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    Separation apparatus and separation method
    1.
    发明申请
    Separation apparatus and separation method 审中-公开
    分离装置和分离方法

    公开(公告)号：US20060000772A1

    公开(公告)日：2006-01-05

    申请号：US10536798

    申请日：2003-11-28

    申请人： Toru Sano ,  Masakazu Baba ,  Kazuhiro Iida ,  Hisa Kawaura ,  Noriyuki Iguchi ,  Hiroko Someya ,  Minoru Asogawa

    发明人： Toru Sano ,  Masakazu Baba ,  Kazuhiro Iida ,  Hisa Kawaura ,  Noriyuki Iguchi ,  Hiroko Someya ,  Minoru Asogawa

    IPC分类号： B01D15/08

    CPC分类号： B01D67/0062 ,  B01D69/00 ,  B01D69/141 ,  B01D71/027 ,  B01L3/502707 ,  B01L3/502746 ,  B01L3/502753 ,  B01L2200/0631 ,  B01L2300/0816 ,  G01N1/34 ,  G01N1/405

    摘要： A channel (103) is formed in a substrate (101), and a portion of the channel (103) is provided with a separating portion (107). A number of pillars are formed in the separating portion (107), and an adsorptive substance layer having an adsorptive substance, which exhibits a specific interaction for a specific substance, immobilized on the surface thereof, is formed. Once a sample is introduced into the channel (103), the specific substance is adsorbed on the adsorptive substance layer to be separated from other components. After washing the inside of the channel (103) with a buffer solution, the specific substance is desorbed from the adsorptive substance layer by flowing a eluting solution through the channel (103) and the specific substance is recovered.

    摘要翻译： 通道（103）形成在基板（101）中，并且通道（103）的一部分设置有分离部分（107）。 在分离部（107）中形成有多个支柱，并且形成了具有固定在其表面上的特定物质的特定相互作用的具有吸附物质的吸附物质层。 一旦将样品引入通道（103）中，特定物质被吸附在吸附物质层上以与其它组分分离。 用缓冲溶液洗涤通道（103）的内部后，通过使通道（103）流过洗脱液，将特定物质从吸附物质层解吸，回收特定物质。

    Microchip, solvent displacement method using the microchip, concentrating method, and mass spectrometry system
    2.
    发明申请
    Microchip, solvent displacement method using the microchip, concentrating method, and mass spectrometry system 审中-公开
    Microchip，使用微芯片的溶剂置换法，浓缩法和质谱系统

    公开(公告)号：US20060070951A1

    公开(公告)日：2006-04-06

    申请号：US10536597

    申请日：2003-11-28

    申请人： Masakazu Baba ,  Toru Sano ,  Kazuhiro Iida ,  Hisao Kawaura ,  Noriyuki Iguchi ,  Wataru Hattori ,  Hiroko Someya ,  Minoru Asogawa

    发明人： Masakazu Baba ,  Toru Sano ,  Kazuhiro Iida ,  Hisao Kawaura ,  Noriyuki Iguchi ,  Wataru Hattori ,  Hiroko Someya ,  Minoru Asogawa

    IPC分类号： C02F1/44 ,  B01D15/08

    CPC分类号： B01D67/0062 ,  B03C5/00 ,  G01N1/40

    摘要： A particular component in a sample is recovered in a high concentration and solvent-replaced. A separator 100 is placed on a microchip and includes a channel 112 for flowing the particular component. The channel 112 includes a sample feeding channel 300 as well as a filtrate discharge channel 302 and a sample recovering part 308 which are branched from the sample feeding channel 300. There is formed a filter 304 for preventing passage of the particular component, at the inlet of the filtrate discharge channel 302 from the sample feeding channel 300. Furthermore, there is formed a damming area (hydrophobic area) 306 for preventing entering of a liquid sample while allowing for passage of the liquid sample by applying an external force equal to or larger than a given level, at the inlet of the sample recovering part 308 from the sample feeding channel 300.

