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公开(公告)号：US09717834B2
公开(公告)日：2017-08-01
申请号：US13480444
申请日：2012-05-24
申请人： Michael J. Wilt , Dirk A. van der Merwe , Todd A. Ballantyne , Kevin L. Grant , Jonathan P. Rosse , Catharine N. Flynn , Brian K. Yee
发明人： Michael J. Wilt , Dirk A. van der Merwe , Todd A. Ballantyne , Kevin L. Grant , Jonathan P. Rosse , Catharine N. Flynn , Brian K. Yee
IPC分类号： B01D61/30 , B01D61/28 , G01N21/59 , B01D61/32 , A61M1/16 , A61M5/172 , A61M1/14 , G06F19/00 , A61M1/10 , A61M1/34 , A61M1/36
CPC分类号： A61M1/1601 , A61K33/00 , A61M1/1006 , A61M1/1037 , A61M1/1062 , A61M1/1087 , A61M1/1096 , A61M1/14 , A61M1/16 , A61M1/1605 , A61M1/1613 , A61M1/1619 , A61M1/1654 , A61M1/1656 , A61M1/1658 , A61M1/166 , A61M1/1664 , A61M1/1666 , A61M1/1668 , A61M1/1692 , A61M1/267 , A61M1/301 , A61M1/34 , A61M1/341 , A61M1/3413 , A61M1/3609 , A61M1/3621 , A61M1/3627 , A61M1/3638 , A61M1/3672 , A61M5/172 , A61M2205/12 , A61M2205/15 , A61M2205/18 , A61M2205/3306 , A61M2205/3313 , A61M2205/3317 , A61M2205/3324 , A61M2205/3331 , A61M2205/3334 , A61M2205/3368 , A61M2205/3379 , A61M2205/3569 , A61M2205/3584 , A61M2205/50 , A61M2205/502 , A61M2205/52 , A61M2230/65 , G06F19/00 , G06F19/3481
摘要： Dialysis systems are disclosed comprising new fluid flow circuits. Systems may include blood and dialysate flow paths, where the dialysate flow path includes balancing, mixing, and/or directing circuits. Dialysate preparation may be decoupled from patient dialysis. Circuits may be defined within one or more cassettes. The fluid circuit fluid flow paths may be isolated from electrical components. A gas supply in fluid communication with the dialysate flow path and/or the dialyzer able to urge dialysate through the dialyzer and urge blood back to the patient may be included for certain emergency situations Fluid handling devices, such as pumps, valves, and mixers that can be actuated using a control fluid, may be included. Control fluid may be delivered by an external pump or other device, which may be detachable and/or generally rigid, optionally with a diaphragm dividing the device into first and second compartments.
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公开(公告)号：US09517295B2
公开(公告)日：2016-12-13
申请号：US13480454
申请日：2012-05-24
申请人： Michael J. Wilt , Dirk A. van der Merwe , Todd A. Ballantyne , Kevin L. Grant , Jonathan P. Rosse , Catharine N. Flynn , Brian K. Yee
发明人： Michael J. Wilt , Dirk A. van der Merwe , Todd A. Ballantyne , Kevin L. Grant , Jonathan P. Rosse , Catharine N. Flynn , Brian K. Yee
CPC分类号： A61M1/1601 , A61K33/00 , A61M1/1006 , A61M1/1037 , A61M1/1062 , A61M1/1087 , A61M1/1096 , A61M1/14 , A61M1/16 , A61M1/1605 , A61M1/1613 , A61M1/1619 , A61M1/1654 , A61M1/1656 , A61M1/1658 , A61M1/166 , A61M1/1664 , A61M1/1666 , A61M1/1668 , A61M1/1692 , A61M1/267 , A61M1/301 , A61M1/34 , A61M1/341 , A61M1/3413 , A61M1/3609 , A61M1/3621 , A61M1/3627 , A61M1/3638 , A61M1/3672 , A61M5/172 , A61M2205/12 , A61M2205/15 , A61M2205/18 , A61M2205/3306 , A61M2205/3313 , A61M2205/3317 , A61M2205/3324 , A61M2205/3331 , A61M2205/3334 , A61M2205/3368 , A61M2205/3379 , A61M2205/3569 , A61M2205/3584 , A61M2205/50 , A61M2205/502 , A61M2205/52 , A61M2230/65 , G06F19/00 , G06F19/3481
摘要： Dialysis systems are disclosed comprising new fluid flow circuits. Systems may include blood and dialysate flow paths, where the dialysate flow path includes balancing, mixing, and/or directing circuits. Dialysis systems may include a safety system utilizing a field programmable gate array (FPGA) that monitors at least conductivity and temperature of dialysate in the flow circuit upstream of a dialyzer and enters a fail-safe state if the measured conductivity is outside of a range of values. The FPGA may be verified to be operating properly by exposing sensors in fluid paths to temperatures or conductivities that are outside pre-determined permissible ranges of values, and confirming that the FPGA safety system enters a fail-safe state in response to the temperatures or conductivities. The FPGA may be configured to monitor an amount of ultrafiltration fluid withdrawn from a patient during dialysis treatment and to enter a fail-safe state if a maximum amount is exceeded.
