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公开(公告)号：US20080287419A1
公开(公告)日：2008-11-20
申请号：US12120914
申请日：2008-05-15
申请人： Milan Bruncko , Hong Ding , Steven W. Elmore , Aaron R. Kunzer , Christopher L. Lynch , William J. McClellan , Cheol Min Park , Xiahong Song , Xilu Wang
发明人： Milan Bruncko , Hong Ding , Steven W. Elmore , Aaron R. Kunzer , Christopher L. Lynch , William J. McClellan , Cheol Min Park , Xiahong Song , Xilu Wang
IPC分类号： A61K31/553 , C07D413/02 , A61K31/5377 , C07D223/02 , A61K31/496 , A61P35/00 , C07D295/00 , A61K31/55 , C07D267/02
CPC分类号： C07D295/155 , C07D487/08 , C07D491/08
摘要： Compounds which inhibit the activity of anti-apoptotic family protein members, compositions containing the compounds and methods of treating diseases during which occur expression one or more than one of an anti-apoptotic family protein member are disclosed.
摘要翻译： 公开了抑制抗凋亡家族蛋白成员的活性的化合物，含有该化合物的组合物和治疗疾病的方法，其中表达一种或多种抗凋亡家族蛋白质成员。
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公开(公告)号：US20100249133A1
公开(公告)日：2010-09-30
申请号：US12772951
申请日：2010-05-03
申请人： Milan Bruncko , Hong Ding , Steven W. Elmore , Aaron R. Kunzer , Christopher L. Lynch , William J. McClellan , Cheol Min Park , Xiahong Song , Xilu Wang
发明人： Milan Bruncko , Hong Ding , Steven W. Elmore , Aaron R. Kunzer , Christopher L. Lynch , William J. McClellan , Cheol Min Park , Xiahong Song , Xilu Wang
IPC分类号： A61K31/496 , A61K31/4965 , A61K31/5377
CPC分类号： C07D295/155 , C07D487/08 , C07D491/08
摘要： Compounds which inhibit the activity of anti-apoptotic family protein members, compositions containing the compounds and methods of treating diseases during which occur expression one or more than one of an anti-apoptotic family protein member are disclosed.
摘要翻译： 公开了抑制抗凋亡家族蛋白成员的活性的化合物，含有该化合物的组合物和治疗疾病的方法，其中表达一种或多种抗凋亡家族蛋白质成员。
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公开(公告)号：US07906505B2
公开(公告)日：2011-03-15
申请号：US12772951
申请日：2010-05-03
申请人： Milan Bruncko , Hong Ding , Steven W. Elmore , Aaron R. Kunzer , Christopher L. Lynch , William J. McClellan , Cheol Min Park , Xiahong Song , Xilu Wang
发明人： Milan Bruncko , Hong Ding , Steven W. Elmore , Aaron R. Kunzer , Christopher L. Lynch , William J. McClellan , Cheol Min Park , Xiahong Song , Xilu Wang
IPC分类号： C07D413/02 , C07D403/02 , A61K31/553 , A61K31/55 , A61K31/5377
CPC分类号： C07D295/155 , C07D487/08 , C07D491/08
摘要： Compounds which inhibit the activity of anti-apoptotic family protein members, compositions containing the compounds and methods of treating diseases during which occur expression one or more than one of an anti-apoptotic family protein member are disclosed.
摘要翻译： 公开了抑制抗凋亡家族蛋白成员的活性的化合物，含有该化合物的组合物和治疗疾病的方法，其中表达一种或多种抗凋亡家族蛋白质成员。
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公开(公告)号：US07709467B2
公开(公告)日：2010-05-04
申请号：US12120914
申请日：2008-05-15
申请人： Milan Bruncko , Hong Ding , Steven W. Elmore , Aaron R. Kunzer , Christopher L. Lynch , William J. McClellan , Cheol Min Park , Xiahong Song , Xilu Wang
发明人： Milan Bruncko , Hong Ding , Steven W. Elmore , Aaron R. Kunzer , Christopher L. Lynch , William J. McClellan , Cheol Min Park , Xiahong Song , Xilu Wang
IPC分类号： C07D241/04 , A61K31/496
CPC分类号： C07D295/155 , C07D487/08 , C07D491/08
摘要： Compounds which inhibit the activity of anti-apoptotic family protein members, compositions containing the compounds and methods of treating diseases during which occur expression one or more than one of an anti-apoptotic family protein member are disclosed.
