Implementation and Fault Control System, Device, and Method 有权
    集成电路实现与故障控制系统，设备及方法

    公开(公告)号：US20110034964A1

    公开(公告)日：2011-02-10

    申请号：US12920086

    申请日：2009-02-27

    申请人： Yafei Bi ,  Haifeng Li ,  Mark Zdeblick ,  Todd Thompson ,  Robert Leichner

    发明人： Yafei Bi ,  Haifeng Li ,  Mark Zdeblick ,  Todd Thompson ,  Robert Leichner

    IPC分类号： A61N1/08 ,  A61N1/362 ,  A61N1/05 ,  A61N1/39

    CPC分类号： A61N1/05 ,  A61N1/025 ,  A61N1/37 ,  A61N1/378

    摘要： Apparatus and methods enable robust, reliable control for implantable medical devices, including cardiac pacemakers, defibrillators and cardiac resynchronization devices. Integrated circuits in the devices have minimized interfaces, can derive power from the interface signals, and have high voltage and latch-up protection. A device lead has a power generation circuit and a switching circuit using cascaded PMOS transistors for operating with a stable voltage despite fluctuations in the supplied voltage. The lead has control electronics that provide a very low impedance between an electrode and a lead conductor during most of the duration of a pacing pulse, but during a brief initial portion of the pacing pulse, provide a very high impedance to permit charging up a power supply that is local to the control electronics. A method of stabilizing the external impedance and a system for fault detection and fault recovery for an implantable device are also provided.

    摘要翻译： 装置和方法能够对可植入医疗装置（包括心脏起搏器，除颤器和心脏再同步装置）进行可靠的，可靠的控制。 器件中的集成电路具有最小化的接口，可以从接口信号中获取功率，并具有高电压和闭锁保护。 器件引线具有发电电路和使用级联PMOS晶体管的开关电路，用于尽管工作电压的波动以稳定的电压工作。 引线具有控制电子学，其在起搏脉冲的大部分持续时间期间在电极和引线导体之间提供非常低的阻抗，但是在起搏脉冲的短暂初始部分期间，提供非常高的阻抗以允许充电电力 供应是本地控制电子产品。 还提供了一种稳定外部阻抗的方法和用于可植入装置的故障检测和故障恢复系统。

    IMPLANTABLE INTEGRATED CIRCUIT
    2.
    发明申请
    IMPLANTABLE INTEGRATED CIRCUIT 审中-公开
    可嵌入式集成电路

    公开(公告)号：US20100204766A1

    公开(公告)日：2010-08-12

    申请号：US12097959

    申请日：2006-12-22

    申请人： Mark Zdeblick ,  Robert Leichner ,  Behrad Aria ,  Nilay Jani ,  Haifeng Li ,  Todd Thompson ,  Lawrence Arne ,  Timothy Robertson ,  Yafei Bi ,  Vladimier Gelfandbein

    发明人： Mark Zdeblick ,  Robert Leichner ,  Behrad Aria ,  Nilay Jani ,  Haifeng Li ,  Todd Thompson ,  Lawrence Arne ,  Timothy Robertson ,  Yafei Bi ,  Vladimier Gelfandbein

    IPC分类号： A61N1/05

    CPC分类号： A61N1/056 ,  A61B5/0422 ,  A61N1/025 ,  A61N1/362 ,  A61N1/3686 ,  A61N1/372 ,  A61N1/37205 ,  A61N1/37276 ,  A61N1/37288 ,  A61N1/3756

    摘要： Embodiments of the present invention enable robust, reliable control functionality for effectors present on intraluminal, e.g., vascular leads, as well as other types of implantable devices. Embodiments of the invention enable the required functionality for accurate long term control of effectors units, even ones present on multiplex carrier configurations, while provide for low power consumption. Aspects of the invention include implantable integrated circuits that have power extraction; energy storage; communication; and device configuration functional blocks, where these functional blocks are all present in a single integrated circuit on an intraluminal-sized support. Also provided by the invention are effector assemblies that include the integrated circuits, as well as implantable medical devices, e.g., pulse generators that include the same, as well as systems and kits thereof and methods of using the same, e.g., in pacing applications, including cardiac resynchronization therapy (CRT) applications.

