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    2-O- (β-D-glucopyranosyl) ascorbic acid, process for its production, and foods and cosmetics containing compositions comprising it
    1.
    发明授权
    2-O- (β-D-glucopyranosyl) ascorbic acid, process for its production, and foods and cosmetics containing compositions comprising it 有权
    2-O-（＆bgr--D-吡喃葡萄糖基）抗坏血酸，其生产方法，以及含有组合物的组合物的食品和化妆品

    公开(公告)号：US08017587B2

    公开(公告)日：2011-09-13

    申请号：US11898121

    申请日：2007-09-10

    申请人： Mitsuru Maeda ,  Masahiro Nakao ,  Harukazu Fukami

    发明人： Mitsuru Maeda ,  Masahiro Nakao ,  Harukazu Fukami

    IPC分类号： A01N43/04 ,  A01N43/08

    CPC分类号： A61K8/676 ,  A23L33/105 ,  A23L33/15 ,  A23V2002/00 ,  A61K8/602 ,  A61K31/375 ,  A61K2800/52 ,  A61Q17/04 ,  A61Q19/00 ,  A61Q19/02 ,  C07H1/08 ,  C07H17/04 ,  C12P19/60 ,  A23V2250/708

    摘要： The present invention provides a novel ascorbic acid derivative as a provitamin C with improved stability in the body and prolonged life in the body compared to conventionally known 2-O-(α-D-glucopyranosyl)ascorbic acid.The composition comprising the novel compound 2-O-(β-D-glucopyranosyl)ascorbic acid has been extracted from plants such as from Ningxia Lycium barbarum L. and/or Lycium chinense Mill. The compositions comprising 2-O-(β-D-glucopyranosyl)ascorbic acid may be enzymatically synthesized using β-D-glucosyltransferase. Pure 2-O-(β-D-glucopyranosyl)ascorbic acid may be produced from such compositions. Alternatively, 2-O-(β-D-glucopyranosyl)ascorbic acid may be produced by chemical synthesis. The 2-O-(β-D-glucopyranosyl)ascorbic acid results in higher stability and a prolonged life of vitamin C when ingested in the body compared to the corresponding α-D-glucopyranosyl derivative, and is therefore highly suitable as a provitamin C to be used in cosmetics and foods.

    摘要翻译： 与常规已知的2-O-（α-D-吡喃葡萄糖基）抗坏血酸相比，本发明提供了一种新型抗坏血酸衍生物作为维生素C，具有改善体内的稳定性和延长的身体寿命。 从宁夏枸杞子和/或枸杞子植物提取含有新化合物2-O-（＆bgr-D-吡喃葡萄糖基）抗坏血酸的组合物。 可以使用β-葡萄糖基转移酶酶法合成包含2-O-（β-谷氨酰-D-吡喃葡萄糖基）抗坏血酸的组合物。 可以从这样的组合物制备纯2-O-（＆bgr-D-吡喃葡萄糖基）抗坏血酸。 或者，可通过化学合成制备2-O-（＆bgr-D-吡喃葡萄糖基）抗坏血酸。 与对应的α-D-吡喃葡萄糖基衍生物相比，2-O-（＆bgr-D-吡喃葡萄糖基）抗坏血酸在身体摄取时导致更高的稳定性和更长的维生素C的使用寿命，因此非常适合作为维生素 C用于化妆品和食品。

    Esterified Catechins, Processes for Producing the Same, and Foods and Beverages as well as Cosmetics Containing Such Esterified Catechins
    2.
    发明申请
    Esterified Catechins, Processes for Producing the Same, and Foods and Beverages as well as Cosmetics Containing Such Esterified Catechins 审中-公开
    酯化儿茶素，其制备方法，食品和饮料以及含有这种酯化儿茶素的化妆品