摘要翻译： 公开了抑制抗凋亡家族蛋白成员的活性的化合物，含有该化合物的组合物和治疗疾病的方法，其中表达一种或多种抗凋亡家族蛋白质成员。
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公开(公告)号：US07390799B2
公开(公告)日：2008-06-24
申请号：US11432937
申请日：2006-05-12
申请人： Milan Bruncko , Hong Ding , Steven W. Elmore , Aaron R. Kunzer , Christopher L. Lynch , William J. McClellan , Cheol Min Park , Xiahong Song , Xilu Wang
发明人： Milan Bruncko , Hong Ding , Steven W. Elmore , Aaron R. Kunzer , Christopher L. Lynch , William J. McClellan , Cheol Min Park , Xiahong Song , Xilu Wang
IPC分类号： C07D413/02 , C07D403/02 , A61K31/553 , A61K31/55 , A61K31/5377 , A61K31/496
CPC分类号： C07D295/155 , C07D487/08 , C07D491/08
摘要： Compounds which inhibit the activity of anti-apoptotic family protein members, compositions containing the compounds and methods of treating diseases during which occur expression one or more than one of an anti-apoptotic family protein member are disclosed.
摘要翻译： 公开了抑制抗凋亡家族蛋白成员的活性的化合物，含有该化合物的组合物和治疗疾病的方法，其中表达一种或多种抗凋亡家族蛋白质成员。
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6.发明授权公开(公告)号：US08586754B2
公开(公告)日：2013-11-19
申请号：US12793418
申请日：2010-06-03
申请人： Milan Bruncko , Hong Ding , George A. Doherty , Steven W. Elmore , Lisa Hasvold , Laura Hexamer , Aaron R. Kunzer , Robert A. Mantei , William J. McClellan , Chang H. Park , Cheol-Min Park , Andrew M. Petros , Xiaohong Song , Andrew J. Souers , Gerard M. Sullivan , Zhi-Fu Tao , Gary T. Wang , Le Wang , Xilu Wang , Michael D. Wendt , Todd M. Hansen
发明人： Milan Bruncko , Hong Ding , George A. Doherty , Steven W. Elmore , Lisa Hasvold , Laura Hexamer , Aaron R. Kunzer , Robert A. Mantei , William J. McClellan , Chang H. Park , Cheol-Min Park , Andrew M. Petros , Xiaohong Song , Andrew J. Souers , Gerard M. Sullivan , Zhi-Fu Tao , Gary T. Wang , Le Wang , Xilu Wang , Michael D. Wendt , Todd M. Hansen
IPC分类号： C07D209/32 , C07D401/10
CPC分类号： C07D215/14 , A61K31/496 , A61K31/5377 , A61K45/06 , C07D209/20 , C07D209/32 , C07D211/96 , C07D213/64 , C07D215/20 , C07D217/16 , C07D231/56 , C07D235/26 , C07D249/04 , C07D295/125 , C07D295/13 , C07D295/14 , C07D295/155 , C07D309/08 , C07D309/14 , C07D309/32 , C07D401/12 , C07D405/12 , C07D417/12 , C07D487/04
摘要： Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-2 or Bcl-xL proteins, compositions containing the compounds and methods of treating diseases during which are expressed anti-apoptotic Bcl-2 protein.