摘要翻译： 公开了透析系统，其包括新的流体流动回路。 系统可以包括血液和透析液流动路径，其中透析液流动路径包括平衡，混合和/或引导电路。 透析系统可以包括使用现场可编程门阵列（FPGA）的安全系统，其至少监测透析器上游的流动回路中透析液的电导率和温度，并且如果测量的电导率在 价值观。 可以通过将流体路径中的传感器暴露于超出预定的允许值范围的温度或电导率，并且确认FPGA安全系统响应于温度或电导率而进入故障安全状态，可以验证FPGA可以正常工作 。 FPGA可以被配置为监测在透析治疗期间从患者抽出的超滤流体的量，并且如果超过最大量则进入故障安全状态。
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公开(公告)号：US20130037485A1
公开(公告)日：2013-02-14
申请号：US13480444
申请日：2012-05-24
申请人： Michael J. Wilt , Dirk A. van der Merwe , Todd A. Ballantyne , Kevin L. Grant , Jonathan P. Rosse , Catharine N. Flynn , Brian K. Yee
发明人： Michael J. Wilt , Dirk A. van der Merwe , Todd A. Ballantyne , Kevin L. Grant , Jonathan P. Rosse , Catharine N. Flynn , Brian K. Yee
CPC分类号： A61M1/1601 , A61K33/00 , A61M1/1006 , A61M1/1037 , A61M1/1062 , A61M1/1087 , A61M1/1096 , A61M1/14 , A61M1/16 , A61M1/1605 , A61M1/1613 , A61M1/1619 , A61M1/1654 , A61M1/1656 , A61M1/1658 , A61M1/166 , A61M1/1664 , A61M1/1666 , A61M1/1668 , A61M1/1692 , A61M1/267 , A61M1/301 , A61M1/34 , A61M1/341 , A61M1/3413 , A61M1/3609 , A61M1/3621 , A61M1/3627 , A61M1/3638 , A61M1/3672 , A61M5/172 , A61M2205/12 , A61M2205/15 , A61M2205/18 , A61M2205/3306 , A61M2205/3313 , A61M2205/3317 , A61M2205/3324 , A61M2205/3331 , A61M2205/3334 , A61M2205/3368 , A61M2205/3379 , A61M2205/3569 , A61M2205/3584 , A61M2205/50 , A61M2205/502 , A61M2205/52 , A61M2230/65 , G06F19/00 , G06F19/3481
摘要： Dialysis systems are disclosed comprising new fluid flow circuits. Systems may include blood and dialysate flow paths, where the dialysate flow path includes balancing, mixing, and/or directing circuits. Dialysate preparation may be decoupled from patient dialysis. Circuits may be defined within one or more cassettes. The fluid circuit fluid flow paths may be isolated from electrical components. A gas supply in fluid communication with the dialysate flow path and/or the dialyzer able to urge dialysate through the dialyzer and urge blood back to the patient may be included for certain emergency situations. Fluid handling devices, such as pumps, valves, and mixers that can be actuated using a control fluid, may be included. Control fluid may be delivered by an external pump or other device, which may be detachable and/or generally rigid, optionally with a diaphragm dividing the device into first and second compartments.