    公开(公告)号：US20080058409A1

    公开(公告)日：2008-03-06

    申请号：US11795959

    申请日：2006-01-25

    申请人： Harukazu Fukami ,  Masahiro Nakao ,  Koshi Namikawa ,  Mitsuru Maeda

    发明人： Harukazu Fukami ,  Masahiro Nakao ,  Koshi Namikawa ,  Mitsuru Maeda

    IPC分类号： A61K31/352 ,  A61P31/04 ,  C07D311/04 ,  C12P17/06

    CPC分类号： C12P17/06 ,  A01N43/16 ,  A23L3/3472 ,  A23L3/3517 ,  A61K8/498 ,  A61Q17/005 ,  C07D311/62

    摘要： The present invention provides substances having sufficiently antibacterial activity against heat-resistant spore-forming bacteria that they can be used to improve the shelf life of beverages and processed foods, as well as to control the growth of microorganisms in cosmetics. The present invention provides a catechin ester in which at least one of the hydroxyl groups of a catechin is esterified with a medium-chain fatty acid. This medium-chain fatty acid ester of a catechin, which may be used either alone or as a composition, shows a strong growth suppressing effect on heat-resistant spore-forming bacteria and, if added to foods or beverages, can prevent them from rotting or deterioration and, if added to cosmetics, can prevent their rotting or deterioration.

    摘要翻译： 本发明提供对耐热孢子形成细菌具有足够抗菌活性的物质，它们可用于改善饮料和加工食品的保质期，以及控制化妆品中微生物的生长。 本发明提供一种儿茶素酯，其中儿茶素的至少一个羟基与中链脂肪酸酯化。 可以单独或作为组合物使用的儿茶素的该中链脂肪酸酯对耐热孢子形成细菌具有强烈的生长抑制作用，如果添加到食品或饮料中，可以防止它们的腐烂 或变质，如果添加到化妆品中，可以防止其腐烂或变质。

    2-O-(beta-D-glucopyranosyl) ascorbic acid, process for its production, and foods cosmetics containing compositions comprising it
    3.
    发明申请
    2-O-(beta-D-glucopyranosyl) ascorbic acid, process for its production, and foods cosmetics containing compositions comprising it 有权
    2-O-（β-D-吡喃葡萄糖基）抗坏血酸，其生产方法，以及含有组合物的食品化妆品

    公开(公告)号：US20070065380A1

    公开(公告)日：2007-03-22

    申请号：US11501074

    申请日：2006-08-09

    申请人： Mitsuru Maeda ,  Masahiro Nakao ,  Harukazu Fukami

    发明人： Mitsuru Maeda ,  Masahiro Nakao ,  Harukazu Fukami

    IPC分类号： A61K31/7048 ,  A61K8/49

    CPC分类号： A61K8/676 ,  A23L33/105 ,  A23L33/15 ,  A23V2002/00 ,  A61K8/602 ,  A61K31/375 ,  A61K2800/52 ,  A61Q17/04 ,  A61Q19/00 ,  A61Q19/02 ,  C07H1/08 ,  C07H17/04 ,  C12P19/60 ,  A23V2250/708

    摘要： The present invention provides a novel ascorbic acid derivative as a provitamin C with improved stability in the body and prolonged life in the body compared to conventionally known 2-O-(α-D-glucopyranosyl)ascorbic acid. The composition comprising the novel compound 2-O-(β-D-glucopyranosyl)ascorbic acid has been extracted from plants such as from Ningxia Lycium barbarum L. and/or Lycium chinense Mill. The compositions comprising 2-O-(β-D-glucopyranosyl)ascorbic acid may be enzymatically synthesized using β-D-glucosyltransferase. Pure 2-O-(β-D-glucopyranosyl)ascorbic acid may be produced from such compositions. Alternatively, 2-O-(β-D-glucopyranosyl)ascorbic acid may be produced by chemical synthesis. The 2-O-(β-D-glucopyranosyl)ascorbic acid results in higher stability and a prolonged life of vitamin C when ingested in the body compared to the corresponding α-D-glucopyranosyl derivative, and is therefore highly suitable as a provitamin C to be used in cosmetics and foods.