    摘要翻译： 本发明的实施例对存在于管腔内（例如血管引线）以及其它类型的可植入装置的效果器提供了鲁棒，可靠的控制功能。 本发明的实施例能够实现对效果器单元的准确的长期控制所需的功能，即使存在于多路载波配置上的单元也能提供低功耗。 本发明的方面包括具有功率提取的可植入集成电路; 储能; 通讯; 以及器件配置功能块，其中这些功能块都存在于腔内尺寸支持体上的单个集成电路中。 本发明还提供了包括集成电路的效应器组件以及可植入的医疗装置，例如包括其的脉冲发生器，以及其系统和套件，以及使用该装置的方法，例如在起搏应用中， 包括心脏再同步治疗（CRT）应用。

    Integrated circuit implementation and fault control system, device, and method
    3.
    发明授权
    Integrated circuit implementation and fault control system, device, and method 有权
    集成电路实现与故障控制系统，设备及方法

    公开(公告)号：US08473069B2

    公开(公告)日：2013-06-25

    申请号：US12920086

    申请日：2009-02-27

    申请人： Yafei Bi ,  Haifeng Li ,  Mark Zdeblick ,  Todd Thompson ,  Robert Leichner

    发明人： Yafei Bi ,  Haifeng Li ,  Mark Zdeblick ,  Todd Thompson ,  Robert Leichner

    IPC分类号： A61N1/08

    CPC分类号： A61N1/05 ,  A61N1/025 ,  A61N1/37 ,  A61N1/378

    摘要： Apparatus and methods enable robust, reliable control for implantable medical devices, including cardiac pacemakers, defibrillators and cardiac resynchronization devices. Integrated circuits in the devices have minimized interfaces, can derive power from the interface signals, and have high voltage and latch-up protection. A device lead has a power generation circuit and a switching circuit using cascaded PMOS transistors for operating with a stable voltage despite fluctuations in the supplied voltage. The lead has control electronics that provide a very low impedance between an electrode and a lead conductor during most of the duration of a pacing pulse, but during a brief initial portion of the pacing pulse, provide a very high impedance to permit charging up a power supply that is local to the control electronics. A method of stabilizing the external impedance and a system for fault detection and fault recovery for an implantable device are also provided.

    摘要翻译： 装置和方法能够对可植入医疗装置（包括心脏起搏器，除颤器和心脏再同步装置）进行可靠的，可靠的控制。 器件中的集成电路具有最小化的接口，可以从接口信号中获取功率，并具有高电压和闭锁保护。 器件引线具有发电电路和使用级联PMOS晶体管的开关电路，用于尽管工作电压的波动以稳定的电压工作。 引线具有控制电子学，其在起搏脉冲的大部分持续时间期间在电极和引线导体之间提供非常低的阻抗，但是在起搏脉冲的短暂初始部分期间，提供非常高的阻抗以允许充电电力 供应是本地控制电子产品。 还提供了一种稳定外部阻抗的方法和用于可植入装置的故障检测和故障恢复系统。

    HIGH PHRENIC, LOW CAPTURE THRESHOLD PACING DEVICES AND METHODS
    7.
    发明申请
    HIGH PHRENIC, LOW CAPTURE THRESHOLD PACING DEVICES AND METHODS 审中-公开
    高光，低电压阈值设备和方法

    公开(公告)号：US20080077186A1

    公开(公告)日：2008-03-27

    申请号：US11734617

    申请日：2007-04-12

    申请人： Todd Thompson ,  Mark Zdeblick ,  Olivier Colliou ,  Benedict Costello ,  Marc Jensen ,  George Savage

    发明人： Todd Thompson ,  Mark Zdeblick ,  Olivier Colliou ,  Benedict Costello ,  Marc Jensen ,  George Savage

    IPC分类号： A61N1/00

    CPC分类号： A61N1/3627

    摘要： Methods of highly selective cardiac tissue stimulation and devices for practicing the same, e.g., implantable segmented electrode devices, are provided. The methods and devices provide a previously unavailable high phrenic nerve capture voltage paired with a low pacing capture voltage threshold. The subject methods and devices provide a number of benefits. For example, patients who previously would have been required to have their resynchronization device turned off due to phrenic nerve capture will now be able to reap the benefits of resynchronization therapy.

