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公开(公告)号：US20090149445A1
公开(公告)日：2009-06-11
申请号：US12173059
申请日：2008-07-15
申请人： Michael Joseph Coghlan , Jonathan Edward Green , Timothy Alan Grese , Prabhakar Kondaji Jadhav , Donald Paul Matthews , Mitchell Irvin Steinberg , Kevin Robert Fales , Michael Gregory Bell
发明人： Michael Joseph Coghlan , Jonathan Edward Green , Timothy Alan Grese , Prabhakar Kondaji Jadhav , Donald Paul Matthews , Mitchell Irvin Steinberg , Kevin Robert Fales , Michael Gregory Bell
IPC分类号： A61K31/55 , A61K31/18 , A61K31/5375 , A61K31/035 , A61K31/4184 , A61K31/085 , A61K31/435
CPC分类号： C07D213/16 , C07C22/04 , C07C22/08 , C07C25/24 , C07C33/38 , C07C39/17 , C07C39/23 , C07C39/42 , C07C43/215 , C07C43/225 , C07C43/23 , C07C47/548 , C07C47/57 , C07C49/835 , C07C69/00 , C07C69/618 , C07C69/65 , C07C205/06 , C07C205/34 , C07C205/35 , C07C211/28 , C07C211/32 , C07C211/45 , C07C215/76 , C07C217/84 , C07C233/07 , C07C233/65 , C07C233/84 , C07C235/16 , C07C251/40 , C07C251/48 , C07C255/50 , C07C261/04 , C07C271/14 , C07C275/28 , C07C307/10 , C07C311/03 , C07C311/08 , C07C311/09 , C07C311/16 , C07C311/20 , C07C311/21 , C07C311/29 , C07C317/14 , C07C317/32 , C07C321/28 , C07C323/49 , C07C2601/02 , C07C2603/32 , C07C2603/40 , C07C2603/78 , C07C2603/86 , C07D209/08 , C07D209/34 , C07D211/96 , C07D213/06 , C07D213/73 , C07D213/76 , C07D213/81 , C07D221/16 , C07D223/20 , C07D231/12 , C07D231/18 , C07D233/26 , C07D233/68 , C07D233/84 , C07D235/26 , C07D241/12 , C07D241/20 , C07D261/08 , C07D261/10 , C07D263/52 , C07D263/56 , C07D263/58 , C07D277/60 , C07D295/088 , C07D295/26 , C07D313/12 , C07D333/78 , C07D333/80 , C07D337/12 , C07D401/06 , C07D405/06 , C07D409/04 , C07D471/04 , C07D471/06 , C07D487/04 , C07D491/044
摘要： The present invention relates to methods of treating pathological disorders susceptible to steroid hormone nuclear receptor modulation comprising administering to a patient in need thereof an effective amount of a compound of the formula: or a pharmaceutically acceptable salt thereof. In addition, the present invention provides novel pharmaceutical compounds of Formula I, including the pharmaceutically acceptable salts thereof, as well as pharmaceutical compositions which comprise as an active ingredient a compound of Formula I.
