专利检索 ap:("Murty Arimilli" OR "Mark Becker" OR "Gabriel Birkus" OR "Clifford Bryant" OR "James Chen" OR "Xiaowu Chen" OR "Tomas Cihlar" OR "Azar Dastgah" OR "Eugene Eisenberg" OR "Maria Fardis" OR "Marcos Hatada" OR "Gong-Xin He" OR "Haolun Jin" OR "Choung Kim" OR "William Lee" OR "Christopher Lee" OR "Kuei-Ying Lin" OR "Hongtao Liu" OR "Richard MacKman" OR "Martin McDermott" OR "Michael Mitchell" OR "Peter Nelson" OR "Hyung-Jung Pyun" OR "Tanisha Rowe" OR "Mark Sparacino" OR "Sundaramoorthi Swaminathan" OR "James Tario" OR "Jianying Wang" OR "Matthew Williams" OR "Lianhong Xu" OR "Zheng-Yu Yang" OR "Richard Yu" OR "Jiancun Zhang" OR "Lijun Zhang") AND inv:"Hongtao Liu" 第 1 页

1.

发明申请
Method and compositions for identifying anti-HIV therapeutic compounds 审中-公开
标题翻译：用于鉴定抗HIV治疗化合物的方法和组合物

公开(公告)号：US20050239054A1

公开(公告)日：2005-10-27

申请号：US10740694

申请日：2003-12-22

申请人： Murty Arimilli , Mark Becker , Gabriel Birkus , Clifford Bryant , James Chen , Xiaowu Chen , Tomas Cihlar , Azar Dastgah , Eugene Eisenberg , Maria Fardis , Marcos Hatada , Gong-Xin He , Haolun Jin , Choung Kim , William Lee , Christopher Lee , Kuei-Ying Lin , Hongtao Liu , Richard MacKman , Martin McDermott , Michael Mitchell , Peter Nelson , Hyung-Jung Pyun , Tanisha Rowe , Mark Sparacino , Sundaramoorthi Swaminathan , James Tario , Jianying Wang , Matthew Williams , Lianhong Xu , Zheng-Yu Yang , Richard Yu , Jiancun Zhang , Lijun Zhang

发明人： Murty Arimilli , Mark Becker , Gabriel Birkus , Clifford Bryant , James Chen , Xiaowu Chen , Tomas Cihlar , Azar Dastgah , Eugene Eisenberg , Maria Fardis , Marcos Hatada , Gong-Xin He , Haolun Jin , Choung Kim , William Lee , Christopher Lee , Kuei-Ying Lin , Hongtao Liu , Richard MacKman , Martin McDermott , Michael Mitchell , Peter Nelson , Hyung-Jung Pyun , Tanisha Rowe , Mark Sparacino , Sundaramoorthi Swaminathan , James Tario , Jianying Wang , Matthew Williams , Lianhong Xu , Zheng-Yu Yang , Richard Yu , Jiancun Zhang , Lijun Zhang

IPC分类号： C12N9/99 , A61K31/4155 , A61K31/66 , A61K31/665 , A61K31/675 , A61P31/18 , A61P43/00 , C07D213/75 , C07D213/85 , C07D231/12 , C07D231/20 , C07D233/42 , C07D239/48 , C07D239/80 , C07D243/04 , C07D265/18 , C07D307/68 , C07D401/06 , C07D403/06 , C07D471/14 , C07D491/04 , C07F20060101 , C07F9/02 , C07F9/38 , C07F9/40 , C07F9/44 , C07F9/58 , C07F9/62 , C07F9/645 , C07F9/6506 , C07F9/6509 , C07F9/6512 , C07F9/653 , C07F9/6533 , C07F9/655 , C07F9/6558 , C07F9/6561 , C07F9/6584 , C12N9/16 , C12Q1/18 , C12Q1/37 , C12Q1/44 , C12Q1/70 , G01N33/04 , G01N33/50