    摘要翻译： 提供了高选择性心脏组织刺激的方法和用于实施该方法的装置，例如可植入分段的电极装置。 这些方法和装置提供了与低起搏捕获电压阈值配对的先前不可用的高膈神经捕获电压。 主题方法和设备提供了许多好处。 例如，以前由于膈神经捕获而被关闭的再同步装置的患者现在将能够获得再同步治疗的好处。

    Multiplexed multi-electrode neurostimulation devices
    8.
    发明授权
    Multiplexed multi-electrode neurostimulation devices 有权
    复用多电极神经刺激装置

    公开(公告)号：US08738154B2

    公开(公告)日：2014-05-27

    申请号：US13115031

    申请日：2011-05-24

    申请人： Mark Zdeblick ,  Todd Thompson ,  Marc Jensen ,  Olivier Colliou ,  Angela Strand

    发明人： Mark Zdeblick ,  Todd Thompson ,  Marc Jensen ,  Olivier Colliou ,  Angela Strand

    IPC分类号： A61N1/05

    CPC分类号： A61N1/375 ,  A61N1/025 ,  A61N1/0551 ,  A61N1/0553 ,  A61N1/36017 ,  A61N1/36185

    摘要： Implantable stimulation devices are provided. Aspects of the devices include a multiplexed multi-electrode component configured for neural stimulation. The multiplexed multi-electrode component includes two or more individually addressable satellite electrode structures electrically coupled to a common conductor. The satellite structures include a hermetically sealed integrated circuit controller operatively coupled to one or more electrodes. Also provided are systems that include the devices of the invention, as well as methods of using the systems and devices in a variety of different applications.

    摘要翻译： 提供可植入的刺激装置。 器件的方面包括配置用于神经刺激的复用多电极部件。 多路复用多电极部件包括电耦合到公共导体的两个或更多个可单独寻址的卫星电极结构。 卫星结构包括可操作地耦合到一个或多个电极的密封的集成电路控制器。 还提供了包括本发明的装置的系统，以及在各种不同应用中使用系统和装置的方法。

    Multiplexed multi-electrode neurostimulation devices
    10.
    发明授权
    Multiplexed multi-electrode neurostimulation devices 有权
    复用多电极神经刺激装置

    公开(公告)号：US07974705B2

    公开(公告)日：2011-07-05

    申请号：US12665030

    申请日：2009-11-13

    申请人： Mark Zdeblick ,  Todd Thompson ,  Marc Jensen ,  Olivier Colliou ,  Angela Strand

    发明人： Mark Zdeblick ,  Todd Thompson ,  Marc Jensen ,  Olivier Colliou ,  Angela Strand

    IPC分类号： A61N1/05

    CPC分类号： A61N1/375 ,  A61N1/025 ,  A61N1/0551 ,  A61N1/0553 ,  A61N1/36017 ,  A61N1/36185

    摘要： Implantable stimulation devices are provided. Aspects of the devices include a multiplexed multi-electrode component configured for neural stimulation. The multiplexed multi-electrode component includes two or more individually addressable satellite electrode structures electrically coupled to a common conductor. The satellite structures include a hermetically sealed integrated circuit controller operatively coupled to one or more electrodes. Also provided are systems that include the devices of the invention, as well as methods of using the systems and devices in a variety of different applications.

    摘要翻译： 提供可植入的刺激装置。 器件的方面包括配置用于神经刺激的复用多电极部件。 多路复用多电极部件包括电耦合到公共导体的两个或更多个可单独寻址的卫星电极结构。 卫星结构包括可操作地耦合到一个或多个电极的密封的集成电路控制器。 还提供了包括本发明的装置的系统，以及在各种不同应用中使用系统和装置的方法。