摘要翻译： 本发明涉及治疗对类固醇激素核受体调节敏感的病理学障碍的方法，其包括向有需要的患者施用有效量的下式化合物或其药学上可接受的盐。 此外，本发明提供了新颖的式I的药物化合物，包括其药学上可接受的盐，以及包含式I化合物作为活性成分的药物组合物。
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公开(公告)号：US07411072B2
公开(公告)日：2008-08-12
申请号：US10517010
申请日：2003-06-13
申请人： Michael Joseph Coghlan , Jonathan Edward Green , Timothy Alan Grese , Prabhakar Kondaji Jadhav , Donald Paul Matthews , Mitchell Irvin Steinberg , Kevin Robert Fales , Michael Gregory Bell
发明人： Michael Joseph Coghlan , Jonathan Edward Green , Timothy Alan Grese , Prabhakar Kondaji Jadhav , Donald Paul Matthews , Mitchell Irvin Steinberg , Kevin Robert Fales , Michael Gregory Bell
IPC分类号： A01N43/52 , C07D235/04
CPC分类号： C07D213/16 , C07C22/04 , C07C22/08 , C07C25/24 , C07C33/38 , C07C39/17 , C07C39/23 , C07C39/42 , C07C43/215 , C07C43/225 , C07C43/23 , C07C47/548 , C07C47/57 , C07C49/835 , C07C69/00 , C07C69/618 , C07C69/65 , C07C205/06 , C07C205/34 , C07C205/35 , C07C211/28 , C07C211/32 , C07C211/45 , C07C215/76 , C07C217/84 , C07C233/07 , C07C233/65 , C07C233/84 , C07C235/16 , C07C251/40 , C07C251/48 , C07C255/50 , C07C261/04 , C07C271/14 , C07C275/28 , C07C307/10 , C07C311/03 , C07C311/08 , C07C311/09 , C07C311/16 , C07C311/20 , C07C311/21 , C07C311/29 , C07C317/14 , C07C317/32 , C07C321/28 , C07C323/49 , C07C2601/02 , C07C2603/32 , C07C2603/40 , C07C2603/78 , C07C2603/86 , C07D209/08 , C07D209/34 , C07D211/96 , C07D213/06 , C07D213/73 , C07D213/76 , C07D213/81 , C07D221/16 , C07D223/20 , C07D231/12 , C07D231/18 , C07D233/26 , C07D233/68 , C07D233/84 , C07D235/26 , C07D241/12 , C07D241/20 , C07D261/08 , C07D261/10 , C07D263/52 , C07D263/56 , C07D263/58 , C07D277/60 , C07D295/088 , C07D295/26 , C07D313/12 , C07D333/78 , C07D333/80 , C07D337/12 , C07D401/06 , C07D405/06 , C07D409/04 , C07D471/04 , C07D471/06 , C07D487/04 , C07D491/044
摘要： The present invention relates to methods of treating pathological disorders susceptible to steroid hormone nuclear receptor modulation comprising administering to a patient in need thereof an effective amount of a compound of the formula: or a pharmaceutically acceptable salt thereof. In addition, the present invention provides novel pharmaceutical compounds of Formula I, including the pharmaceutically acceptable salts thereof, as well as pharmaceutical compositions which comprise as an active ingredient a compound of Formula I.
摘要翻译： 本发明涉及治疗对类固醇激素核受体调节敏感的病理学障碍的方法，其包括向有需要的患者施用有效量的下式化合物或其药学上可接受的盐。 此外，本发明提供了新颖的式I的药物化合物，包括其药学上可接受的盐，以及包含式I化合物作为活性成分的药物组合物。
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公开(公告)号：US6075040A
公开(公告)日：2000-06-13
申请号：US850562
申请日：1997-05-02
申请人： Michael Gregory Bell , Thomas Alan Crowell , Cynthia Darshini Jesudason , Donald Paul Matthews , John Hampton McDonald, III , David Andrew Neel , Christopher John Rito , Anthony John Shuker , Mark Alan Winter
