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    Microchip, solvent displacement method using the microchip, concentrating method, and mass spectrometry system
    1.
    发明申请
    Microchip, solvent displacement method using the microchip, concentrating method, and mass spectrometry system 审中-公开
    Microchip，使用微芯片的溶剂置换法，浓缩法和质谱系统

    公开(公告)号：US20060070951A1

    公开(公告)日：2006-04-06

    申请号：US10536597

    申请日：2003-11-28

    申请人： Masakazu Baba ,  Toru Sano ,  Kazuhiro Iida ,  Hisao Kawaura ,  Noriyuki Iguchi ,  Wataru Hattori ,  Hiroko Someya ,  Minoru Asogawa

    发明人： Masakazu Baba ,  Toru Sano ,  Kazuhiro Iida ,  Hisao Kawaura ,  Noriyuki Iguchi ,  Wataru Hattori ,  Hiroko Someya ,  Minoru Asogawa

    IPC分类号： C02F1/44 ,  B01D15/08

    CPC分类号： B01D67/0062 ,  B03C5/00 ,  G01N1/40

    摘要： A particular component in a sample is recovered in a high concentration and solvent-replaced. A separator 100 is placed on a microchip and includes a channel 112 for flowing the particular component. The channel 112 includes a sample feeding channel 300 as well as a filtrate discharge channel 302 and a sample recovering part 308 which are branched from the sample feeding channel 300. There is formed a filter 304 for preventing passage of the particular component, at the inlet of the filtrate discharge channel 302 from the sample feeding channel 300. Furthermore, there is formed a damming area (hydrophobic area) 306 for preventing entering of a liquid sample while allowing for passage of the liquid sample by applying an external force equal to or larger than a given level, at the inlet of the sample recovering part 308 from the sample feeding channel 300.

    摘要翻译： 样品中的特定组分以高浓度回收并进行溶剂置换。 分离器100放置在微芯片上，并且包括用于流动特定部件的通道112。 通道112包括样品供给通道300以及从样品供给通道300分支的滤液排出通道302和样品回收部分308。 在滤液排出通道302的入口处，从样品供给通道300形成防止特定成分通过的过滤器304。 此外，在样品回收部的入口处形成防止液体样品进入的阻止区域（疏水区域）306，同时允许通过施加等于或大于给定水平的外力使液体样品通过 308。

    Separating apparatus, separating method, and mass analyzing system
    4.
    发明申请
    Separating apparatus, separating method, and mass analyzing system 审中-公开
    分离装置，分离方法和质量分析系统

    公开(公告)号：US20060063273A1

    公开(公告)日：2006-03-23

    申请号：US10536908

    申请日：2003-12-01

    申请人： Minoru Asogawa ,  Masakazu Baba ,  Hisao Kawaura ,  Toru Sano ,  Kazuhiro Iida ,  Noriyuki Iguchi ,  Hiroko Someya

    发明人： Minoru Asogawa ,  Masakazu Baba ,  Hisao Kawaura ,  Toru Sano ,  Kazuhiro Iida ,  Noriyuki Iguchi ,  Hiroko Someya

    IPC分类号： G01N1/10

    CPC分类号： G01N30/72 ,  Y10T436/2575

    摘要： Individual components are separated with a high concentration and accurately, from a sample containing components-to-be-separated. The separation apparatus includes a channel through which a sample containing components-to-be-separated moves; and gateway portions partitioning the separation channel into a plurality of compartments. The separation apparatus further includes an external force imposing unit, which imposes external force to the components-to-be-separated so as to allow them to move through the channel. The external force imposing unit is configured so as to alternately repeatedly execute a first external force imposing pattern by which the external force is imposed in the forward direction of the channel, and a second external force imposing pattern by which the external force is imposed in the direction opposite to the forward direction along the channel. This makes it possible to fractionate the components-to-be-separated into any of the compartments.