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7.发明申请APOPTOSIS-INDUCING AGENTS FOR THE TREATMENT OF CANCER AND IMMUNE AND AUTOIMMUNE DISEASES 有权用于治疗癌症和免疫和自发性疾病的病毒诱导剂公开(公告)号：US20100298323A1
公开(公告)日：2010-11-25
申请号：US12793413
申请日：2010-06-03
申请人： Milan Bruncko , Yujia Dai , Hong Ding , George A. Doherty , Steven W. Elmore , Lisa Hasvold , Laura Hexamer , Aaron R. Kunzer , Robert A. Mantei , William J. McClellan , Chang H. Park , Cheol-Min Park , Andrew M. Petros , Xiaohong Song , Andrew J. Souers , Gerard M. Sullivan , Zhi-Fu Tao , Gary T. Wang , Le Wang , Xilu Wang , Michael D. Wendt , Todd M. Hansen
发明人： Milan Bruncko , Yujia Dai , Hong Ding , George A. Doherty , Steven W. Elmore , Lisa Hasvold , Laura Hexamer , Aaron R. Kunzer , Robert A. Mantei , William J. McClellan , Chang H. Park , Cheol-Min Park , Andrew M. Petros , Xiaohong Song , Andrew J. Souers , Gerard M. Sullivan , Zhi-Fu Tao , Gary T. Wang , Le Wang , Xilu Wang , Michael D. Wendt , Todd M. Hansen
IPC分类号： A61K31/496 , C07D405/12 , C07D405/14 , C07D413/14 , C07D413/12 , C07D295/155 , C07D403/14 , C07D401/12 , C07D417/14 , A61K31/5377 , A61K31/495 , A61P35/00 , A61P35/02
CPC分类号： C07D213/76 , A61K31/495 , A61K31/496 , A61K31/5377 , A61K45/06 , C07D209/08 , C07D211/06 , C07D211/58 , C07D213/74 , C07D213/84 , C07D231/56 , C07D235/06 , C07D277/24 , C07D295/14 , C07D295/30 , C07D309/04 , C07D309/32 , C07D401/14 , C07D403/12 , C07D405/12 , C07D405/14 , C07D413/12 , C07D417/12 , C07D471/04
摘要： Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-2 proteins, compositions containing the compounds and methods of treating diseases during which is expressed anti-apoptotic Bcl-2 protein.
摘要翻译： 公开了抑制抗凋亡Bcl-2蛋白活性的化合物，含有化合物的组合物和治疗疾病的方法，其中表达抗凋亡Bcl-2蛋白。
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8.发明申请公开(公告)号：US20100298321A1
公开(公告)日：2010-11-25
申请号：US12793418
申请日：2010-06-03
申请人： Milan Bruncko , Hong Ding , George A. Doherty , Steven W. Elmore , Lisa Hasvold , Laura Hexamer , Aaron R. Kunzer , Robert A. Mantei , William J. McClellan , Chang H. Park , Cheol-Min Park , Andrew M. Petros , Xiaohong Song , Andrew J. Souers , Gerard M. Sullivan , Zhi-Fu Tao , Gary T. Wang , Le Wang , Xilu Wang , Michael D. Wendt , Todd M. Hansen
发明人： Milan Bruncko , Hong Ding , George A. Doherty , Steven W. Elmore , Lisa Hasvold , Laura Hexamer , Aaron R. Kunzer , Robert A. Mantei , William J. McClellan , Chang H. Park , Cheol-Min Park , Andrew M. Petros , Xiaohong Song , Andrew J. Souers , Gerard M. Sullivan , Zhi-Fu Tao , Gary T. Wang , Le Wang , Xilu Wang , Michael D. Wendt , Todd M. Hansen
IPC分类号： A61K31/5377 , A61P35/04 , A61K31/497 , A61K31/4439 , A61K31/415 , A61K31/405 , A61K31/18 , C07D413/02 , C07D413/12 , C07D413/14 , C07D401/12 , C07D235/04 , C07D209/04 , C07C311/00 , A61P35/00
CPC分类号： C07D215/14 , A61K31/496 , A61K31/5377 , A61K45/06 , C07D209/20 , C07D209/32 , C07D211/96 , C07D213/64 , C07D215/20 , C07D217/16 , C07D231/56 , C07D235/26 , C07D249/04 , C07D295/125 , C07D295/13 , C07D295/14 , C07D295/155 , C07D309/08 , C07D309/14 , C07D309/32 , C07D401/12 , C07D405/12 , C07D417/12 , C07D487/04
摘要： Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-2 or Bcl-xL proteins, compositions containing the compounds and methods of treating diseases during which are expressed anti-apoptotic Bcl-2 protein.