发明人： Michael Gregory Bell , Thomas Alan Crowell , Cynthia Darshini Jesudason , Donald Paul Matthews , John Hampton McDonald, III , David Andrew Neel , Christopher John Rito , Anthony John Shuker , Mark Alan Winter
IPC分类号： A61K31/404 , A61K31/4192 , A61K31/4439 , C07D209/04 , C07D209/08 , C07D235/06 , C07D235/26 , C07D249/18 , C07D263/58 , C07D285/14 , C07D401/00 , C07D401/12 , C07D403/12 , C07D409/12 , C07D413/12 , C07D417/12 , A61K31/41 , A61K31/415 , C07D235/04 , C07D271/12
CPC分类号： C07D235/06 , A61K31/404 , A61K31/4192 , A61K31/4439 , C07D209/08 , C07D235/26 , C07D249/18 , C07D263/58 , C07D285/14 , C07D401/12 , C07D403/12 , C07D409/12 , C07D413/12 , C07D417/12
摘要： The present invention is in the field of medicine, particularly in the treatment of Type II diabetes and obesity. More specifically, the present invention relates to selective .beta.3 adrenergic receptor agonists useful in the treatment of Type II diabetes and obesity. The invention provides compounds and method of treating type II diabetes, comprising administering to a mammal in need thereof compounds of the Formulas I and II: ##STR1##
摘要翻译： 本发明在医药领域，特别是治疗II型糖尿病和肥胖症。 更具体地，本发明涉及可用于治疗II型糖尿病和肥胖症的选择性β3肾上腺素能受体激动剂。 本发明提供了治疗II型糖尿病的化合物和方法，包括向有需要的哺乳动物施用式I和II的化合物：
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公开(公告)号：US6060492A
公开(公告)日：2000-05-09
申请号：US882587
申请日：1997-06-25
申请人： Michael Gregory Bell , Thomas Alan Crowell , Donald Paul Matthews , John Hampton McDonald, III , David Andrew Neel , Anthony John Shuker , Mark Alan Winter
发明人： Michael Gregory Bell , Thomas Alan Crowell , Donald Paul Matthews , John Hampton McDonald, III , David Andrew Neel , Anthony John Shuker , Mark Alan Winter
IPC分类号： A61K31/00 , A61K31/40 , A61K31/403 , A61K31/404 , A61K31/41 , A61K31/415 , A61K31/4164 , A61K31/4184 , A61K31/4192 , A61K31/42 , A61K31/423 , A61K31/433 , A61K31/44 , A61K31/4427 , A61K31/4433 , A61K31/4439 , A61K31/496 , A61K31/50 , A61K31/501 , A61K31/53 , A61K31/535 , A61K31/5355 , A61K31/537 , A61K31/5375 , A61K31/5377 , A61P3/00 , A61P3/10 , A61P43/00 , C07C235/46 , C07C255/54 , C07D209/08 , C07D213/63 , C07D235/06 , C07D235/08 , C07D235/26 , C07D249/18 , C07D257/04 , C07D263/56 , C07D263/58 , C07D285/14 , C07D295/18 , C07D333/34 , C07D401/12 , C07D403/12 , C07D409/12 , C07D413/12 , C07D417/12
CPC分类号： C07D209/08 , A61K31/404 , A61K31/4192 , C07D235/06 , C07D235/26 , C07D249/18 , C07D263/58 , C07D285/14 , C07D401/12 , C07D403/12 , C07D409/12 , C07D413/12 , C07D417/12
摘要： The present invention is in the field of medicine, particularly in the treatment of Type II diabetes and obesity. More specifically, the present invention relates to selective .beta.3 adrenergic receptor agonists useful in the treatment of Type II diabetes and obesity. The invention provides compounds and method of treating type II diabetes, comprising administering to a mammal in need thereof compounds of the Formula II: ##STR1## The variables in Formula II are defined herein.
