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    HETEROCYCLIC COMPOUNDS AND THEIR USES
    1.
    发明申请
    HETEROCYCLIC COMPOUNDS AND THEIR USES 审中-公开
    杂环化合物及其用途

    公开(公告)号：US20130085131A1

    公开(公告)日：2013-04-04

    申请号：US13702368

    申请日：2011-06-30

    申请人： Minna Bui ,  Benjamin Fisher ,  Xiaolin Hao ,  Brian Lucas

    发明人： Minna Bui ,  Benjamin Fisher ,  Xiaolin Hao ,  Brian Lucas

    IPC分类号： C07D413/14 ,  C07D401/14 ,  C07D401/12

    CPC分类号： C07D413/14 ,  C07D401/12 ,  C07D401/14 ,  C07D405/14

    摘要： Substituted bicyclic heteroaryls and compositions containing them, for the treatment of general inflammation, arthritis, rheumatic diseases, osteoarthritis, inflammatory bowel disorders, inflammatory eye disorders, inflammatory or unstable bladder disorders, psoriasis, skin complaints with inflammatory components, chronic inflammatory conditions, including but not restricted to autoimmune diseases such as systemic lupus erythematosis (SLE), myestenia gravis, rheumatoid arthritis, acute disseminated encephalomyelitis, idiopathic thrombocytopenic purpura, multiples sclerosis, Sjoegren's syndrome and autoimmune hemolytic anemia, allergic conditions including all forms of hypersensitivity, The present invention also enables methods for treating cancers that are mediated, dependent on or associated with pi 110δ activity, including but not restricted to leukemias, such as Acute Myeloid leukaemia (AML) Myelo-dysplastic syndrome (MDS) myelo-proliferative diseases (MPD) Chronic Myeloid Leukemia (CML) T-cell Acute Lymphoblastic leukaemia (T-ALL) B-cell Acute Lymphoblastic leukaemia (B-ALL) Non Hodgkins Lymphoma (NHL) B-cell lymphoma and solid tumors, such as breast cancer.

    摘要翻译： 取代的双环杂芳基和含有它们的组合物，用于治疗一般炎症，关节炎，风湿性疾病，骨关节炎，炎性肠病，炎症性眼病，炎症性或不稳定性膀胱病，牛皮癣，皮肤炎症成分的投诉，慢性炎性病症 不限于自身免疫性疾病如系统性红斑狼疮（SLE），重症肌无力，类风湿性关节炎，急性播散性脑脊髓炎，特发性血小板减少性紫癜，多发性硬化症，Sjoegren综合征和自身免疫性溶血性贫血，包括所有形式的超敏反应的过敏症状 包括但不限于白血病，如急性骨髓性白血病（AML）Myelo-dysplastic综合征（MDS）骨髓增生性疾病（MPD）慢性骨髓性白血病 （CML）T细胞急性淋巴细胞白血病（T-ALL）B细胞急性淋巴细胞白血病（B-ALL）非霍奇金淋巴瘤（NHL）B细胞淋巴瘤和实体瘤如乳腺癌。

    HETEROCYCLIC COMPOUNDS AND THEIR USES
    2.
    发明申请
    HETEROCYCLIC COMPOUNDS AND THEIR USES 审中-公开
    杂环化合物及其用途

    公开(公告)号：US20130267526A1

    公开(公告)日：2013-10-10

    申请号：US13994332

    申请日：2011-12-16

    申请人： Yi Chen ,  Timothy David Cushing ,  Benjamin Fisher ,  Felix Gonzalez Lopez De Turiso ,  Xiaolin Hao ,  Youngsook Shin

    发明人： Yi Chen ,  Timothy David Cushing ,  Benjamin Fisher ,  Felix Gonzalez Lopez De Turiso ,  Xiaolin Hao ,  Youngsook Shin

    IPC分类号： C07D471/04 ,  C07D473/00 ,  C07D403/12

    CPC分类号： C07D471/04 ,  C07D241/42 ,  C07D403/12 ,  C07D473/00

    摘要： Substituted bicyclic heteroaryls and compositions containing them, for the treatment of general inflammation, arthritis, rheumatic diseases, osteoarthritis, inflammatory bowel disorders, inflammatory eye disorders, inflammatory or unstable bladder disorders, psoriasis, skin complaints with inflammatory components, chronic inflammatory conditions, including but not restricted to autoimmune diseases such as systemic lupus erythematosis (SLE), myestenia gravis, rheumatoid arthritis, acute disseminated encephalomyelitis, idiopathic thrombocytopenic purpura, multiples sclerosis, Sjoegren's syndrome and autoimmune hemolytic anemia, allergic conditions including all forms of hypersensitivity, The present invention also enables methods for treating cancers that are mediated, dependent on or associated with p110 activity, including but not restricted to leukemias, such as Acute Myeloid leukaemia AML) Myelo-dysplastic syndrome (MDS) myelo-proliferative diseases (MPD) Chronic Myeloid Leukemia (CML) T-cell Acute Lymphoblastic leukaemia (T-ALL) B-cell Acute Lymphoblastic leukaemia (B-ALL) Non Hodgkins Lymphoma (NHL) B-cell lymphoma and solid tumors, such as breast cancer.

