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公开(公告)号：US09175234B2
公开(公告)日：2015-11-03
申请号：US12645497
申请日：2009-12-23
申请人： Louis Hom , Na Trinh , Murtaza Alibhai , Zhihao Hu , Eli Groban , Vikranth Arlagadda , Elizabeth Clarke
发明人： Louis Hom , Na Trinh , Murtaza Alibhai , Zhihao Hu , Eli Groban , Vikranth Arlagadda , Elizabeth Clarke
摘要： The present invention relates to novel mutant thioesterase enzymes and naturally-occurring equivalents thereof, compositions made from such enzymes and uses of thioesterase enzymes. In particular, the present invention provides mutant thioesterase enzymes that have altered properties, for example, altered substrate specificity, altered activity, altered selectivity, and/or altered proportional yields in the product mixtures. The present invention also provides polynucleotides encoding such mutant thioesterase enzymes, and vectors and host cells comprising such polynucleotides. The invention further provides for novel uses of thioesterases in the production of various fatty acid derivatives, which are useful as, or as components of, industrial chemicals and fuels.
摘要翻译： 本发明涉及新的突变硫酯酶及其天然存在的等同物，由这些酶制成的组合物和硫酯酶的用途。 特别地，本发明提供突变体硫酯酶，其具有改变的性质，例如改变的底物特异性，改变的活性，改变的选择性和/或在产物混合物中改变的比例产率。 本发明还提供了编码这种突变体硫酯酶的多核苷酸，以及包含这种多核苷酸的载体和宿主细胞。 本发明进一步提供硫酯酶在生产各种脂肪酸衍生物中的新用途，其可用作或作为工业化学品和燃料的组分。
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公开(公告)号：US08999686B2
公开(公告)日：2015-04-07
申请号：US12575430
申请日：2009-10-07
申请人： Zhihao Hu , Vikranth Arlagadda
发明人： Zhihao Hu , Vikranth Arlagadda
CPC分类号： C12P7/64 , A61K31/045 , C12N1/20 , C12N9/0004 , C12N2501/71 , C12N2502/99 , C12P7/04 , C12R1/01 , Y02A50/473
摘要： Methods and compositions, including nucleotide sequences, amino acid sequences, and host cells, for producing fatty alcohols are described.
摘要翻译： 描述了用于生产脂肪醇的方法和组合物，包括核苷酸序列，氨基酸序列和宿主细胞。
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3.发明申请METHODS AND COMPOSITIONS FOR ENHANCED PRODUCTION OF FATTY ALDEHYDES AND FATTY ALCOHOLS 审中-公开增强脂肪酸和脂肪醇的生产方法和组合物公开(公告)号：US20130035513A1
公开(公告)日：2013-02-07
申请号：US13359127
申请日：2012-01-26
IPC分类号： C12P7/64 , C12N5/10 , C12N1/13 , C07C47/00 , C12N15/09 , C07C31/00 , C07C33/00 , C12N1/21 , C12N1/15
CPC分类号： C12P7/24 , C12N9/1288 , C12N15/70 , C12P7/02 , C12P7/04 , C12P13/001 , C12Y102/01003 , C12Y102/0103 , C12Y207/08007
摘要： The invention relates to the use of EntD polypeptides, polynucleotides encoding the same, and homologues thereof to enhance the production of fatty aldehydes and fatty alcohols in a host cell.
摘要翻译： 本发明涉及使用EntD多肽，编码它们的多核苷酸及其同源物来增强宿主细胞中脂肪醛和脂肪醇的产生。
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公开(公告)号：US20130115665A1
公开(公告)日：2013-05-09
申请号：US13647185
申请日：2012-10-08
申请人： Zhihao HU , Vikranth Arlagadda
发明人： Zhihao HU , Vikranth Arlagadda
CPC分类号： C12P7/64 , A61K31/045 , C12N1/20 , C12N9/0004 , C12N2501/71 , C12N2502/99 , C12P7/04 , C12R1/01 , Y02A50/473
摘要： Methods and compositions, including nucleotide sequences, amino acid sequences, and host cells, for producing fatty alcohols are described.
摘要翻译： 描述了用于生产脂肪醇的方法和组合物，包括核苷酸序列，氨基酸序列和宿主细胞。
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公开(公告)号：US20150064757A1
公开(公告)日：2015-03-05
申请号：US14390350
申请日：2013-04-02
申请人： Derek L. Greenfield , Elizabeth J. Clarke , Eli S. Groban , Vikranth Arlagadda , Sungwon Lee , Xuezhi Li , Zhihao Hu
发明人： Derek L. Greenfield , Elizabeth J. Clarke , Eli S. Groban , Vikranth Arlagadda , Sungwon Lee , Xuezhi Li , Zhihao Hu
CPC分类号： C12N9/0008 , C12P7/04 , C12P7/6409 , C12Y102/99006 , Y02P20/52
摘要： The disclosure relates to variant carboxylic acid reductase (CAR) enzymes for the improved production of fatty alcohols in recombinant host cells.