摘要翻译： 本发明在医药领域，特别是治疗II型糖尿病和肥胖症。 更具体地，本发明涉及可用于治疗II型糖尿病和肥胖症的选择性β3肾上腺素能受体激动剂。 本发明提供了治疗II型糖尿病的化合物和方法，包括向有需要的哺乳动物施用式II化合物：式II中的变量在本文中定义。
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公开(公告)号：US5939443A
公开(公告)日：1999-08-17
申请号：US882503
申请日：1997-06-25
申请人： Michael Gregory Bell , Thomas Alan Crowell , Christine Ann Droste , Donald Paul Matthews , John Hampton McDonald, III , Christopher John Rito , Anthony John Shuker , Mark Alan Winter
发明人： Michael Gregory Bell , Thomas Alan Crowell , Christine Ann Droste , Donald Paul Matthews , John Hampton McDonald, III , Christopher John Rito , Anthony John Shuker , Mark Alan Winter
IPC分类号： A61K31/00 , A61K31/40 , A61K31/403 , A61K31/404 , A61K31/41 , A61K31/415 , A61K31/4164 , A61K31/4184 , A61K31/4192 , A61K31/42 , A61K31/423 , A61K31/433 , A61K31/44 , A61K31/4427 , A61K31/4433 , A61K31/4439 , A61K31/496 , A61K31/50 , A61K31/501 , A61K31/53 , A61K31/535 , A61K31/5355 , A61K31/537 , A61K31/5375 , A61K31/5377 , A61P3/00 , A61P3/10 , A61P43/00 , C07C235/46 , C07C255/54 , C07D209/08 , C07D213/63 , C07D235/06 , C07D235/08 , C07D235/26 , C07D249/18 , C07D257/04 , C07D263/56 , C07D263/58 , C07D285/14 , C07D295/18 , C07D333/34 , C07D401/12 , C07D403/12 , C07D409/12 , C07D413/12 , C07D417/12
CPC分类号： C07D209/08 , A61K31/404 , A61K31/4192 , C07D235/06 , C07D235/26 , C07D249/18 , C07D263/58 , C07D285/14 , C07D401/12 , C07D403/12 , C07D409/12 , C07D413/12 , C07D417/12
摘要： The present invention is in the field of medicine, particularly in the treatment of Type II diabetes and obesity. More specifically, the present invention relates to selective .beta.3 adrenergic receptor agonists useful in the treatment of Type II diabetes and obesity. The invention provides compounds and method of treating type II diabetes, comprising administering to a mammal in need thereof compounds of the Formula II: ##STR1## The variables in Formula II are defined herein.
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公开(公告)号：US5786356A
公开(公告)日：1998-07-28
申请号：US882549
申请日：1997-06-25
申请人： Michael Gregory Bell , Thomas Alan Crowell , Donald Paul Matthews , John Hampton McDonald, III , David Andrew Neel , Anthony John Shuker , Mark Alan Winter
发明人： Michael Gregory Bell , Thomas Alan Crowell , Donald Paul Matthews , John Hampton McDonald, III , David Andrew Neel , Anthony John Shuker , Mark Alan Winter
IPC分类号： A61K31/00 , A61K31/40 , A61K31/403 , A61K31/404 , A61K31/41 , A61K31/415 , A61K31/4164 , A61K31/4184 , A61K31/4192 , A61K31/42 , A61K31/423 , A61K31/433 , A61K31/44 , A61K31/4427 , A61K31/4433 , A61K31/4439 , A61K31/496 , A61K31/50 , A61K31/501 , A61K31/53 , A61K31/535 , A61K31/5355 , A61K31/537 , A61K31/5375 , A61K31/5377 , A61P3/00 , A61P3/10 , A61P43/00 , C07C235/46 , C07C255/54 , C07D209/08 , C07D213/63 , C07D235/06 , C07D235/08 , C07D235/26 , C07D249/18 , C07D257/04 , C07D263/56 , C07D263/58 , C07D285/14 , C07D295/18 , C07D333/34 , C07D401/12 , C07D403/12 , C07D409/12 , C07D413/12 , C07D417/12 , A61K31/495
CPC分类号： C07D209/08 , A61K31/404 , A61K31/4192 , C07D235/06 , C07D235/26 , C07D249/18 , C07D263/58 , C07D285/14 , C07D401/12 , C07D403/12 , C07D409/12 , C07D413/12 , C07D417/12