    摘要翻译： 与常规已知的2-O-（α-D-吡喃葡萄糖基）抗坏血酸相比，本发明提供了一种新型抗坏血酸衍生物作为维生素C，其具有改善的身体稳定性和延长的身体寿命。 含有新化合物2-O-（β-D-吡喃葡萄糖基）抗坏血酸的组合物已经从宁夏枸杞子和/或枸杞子等植物中提取出来。 包含2-O-（β-D-吡喃葡萄糖基）抗坏血酸的组合物可以使用β-D-葡糖基转移酶酶促合成。 可以从这样的组合物制备纯的2-O-（β-D-吡喃葡萄糖基）抗坏血酸。 或者，可通过化学合成制备2-O-（β-D-吡喃葡萄糖基）抗坏血酸。 与相应的α-D-吡喃葡萄糖基衍生物相比，2-O-（β-D-吡喃葡萄糖基）抗坏血酸产生更高的稳定性和摄取维生素C的寿命，因此非常适合作为维生素C 用于化妆品和食品。

    2-O- (Beta-D-Glucopyranosyl) ascorbic acid, process for its production, and foods and cosmetics containing compositions comprising it
    5.
    发明申请
    2-O- (Beta-D-Glucopyranosyl) ascorbic acid, process for its production, and foods and cosmetics containing compositions comprising it 有权
    2-O-（β-D-吡喃葡糖基）抗坏血酸，其生产方法，以及含有组合物的食品和化妆品

    公开(公告)号：US20080070983A1

    公开(公告)日：2008-03-20

    申请号：US11898121

    申请日：2007-09-10

    申请人： Mitsuru Maeda ,  Masahiro Nakao ,  Harukazu Fukami

    发明人： Mitsuru Maeda ,  Masahiro Nakao ,  Harukazu Fukami

    IPC分类号： A61K31/375 ,  A61P43/00

    CPC分类号： A61K8/676 ,  A23L33/105 ,  A23L33/15 ,  A23V2002/00 ,  A61K8/602 ,  A61K31/375 ,  A61K2800/52 ,  A61Q17/04 ,  A61Q19/00 ,  A61Q19/02 ,  C07H1/08 ,  C07H17/04 ,  C12P19/60 ,  A23V2250/708

    摘要： The present invention provides a novel ascorbic acid derivative as a provitamin C with improved stability in the body and prolonged life in the body compared to conventionally known 2-O-(α-D-glucopyranosyl)ascorbic acid. The composition comprising the novel compound 2-O-(β-D-glucopyranosyl)ascorbic acid has been extracted from plants such as from Ningxia Lycium barbarum L. and/or Lycium chinense Mill. The compositions comprising 2-O-(β-D-glucopyranosyl)ascorbic acid may be enzymatically synthesized using β-D-glucosyltransferase. Pure 2-O-(β-D-glucopyranosyl)ascorbic acid may be produced from such compositions. Alternatively, 2-O-(β-D-glucopyranosyl)ascorbic acid may be produced by chemical synthesis. The 2-O-(β-D-glucopyranosyl)ascorbic acid results in higher stability and a prolonged life of vitamin C when ingested in the body compared to the corresponding α-D-glucopyranosyl derivative, and is therefore highly suitable as a provitamin C to be used in cosmetics and foods.

    摘要翻译： 与常规已知的2-O-（α-D-吡喃葡萄糖基）抗坏血酸相比，本发明提供了一种新型抗坏血酸衍生物作为维生素C，其具有改善的身体稳定性和延长的身体寿命。 含有新化合物2-O-（β-D-吡喃葡萄糖基）抗坏血酸的组合物已经从宁夏枸杞子和/或枸杞子等植物中提取出来。 包含2-O-（β-D-吡喃葡萄糖基）抗坏血酸的组合物可以使用β-D-葡糖基转移酶酶促合成。 可以从这样的组合物制备纯的2-O-（β-D-吡喃葡萄糖基）抗坏血酸。 或者，可通过化学合成制备2-O-（β-D-吡喃葡萄糖基）抗坏血酸。 与相应的α-D-吡喃葡萄糖基衍生物相比，2-O-（β-D-吡喃葡萄糖基）抗坏血酸产生更高的稳定性和摄取维生素C的寿命，因此非常适合作为维生素C 用于化妆品和食品。