摘要翻译： 本公开涉及用于改善重组宿主细胞中脂肪醇生产的变体羧酸还原酶（CAR）酶。
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公开(公告)号：US11066682B2
公开(公告)日：2021-07-20
申请号：US14007857
申请日：2012-04-02
申请人： Derek L. Greenfield , Louis G. Hom , Fernando A. Sanchez-Riera , Zhihao Hu , Vikranth Arlagadda , Eli S. Groban , Scott A. Frykman
发明人： Derek L. Greenfield , Louis G. Hom , Fernando A. Sanchez-Riera , Zhihao Hu , Vikranth Arlagadda , Eli S. Groban , Scott A. Frykman
IPC分类号： C12P7/62 , C12P7/64 , C07K14/245 , C07K14/195 , C07C31/125 , C07C33/02 , C07C53/126 , A61K38/00
摘要： The invention relates to compositions and methods, including polynucleotide sequences, amino acid sequences, and engineered host cells for producing fatty acids and derivates of fatty acids such as acyl-CoA, terminal olefins, fatty aldehydes, fatty alcohols, alkanes, alkenes, wax esters, ketones and internal olefins through altered expression of the transcription factor, fadR.
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7.发明申请PRODUCTION OF FATTY ACIDS AND DERIVATIVES THEREOF HAVING IMPROVED ALIPHATIC CHAIN LENGTH AND SATURATION CHARACTERISTICS 审中-公开具有改善的脂肪链长度和饱和度特征的脂肪酸及其衍生物的生产公开(公告)号：US20150125933A1
公开(公告)日：2015-05-07
申请号：US14236883
申请日：2012-08-17
CPC分类号： C12N15/70 , C12N9/0008 , C12N9/001 , C12N9/1029 , C12N9/16 , C12N9/18 , C12N9/20 , C12N9/88 , C12N9/93 , C12N15/52 , C12P7/04 , C12P7/6409 , C12P7/6436 , C12P7/649 , C12Y102/01042 , C12Y203/01041 , C12Y203/01179 , C12Y301/01005 , C12Y402/01059 , C12Y602/01003 , Y02E50/13
摘要： The invention relates to compositions, including polynucleotide sequences, amino acid sequences, recombinant microorganisms, and recombinant microorganism cultures that produce compositions of fatty acids and derivatives having target aliphatic chain lengths and/or preferred percent saturation. Further, the invention relates to methods of making and using the compositions. The compositions and methods provide for high titers, high yields, and high productivities of fatty acids and derivatives thereof.
摘要翻译： 本发明涉及组合物，包括多核苷酸序列，氨基酸序列，重组微生物和重组微生物培养物，其产生具有目标脂肪链长度和/或优选饱和饱和度的脂肪酸和衍生物的组合物。 此外，本发明涉及制备和使用组合物的方法。 组合物和方法提供高滴度，高产率和高生产率的脂肪酸及其衍生物。
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8.发明申请METHODS AND COMPOSITIONS FOR IMPROVED PRODUCTION OF FATTY ACIDS AND DERIVATIVES THEREOF 审中-公开改善脂肪酸及其衍生物生产的方法和组合物公开(公告)号：US20140179940A1
公开(公告)日：2014-06-26
申请号：US14007857
申请日：2012-04-02
申请人： Derek L. Greenfield , Louis G. Hom , Fernando A. Sanchez-Riera , Zhihao Hu , Vikranth Arlagadda , Eli S. Groban , Scott A. Frykman
发明人： Derek L. Greenfield , Louis G. Hom , Fernando A. Sanchez-Riera , Zhihao Hu , Vikranth Arlagadda , Eli S. Groban , Scott A. Frykman
IPC分类号： C12P7/64 , C07C31/125 , C07C33/02 , C07C53/126
CPC分类号： C12P7/6409 , C07C31/125 , C07C33/02 , C07C53/126 , C07K14/195 , C07K14/245 , Y02E50/13
摘要： The invention relates to compositions and methods, including polynucleotide sequences, amino acid sequences, and engineered host cells for producing fatty acids and derivates of fatty acids such as acyl-CoA, terminal olefins, fatty aldehydes, fatty alcohols, alkanes, alkenes, wax esters, ketones and internal olefins through altered expression of the transcription factor, fadR.
摘要翻译： 本发明涉及组合物和方法，包括多核苷酸序列，氨基酸序列和用于产生脂肪酸的工程化宿主细胞和脂肪酸衍生物，例如酰基辅酶A，末端烯烃，脂肪醛，脂肪醇，烷烃，烯烃，蜡酯 ，酮和内烯，通过改变转录因子fadR的表达。
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