    摘要翻译： 取代的双环杂芳基和含有它们的组合物，用于治疗一般炎症，关节炎，风湿性疾病，骨关节炎，炎性肠病，炎症性眼病，炎症性或不稳定性膀胱病，牛皮癣，皮肤炎症成分的投诉，慢性炎性病症 不限于自身免疫性疾病如系统性红斑狼疮（SLE），重症肌无力，类风湿性关节炎，急性播散性脑脊髓炎，特发性血小板减少性紫癜，多发性硬化症，Sjoegren综合征和自身免疫性溶血性贫血，包括所有形式的超敏反应的过敏症状 包括但不限于白血病（如急性骨髓性白血病AML）介导的，依赖于或与p110活性相关的癌症的方法，包括骨髓增生异常综合征（MDS）骨髓增殖性疾病（MPD）慢性骨髓性白血病（CMD） L）T细胞急性淋巴细胞白血病（T-ALL）B细胞急性淋巴细胞白血病（B-ALL）非霍奇金淋巴瘤（NHL）B细胞淋巴瘤和实体瘤如乳腺癌。

    Binary-valued signal modulation compression for high speed cross-correlation
    4.
    发明授权
    Binary-valued signal modulation compression for high speed cross-correlation 有权

    公开(公告)号：US07403559B1

    公开(公告)日：2008-07-22

    申请号：US10336103

    申请日：2003-01-03

    申请人： Benjamin Fisher ,  Lawrence Weill

    发明人： Benjamin Fisher ,  Lawrence Weill

    IPC分类号： H04B1/00

    CPC分类号： G01S19/22 ,  G01S19/24

    摘要： A method of forming a cross-correlation function R ⁡ ( τ ) = ∑ N 2 k = N 1 ⁢ r ⁡ ( k ) ⁢ m ⁡ ( k - τ ) , mathematically as an inner product of the samples of a received signal r(t) and a replica of the signal modulation function m(t), with a computational burden reduced by many orders of magnitude in pseudonoise (PN) coded ranging applications is accomplished by a two step process. First, a single weighted sum of the signal samples forms a small dimension vector, of the order of tens of elements. Second, the inner product of this vector and vectors of the same dimension of samples of the signal modulation generating function, delayed by arbitrarily many values of the delay parameter τ, result in fine delay resolution correlation function values. The process comparatively entails a relatively small computational burden, does not compromise fidelity, and makes real-time optimal range estimation practical.

    Method for improving multipath mitigator low path separation error behavior
    6.
    发明授权
    Method for improving multipath mitigator low path separation error behavior 失效
    改善多径减速器低路径分离误差行为的方法

    公开(公告)号：US07486745B2

    公开(公告)日：2009-02-03

    申请号：US11158137

    申请日：2005-06-20

    申请人： Benjamin Fisher ,  Lawrence Weill

    发明人： Benjamin Fisher ,  Lawrence Weill

    IPC分类号： H03K9/00

    CPC分类号： H04L25/03006 ,  G01S7/292 ,  G01S19/22

    摘要： A process is disclosed for discriminating between received ranging signals, such as GPS, GNSS, and radar signals, which arrive via a single path and those which arrive via multiple paths. The number of paths is also estimated. This is accomplished by comparing the residual for an ith order ML estimator of signal time of arrival, where order refers to the number of signal paths for which the estimator is optimal, to a discriminant determined either analytically or empirically and deciding that i distinct signal path components are present in the observation of the signal if for all kth order estimators where k

    摘要翻译： 公开了一种用于区分经由单个路径到达的接收的测距信号（例如GPS，GNSS和雷达信号）的过程以及经由多个路径到达的测距信号。 也估计路径的数量。 这是通过将信号到达时间的第i阶ML估计器的残差与分析或经验确定的判别式进行比较，其中秩序是指估计器最优的信号路径的数量，并且决定了不同的信号路径 如果对于所有第k阶估计器，其中k

    Method for mitigating multipath effects in radio systems
    7.
    发明授权
    Method for mitigating multipath effects in radio systems 有权
    减轻无线电系统中多径效应的方法

    公开(公告)号：US06370207B1

    公开(公告)日：2002-04-09

    申请号：US09472638

    申请日：1999-12-27

    申请人： Lawrence Weill ,  Benjamin Fisher

    发明人： Lawrence Weill ,  Benjamin Fisher

    IPC分类号： H03D100

    CPC分类号： H04B1/71057 ,  G01S7/285 ,  G01S19/22 ,  G01S2013/466 ,  H04B1/7115 ,  H04B2201/70715

    摘要： A method for mitigating multipath effects in radio systems which is based on searching for and finding a maximum likelihood estimate of range for a received signal is provided. In determining the maximum likelihood estimate, the correlation process uses a high resolution step method in processing the received signal sample values to develop an estimation statistic. The estimation statistic using the correlations of the received signal is based on a new derived representative set of coefficients formed from a nonlinear combination of parameters of the received signal transformed into a linearly solvable invertible parameter set allowing solution of the maximization process of the estimation statistic over a reduced dimension search space. Additionally there is a method of constraining the relative amplitude of received secondary signals to obtain a refinement of the optimal solution of range. The method includes a process to reduce the magnitude of the processing required by the receiver by reducing the size of the overall sample of the signal that must be managed by the receiver. The method may be used in a signal environment where multiple secondary path signals are received by the signal ranging system.

