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    Probe set for detection of target substance and detection method using the same
    1.
    发明申请
    Probe set for detection of target substance and detection method using the same 失效
    用于检测目标物质的探针和使用其的检测方法

    公开(公告)号：US20050208556A1

    公开(公告)日：2005-09-22

    申请号：US11083951

    申请日：2005-03-21

    申请人： Motonari Daito ,  Koichi Yamagata ,  Yasuyuki Imura

    发明人： Motonari Daito ,  Koichi Yamagata ,  Yasuyuki Imura

    IPC分类号： C07H21/04 ,  C12Q1/68

    CPC分类号： C12Q1/6813 ,  C12Q2533/107 ,  C12Q2525/161

    摘要： A probe set is described that includes a first probe having a target-binding substance and a base sequence X1, a second probe having a base sequence X2c and a base sequence X1c hybridizable with the base sequence X1, and a third probe having a base sequence X2 hybridizable with the base sequence X2c. A method for detecting a target substance is also described.

    摘要翻译： 描述了一种探针组，其包括具有靶结合物质和碱基序列X1的第一探针，具有碱基序列X2c的第二探针和与碱基序列X1可杂交的碱基序列X1c，以及具有碱基序列的第三探针 X2可与碱基序列X2c杂交。 还描述了用于检测目标物质的方法。

    Method for screening cervical cancer
    3.
    发明申请
    Method for screening cervical cancer 审中-公开
    筛查宫颈癌的方法

    公开(公告)号：US20050221399A1

    公开(公告)日：2005-10-06

    申请号：US11092944

    申请日：2005-03-30

    申请人： Koichi Nakano ,  Masaki Ishisaka ,  Kazuki Kishi ,  Miharu Watanabe ,  Yasuyuki Imura

    发明人： Koichi Nakano ,  Masaki Ishisaka ,  Kazuki Kishi ,  Miharu Watanabe ,  Yasuyuki Imura

    IPC分类号： G01N33/574 ,  G01N33/58 ,  G01N33/567

    CPC分类号： G01N33/57411 ,  G01N33/582

    摘要： The invention provides a reagent for diagnosing cervical cancer, which can not only detect the presence or absence of cervical cancer but can also distinguish squamous cell carcinoma and adenocarcinoma from each other, a method for screening cervical cancer by using the reagent, particularly a screening method capable high speed processing by utilizing flow cytometry. The reagent comprises a first labeled antibody reacting with gland cells, a second labeled antibody reacting with adenocarcinoma cells and a third labeled antibody reacting with atypical cervical squamous cells, the antibodies being labeled with mutually distinguishable labels respectively. Preferably, at least one selected from the group consisting of MUC1 antibody, cytokeratin 7 antibody, and cytokeratin 18 antibody is used as the first labeled antibody, at least one selected from the group consisting of cytokeratin 8 antibody and HIK1083 antibody is used as the second labeled antibody, and at least one member selected from the group consisting of NMP179 antibody, p16INK4A antibody, Ki-67 antibody, p53 antibody, p21 antibody, EMA antibody, CEA antibody and MIB-1 antibody is used as the third labeled antibody.

    摘要翻译： 本发明提供了一种用于诊断宫颈癌的试剂，其不仅可以检测宫颈癌的存在或不存在，还可以区分鳞状细胞癌和腺癌，通过使用试剂筛选子宫颈癌的方法，特别是筛选方法 利用流式细胞仪进行高速处理。 试剂包含与腺体细胞反应的第一标记抗体，与腺癌细胞反应的第二标记抗体和与非典型宫颈鳞状细胞反应的第三标记抗体，所述抗体分别用相互区分的标记标记。 优选使用选自MUC1抗体，细胞角蛋白7抗体和细胞角蛋白18抗体的至少一种作为第一标记抗体，使用选自细胞角蛋白8抗体和HIK1083抗体的至少一种作为第二标记抗体 标记抗体，选自NMP179抗体，p16，INK4A抗体，Ki-67抗体，p53抗体，p21抗体，EMA抗体，CEA抗体和MIB-1抗体中的至少一种是 用作第三标记抗体。

    Optical information measuring apparatus
    4.
    发明授权
    Optical information measuring apparatus 失效
    光信息测量装置

