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    METHODS AND COMPOSITIONS RELATED TO THIOESTERASE ENZYMES
    2.
    发明申请
    METHODS AND COMPOSITIONS RELATED TO THIOESTERASE ENZYMES 有权
    与硫代酯酶相关的方法和组合物

    公开(公告)号：US20100154293A1

    公开(公告)日：2010-06-24

    申请号：US12645497

    申请日：2009-12-23

    申请人： Louis Hom ,  Na Trinh ,  Murtaza Alibhai

    发明人： Louis Hom ,  Na Trinh ,  Murtaza Alibhai

    IPC分类号： C10L1/188 ,  C12N9/16 ,  C07H21/00 ,  C12N15/63 ,  C12N1/00 ,  C12P7/64 ,  C08G63/48

    CPC分类号： C12N9/18 ,  C07H21/04 ,  C10L1/02 ,  C12N9/16 ,  C12N15/00 ,  C12N15/63 ,  C12P21/06

    摘要： The present invention relates to novel mutant thioesterase enzymes and naturally-occurring equivalents thereof, compositions made from such enzymes and uses of thioesterase enzymes. In particular, the present invention provides mutant thioesterase enzymes that have altered properties, for example, altered substrate specificity, altered activity, altered selectivity, and/or altered proportional yields in the product mixtures. The present invention also provides polynucleotides encoding such mutant thioesterase enzymes, and vectors and host cells comprising such polynucleotides. The invention further provides for novel uses of thioesterases in the production of various fatty acid derivatives, which are useful as, or as components of, industrial chemicals and fuels.

    摘要翻译： 本发明涉及新的突变硫酯酶及其天然存在的等同物，由这些酶制成的组合物和硫酯酶的用途。 特别地，本发明提供突变体硫酯酶，其具有改变的性质，例如改变的底物特异性，改变的活性，改变的选择性和/或在产物混合物中改变的比例产率。 本发明还提供了编码这种突变体硫酯酶的多核苷酸，以及包含这种多核苷酸的载体和宿主细胞。 本发明进一步提供硫酯酶在生产各种脂肪酸衍生物中的新用途，其可用作或作为工业化学品和燃料的组分。

    Nucleic acids encoding deallergenized proteins and permuteins
    4.
    发明申请
    Nucleic acids encoding deallergenized proteins and permuteins 有权
    核酸编码脱敏蛋白和泛醇蛋白

    公开(公告)号：US20080010700A1

    公开(公告)日：2008-01-10

    申请号：US11823825

    申请日：2007-06-28

    申请人： Murtaza Alibhai ,  James Astwood ,  Charles McWherter ,  Hugh Sampson

    发明人： Murtaza Alibhai ,  James Astwood ,  Charles McWherter ,  Hugh Sampson

    IPC分类号： A01H5/00 ,  C12N9/20

    CPC分类号： C12N15/8286 ,  C07K14/415 ,  C12N9/14 ,  C12N9/18 ,  C12N15/8242 ,  Y02A40/162 ,  Y10S930/13

    摘要： Modified proteins are disclosed that maintain enzymatic and insecticidal activity while displaying reduced or eliminated allergenicity. Epitopes which bind to anti-patatin antibodies were identified, and removed via site directed mutagenesis. Tyrosines were observed to generally contribute to the allergenic properties of patatin proteins. Removal of glycosylation sites was observed to reduce or eliminate antibody binding. Permuteins are also disclosed which have a rearranged amino acid sequence while retaining enzymatic activity. Deallergenized proteins and permuteins can be used as insecticidal materials, as nutritional supplements, and as immunotherapeutic agents.

    摘要翻译： 公开了修饰的蛋白质，其在显示减少或消除的变应原性的同时保持酶促和杀虫活性。 鉴定结合抗patatin抗体的表位，并通过定点诱变去除。 观察到酪氨酸通常有助于patatin蛋白的过敏性质。 观察到去除糖基化位点以减少或消除抗体结合。 还公开了具有重排的氨基酸序列同时保留酶活性的泛珠菌素。 脱敏蛋白和泛醇蛋白可用作杀虫剂，作为营养补充剂，以及作为免疫治疗剂。