    摘要翻译： 样品中的特定组分以高浓度回收并进行溶剂置换。 分离器100放置在微芯片上，并且包括用于流动特定部件的通道112。 通道112包括样品供给通道300以及从样品供给通道300分支的滤液排出通道302和样品回收部分308。 在滤液排出通道302的入口处，从样品供给通道300形成防止特定成分通过的过滤器304。 此外，在样品回收部的入口处形成防止液体样品进入的阻止区域（疏水区域）306，同时允许通过施加等于或大于给定水平的外力使液体样品通过 308。

    Separating apparatus, separating method, and mass analyzing system
    5.
    发明申请
    Separating apparatus, separating method, and mass analyzing system 审中-公开
    分离装置，分离方法和质量分析系统

    公开(公告)号：US20060063273A1

    公开(公告)日：2006-03-23

    申请号：US10536908

    申请日：2003-12-01

    申请人： Minoru Asogawa ,  Masakazu Baba ,  Hisao Kawaura ,  Toru Sano ,  Kazuhiro Iida ,  Noriyuki Iguchi ,  Hiroko Someya

    发明人： Minoru Asogawa ,  Masakazu Baba ,  Hisao Kawaura ,  Toru Sano ,  Kazuhiro Iida ,  Noriyuki Iguchi ,  Hiroko Someya

    IPC分类号： G01N1/10

    CPC分类号： G01N30/72 ,  Y10T436/2575

    摘要： Individual components are separated with a high concentration and accurately, from a sample containing components-to-be-separated. The separation apparatus includes a channel through which a sample containing components-to-be-separated moves; and gateway portions partitioning the separation channel into a plurality of compartments. The separation apparatus further includes an external force imposing unit, which imposes external force to the components-to-be-separated so as to allow them to move through the channel. The external force imposing unit is configured so as to alternately repeatedly execute a first external force imposing pattern by which the external force is imposed in the forward direction of the channel, and a second external force imposing pattern by which the external force is imposed in the direction opposite to the forward direction along the channel. This makes it possible to fractionate the components-to-be-separated into any of the compartments.

    摘要翻译： 从含有待分离成分的样品中分离高浓度和准确的各组分。 分离装置包括通道，通过该通道将含有要分离的成分的样品移动; 以及将分离通道分隔成多个隔室的通道部分。 分离装置还包括外力施加单元，其向待分离的部件施加外力，以允许它们移动通过通道。 外力施加单元被配置为交替地重复地执行第一外力施加模式，外力施加在通道的向前方向上，第二外力施加模式，外力施加在通道中 方向与通道的向前方向相反。 这使得可以将要分离的组分分馏成任何隔室。

    Temperature control method and system
    8.
    发明授权
    Temperature control method and system 有权
    温度控制方法和系统

    公开(公告)号：US08202722B2

    公开(公告)日：2012-06-19

    申请号：US12679358

    申请日：2008-09-16

    申请人： Minoru Asogawa ,  Hisashi Hagiwara ,  Tohru Hiramatsu

    发明人： Minoru Asogawa ,  Hisashi Hagiwara ,  Tohru Hiramatsu

    IPC分类号： C12M1/38 ,  F28F13/00 ,  F28F7/00

    CPC分类号： B01L3/502715 ,  B01L3/50273 ,  B01L3/505 ,  B01L7/52 ,  B01L2200/0689 ,  B01L2300/0867 ,  B01L2300/087 ,  B01L2300/0887 ,  B01L2300/123 ,  B01L2300/14 ,  B01L2300/1822 ,  B01L2300/1827 ,  B01L2400/0481 ,  B01L2400/0655 ,  G01N2035/00158 ,  G01N2035/00346

    摘要： For heating or cooling a sample contained in a vessel portion through a heat transfer member held in contact with the vessel portion, there is used the vessel portion, which has a part formed of an elastic member, expands and contracts for injection and discharge of the sample, is closed other than a connecting port with a channel connected to the vessel, and expands and contracts for injection and discharge of the sample. The vessel portion expands correspondingly to the injection when the sample is injected through an inflow path serving as the channel into the vessel portion contracting in a non-contacting state with the heat transfer member. A predetermined amount of sample is injected into the vessel portion so as to expand the vessel portion, and the vessel portion comes into contact with the heat transfer member. The vessel portion is heated or cooled through the heat transfer member.

