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17 条记录 (耗时 0.017 秒)

    CRYOPRESERVATION VESSEL
    1.
    发明申请
    CRYOPRESERVATION VESSEL 审中-公开

    公开(公告)号：US20190327959A1

    公开(公告)日：2019-10-31

    申请号：US16310325

    申请日：2017-06-09

    申请人： NISSAN CHEMICAL CORPORATION

    发明人： Yoshiomi HIROI ,  Hiroyuki NAKAJIMA ,  Taito NISHINO

    IPC分类号： A01N1/02 ,  C09D143/02

    摘要： An object of the present invention is to provide a cryopreservation vessel which has a coating that is capable of inhibiting the adhesion of cells or proteins and is resistant not only to aqueous solvents but also to organic solvents (for example, cryoprotectants, in particular, dimethyl sulfoxide). The invention provides a cell or protein cryopreservation vessel including, on at least a portion of the surface thereof, a coating that includes a repeating unit containing a group represented by the following formula (a), and a repeating unit containing a group represented by the following formula (b) (wherein Ua1, Ua2, Ua3, Ub1, Ub2, Ub3 and An− are as defined in the description and the claims)

    IRRADIATED RESIN MOLDING
    3.
    发明申请
    IRRADIATED RESIN MOLDING 有权

    公开(公告)号：US20230136856A1

    公开(公告)日：2023-05-04

    申请号：US17906592

    申请日：2021-03-24

    申请人： NISSAN CHEMICAL CORPORATION

    发明人： Yoshiomi HIROI ,  Kohei SUZUKI ,  Miya HIROI

    IPC分类号： B65D81/26 ,  C12M1/32 ,  D04H1/4291

    摘要： The invention provides a resin molding and a method of producing the same in which sterilizability thereof is secured and discoloration (yellowing) thereof is reduced even when the resin molding is radiation-irradiated under anaerobic conditions (deoxidation conditions). The radiation-irradiated and packaged resin molding is primarily packaged with a packaging material having oxygen permeability and then secondarily packaged with an oxygen impermeable packaging material together with a deoxidizer. The method of producing a radiation-irradiated and packaged resin molding involves a step of primarily packaging a resin molding before radiation irradiation with a packaging material having oxygen permeability, a step of subsequently secondarily packaging with an oxygen impermeable packaging material together with a deoxidizer, and then a step of conducting radiation irradiation. A step of opening the secondary packaging under the atmosphere, following the radiation irradiation step, is preferred.

    METHOD FOR PRODUCING POLYMER COMPATIBLE WITH BIOMATERIALS
    4.
    发明申请
    METHOD FOR PRODUCING POLYMER COMPATIBLE WITH BIOMATERIALS 有权

    公开(公告)号：US20220135806A1

    公开(公告)日：2022-05-05

    申请号：US17429975

    申请日：2020-02-12

    申请人： NISSAN CHEMICAL CORPORATION

    发明人： Miya HIROI ,  Yoshiomi HIROI ,  Kohei SUZUKI ,  Takeaki SHOJI ,  Natsuki ABE ,  Hiroyuki NAKAJIMA

    IPC分类号： C09D4/00 ,  C08F220/28 ,  C08F220/36 ,  C08F220/34 ,  C09D133/14 ,  C12N5/073

    摘要： The invention provides a method for producing a copolymer-containing varnish using a monomer having a specific unsaturated bond which does not cause the problem of gelation, a method for producing a composition, a method for producing a coating film, preferably compatible with biomaterials. The method for producing a copolymer-containing varnish comprises copolymerizing a monomer mixture containing compounds of formulas (1) and (2): wherein R1 represents a hydrogen atom or a methyl group, R2 represents an alkylene group having 1 to 6 carbon atoms, n represents an integer of 1 to 30, R11 represents a hydrogen atom or a methyl group, and A1 represents a monovalent organic group having a cationic property, in a solvent for polymerization, in the presence of a radical polymerization initiator, wherein % by mass of the compound of formula (1) in a phosphorus-containing compound contained in the monomer mixture is 70% by mass or more.