摘要翻译： 公开了透析系统，其包括新的流体流动回路。 系统可以包括血液和透析液流动路径，其中透析液流动路径包括平衡，混合和/或引导电路。 透析液的制备可能与患者透析分离。 电路可以被定义在一个或多个盒中。 流体回路流体流动路径可以与电气部件隔离。 可以包括与透析液流路和/或透析器流体连通的能够通过透析器促进透析液并将血液推回到患者的气体供应用于某些紧急情况。 可以包括可以使用控制流体致动的流体处理装置，例如泵，阀和混合器。 控制流体可以由外部泵或其它装置输送，外部泵或其它装置可以是可拆卸的和/或大致刚性的，可选地具有将装置分隔成第一和第二隔室的隔膜。
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公开(公告)号：US20130020237A1
公开(公告)日：2013-01-24
申请号：US13480454
申请日：2012-05-24
申请人： Michael J. Wilt , Dirk A. van der Merwe , Todd A. Ballantyne , Kevin L. Grant , Johnathan P. Rosse , Catharine N. Flynn , Brian K. Yee
发明人： Michael J. Wilt , Dirk A. van der Merwe , Todd A. Ballantyne , Kevin L. Grant , Johnathan P. Rosse , Catharine N. Flynn , Brian K. Yee
IPC分类号： A61M1/14
CPC分类号： A61M1/1601 , A61K33/00 , A61M1/1006 , A61M1/1037 , A61M1/1062 , A61M1/1087 , A61M1/1096 , A61M1/14 , A61M1/16 , A61M1/1605 , A61M1/1613 , A61M1/1619 , A61M1/1654 , A61M1/1656 , A61M1/1658 , A61M1/166 , A61M1/1664 , A61M1/1666 , A61M1/1668 , A61M1/1692 , A61M1/267 , A61M1/301 , A61M1/34 , A61M1/341 , A61M1/3413 , A61M1/3609 , A61M1/3621 , A61M1/3627 , A61M1/3638 , A61M1/3672 , A61M5/172 , A61M2205/12 , A61M2205/15 , A61M2205/18 , A61M2205/3306 , A61M2205/3313 , A61M2205/3317 , A61M2205/3324 , A61M2205/3331 , A61M2205/3334 , A61M2205/3368 , A61M2205/3379 , A61M2205/3569 , A61M2205/3584 , A61M2205/50 , A61M2205/502 , A61M2205/52 , A61M2230/65 , G06F19/00 , G06F19/3481
摘要： Dialysis systems are disclosed comprising new fluid flow circuits. Systems may include blood and dialysate flow paths, where the dialysate flow path includes balancing, mixing, and/or directing circuits. Dialysate preparation may be decoupled from patient dialysis. Circuits may be defined within one or more cassettes. The fluid circuit fluid flow paths may be isolated from electrical components. A gas supply in fluid communication with the dialysate flow path and/or the dialyzer able to urge dialysate through the dialyzer and urge blood back to the patient may be included for certain emergency situations. Fluid handling devices, such as pumps, valves, and mixers that can be actuated using a control fluid, may be included. Control fluid may be delivered by an external pump or other device, which may be detachable and/or generally rigid, optionally with a diaphragm, dividing the device into first and second compartments.
摘要翻译： 公开了透析系统，其包括新的流体流动回路。 系统可以包括血液和透析液流动路径，其中透析液流动路径包括平衡，混合和/或引导电路。 透析液的制备可能与患者透析分离。 电路可以被定义在一个或多个盒中。 流体回路流体流动路径可以与电气部件隔离。 可以包括与透析液流路和/或透析器流体连通的能够通过透析器促进透析液并将血液推回到患者的气体供应用于某些紧急情况。 可以包括可以使用控制流体致动的流体处理装置，例如泵，阀和混合器。 控制流体可以由外部泵或其他装置输送，外部泵或其它装置可以是可拆卸的和/或大致刚性的，可选地具有隔膜，将装置分成第一和第二隔室。
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公开(公告)号：US08357298B2
公开(公告)日：2013-01-22
申请号：US12199452
申请日：2008-08-27
CPC分类号： A61M1/1601 , A61M1/16 , A61M1/1613 , A61M1/1635 , A61M1/341 , A61M1/3434 , A61M1/3437 , A61M1/3441 , A61M1/3465 , A61M1/3609 , A61M1/3646 , A61M1/365 , A61M1/3652 , A61M2202/0413 , A61M2205/12 , A61M2205/18 , A61M2205/3317 , A61M2205/3324 , A61M2205/3331 , A61M2205/3334 , A61M2205/3368 , A61M2205/502 , F04B45/0536 , G06F19/00 , G06F19/3481 , G16H40/63
摘要： Hemodialysis dialysis systems are disclosed. Hemodialysis systems of the invention may include a dialysate flow path including a balancing circuit, a mixing circuit, and/or a directing circuit. The circuits may be defined within one or more cassettes. The fluid circuits may be at least partially isolated, spatially and/or thermally, from electrical components of the system. A gas supply may be provided in fluid communication with the dialysate flow path and/or the dialyzer to urge dialysate through the dialyzer and blood back to the patient. The hemodialysis systems may include fluid handling devices, actuated using a control fluid, optionally delivered using a detachable pump. Fluid handling devices may be generally rigid and of a spheroid shape, optionally with a diaphragm dividing the device into compartments.