    摘要翻译： 为了通过与容器部分保持接触的传热构件来加热或冷却包含在容器部分中的样品，使用具有由弹性构件形成的部分的容器部分，其膨胀和收缩用于注射和排出 样品，除了具有连接到容器的通道的连接端口之外，并且扩展并收缩样品的注入和排出。 当样品通过用作通道的流入路径注入到与传热构件非接触状态收缩的容器部分中时，容器部分对应于注射膨胀。 将预定量的样品注入到容器部分中以使容器部分膨胀，并且容器部分与传热构件接触。 容器部分通过传热构件被加热或冷却。

    FLOW PASSAGE CONTROL MECHANISM FOR MICROCHIP
    9.
    发明申请
    FLOW PASSAGE CONTROL MECHANISM FOR MICROCHIP 有权
    流量控制机制的MICROCHIP

    公开(公告)号：US20110000561A1

    公开(公告)日：2011-01-06

    申请号：US12920256

    申请日：2009-03-18

    申请人： Minoru Asogawa ,  Hisashi Hagiwara ,  Tohru Hiramatsu

    发明人： Minoru Asogawa ,  Hisashi Hagiwara ,  Tohru Hiramatsu

    IPC分类号： F03B11/02

    CPC分类号： B01L3/502738 ,  B01L3/50273 ,  B01L2300/0816 ,  B01L2300/0864 ,  B01L2300/0867 ,  B01L2300/0887 ,  B01L2300/123 ,  B01L2400/0481 ,  B01L2400/0655 ,  G01N35/1095 ,  G01N2035/00158 ,  G01N2035/1034 ,  Y10T137/8593 ,  Y10T436/11 ,  Y10T436/25 ,  Y10T436/2575

    摘要： A channel control mechanism for a microchip has a laminated structure formed of members including elastic members, and includes: a sample reservoir for packing a sample therein; a reaction reservoir in which mixture and reaction of the sample are performed; and a channel formed in a middle layer of the laminated structure, for bringing the sample reservoir and the reaction reservoir into communication with each other. The channel control mechanism performs the reaction and analysis in such a manner that the sample is delivered into the reaction reservoir through the channel. A shutter channel (pressurizing channel) is provided in a layer different from a layer in which the channel is formed so that the pressurizing channel partially overlaps the channel. The channel is closed through applying a pressurized medium to the shutter channel (pressurizing channel), and the channel is opened through releasing a pressure of the pressurized medium.

    摘要翻译： 用于微芯片的通道控制机构具有由包括弹性构件的构件形成的层压结构，并且包括：用于在其中包装样品的样品容器; 反应容器，其中进行混合物和样品的反应; 以及形成在层叠结构的中间层中的通道，用于使样本储存器和反应容器彼此连通。 通道控制机构以通过通道将样品输送到反应容器中的方式进行反应和分析。 快门通道（加压通道）设置在与形成通道的层不同的层中，使得加压通道与通道部分重叠。 通过将加压介质施加到闸门通道（加压通道）来关闭通道，并且通过释放加压介质的压力来打开通道。

    INDIVIDUAL IDENTIFICATION METHOD AND APPARATUS
    10.
    发明申请
    INDIVIDUAL IDENTIFICATION METHOD AND APPARATUS 审中-公开
    个人识别方法和设备

    公开(公告)号：US20090277790A1

    公开(公告)日：2009-11-12

    申请号：US12297204

    申请日：2007-04-12

    申请人： Minoru Asogawa ,  Masatoshi Sugisawa ,  Shinji Okui

    发明人： Minoru Asogawa ,  Masatoshi Sugisawa ,  Shinji Okui

    IPC分类号： G01N27/453 ,  G01N27/447

    CPC分类号： G16B20/00 ,  G16B30/00 ,  G16B50/00

    摘要： An individual identification method for identifying an individual by analyzing a DNA sample through electrophoresis, comprises: a first analysis step of analyzing an identifier-attached DNA sample which is given an identifier for an individual; a step of storing a result obtained by analyzing the identifier-attached DNA sample together with a corresponding identifier in a database; a second analysis step of analyzing a new sample which is a DNA sample subjected to individual identification with an accuracy lower than the accuracy when the identifier-attached DNA sample is analyzed, and using the result as a new sample analysis result; and a step of searching the database based on the new sample analysis result.

    摘要翻译： 用于通过电泳分析DNA样品来识别个体的个体识别方法包括：分析给予个体标识符的标识符附着DNA样品的第一分析步骤; 将通过分析标识符附着的DNA样本获得的结果与相应的标识符一起存储在数据库中的步骤; 第二分析步骤，以分析标识符附着的DNA样品的精度以下的精度分析作为进行个体识别的DNA样品的新样品，并使用该结果作为新的样本分析结果; 并且基于新的样本分析结果搜索数据库的步骤。