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22 条记录 (耗时 0.031 秒)

    Targeting and tracking of cells to specific organs and tissues in vivo
    4.
    发明申请
    Targeting and tracking of cells to specific organs and tissues in vivo 审中-公开
    靶向和跟踪体内特定器官和组织的细胞

    公开(公告)号：US20060034767A1

    公开(公告)日：2006-02-16

    申请号：US10520431

    申请日：2003-07-03

    申请人： Lawrence Lum ,  Randall Lee ,  Nicola Kouttab

    发明人： Lawrence Lum ,  Randall Lee ,  Nicola Kouttab

    IPC分类号： A61K49/00 ,  A61K39/395

    CPC分类号： G01N33/5005 ,  A61K49/0097 ,  A61K2035/124 ,  C07K16/2803 ,  C07K16/2809 ,  C07K16/2836 ,  C07K16/32 ,  C07K2317/31 ,  G01N33/505 ,  G01N33/5091 ,  G01N33/564 ,  G01N33/566 ,  G01N33/574

    摘要： The present invention provides a method for tracking and targeting cells in viva. In particular, cells are isolated purified and armed with bispecific antibodies which are directly labeled with a detectable marker, or a second antibody specific for a region of the bispecific antibody is labeled with a detectable marker. The bispecific antibody is specific for a surface antigen of the cell and the second specificity of the specific antigen is for an antigen expressed on cells of tissues, organs or tumors. The armed and labeled cells can be tracked starting from the point of introduction into the animal until the cell reaches the target of interest by phenotyping cells from patient samples, obtained at different time intervals and locations, post-infusion. The isolated and purified cells are useful in any functional assay.

    摘要翻译： 本发明提供了一种用于跟踪和靶向细胞的方法。 特别地，分离纯化细胞并用双特异性抗体装载，所述双特异性抗体用可检测标记物直接标记，或者用双重特异性抗体区域特异性的第二抗体用可检测标记物标记。 双特异性抗体对细胞的表面抗原是特异性的，特异性抗原的第二特异性是针对在组织，器官或肿瘤细胞上表达的抗原。 可以从引入到动物的角度开始追踪和标记的细胞，直到细胞通过表达来自患者样品的细胞达到感兴趣的目标，在不同的时间间隔和位置获得，在输注后。 分离和纯化的细胞可用于任何功能测定。

    System and method for forming a non-ablative cardiac conduction block
    6.
    发明申请
    System and method for forming a non-ablative cardiac conduction block 审中-公开
    用于形成非烧蚀性心脏传导阻滞的系统和方法

    公开(公告)号：US20050233444A1

    公开(公告)日：2005-10-20

    申请号：US11142180

    申请日：2005-05-31

    申请人： Randall Lee

    发明人： Randall Lee

    IPC分类号： A61M31/00 ,  C12N5/06

    CPC分类号： A61M25/0026 ,  A61B5/042 ,  A61B5/6852 ,  A61B17/00491 ,  A61B2017/00044 ,  A61B2017/00243 ,  A61B2017/00323 ,  A61B2017/00495 ,  A61M25/0084 ,  A61M25/0147 ,  A61M2025/0085 ,  A61M2025/0089 ,  A61M2025/105 ,  A61M2025/1086

    摘要： A system forms a cardiac conduction block at a location in a heart of a patient without substantially ablating cardiac tissue. The system includes a delivery system coupled to a source of material that is substantially non-ablative with respect to cardiac tissue. The delivery system delivers the material to the location, and the material at the location forms a conduction block without ablating the cardiac cells there. The material may include living cells, such as for example skeletal myocytes, and/or may include a non-living matter such as biopolymers such as a fibrin glue agent, or collagen agents. An expandable member with needle assembly is used to deliver the material so as to form a non-ablative circumferential conduction block at a location where a pulmonary vein extends from an atrium.