CPC分类号： A61K31/66 , A61K31/675 , C07D213/75 , C07D213/85 , C07D231/12 , C07D231/20 , C07D233/42 , C07D239/49 , C07D239/80 , C07D243/04 , C07D265/18 , C07D307/68 , C07D401/06 , C07D403/06 , C07D471/14 , C07D491/04 , C07F9/4006 , C07F9/58 , C07F9/645 , C07F9/6506 , C07F9/650905 , C07F9/650947 , C07F9/6512 , C07F9/65128 , C07F9/65335 , C07F9/65515 , C07F9/65583 , C07F9/6561 , C12N9/16 , C12Q1/18 , C12Q1/37 , C12Q1/44 , C40B40/04 , G01N33/5038 , G01N2333/16 , G01N2500/04 , G01N2500/20

摘要： Methods are provided for identifying anti-HIV therapeutic compounds substituted with carboxyl ester or phosphonate ester groups. Libraries of such compounds are screened optionally using the novel enzyme GS-7340 Ester Hydrolase. Compositions and methods relating to GS-7340 Ester Hydrolase also are provided.

摘要翻译： 提供了用于鉴定被羧基酯或膦酸酯基取代的抗HIV治疗化合物的方法。可以使用新型GS-7340酯水解酶来筛选这些化合物的文库。还提供了与GS-7340酯水解酶有关的组合物和方法。

2.

发明申请
Cellular accumulation of phosphonate analogs of HIV protease inhibitor compounds 有权
标题翻译： HIV蛋白酶抑制剂化合物的膦酸酯类似物的细胞积累

公开(公告)号：US20050209197A1

公开(公告)日：2005-09-22

申请号：US10423496

申请日：2003-04-25

申请人： Murty Arimilli , Mark Becker , Clifford Bryant , James Chen , Xiaowu Chen , Azar Dastgah , Maria Fardis , Gong-Xin He , Haolun Jin , Choung Kim , William Lee , Christopher Lee , Kuei-Ying Lin , Hongtao Liu , Richard Mackman , Michael Mitchell , Peter Nelson , Hyung-Jung Pyun , Tanisha Rowe , Mark Sparacino , Sundaramoorthi Swaminathan , James Tario , Jianying Wang , Matthew Williams , Lianhong Xu , Zheng-Yu Yang , Richard Yu , Jiancun Zhang , Lijun Zhang

发明人： Murty Arimilli , Mark Becker , Clifford Bryant , James Chen , Xiaowu Chen , Azar Dastgah , Maria Fardis , Gong-Xin He , Haolun Jin , Choung Kim , William Lee , Christopher Lee , Kuei-Ying Lin , Hongtao Liu , Richard Mackman , Michael Mitchell , Peter Nelson , Hyung-Jung Pyun , Tanisha Rowe , Mark Sparacino , Sundaramoorthi Swaminathan , James Tario , Jianying Wang , Matthew Williams , Lianhong Xu , Zheng-Yu Yang , Richard Yu , Jiancun Zhang , Lijun Zhang

IPC分类号： C12N9/99 , A61K31/4155 , A61K31/66 , A61K31/665 , A61K31/675 , A61P31/18 , A61P43/00 , C07D213/75 , C07D213/85 , C07D231/12 , C07D231/20 , C07D233/42 , C07D239/48 , C07D239/80 , C07D243/04 , C07D265/18 , C07D307/68 , C07D401/06 , C07D403/06 , C07D471/14 , C07D491/04 , C07F20060101 , C07F9/02 , C07F9/38 , C07F9/40 , C07F9/44 , C07F9/58 , C07F9/62 , C07F9/645 , C07F9/6506 , C07F9/6509 , C07F9/6512 , C07F9/653 , C07F9/6533 , C07F9/655 , C07F9/6558 , C07F9/6561 , C07F9/6584 , C12N9/16 , C12Q1/18 , C12Q1/37 , C12Q1/44 , C12Q1/70 , G01N33/04 , G01N33/50

CPC分类号： A61K31/66 , A61K31/675 , C07D213/75 , C07D213/85 , C07D231/12 , C07D231/20 , C07D233/42 , C07D239/49 , C07D239/80 , C07D243/04 , C07D265/18 , C07D307/68 , C07D401/06 , C07D403/06 , C07D471/14 , C07D491/04 , C07F9/4006 , C07F9/58 , C07F9/645 , C07F9/6506 , C07F9/650905 , C07F9/650947 , C07F9/6512 , C07F9/65128 , C07F9/65335 , C07F9/65515 , C07F9/65583 , C07F9/6561 , C12N9/16 , C12Q1/18 , C12Q1/37 , C12Q1/44 , C40B40/04 , G01N33/5038 , G01N2333/16 , G01N2500/04

摘要： Phosphonate substituted compounds with HIV protease inhibitory properties having use as therapeutics and for other industrial purposes are disclosed. The compositions inhibit HIV protease activity and/or are useful therapeutically for the treatment of AIDS and other antiviral infections, as well as in assays for the detection of HIV protease.