    公开(公告)号：US06707555B1

    公开(公告)日：2004-03-16

    申请号：US09411656

    申请日：1999-10-04

    申请人： Hideo Kusuzawa ,  Yasuyuki Imura ,  Hironori Kobayashi ,  Masaki Ishisaka

    发明人： Hideo Kusuzawa ,  Yasuyuki Imura ,  Hironori Kobayashi ,  Masaki Ishisaka

    IPC分类号： G01N2100

    CPC分类号： G01N21/59 ,  G01J3/0202 ,  G01J3/0291 ,  G01N21/474 ,  G01N21/84 ,  G01N2021/0112 ,  G01N2201/0221

    摘要： An optical information measuring apparatus includes: a light source section capable of emitting a plurality of light beams; a light guiding section for directing and supplying the plurality of light beams from the light source section to an object; an object lens arranged facing the object; a plurality of light receiving sections for respectively receiving the light beams from the object via the object lens; and a frame section for integrally mounting a plurality of optical elements including the light source section, the light guiding section, the object lens, and the light-receiving sections.

    摘要翻译： 光学信息测量装置包括：能够发射多个光束的光源部; 导光部，用于将多个光束从光源部引导并供给到物体; 面对物体的物镜; 多个光接收部分，用于经由物镜分别接收来自物体的光束; 以及用于整体地安装包括光源部分，导光部分，物镜和光接收部分的多个光学元件的框架部分。

    Nucleic acid amplification primers for detecting cytokeratins and examination method with the use of the primers
    5.
    发明申请
    Nucleic acid amplification primers for detecting cytokeratins and examination method with the use of the primers 有权
    用于检测细胞角蛋白的核酸扩增引物和使用引物的检查方法

    公开(公告)号：US20060094008A1

    公开(公告)日：2006-05-04

    申请号：US10514776

    申请日：2003-05-20

    申请人： Sachiyo Tada ,  Yasumasa Akai ,  Yasuyuki Imura ,  Shigeki Abe ,  Harumi Minekawa

    发明人： Sachiyo Tada ,  Yasumasa Akai ,  Yasuyuki Imura ,  Shigeki Abe ,  Harumi Minekawa

    IPC分类号： C12Q1/68 ,  C07H21/04 ,  C12P19/34

    CPC分类号： C12Q1/6844 ,  C12Q1/686 ,  C12Q1/6886 ,  C12Q2600/112 ,  C12Q2531/119 ,  C12Q2527/101

    摘要： It is intended to provide novel primers to be used in gene amplification reactions for detecting human cytokeratins (Human CK). A primer containing an oligonucleotide comprising a base sequence which is selected from among the the 270- to 1375-th regions of the base sequence represented by SEQ ID NO:1 and the regions of complementary strands thereof and represented by, for example, any of SEQ ID NOS:2 to 341 is constructed. Further, a primer containing an oligonucleotide comprising a base sequence which is selected from among the 270- to 930-th regions of the base sequence represented by SEQ ID NO:342 and the regions of complementary strands thereof and represented by, for example, any of SEQ ID NOS:343 to 434 is constructed. Furthermore, a primer containing an oligonucleotide comprising a base sequence which is selected from among the 340 to 490-th regions or the 495- to 1050-th regions of the base sequence represented by SEQ ID NO:435 and the regions of complementary strands thereof and represented by, for example, any of SEQ ID NOS:436 to 474 is constructed.

    摘要翻译： 旨在提供用于检测人细胞角蛋白（Human CK）的基因扩增反应中使用的新引物。 一种含有寡核苷酸的引物，其包含选自SEQ ID NO：1所示的碱基序列的270〜1375位的碱基序列及其互补链的区域， 构建SEQ ID NOS：2至341。 此外，含有包含选自SEQ ID NO：342所示的碱基序列的270〜930区域的碱基序列的寡核苷酸的引物及其互补链的区域，例如任何 构建为SEQ ID NO：343〜434。 此外，含有选自SEQ ID NO：435表示的碱基序列的340〜490个区域或495〜1050个区域的碱基序列的寡核苷酸的引物及其互补链的区域 并且由例如SEQ ID NO：436至474中的任一个表示。