    2-O-(β-D-glucopyranosyl) ascorbic acid, process for its production, and foods and cosmetics containing compositions comprising it
    6.
    发明授权
    2-O-(β-D-glucopyranosyl) ascorbic acid, process for its production, and foods and cosmetics containing compositions comprising it 有权
    2-O-（β-D-吡喃葡萄糖基）抗坏血酸，其生产方法，以及含有组合物的食品和化妆品

    公开(公告)号：US07566698B2

    公开(公告)日：2009-07-28

    申请号：US10500334

    申请日：2002-12-27

    申请人： Mitsuru Maeda ,  Masahiro Nakao ,  Harukazu Fukami

    发明人： Mitsuru Maeda ,  Masahiro Nakao ,  Harukazu Fukami

    IPC分类号： A01N43/04 ,  A01N43/08 ,  C07H15/00 ,  C07H15/06

    CPC分类号： A61K8/676 ,  A23L33/105 ,  A23L33/15 ,  A23V2002/00 ,  A61K8/602 ,  A61K31/375 ,  A61K2800/52 ,  A61Q17/04 ,  A61Q19/00 ,  A61Q19/02 ,  C07H1/08 ,  C07H17/04 ,  C12P19/60 ,  A23V2250/708

    摘要： The present invention provides a novel ascorbic acid derivative as a provitamin C with improved stability in the body and prolonged life in the body compared to conventionally known 2-O-(α-D-glucopyranosyl)ascorbic acid. The composition comprising the novel compound 2-O-(β-D-glucopyranosyl)ascorbic acid has been extracted from plants such as from Ningxia Lycium barbarum L. and/or Lycium chinense Mill. The compositions comprising 2-O-(β-D-glucopyranosyl)ascorbic acid may be enzymatically synthesized using β-D-glucosyltransferase. Pure 2-O-(β-D-glucopyranosyl)ascorbic acid may be produced from such compositions. Alternatively, 2-O-(β-D-glucopyranosyl)ascorbic acid may be produced by chemical synthesis. The 2-O-(β-D-glucopyranosyl)ascorbic acid results in higher stability and a prolonged life of vitamin C when ingested in the body compared to the corresponding α-D-glucopyranosyl derivative, and is therefore highly suitable as a provitamin C to be used in cosmetics and foods.

    摘要翻译： 与常规已知的2-O-（α-D-吡喃葡萄糖基）抗坏血酸相比，本发明提供了一种新型抗坏血酸衍生物作为维生素C，其具有改善的身体稳定性和延长的身体寿命。 含有新化合物2-O-（β-D-吡喃葡萄糖基）抗坏血酸的组合物已经从宁夏枸杞子和/或枸杞子等植物中提取出来。 包含2-O-（β-D-吡喃葡萄糖基）抗坏血酸的组合物可以使用β-D-葡糖基转移酶酶促合成。 可以从这样的组合物制备纯的2-O-（β-D-吡喃葡萄糖基）抗坏血酸。 或者，可通过化学合成制备2-O-（β-D-吡喃葡萄糖基）抗坏血酸。 与相应的α-D-吡喃葡萄糖基衍生物相比，2-O-（β-D-吡喃葡萄糖基）抗坏血酸产生更高的稳定性和摄取维生素C的寿命，因此非常适合作为维生素C 用于化妆品和食品。

    2-O-(β-D-glucopyranosyl) ascorbic acid, process for its production, and foods cosmetics containing compositions comprising it
    8.
    发明授权
    2-O-(β-D-glucopyranosyl) ascorbic acid, process for its production, and foods cosmetics containing compositions comprising it 有权
    2-O-（＆bgr-D-吡喃葡萄糖基）抗坏血酸，其生产方法，以及含有组合物的食品化妆品

