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26 条记录 (耗时 0.02 秒)

    5-(Pyrrol-2-oyl)-1,2-dihydro-3H-pyrrolo [1,2-a]pyrrole derivatives as anti-inflammatory and analgesic agents
    2.
    发明授权
    5-(Pyrrol-2-oyl)-1,2-dihydro-3H-pyrrolo [1,2-a]pyrrole derivatives as anti-inflammatory and analgesic agents 失效
    5-（吡咯-2-基）-1,2-二氢-3H-吡咯并[1,2-a]吡咯衍生物作为抗炎和止痛剂

    公开(公告)号：US4511724A

    公开(公告)日：1985-04-16

    申请号：US449302

    申请日：1982-12-13

    申请人： Michael N. Chang ,  Tesfaye Biftu

    发明人： Michael N. Chang ,  Tesfaye Biftu

    IPC分类号： C07D207/34 ,  C07D207/36 ,  C07D487/04 ,  C07H13/10 ,  C07D487/06 ,  A61K31/40

    CPC分类号： C07D487/04 ,  C07D207/34 ,  C07D207/36 ,  C07H13/10 ,  Y10S514/825

    摘要： Substituted 5-(pyrrol-2-oyl)1,2-dihydropyrrolo[1,2-a]-pyrrole derivatives have been prepared via decarboxylation of the corresponding 1,7-dicarboxylate prepared from condensation of a dialkyl 1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-1-7-dicarboxylate-7-carboxylic acid with an appropriately substituted 2-pyrroyl chloride, or conversely, an acid chloride of the former bicyclic compounds with a substituted pyrrole. The compounds are analgesic and anti-inflammatory agents of high activities but low ulcerogenic side effects.

    摘要翻译： 已经通过将1,2-二氢 - 吡咯并[1,2-a]吡咯衍生物的缩合制备的相应的1,7-二羧酸酯脱羧制备取代的5-（吡咯-2-基） 3H-吡咯并[1,2-a]吡咯-1,7-二羧酸酯-7-羧酸与适当取代的2-吡咯酰氯反应，前者的双环化合物与取代的吡咯的酰氯。 该化合物是具有高活性但低溃疡性副作用的止痛和抗炎药。

    Substituted 2,3,3a,6-tetrahydro-6-oxobenzofuran derivative useful as PAF antagonist
    8.
    发明授权
    Substituted 2,3,3a,6-tetrahydro-6-oxobenzofuran derivative useful as PAF antagonist 失效
    取代的2,3,3a，6-四氢-6-氧代苯并呋喃衍生物可用作PAF拮抗剂

    公开(公告)号：US4704462A

    公开(公告)日：1987-11-03

    申请号：US768009

    申请日：1985-08-22

    申请人： Michael N. Chang ,  San-Bao Hwang ,  Mitree M. Ponpipom ,  Robert L. Bugianesi

    发明人： Michael N. Chang ,  San-Bao Hwang ,  Mitree M. Ponpipom ,  Robert L. Bugianesi

    IPC分类号： C07D307/83

    CPC分类号： C07D307/83

    摘要： Substituted 2,3,3a,6-tetrahydro-6-oxobenzofuran derivatives have been prepared. These neolignans are found to have potent and specific PAF (Platelet-Activating-Factor) antagonistic activities and thereby useful in the treatment of various diseases or disorders mediated by PAF, for example, pain, fever, inflammation, cardiovascular disorder, asthma, lung edema, allergic disorders, skin diseases, psoriasis, toxic shock syndrome and adult respiratory distress syndrome.

    摘要翻译： 已经制备了取代的2,3,3a，6-四氢-6-氧代苯并呋喃衍生物。 发现这些新西兰人具有强效和特异性的PAF（血小板活化因子）拮抗活性，从而可用于治疗PAF介导的各种疾病或病症，例如疼痛，发烧，炎症，心血管疾病，哮喘，肺水肿 过敏性疾病，皮肤疾病，牛皮癣，中毒性休克综合症和成人呼吸窘迫综合征。

    Tea catechins in sustained release formulations as cancer specific proliferation inhibitors
    10.
    发明授权
    Tea catechins in sustained release formulations as cancer specific proliferation inhibitors 有权
    持久释放制剂中的茶儿茶素作为癌症特异性增殖抑制剂

    公开(公告)号：US06410052B1

    公开(公告)日：2002-06-25

    申请号：US09637840

    申请日：2000-08-10

    申请人： Dorothy M. Morré ,  D. James Morré ,  Raymond Cooper ,  Michael N. Chang

    发明人： Dorothy M. Morré ,  D. James Morré ,  Raymond Cooper ,  Michael N. Chang

    IPC分类号： A61K922

    CPC分类号： A61K36/82 ,  A23L33/105 ,  A61K9/2081 ,  A61K9/5047 ,  A61K31/35 ,  A61K31/353 ,  A61K45/06 ,  A61K2300/00

    摘要： The invention described herein encompasses a methods and compositions of treating cancer or solid tumors comprising the administration of a therapeutically effective amount of catechins, a group of polyphenols found in green tea, to a mammal in need of such therapy. Compositions of catechins include but not limited to, epigallocatechin gallate (EGCg), epicatechin (EC), epicatechin gallate (ECG), epigallocatechin (EGC). The unique compositions of the invention contain various combinations of the catechins, alone or in combination with each other or other therapeutic agents and are used to treat primary and metastatic cancers in humans. The invention also encompasses the varying modes of administration of the therapeutic compounds, including a sustained release formulation which may be used as a therapeutic compound for the treatment of cancer or as a dietary supplement for the prevention of cancer.

    摘要翻译： 本文描述的发明包括治疗癌症或实体肿瘤的方法和组合物，包括向需要这种治疗的哺乳动物施用治疗有效量的儿茶素（一组在绿茶中发现的多酚）。 儿茶素的组合物包括但不限于表没食子儿茶素没食子酸酯（EGCg），表儿茶素（EC），表儿茶素没食子酸酯（ECG），表没食子儿茶素（EGC））。 本发明的独特组合包含儿茶素的单独或彼此组合或其它治疗剂的各种组合，并且用于治疗人类的原发性和转移性癌症。 本发明还包括治疗化合物的不同给药方式，包括可用作治疗癌症的治疗化合物或作为预防癌症的膳食补充剂的持续释放制剂。