    Multiple light source unit and optical system using the same
    6.
    发明授权
    Multiple light source unit and optical system using the same 失效
    多个光源单元和使用其的光学系统

    公开(公告)号：US06219476B1

    公开(公告)日：2001-04-17

    申请号：US09369314

    申请日：1999-08-06

    申请人： Hideo Kususawa ,  Yasuyuki Imura ,  Masaki Ishisaka

    发明人： Hideo Kususawa ,  Yasuyuki Imura ,  Masaki Ishisaka

    IPC分类号： G02B632

    CPC分类号： G02B27/143 ,  G01N15/14 ,  G02B6/4204 ,  G02B6/4206

    摘要： A multiple light source unit includes a plurality of light sources for emitting light beams. There is a condensing lens and the light beams are parallel to an optical axis of the condensing lens. Included is a mirror for directing the light beams from the plurality of light sources to the condensing lens. A light guiding element for receiving the condensed light beams through a light receiving section and for emitting the light beams through a light emitting section is also provided. The light beams from the plurality of light sources are incident, through respective positions on the condensing lens, into the light receiving section of the light guiding element.

    摘要翻译： 多个光源单元包括用于发射光束的多个光源。 存在聚光透镜，并且光束平行于聚光透镜的光轴。 包括用于将来自多个光源的光束引导到聚光透镜的反射镜。 还提供了一种用于通过光接收部分接收聚光的光束并用于通过发光部分发射光束的导光元件。 来自多个光源的光束通过聚光透镜上的相应位置入射到光导元件的光接收部分。

    Nucleic acid amplification primers for detecting cytokeratins and examination method with the use of the primers
    7.
    发明授权
    Nucleic acid amplification primers for detecting cytokeratins and examination method with the use of the primers 有权
    用于检测细胞角蛋白的核酸扩增引物和使用引物的检查方法

    公开(公告)号：US08076080B2

    公开(公告)日：2011-12-13

    申请号：US10514776

    申请日：2003-05-20

    申请人： Sachiyo Tada ,  Yasumasa Akai ,  Yasuyuki Imura ,  Shigeki Abe ,  Harumi Minekawa

    发明人： Sachiyo Tada ,  Yasumasa Akai ,  Yasuyuki Imura ,  Shigeki Abe ,  Harumi Minekawa

    IPC分类号： C12Q1/68 ,  C12P19/34 ,  C07H21/04

    CPC分类号： C12Q1/6844 ,  C12Q1/686 ,  C12Q1/6886 ,  C12Q2600/112 ,  C12Q2531/119 ,  C12Q2527/101

    摘要： It is intended to provide novel primers to be used in gene amplification reactions for detecting human cytokeratins (Human CK). A primer containing an oligonucleotide comprising a base sequence which is selected from among the the 270- to 1375-th regions of the base sequence represented by SEQ ID NO:1 and the regions of complementary strands thereof and represented by, for example, any of SEQ ID NOS:2 to 341 is constructed. Further, a primer containing an oligonucleotide comprising a base sequence which is selected from among the 270- to 930-th regions of the base sequence represented by SEQ ID NO:342 and the regions of complementary strands thereof and represented by, for example, any of SEQ ID NOS:343 to 434 is constructed. Furthermore, a primer containing an oligonucleotide comprising a base sequence which is selected from among the 340 to 490-th regions or the 495- to 1050-th regions of the base sequence represented by SEQ ID NO:435 and the regions of complementary strands thereof and represented by, for example, any of SEQ ID NOS:436 to 474 is constructed.

    摘要翻译： 旨在提供用于检测人细胞角蛋白（Human CK）的基因扩增反应中使用的新引物。 一种含有寡核苷酸的引物，其包含选自SEQ ID NO：1所示的碱基序列的270〜1375位的碱基序列及其互补链的区域， 构建SEQ ID NOS：2至341。 此外，含有包含选自SEQ ID NO：342所示的碱基序列的270〜930区域的碱基序列的寡核苷酸的引物及其互补链的区域，例如任何 构建为SEQ ID NO：343〜434。 此外，含有选自SEQ ID NO：435表示的碱基序列的340〜490个区域或495〜1050个区域的碱基序列的寡核苷酸的引物及其互补链的区域 并且由例如SEQ ID NO：436至474中的任一个表示。