摘要翻译： 公开了具有用作治疗剂和其它工业目的的具有HIV蛋白酶抑制性质的膦酸酯取代的化合物。组合物抑制HIV蛋白酶活性和/或可用于治疗AIDS和其它抗病毒感染以及用于检测HIV蛋白酶的测定。

3.

发明申请
Cellular accumulation of phosphonate analogs of hiv protease inhibitor compounds 审中-公开
标题翻译：蜂窝状蛋白酶抑制剂化合物的膦酸酯类似物的细胞积累

公开(公告)号：US20070010489A1

公开(公告)日：2007-01-11

申请号：US10511998

申请日：2003-04-25

申请人： Murty Arimilli , Mark Becker , Clifford Bryant , James Chen , Xiaowu Chen , Azar Dastgah , Maria Fardis , Gong-Xin He , Haolun Jin , Choung Kim , William Lee , Christopher Lee , Kuei-Ying Lin , Hongtao Liu , Richard Mackman , Michael Mitchell , Peter Nelson , Hyung-Jung Pyun , Tanisha Rowe , Mark Sparacino , Sundaramoorthi Swaminathan , James Tario , Jianying Wang , Matthew Wiliams , Lianhong Xu , Zheng-Yu Yang , Richard Yu , Jiancun Zhang , Lijun Zhang

发明人： Murty Arimilli , Mark Becker , Clifford Bryant , James Chen , Xiaowu Chen , Azar Dastgah , Maria Fardis , Gong-Xin He , Haolun Jin , Choung Kim , William Lee , Christopher Lee , Kuei-Ying Lin , Hongtao Liu , Richard Mackman , Michael Mitchell , Peter Nelson , Hyung-Jung Pyun , Tanisha Rowe , Mark Sparacino , Sundaramoorthi Swaminathan , James Tario , Jianying Wang , Matthew Wiliams , Lianhong Xu , Zheng-Yu Yang , Richard Yu , Jiancun Zhang , Lijun Zhang

IPC分类号： A61K31/663 , C07F9/6515 , C07F9/6512

CPC分类号： A61K31/66 , A61K31/675 , C07D213/75 , C07D213/85 , C07D231/12 , C07D231/20 , C07D233/42 , C07D239/49 , C07D239/80 , C07D243/04 , C07D265/18 , C07D307/68 , C07D401/06 , C07D403/06 , C07D471/14 , C07D491/04 , C07F9/4006 , C07F9/58 , C07F9/645 , C07F9/6506 , C07F9/650905 , C07F9/650947 , C07F9/6512 , C07F9/65128 , C07F9/65335 , C07F9/65515 , C07F9/65583 , C07F9/6561 , C12N9/16 , C12Q1/18 , C12Q1/37 , C12Q1/44 , C40B40/04 , G01N33/5038 , G01N2333/16 , G01N2500/04

摘要： Phosphonate substituted compounds with HIV protease inhibitory properties having use as therapeutics and for other industrial purposes are disclosed. The compositions inhibit 5 HIV protease activity and/or are useful therapeutically for the treatment of AIDS and other antiviral infections, as well as in assays for the detection of HIV protease.

摘要翻译： 公开了具有用作治疗剂和其它工业目的的具有HIV蛋白酶抑制性质的膦酸酯取代的化合物。该组合物抑制5种HIV蛋白酶活性和/或用于治疗AIDS和其它抗病毒感染以及用于检测HIV蛋白酶的测定。

4.