摘要翻译： 公开了血液透析透析系统。 本发明的血液透析系统可以包括透析液流路，其包括平衡电路，混合电路和/或定向电路。 电路可以被定义在一个或多个盒中。 流体回路可以与系统的电气部件至少部分隔离，空间和/或热。 可以提供气体供应，其与透析液流动路径和/或透析器流体连通，以促使透析液通过透析器和血液返回给患者。 血液透析系统可以包括使用控制流体致动的流体处理装置，可选择地使用可拆卸的泵输送。 流体处理装置通常可以是刚性的并且具有球形形状，任选地具有将装置分隔成隔室的隔膜。
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公开(公告)号：US20090095679A1
公开(公告)日：2009-04-16
申请号：US12199452
申请日：2008-08-27
CPC分类号： A61M1/1601 , A61M1/16 , A61M1/1613 , A61M1/1635 , A61M1/341 , A61M1/3434 , A61M1/3437 , A61M1/3441 , A61M1/3465 , A61M1/3609 , A61M1/3646 , A61M1/365 , A61M1/3652 , A61M2202/0413 , A61M2205/12 , A61M2205/18 , A61M2205/3317 , A61M2205/3324 , A61M2205/3331 , A61M2205/3334 , A61M2205/3368 , A61M2205/502 , F04B45/0536 , G06F19/00 , G06F19/3481 , G16H40/63
摘要： Hemodialysis dialysis systems are disclosed. Hemodialysis systems of the invention may include a dialysate flow path including a balancing circuit, a mixing circuit, and/or a directing circuit. The circuits may be defined within one or more cassettes. The fluid circuits may be at least partially isolated, spatially and/or thermally, from electrical components of the system. A gas supply may be provided in fluid communication with the dialysate flow path and/or the dialyzer to urge dialysate through the dialyzer and blood back to the patient. The hemodialysis systems may include fluid handling devices, actuated using a control fluid, optionally delivered using a detachable pump. Fluid handling devices may be generally rigid and of a spheroid shape, optionally with a diaphragm dividing the device into compartments.
摘要翻译： 公开了血液透析透析系统。 本发明的血液透析系统可以包括透析液流路，其包括平衡电路，混合电路和/或定向电路。 电路可以被定义在一个或多个盒中。 流体回路可以与系统的电气部件至少部分隔离，空间和/或热。 可以提供气体供应，其与透析液流动路径和/或透析器流体连通，以促使通过透析器的透析液和血液返回给患者。 血液透析系统可以包括使用控制流体致动的流体处理装置，可选择地使用可拆卸的泵输送。 流体处理装置通常可以是刚性的并且具有球形形状，任选地具有将装置分隔成隔室的隔膜。
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公开(公告)号：US08992189B2
公开(公告)日：2015-03-31
申请号：US13619343
申请日：2012-09-14
CPC分类号： F04B43/06 , A61M1/1006 , A61M1/1037 , A61M1/1062 , A61M1/16 , A61M1/1601 , A61M1/1639 , A61M2205/12 , A61M2205/3317 , A61M2205/3324 , A61M2205/3331 , A61M2205/3368 , F04B45/053 , Y10T137/0329 , Y10T137/2521 , Y10T137/2931 , Y10T137/7879 , Y10T137/85978 , Y10T137/86139
摘要： A cassette integrated system. The cassette integrated system includes a mixing cassette, a balancing cassette, a middle cassette fluidly connected to the mixing cassette and the balancing cassette and at least one pod. The mixing cassette is fluidly connected to the middle cassette by at least one fluid line and the middle cassette is fluidly connected to the balancing cassette by at least one fluid line. The at least one pod is connected to at least two of the cassettes wherein the pod is located in an area between the cassettes.