摘要： The present invention is in the field of medicine, particularly in the treatment of Type II diabetes and obesity. More specifically, the present invention relates to selective .beta.3 adrenergic receptor agonists useful in the treatment of Type II diabetes and obesity. The invention provides compounds and method of treating type II diabetes, comprising administering to a mammal in need thereof compounds of the Formulas I and II: ##STR1##
摘要翻译： 本发明在医药领域，特别是治疗II型糖尿病和肥胖症。 更具体地，本发明涉及可用于治疗II型糖尿病和肥胖症的选择性β3肾上腺素能受体激动剂。 本发明提供了治疗II型糖尿病的化合物和方法，包括向有需要的哺乳动物施用式I和II的化合物：（I），（II）
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公开(公告)号：US06265581B1
公开(公告)日：2001-07-24
申请号：US09551184
申请日：2000-04-17
申请人： Michael Gregory Bell , Thomas Alan Crowell , Christine Ann Droste , Cynthia Darshini Jesudason , Donald Paul Matthews , John Hampton McDonald, III , David Andrew Neel , Christopher John Rito , Anthony John Shuker , Mark Alan Winter
发明人： Michael Gregory Bell , Thomas Alan Crowell , Christine Ann Droste , Cynthia Darshini Jesudason , Donald Paul Matthews , John Hampton McDonald, III , David Andrew Neel , Christopher John Rito , Anthony John Shuker , Mark Alan Winter
IPC分类号： C07D40100
CPC分类号： C07D235/06 , A61K31/404 , A61K31/4192 , A61K31/4439 , C07D209/08 , C07D235/26 , C07D249/18 , C07D263/58 , C07D285/14 , C07D401/12 , C07D403/12 , C07D409/12 , C07D413/12 , C07D417/12
摘要： The present invention is in the field of medicine, particularly in the treatment of Type II diabetes and obesity. More specifically, the present invention relates to selective &bgr;3 adrenergic receptor agonists useful in the treatment of Type II diabetes and obesity. The invention provides compounds and method of treating type II diabetes, comprising administering to a mammal in need thereof compounds of the Formulas I and II:
摘要翻译： 本发明在医药领域，特别是治疗II型糖尿病和肥胖症。 更具体地，本发明涉及可用于治疗II型糖尿病和肥胖症的选择性β3肾上腺素能受体激动剂。 本发明提供了治疗II型糖尿病的化合物和方法，包括向有需要的哺乳动物施用式I和II的化合物：
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公开(公告)号：US5840738A
公开(公告)日：1998-11-24
申请号：US882623
申请日：1997-06-25
申请人： Michael Gregory Bell , Thomas Alan Crowell , Christine Ann Droste , Cynthia Darshini Jesudason , Donald Paul Matthews , John Hampton McDonald, III , David Andrew Neel , Christopher John Rito , Anthony John Shuker , Mark Alan Winter
发明人： Michael Gregory Bell , Thomas Alan Crowell , Christine Ann Droste , Cynthia Darshini Jesudason , Donald Paul Matthews , John Hampton McDonald, III , David Andrew Neel , Christopher John Rito , Anthony John Shuker , Mark Alan Winter
IPC分类号： A61K31/404 , A61K31/4192 , A61K31/4439 , C07D209/04 , C07D209/08 , C07D235/06 , C07D235/26 , C07D249/18 , C07D263/58 , C07D285/14 , C07D401/00 , C07D401/12 , C07D403/12 , C07D409/12 , C07D413/12 , C07D417/12 , A61K31/415
CPC分类号： C07D235/06 , A61K31/404 , A61K31/4192 , A61K31/4439 , C07D209/08 , C07D235/26 , C07D249/18 , C07D263/58 , C07D285/14 , C07D401/12 , C07D403/12 , C07D409/12 , C07D413/12 , C07D417/12
摘要： The present invention is in the field of medicine, particularly in the treatment of Type II diabetes and obesity. More specifically, the present invention relates to selective .beta.3 adrenergic receptor agonists useful in the treatment of Type II diabetes and obesity. The invention provides compounds and method of treating type II diabetes, comprising administering to a mammal in need thereof compounds of the Formulas I and II: ##STR1##