    摘要翻译： 提供了一种减轻无线电系统中的多路径效应的方法，其基于搜索并找到接收信号的范围的最大似然估计。 在确定最大似然估计时，相关处理使用高分辨率步进方法来处理接收到的信号样本值以产生估计统计量。 使用接收信号的相关性的估计统计量是基于从被转换成可线性可解的可逆参数集的接收信号的参数的非线性组合形成的系数的新的导出的代表性集合，其允许解估计统计量的最大化过程 缩小的维度搜索空间。 另外还有一种限制接收到的二次信号的相对幅度以获得范围最优解的细化的方法。 该方法包括通过减小必须由接收机管理的信号的整体样本的大小来减小接收机所需的处理量的过程。 该方法可以用于由信号测距系统接收多个次要路径信号的信号环境中。

    Method for mitigating multipath effects in radio ranging systems
    8.
    发明授权
    Method for mitigating multipath effects in radio ranging systems 失效
    在无线电测距系统中减轻多路径效应的方法

    公开(公告)号：US6031881A

    公开(公告)日：2000-02-29

    申请号：US934493

    申请日：1997-09-19

    申请人： Lawrence Weill ,  Benjamin Fisher

    发明人： Lawrence Weill ,  Benjamin Fisher

    IPC分类号： G01S1/00 ,  G01S7/285 ,  H04B1/7105 ,  H04B1/7115 ,  H03D1/00

    CPC分类号： H04B1/71057 ,  G01S19/22 ,  G01S7/285 ,  H04B1/7115 ,  G01S2013/466 ,  H04B2201/70715

    摘要： This invention involves a method for mitigating multipath effects in radio ranging systems which is based on searching for and finding a maximum likelihood estimate of range for a received signal in a signal ranging system. In determining the maximum likelihood estimate, the correlation process uses a high resolution step method in processing the received signal sample values to develop an estimation statistic. The estimation statistic using the correlations of the received signal is based on a new derived representative set of coefficients formed from a nonlinear combination of parameters of the received signal transformed into an invertible linear combination which allows solution of the maximization process of the estimation statistic. Additionally there is a method of constraining the relative amplitude of received secondary signals to obtain a refinement of the optimal solution of range. Also the method includes a process to reduce the magnitude of the processing required by the receiver by reducing the size of the overall sample of the signal that must be managed by the receiver. The method may be used in a signal environment where multiple secondary path signals are received by the signal ranging system.

    摘要翻译： 本发明涉及一种用于减轻无线电测距系统中的多路径效应的方法，其基于在信号测距系统中搜索并找到接收信号的范围的最大似然估计。 在确定最大似然估计时，相关处理使用高分辨率步进方法来处理接收到的信号样本值以产生估计统计量。 使用接收信号的相关性的估计统计量基于由转换成可逆线性组合的接收信号的参数的非线性组合形成的系数的新的导出代表集合，其允许求解估计统计量的最大化处理。 另外还有一种限制接收到的二次信号的相对幅度以获得范围最优解的细化的方法。 此外，该方法包括通过减小必须由接收机管理的信号的整体样本的大小来减小接收机所需的处理的幅度的过程。 该方法可以用于由信号测距系统接收多个次要路径信号的信号环境中。

    Anchor Deployment System, Device, and Method of Treatment
    9.
    发明申请
    Anchor Deployment System, Device, and Method of Treatment 审中-公开
    锚定部署系统，设备和治疗方法

    公开(公告)号：US20160022259A1

    公开(公告)日：2016-01-28

    申请号：US14798946

    申请日：2015-07-14

    申请人： Benjamin Fisher

    发明人： Benjamin Fisher

    IPC分类号： A61B17/04

    CPC分类号： A61B17/0401 ,  A61B17/0483 ,  A61B2017/00367 ,  A61B2017/00818 ,  A61B2017/0409 ,  A61B2017/0417 ,  A61B2017/0448 ,  A61B2017/0464 ,  A61B2017/061 ,  A61B2090/395

    摘要： Anchor deployment systems, anchor deployment devices, and methods of treatment are described herein. An embodiment of an anchor deployment system comprises a deployment device, a retention mechanism, an anchor, and a connector. The deployment device has a handle, an elongate member, a stylet, a spring, and an actuator. The deployment device has a first configuration in which the connector is releasably attached to the handle and a second configuration in which the connector is free of attachment to the handle.

    摘要翻译： 这里描述了锚定部署系统，锚定部署装置和治疗方法。 锚定部署系统的一个实施例包括展开装置，保持机构，锚和连接器。 展开装置具有把手，细长构件，探针，弹簧和致动器。 所述展开装置具有第一构造，其中所述连接器可释放地附接到所述手柄，并且所述连接器不连接到所述手柄的第二构造。