    公开(公告)号：US07943583B2

    公开(公告)日：2011-05-17

    申请号：US11501074

    申请日：2006-08-09

    申请人： Mitsuru Maeda ,  Masahiro Nakao ,  Harukazu Fukami

    发明人： Mitsuru Maeda ,  Masahiro Nakao ,  Harukazu Fukami

    IPC分类号： A01N43/04 ,  A01N43/06

    CPC分类号： A61K8/676 ,  A23L33/105 ,  A23L33/15 ,  A23V2002/00 ,  A61K8/602 ,  A61K31/375 ,  A61K2800/52 ,  A61Q17/04 ,  A61Q19/00 ,  A61Q19/02 ,  C07H1/08 ,  C07H17/04 ,  C12P19/60 ,  A23V2250/708

    摘要： The present invention provides a novel ascorbic acid derivative as a provitamin C with improved stability in the body and prolonged life in the body compared to conventionally known 2-O-(β-D-glucopyranosyl)ascorbic acid. The composition comprising the novel compound 2-O- (β-D-glucopyranosyl)ascorbic acid has been extracted from plants such as from Ningxia Lycium barbarum L. and/or Lycium chinense Mill. The compositions comprising 2-O-(βD-glucopyranosyl) ascorbic acid may be enzymatically synthesized using β-D-glucosyltransferase. Pure 2-O-(β-D-glucopyranosyl)ascorbic acid may be produced from such compositions. Alternatively, 2-O-(β-D-glucopyranosyl)ascorbic acid may be produced by chemical synthesis. The 2-O-(β-D-glucopyranosyl)ascorbic acid results in higher stability and a prolonged life of vitamin C when ingested in the body compared to the corresponding α-D-glucopyranosyl derivative, and is therefore highly suitable as a provitamin C to be used in cosmetics and foods.

    摘要翻译： 本发明提供了一种新颖的抗坏血酸衍生物作为前维生素C，与常规已知的2-O-（β-葡萄糖-D-吡喃葡萄糖基）抗坏血酸相比，体内的稳定性和体内寿命延长。 含有新化合物2-O-（＆bgr-D-吡喃葡萄糖基）抗坏血酸的组合物已经从宁夏枸杞子和/或枸杞子等植物中提取出来。 包含2-O-（β-葡萄糖吡喃糖基）抗坏血酸的组合物可以使用β-葡糖基转移酶酶促合成。 可以从这样的组合物制备纯2-O-（＆bgr-D-吡喃葡萄糖基）抗坏血酸。 或者，可通过化学合成制备2-O-（＆bgr-D-吡喃葡萄糖基）抗坏血酸。 与对应的α-D-吡喃葡萄糖基衍生物相比，2-O-（＆bgr-D-吡喃葡萄糖基）抗坏血酸在身体摄取时导致更高的稳定性和更长的维生素C的使用寿命，因此非常适合作为维生素 C用于化妆品和食品。

    Polypeptide having glycosylation activity on a flavonoid
    10.
    发明授权
    Polypeptide having glycosylation activity on a flavonoid 失效
    对黄酮具有糖基化活性的多肽

    公开(公告)号：US08383384B2

    公开(公告)日：2013-02-26

    申请号：US13530914

    申请日：2012-06-22

    申请人： Misa Ochiai ,  Harukazu Fukami ,  Masahiro Nakao ,  Akio Noguchi

    发明人： Misa Ochiai ,  Harukazu Fukami ,  Masahiro Nakao ,  Akio Noguchi

    IPC分类号： C12N9/28

    CPC分类号： C12N9/1048

    摘要： The present invention provides novel glycosyltransferase proteins produced by ascomycetous filamentous fungi (preferably species belonging to the genus Trichoderma, more preferably Trichoderma viride), as well as genes encoding the same. Among novel enzyme proteins provided by the present invention, particularly preferred is an enzyme protein obtained from the culture supernatant of Trichoderma viride strain IAM5141. The novel enzymes of the present invention allow glycosylation of flavonoid compounds to thereby improve their water solubility.

    摘要翻译： 本发明提供了由Ascomycetoto丝状真菌（优选属于木霉属，更优选绿色木霉）的物质以及编码它们的基因产生的新的糖基转移酶蛋白质。 在本发明提供的新型酶蛋白中，特别优选从绿色木霉菌株IAM5141的培养物上清液获得的酶蛋白质。 本发明的新型酶可以使类黄酮化合物进行糖基化从而提高其水溶性。