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公开(公告)号：US08084607B2
公开(公告)日：2011-12-27
申请号：US12390945
申请日：2009-02-23
申请人： Milan Bruncko , Hong Ding , Steven Elmore , Aaron R. Kunzer , Christopher L. Lynch , William J. McClellan , Cheol-min Park , Andrew M. Petros , Xiaohong Song , Noah P. Tu , Xilu Wang , Michael D. Wendt
发明人： Milan Bruncko , Hong Ding , Steven Elmore , Aaron R. Kunzer , Christopher L. Lynch , William J. McClellan , Cheol-min Park , Andrew M. Petros , Xiaohong Song , Noah P. Tu , Xilu Wang , Michael D. Wendt
IPC分类号： C07D241/04 , C07D295/00
CPC分类号： C07D277/74 , C04B35/632 , C07C323/25 , C07C2601/16 , C07D205/04 , C07D207/16 , C07D211/46 , C07D211/60 , C07D211/74 , C07D213/70 , C07D213/75 , C07D233/06 , C07D233/84 , C07D239/06 , C07D263/58 , C07D277/36 , C07D295/13 , C07D295/192 , C07D307/64 , C07D335/02 , C07D401/12 , C07D403/04 , C07D409/12 , C07D487/04 , C07D487/08
摘要： Disclosed are compounds which inhibit the activity of anti-apoptotic protein family members, compositions containing the compounds and uses of the compounds for preparing medicaments for treating diseases during which occurs expression one or more than one of an anti-apoptotic protein family member.
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10.发明申请公开(公告)号：US20100160322A1
公开(公告)日：2010-06-24
申请号：US12631367
申请日：2009-12-04
申请人： Milan Bruncko , Yujia Dai , Hong Ding , George A. Doherty , Steven W. Elmore , Lisa Hasvold , Laura Hexamer , Aaron Kunzer , Robert A. Mantei , William J. McClellan , Chang H. Park , Cheol-Min Park , Andrew M. Petros , Xiaohong Song , Andrew J. Souers , Gerard M. Sullivan , Zhi-Fu Tao , Gary T. Wang , Le Wang , Xilu Wang , Michael D. Wendt
发明人： Milan Bruncko , Yujia Dai , Hong Ding , George A. Doherty , Steven W. Elmore , Lisa Hasvold , Laura Hexamer , Aaron Kunzer , Robert A. Mantei , William J. McClellan , Chang H. Park , Cheol-Min Park , Andrew M. Petros , Xiaohong Song , Andrew J. Souers , Gerard M. Sullivan , Zhi-Fu Tao , Gary T. Wang , Le Wang , Xilu Wang , Michael D. Wendt
IPC分类号： A61K31/5377 , C07D405/02 , A61K31/496 , C07D403/02 , C07D401/02 , C07D413/02 , A61P35/00
CPC分类号： C07D209/08 , A61K31/635 , C07D211/58 , C07D213/74 , C07D213/84 , C07D231/56 , C07D235/06 , C07D277/24 , C07D295/30 , C07D309/04 , C07D309/08 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D405/14 , C07D413/12 , C07D417/12 , C07D471/04 , Y02A50/401 , Y02A50/409 , Y02A50/411
摘要： Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-2 proteins, compositions containing the compounds and methods of treating diseases during which is expressed anti-apoptotic Bcl-2 protein.
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