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公开(公告)号：US08425471B2
公开(公告)日：2013-04-23
申请号：US12199196
申请日：2008-08-27
申请人： Kevin L. Grant , Michael J. Wilt , Jason A. Demers
发明人： Kevin L. Grant , Michael J. Wilt , Jason A. Demers
IPC分类号： A61M5/00
CPC分类号： A61M1/1656 , A61M1/1668 , A61M2205/6045 , A61M2205/6081
摘要： A reagent supply arrangement for a hemodialysis system may include an E-prong connector having three parallel prongs with two outer prongs arranged in a common plane and a center prong arranged above the common plane, a first supply line for a first reagent connected in fluid communication with one of the outer prongs, a second supply line for a second reagent connected in fluid communication with the other of the outer prongs, a liquid line connected in fluid communication with the center prong, and a container for housing the first reagent having an inlet connected to the liquid line and an outlet connected to the first supply line for the first reagent. The E-prong connector may help prevent the improper connection to the dialysis unit, e.g., because the prong arrangement ensures connection in only one way to the dialysis unit.
摘要翻译： 用于血液透析系统的试剂供应装置可以包括具有三个平行插脚的E形插脚连接器，其中两个外部插脚布置在公共平面中，并且布置在公共平面上方的中心插脚，用于连接在流体连通中的第一试剂的第一供应管线 其中一个外部插脚，用于与另一个外部插脚流体连通的第二试剂的第二供应管线，与中心插脚流体连通的液体管线和用于容纳具有入口的第一试剂的容器 连接到液体管线和连接到用于第一试剂的第一供应管线的出口。 E-pin连接器可以有助于防止与透析单元的不正确连接，例如因为插脚布置确保仅以一种方式连接到透析单元。
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公开(公告)号：US20110299358A1
公开(公告)日：2011-12-08
申请号：US13156282
申请日：2011-06-08
IPC分类号： B01F15/02
CPC分类号： F04B53/10 , A61M1/1006 , A61M1/1037 , A61M1/106 , A61M1/1062 , A61M1/1087 , A61M1/1096 , A61M1/16 , A61M1/1605 , A61M1/1639 , A61M1/1656 , A61M1/1664 , A61M1/1666 , A61M1/287 , A61M2205/12 , A61M2205/128 , A61M2205/3317 , A61M2205/3324 , A61M2205/3368 , F04B7/02 , F04B9/109 , F04B13/02 , F04B23/06 , F04B41/06 , F04B43/00 , F04B43/02 , F04B43/06 , F04B43/073 , F04B43/0733 , F04B43/0736 , F04B45/02 , F04B45/0536 , F04B49/22 , F04B53/06 , F04B53/16 , F17D3/00 , Y10T137/0324 , Y10T137/0379 , Y10T137/2521 , Y10T137/85978 , Y10T137/86139
摘要： A cassette integrated system. The cassette integrated system includes a mixing cassette, a balancing cassette, a middle cassette fluidly connected to the mixing cassette and the balancing cassette and at least one pod. The mixing cassette is fluidly connected to the middle cassette by at least one fluid line and the middle cassette is fluidly connected to the balancing cassette by at least one fluid line. The at least one pod is connected to at least two of the cassettes wherein the pod is located in an area between the cassettes.
摘要翻译： 盒式集成系统。 盒式集成系统包括混合盒，平衡盒，流体连接到混合盒和平衡盒以及至少一个盒的中间盒。 混合盒通过至少一个流体管线流体地连接到中间盒，并且中间盒通过至少一个流体管线流体地连接到平衡盒。 至少一个容器连接到盒中的至少两个盒，其中盒位于盒之间的区域中。
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公开(公告)号：US08042563B2
公开(公告)日：2011-10-25
申请号：US12038648
申请日：2008-02-27
IPC分类号： G05D11/00
CPC分类号： F04B43/06 , A61M1/1006 , A61M1/1037 , A61M1/1062 , A61M1/16 , A61M1/1601 , A61M1/1639 , A61M2205/12 , A61M2205/3317 , A61M2205/3324 , A61M2205/3331 , A61M2205/3368 , F04B45/053 , Y10T137/0329 , Y10T137/2521 , Y10T137/2931 , Y10T137/7879 , Y10T137/85978 , Y10T137/86139
摘要： A cassette integrated system. The cassette integrated system includes a mixing cassette, a balancing cassette, a middle cassette fluidly connected to the mixing cassette and the balancing cassette and at least one pod. The mixing cassette is fluidly connected to the middle cassette by at least one fluid line and the middle cassette is fluidly connected to the balancing cassette by at least one fluid line. The at least one pod is connected to at least two of the cassettes wherein the pod is located in an area between the cassettes.
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