摘要翻译： 本发明在医药领域，特别是治疗II型糖尿病和肥胖症。 更具体地，本发明涉及可用于治疗II型糖尿病和肥胖症的选择性β3肾上腺素能受体激动剂。 本发明提供了治疗II型糖尿病的化合物和方法，包括向有需要的哺乳动物施用式I和II的化合物：
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公开(公告)号：US6093735A
公开(公告)日：2000-07-25
申请号：US345976
申请日：1999-07-01
申请人： Michael Gregory Bell , Thomas Alan Crowell , Christine Ann Droste , Cynthia Darshini Jesudason , Donald Paul Matthews , John Hampton McDonald, III , David Andrew Neel , Christopher John Rito , Anthony John Shuker , Mark Alan Winter
发明人： Michael Gregory Bell , Thomas Alan Crowell , Christine Ann Droste , Cynthia Darshini Jesudason , Donald Paul Matthews , John Hampton McDonald, III , David Andrew Neel , Christopher John Rito , Anthony John Shuker , Mark Alan Winter
IPC分类号： A61K31/00 , A61K31/40 , A61K31/403 , A61K31/404 , A61K31/41 , A61K31/415 , A61K31/4164 , A61K31/4184 , A61K31/4192 , A61K31/42 , A61K31/423 , A61K31/433 , A61K31/44 , A61K31/4427 , A61K31/4433 , A61K31/4439 , A61K31/496 , A61K31/50 , A61K31/501 , A61K31/53 , A61K31/535 , A61K31/5355 , A61K31/537 , A61K31/5375 , A61K31/5377 , A61P3/00 , A61P3/10 , A61P43/00 , C07C235/46 , C07C255/54 , C07D209/08 , C07D213/63 , C07D235/06 , C07D235/08 , C07D235/26 , C07D249/18 , C07D257/04 , C07D263/56 , C07D263/58 , C07D285/14 , C07D295/18 , C07D333/34 , C07D401/12 , C07D403/12 , C07D409/12 , C07D413/12 , C07D417/12
CPC分类号： C07D209/08 , A61K31/404 , A61K31/4192 , C07D235/06 , C07D235/26 , C07D249/18 , C07D263/58 , C07D285/14 , C07D401/12 , C07D403/12 , C07D409/12 , C07D413/12 , C07D417/12
摘要： The present invention is in the field of medicine, particularly in the treatment of Type II diabetes and obesity. More specifically, the present invention relates to selective .beta.3 adrenergic receptor agonists useful in the treatment of Type II diabetes and obesity. The invention provides compounds and method of treating type II diabetes, comprising administering to a mammal in need thereof compounds of the Formulas I and II: ##STR1##
摘要翻译： 本发明在医药领域，特别是治疗II型糖尿病和肥胖症。 更具体地，本发明涉及可用于治疗II型糖尿病和肥胖症的选择性β3肾上腺素能受体激动剂。 本发明提供了治疗II型糖尿病的化合物和方法，包括向有需要的哺乳动物施用式I和II的化合物：
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公开(公告)号：US07846960B2
公开(公告)日：2010-12-07
申请号：US12296534
申请日：2007-05-22
申请人： Michael Gregory Bell , Robert Anthony Doti , Michael James Genin , Peter Ambrose Lander , Tianwei Ma , Peter Rudolph Manninen , Jason Matthew Ochoada , Fucheng Qu , Lindsay Scott Stelzer , Ryan Edward Stites , Alan M. Warshawsky
发明人： Michael Gregory Bell , Robert Anthony Doti , Michael James Genin , Peter Ambrose Lander , Tianwei Ma , Peter Rudolph Manninen , Jason Matthew Ochoada , Fucheng Qu , Lindsay Scott Stelzer , Ryan Edward Stites , Alan M. Warshawsky
IPC分类号： A61K31/415 , C07D231/10
CPC分类号： C07D231/12 , C07D231/56 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12
摘要： Compounds of formula wherein variables are as defined herein and their pharmaceutical compositions and methods of use are disclosed as useful for treating dyslipidemia and related diseases.
摘要翻译： 公开的其中变量如本文所定义的化合物及其药物组合物和使用方法被公开用于治疗血脂异常和相关疾病。
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