    摘要翻译： 系统在患者的心脏中的位置处形成心脏传导阻滞，而基本上不消融心脏组织。 该系统包括耦合到相对于心脏组织基本上不消融的材料源的递送系统。 递送系统将材料递送到位置，并且位置处的材料形成传导阻滞，而不会在其处消融心脏细胞。 该材料可以包括活细胞，例如骨骼肌细胞，和/或可以包括诸如生物聚合物如纤维蛋白胶剂或胶原剂的非生物物质。 使用具有针组件的可扩张构件来输送材料，以便在肺静脉从心房延伸的位置处形成非烧蚀性周缘传导阻滞。

    System and method for forming a non-ablative cardiac conduction block
    8.
    发明申请
    System and method for forming a non-ablative cardiac conduction block 审中-公开
    用于形成非烧蚀性心脏传导阻滞的系统和方法

    公开(公告)号：US20060083717A1

    公开(公告)日：2006-04-20

    申请号：US11236416

    申请日：2005-09-26

    申请人： Randall Lee ,  Mark MaCiejewski

    发明人： Randall Lee ,  Mark MaCiejewski

    IPC分类号： A61K48/00 ,  A61K38/17 ,  A61K9/14

    CPC分类号： A61B17/3478 ,  A61B17/00491 ,  A61B2017/00247 ,  A61B2017/22061 ,  A61B2018/00392 ,  A61K35/12 ,  C12N5/0656 ,  C12N5/0658

    摘要： A system forms a cardiac conduction block at a location in a heart of a patient, generally without substantially ablating cardiac tissue. The system includes a delivery system coupled to a source of material that is substantially non-ablative with respect to cardiac tissue but that substantially interrupts and thus blocks cardiac conduction. The delivery system delivers the material to the location, and the material at the location forms a conduction block without substantially ablating the cardiac cells there. The material includes a synthetic polymer, a polysaccharide (e.g. block polysaccharide, alginate, etc.), or a protein, or an analog, derivative, precursor, or agent thereof, or a combination or blend thereof. The material may include living cells. The delivery assembly may include a needle for injecting the material. An expandable member is provided with a needle assembly to deliver the material and form a non-ablative circumferential conduction block where a pulmonary vein extends from an atrium.

    摘要翻译： 系统在患者的心脏中的位置处形成心脏传导阻滞，通常基本上不消融心脏组织。 该系统包括耦合到相对于心脏组织基本上不消融的材料源的递送系统，但基本上中断并因此阻止心脏传导。 递送系统将材料递送到位置，并且位置处的材料形成传导阻滞，而基本上不消融那里的心脏细胞。 该材料包括合成聚合物，多糖（例如嵌段多糖，藻酸盐等）或蛋白质，或其类似物，衍生物，前体或试剂，或其组合或共混物。 该材料可以包括活细胞。 输送组件可以包括用于注射材料的针。 可扩张构件设置有针组件以递送材料并形成非烧蚀性周缘传导阻滞，其中肺静脉从心房延伸。

    Directed growth of nanotubes on a catalyst
    10.
    发明授权
    Directed growth of nanotubes on a catalyst 有权
    纳米管在催化剂上的定向生长

    公开(公告)号：US07258901B1

    公开(公告)日：2007-08-21

    申请号：US11387561

    申请日：2006-03-23

    申请人： Randall Lee ,  Thomas Owen Mitchell ,  Johannes Jacobus Lambertus Mulders

    发明人： Randall Lee ,  Thomas Owen Mitchell ,  Johannes Jacobus Lambertus Mulders

    IPC分类号： C23C14/14 ,  C23C14/30 ,  B05D3/00 ,  G01B5/28

    CPC分类号： G01Q70/12 ,  G01Q60/38

    摘要： A nanostructure is fabricated using charged particle deposition to deposit a catalyst on a substrate. A charged particle beam is directed to location on the substrate where the catalyst is to be deposited, with a beam-activated precursor gas also being directed to the location. For example, a nickel dot can be selectively deposited onto a substrate by using a charged particle beam to decompose a nickel-containing precursor gas, and then a carbon nanotube can be grown on the nickel dot, with the diameter of the nanotube conforming to the size of the nickel dot.

    摘要翻译： 使用带电粒子沉积法在基底上沉积催化剂制造纳米结构。 带电的粒子束被引导到衬底上要沉积催化剂的位置，而束激活的前体气体也被引导到该位置。 例如，可以通过使用带电粒子束将镍点选择性地沉积在基底上以分解含镍前体气体，然后可以在镍点上生长碳纳米管，纳米管的直径符合 镍点的大小。