    Preparation of deallergenized proteins and permuteins
    6.
    发明申请
    Preparation of deallergenized proteins and permuteins 有权
    脱皮蛋白和泛醇蛋白的制备

    公开(公告)号：US20060206962A1

    公开(公告)日：2006-09-14

    申请号：US11220856

    申请日：2005-09-07

    申请人： Murtaza Alibhai ,  James Astwood ,  Charles McWherter ,  Hugh Sampson

    发明人： Murtaza Alibhai ,  James Astwood ,  Charles McWherter ,  Hugh Sampson

    IPC分类号： A01H1/00 ,  C07H21/04 ,  C12N9/20 ,  C12N15/82 ,  C12N5/04

    CPC分类号： C12N15/8286 ,  C07K14/415 ,  C12N9/14 ,  C12N9/18 ,  C12N15/8242 ,  Y02A40/162 ,  Y10S930/13

    摘要： Modified proteins are disclosed that maintain enzymatic and insecticidal activity while displaying reduced or eliminated allergenicity. Epitopes which bind to anti-patatin antibodies were identified, and removed via site directed mutagenesis. Tyrosines were observed to generally contribute to the allergenic properties of patatin proteins. Removal of glycosylation sites was observed to reduce or eliminate antibody binding. Permuteins are also disclosed which have a rearranged amino acid sequence while retaining enzymatic activity. Deallergenized proteins and permuteins can be used as insecticidal materials, as nutritional supplements, and as immunotherapeutic agents.

    摘要翻译： 公开了修饰的蛋白质，其在显示减少或消除的变应原性的同时保持酶促和杀虫活性。 鉴定结合抗patatin抗体的表位，并通过定点诱变去除。 观察到酪氨酸通常有助于patatin蛋白的过敏性质。 观察到去除糖基化位点以减少或消除抗体结合。 还公开了具有重排的氨基酸序列同时保留酶活性的泛珠菌素。 脱敏蛋白和泛醇蛋白可用作杀虫剂，作为营养补充剂，以及作为免疫治疗剂。

    Methods and compositions related to thioesterase enzymes
    7.
    发明授权
    Methods and compositions related to thioesterase enzymes 有权
    与硫酯酶相关的方法和组合物

    公开(公告)号：US09175234B2

    公开(公告)日：2015-11-03

    申请号：US12645497

    申请日：2009-12-23

    申请人： Louis Hom ,  Na Trinh ,  Murtaza Alibhai ,  Zhihao Hu ,  Eli Groban ,  Vikranth Arlagadda ,  Elizabeth Clarke

    发明人： Louis Hom ,  Na Trinh ,  Murtaza Alibhai ,  Zhihao Hu ,  Eli Groban ,  Vikranth Arlagadda ,  Elizabeth Clarke

    IPC分类号： C12N9/18 ,  C12N15/00 ,  C12P21/06 ,  C12P21/04 ,  C07H21/04 ,  C10L1/02 ,  C12N9/16

    CPC分类号： C12N9/18 ,  C07H21/04 ,  C10L1/02 ,  C12N9/16 ,  C12N15/00 ,  C12N15/63 ,  C12P21/06

    摘要： The present invention relates to novel mutant thioesterase enzymes and naturally-occurring equivalents thereof, compositions made from such enzymes and uses of thioesterase enzymes. In particular, the present invention provides mutant thioesterase enzymes that have altered properties, for example, altered substrate specificity, altered activity, altered selectivity, and/or altered proportional yields in the product mixtures. The present invention also provides polynucleotides encoding such mutant thioesterase enzymes, and vectors and host cells comprising such polynucleotides. The invention further provides for novel uses of thioesterases in the production of various fatty acid derivatives, which are useful as, or as components of, industrial chemicals and fuels.

    摘要翻译： 本发明涉及新的突变硫酯酶及其天然存在的等同物，由这些酶制成的组合物和硫酯酶的用途。 特别地，本发明提供突变体硫酯酶，其具有改变的性质，例如改变的底物特异性，改变的活性，改变的选择性和/或在产物混合物中改变的比例产率。 本发明还提供了编码这种突变体硫酯酶的多核苷酸，以及包含这种多核苷酸的载体和宿主细胞。 本发明进一步提供硫酯酶在生产各种脂肪酸衍生物中的新用途，其可用作或作为工业化学品和燃料的组分。