    摘要翻译： 从含有待分离成分的样品中分离高浓度和准确的各组分。 分离装置包括通道，通过该通道将含有要分离的成分的样品移动; 以及将分离通道分隔成多个隔室的通道部分。 分离装置还包括外力施加单元，其向待分离的部件施加外力，以允许它们移动通过通道。 外力施加单元被配置为交替地重复地执行第一外力施加模式，外力施加在通道的向前方向上，第二外力施加模式，外力施加在通道中 方向与通道的向前方向相反。 这使得可以将要分离的组分分馏成任何隔室。

    Separation apparatus and separation method
    6.
    发明申请
    Separation apparatus and separation method 审中-公开
    分离装置和分离方法

    公开(公告)号：US20060000772A1

    公开(公告)日：2006-01-05

    申请号：US10536798

    申请日：2003-11-28

    申请人： Toru Sano ,  Masakazu Baba ,  Kazuhiro Iida ,  Hisa Kawaura ,  Noriyuki Iguchi ,  Hiroko Someya ,  Minoru Asogawa

    发明人： Toru Sano ,  Masakazu Baba ,  Kazuhiro Iida ,  Hisa Kawaura ,  Noriyuki Iguchi ,  Hiroko Someya ,  Minoru Asogawa

    IPC分类号： B01D15/08

    CPC分类号： B01D67/0062 ,  B01D69/00 ,  B01D69/141 ,  B01D71/027 ,  B01L3/502707 ,  B01L3/502746 ,  B01L3/502753 ,  B01L2200/0631 ,  B01L2300/0816 ,  G01N1/34 ,  G01N1/405

    摘要： A channel (103) is formed in a substrate (101), and a portion of the channel (103) is provided with a separating portion (107). A number of pillars are formed in the separating portion (107), and an adsorptive substance layer having an adsorptive substance, which exhibits a specific interaction for a specific substance, immobilized on the surface thereof, is formed. Once a sample is introduced into the channel (103), the specific substance is adsorbed on the adsorptive substance layer to be separated from other components. After washing the inside of the channel (103) with a buffer solution, the specific substance is desorbed from the adsorptive substance layer by flowing a eluting solution through the channel (103) and the specific substance is recovered.

    摘要翻译： 通道（103）形成在基板（101）中，并且通道（103）的一部分设置有分离部分（107）。 在分离部（107）中形成有多个支柱，并且形成了具有固定在其表面上的特定物质的特定相互作用的具有吸附物质的吸附物质层。 一旦将样品引入通道（103）中，特定物质被吸附在吸附物质层上以与其它组分分离。 用缓冲溶液洗涤通道（103）的内部后，通过使通道（103）流过洗脱液，将特定物质从吸附物质层解吸，回收特定物质。

    Diagnosis supporting system
    10.
    发明申请
    Diagnosis supporting system 审中-公开
    诊断支持系统

    公开(公告)号：US20060172436A1

    公开(公告)日：2006-08-03

    申请号：US10549116

    申请日：2004-02-26

    申请人： Wataru Hattori ,  Toru Sano ,  Masakazu Baba ,  Kazuhiro Iida ,  Hisao Kawaura ,  Noriyuki Iguchi ,  Hiroko Someya

    发明人： Wataru Hattori ,  Toru Sano ,  Masakazu Baba ,  Kazuhiro Iida ,  Hisao Kawaura ,  Noriyuki Iguchi ,  Hiroko Someya

    IPC分类号： G01N33/543 ,  G06F19/00

    CPC分类号： G01N27/44717 ,  G16H10/60 ,  G16H15/00

    摘要： A diagnosis supporting system (10) includes a diagnosis data obtaining unit (20) that obtains diagnosis data in which a movement parameter reflecting a movement speed of each component in separating a sample collected from a test subject into plural components with a chip (12) and a character of each component is in correspondence, a parameter storing unit (34) that stores the movement parameter of a characteristic component showing a state of suffering from a specific disease in correspondence with the disease, a relationship data storing unit (35) that stores relationship data showing a relationship between the character of the characteristic component and a possibility of suffering from a specific disease, a detecting unit (21) that detects the characteristic component from the diagnosis data based on the movement parameter of the characteristic component and the movement parameter of the diagnosis data by making reference to the parameter storing unit (34), and an inference processing unit (22) that infers the possibility that the test subject is suffering by making reference to the relationship data storing unit (35) based on the character of the detected characteristic component.

    摘要翻译： 诊断支持系统（10）包括诊断数据获取单元（20），该诊断数据获取单元（20）获取诊断数据，其中，用芯片（12）将反映从测试对象收集的样本的每个组件的移动速度反映成多个组件的移动参数， 并且每个部件的字符相对应，存储与疾病相对应地显示出患有特定疾病的状态的特征部件的移动参数的参数存储部（34），关系数据存储部（35），其中， 存储表示特征成分的特征与患有特定疾病的可能性之间的关系的关系数据，根据特征成分的移动参数和运动来检测来自诊断数据的特征成分的检测部（21） 参考存储单元（34）的诊断数据的参数，以及inf （22），其基于检测到的特征成分的特性，通过参照所述关系数据存储部（35）推测出所述检测对象所遭受的可能性。