发明授权
Cellular accumulation of phosphonate analogs of HIV protease inhibitor compounds 有权
标题翻译： HIV蛋白酶抑制剂化合物的膦酸酯类似物的细胞积累

公开(公告)号：US07649015B2

公开(公告)日：2010-01-19

申请号：US10423496

申请日：2003-04-25

申请人： Murty N. Arimili , Xiaowu Chen , Maria Fardis , Gong-Xin He , Haolun Jin , Choung U. Kim , William A. Lee , Kuei-Ying Lin , Hongtao Liu , Richard L. Mackman , Michael L. Mitchell , Hyung-Jung Pyun , Mark Sparacino , Sundaramoorthi Swaminathan , Jianying Wang , Matthew A. Williams , Lianhong Xu , Zheng-Yu Yang , Richard H. Yu , Jiancun Zhang , Lijun Zhang

发明人： Murty N. Arimili , Xiaowu Chen , Maria Fardis , Gong-Xin He , Haolun Jin , Choung U. Kim , William A. Lee , Kuei-Ying Lin , Hongtao Liu , Richard L. Mackman , Michael L. Mitchell , Hyung-Jung Pyun , Mark Sparacino , Sundaramoorthi Swaminathan , Jianying Wang , Matthew A. Williams , Lianhong Xu , Zheng-Yu Yang , Richard H. Yu , Jiancun Zhang , Lijun Zhang

IPC分类号： A61K31/343 , C07F9/28

CPC分类号： A61K31/66 , A61K31/675 , C07D213/75 , C07D213/85 , C07D231/12 , C07D231/20 , C07D233/42 , C07D239/49 , C07D239/80 , C07D243/04 , C07D265/18 , C07D307/68 , C07D401/06 , C07D403/06 , C07D471/14 , C07D491/04 , C07F9/4006 , C07F9/58 , C07F9/645 , C07F9/6506 , C07F9/650905 , C07F9/650947 , C07F9/6512 , C07F9/65128 , C07F9/65335 , C07F9/65515 , C07F9/65583 , C07F9/6561 , C12N9/16 , C12Q1/18 , C12Q1/37 , C12Q1/44 , C40B40/04 , G01N33/5038 , G01N2333/16 , G01N2500/04

摘要： Phosphonate substituted compounds with HIV protease inhibitory properties having use as therapeutics and for other industrial purposes are disclosed. The compositions inhibit HIV protease activity and/or are useful therapeutically for the treatment of AIDS and other antiviral infections, as well as in assays for the detection of HIV protease.

摘要翻译： 公开了具有用作治疗剂和其它工业目的的具有HIV蛋白酶抑制性质的膦酸酯取代的化合物。组合物抑制HIV蛋白酶活性和/或可用于治疗AIDS和其它抗病毒感染以及用于检测HIV蛋白酶的测定。

5.

发明申请
ANTIVIRAL COMPOUNDS 有权
标题翻译：有害化合物

公开(公告)号：US20140039021A1

公开(公告)日：2014-02-06

申请号：US14045717

申请日：2013-10-03

申请人： Elizabeth Bacon , Eda Canales , Aesop Cho , Jeromy Cottell , Mano Desai , Michael Graupe , Hongyan Guo , Randall Halcomb , Darryl Kato , Choung U. Kim , Thorsten A. Kirschberg , Evan Krygowski , Scott Lazerwith , John Link , Hongtao Liu , Qi Liu , Richard Mackman , Michael Mitchell , Jay Parrish , Hyung-Jung Pyun , Joseph Saugier , Scott Schroeder , Jianyu Sun , James Taylor , James Trenkle , Winston Tse , Randall Vivian , William Watkins , Lianhong Xu

发明人： Elizabeth Bacon , Eda Canales , Aesop Cho , Jeromy Cottell , Mano Desai , Michael Graupe , Hongyan Guo , Randall Halcomb , Darryl Kato , Choung U. Kim , Thorsten A. Kirschberg , Evan Krygowski , Scott Lazerwith , John Link , Hongtao Liu , Qi Liu , Richard Mackman , Michael Mitchell , Jay Parrish , Hyung-Jung Pyun , Joseph Saugier , Scott Schroeder , Jianyu Sun , James Taylor , James Trenkle , Winston Tse , Randall Vivian , William Watkins , Lianhong Xu

IPC分类号： C07D403/14

CPC分类号： C07D403/14 , A61K31/4025 , A61K31/4178 , A61K31/4184 , A61K31/427 , A61K31/435 , A61K31/437 , A61K31/4439 , A61K31/454 , A61K31/496 , A61K31/519 , A61K31/5377 , A61K31/5415 , A61K31/55 , A61K45/06 , A61P31/12 , C07D207/16 , C07D401/14 , C07D403/04 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D471/08 , C07D471/10 , C07D487/04 , C07D491/113 , C07D495/04 , C07F5/025

摘要： The invention is related to anti-viral compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.

摘要翻译： 本发明涉及抗病毒化合物，含有这些化合物的组合物和包括施用这些化合物的治疗方法以及可用于制备这些化合物的方法和中间体。

6.

发明授权
Antiviral compounds 有权

公开(公告)号：US08575118B2

公开(公告)日：2013-11-05

申请号：US13553517

申请日：2012-07-19

申请人： Hongyan Guo , Darryl Kato , Thorsten A. Kirschberg , Hongtao Liu , John O. Link , Michael L. Mitchell , Jay P. Parrish , Jianyu Sun , James Taylor , Elizabeth M. Bacon , Eda Canales , Aesop Cho , Choung U. Kim , Jeromy J. Cottell , Manoj C. Desai , Randall L. Halcomb , Michael Graupe , Evan S. Krygowski , Scott E. Lazerwith , Qi Liu , Richard Mackman , Hyung-Jung Pyun , Joseph H. Saugier , James Trenkle , Winston C. Tse , Randall W. Vivian , Scott D. Schroeder , William J. Watkins , Lianhong Xu

发明人： Hongyan Guo , Darryl Kato , Thorsten A. Kirschberg , Hongtao Liu , John O. Link , Michael L. Mitchell , Jay P. Parrish , Jianyu Sun , James Taylor , Elizabeth M. Bacon , Eda Canales , Aesop Cho , Choung U. Kim , Jeromy J. Cottell , Manoj C. Desai , Randall L. Halcomb , Michael Graupe , Evan S. Krygowski , Scott E. Lazerwith , Qi Liu , Richard Mackman , Hyung-Jung Pyun , Joseph H. Saugier , James Trenkle , Winston C. Tse , Randall W. Vivian , Scott D. Schroeder , William J. Watkins , Lianhong Xu

IPC分类号： C07D401/14 , C07D403/04 , C07D403/14 , C07D409/14 , C07D417/04 , C07D417/14 , C07D495/04 , A61K31/4184 , A61K31/501 , A61K31/439 , A61K31/7056 , A61K31/7068 , A61K31/496 , A61P31/14

CPC分类号： C07D403/14 , A61K31/4025 , A61K31/4178 , A61K31/4184 , A61K31/427 , A61K31/435 , A61K31/437 , A61K31/4439 , A61K31/454 , A61K31/496 , A61K31/519 , A61K31/5377 , A61K31/5415 , A61K31/55 , A61K45/06 , A61P31/12 , C07D207/16 , C07D401/14 , C07D403/04 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D471/08 , C07D471/10 , C07D487/04 , C07D491/113 , C07D495/04 , C07F5/025

摘要： The invention is related to anti-viral compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.

7.

发明申请
Therapeutic compounds and methods 审中-公开
标题翻译：治疗化合物和方法

公开(公告)号：US20080070910A1

公开(公告)日：2008-03-20

申请号：US11880743

申请日：2007-07-24

申请人： Manoj Desai , Christopher Lee , Hongtao Liu , Sundaramoorthi Swaminathan , Lianhong Xu

发明人： Manoj Desai , Christopher Lee , Hongtao Liu , Sundaramoorthi Swaminathan , Lianhong Xu

IPC分类号： C07D493/04 , A61K31/341 , A61K31/352 , A61K31/357 , A61K31/427 , A61K31/536 , C12N9/99 , A61P31/18 , C07D277/22 , C07D307/02 , C07D307/77 , C07D413/00

CPC分类号： C07D493/04

摘要： The present invention provides compounds of Formula (I): wherein A, X, Q, R2-R6, m, and W have the values described herein, as well as compositions comprising such compounds. The compounds are protease inhibitors and are useful for inhibiting the development of drug resistance in animals.

摘要翻译： 本发明提供式（I）的化合物：其中A，X，Q，R 2，R 6，M和W也具有本文所述的值作为包含这些化合物的组合物。这些化合物是蛋白酶抑制剂，可用于抑制动物耐药性的发展。