    METHOD FOR PRODUCING POLYMER USED AS BASE FILM FOR CELL CULTURE, AND CELL CULTURE CONTAINER
    5.
    发明申请
    METHOD FOR PRODUCING POLYMER USED AS BASE FILM FOR CELL CULTURE, AND CELL CULTURE CONTAINER 有权

    公开(公告)号：US20210238329A1

    公开(公告)日：2021-08-05

    申请号：US17271154

    申请日：2019-08-22

    申请人： NISSAN CHEMICAL CORPORATION

    发明人： Kohei SUZUKI ,  Yoshiomi HIROI ,  Natsuki ABE

    IPC分类号： C08F220/34 ,  C08J5/18 ,  C08F2/06 ,  C08F2/44 ,  C08F220/06 ,  C12N1/00 ,  C12M1/12

    摘要： The invention provides a method for producing a polymer used as a base film for cell culture which comprises (i) preparing a mixture containing (a) a monomer of formula (I): wherein Ua1 and Ua2 each independently represent a hydrogen atom or a linear or branched alkyl group having 1 to 5 carbon atoms, Ra1 represents a hydrogen atom or a linear or branched alkyl group having 1 to 5 carbon atoms, and Ra2 represents a linear or branched alkylene group having 1 to 5 carbon atoms, (b) a radical polymerization initiator, and (c) an organic solvent, and (ii) preparing a polymer by raising a temperature of the mixture under stirring to polymerize the monomer. The invention also provides methods of producing a base film for cell culture and a cell culture container.

    METHOD FOR PRODUCING CELL AGGREGATES
    7.
    发明申请
    METHOD FOR PRODUCING CELL AGGREGATES 有权

    公开(公告)号：US20230116517A1

    公开(公告)日：2023-04-13

    申请号：US17904628

    申请日：2021-02-19

    申请人： NISSAN CHEMICAL CORPORATION ,  KAKE EDUCATIONAL INSTITUTION

    发明人： Kohei SUZUKI ,  Yoshiomi HIROI ,  Ryosuke IWAI

    IPC分类号： C12N11/087 ,  C08F220/36 ,  C09D11/36 ,  C09D11/107 ,  C09D133/14

    摘要： A substrate for producing cell aggregates provided with a plurality of spots which comprises a polymer containing a recurring unit derived from a monomer represented by the following formula (I): wherein Ua1, Ua2, Ra1 and Ra2 are as defined herein, on a substrate having an ability to inhibit adhesion of cells, wherein a ratio of a total area of the spots to a surface area of the substrate is 30% or more, a diameter of each spot is 50 to 5,000 μm, and a distance between the spots is 30 to 1,000 μm, a method for producing the same, and a method for producing cell aggregates using such a substrate and a method of improving cell utilization efficiency at the time of producing the cell aggregates.

    BASE MATERIAL FOR CELL CULTURE IN SERUM-FREE MEDIUM
    9.
    发明公开
    BASE MATERIAL FOR CELL CULTURE IN SERUM-FREE MEDIUM 审中-公开

    公开(公告)号：US20240336891A1

    公开(公告)日：2024-10-10

    申请号：US18575926

    申请日：2022-07-05

    申请人： NISSAN CHEMICAL CORPORATION

    发明人： Kohei SUZUKI ,  Yuki UEDA ,  Miya HIROI ,  Yoshiomi HIROI ,  Shiho ANNO

    IPC分类号： C12N5/00

    CPC分类号： C12N5/0068 ,  C12N2533/30 ,  C12N2533/50 ,  C12N2533/52

    摘要： Objects of the present invention are to provide a base film for cell culture that enables mass production of homogeneous and high-quality cell aggregates even without the use of a biological serum, and to provide a base film-forming agent for forming the base film, and a substrate for producing cell aggregate. The present inventors provide a base film-forming agent for cell culture including a polymer, a cell adhesive substance, and a solvent, wherein the polymer contains a repeating unit derived from a monomer of formula (I) below:




    wherein Ua1, Ua2, Ra1, and Ra2 are as described in the specification and the claims.

    COMPOSITION FOR FORMING COATING FILM, COATING FILM, AND CELL CULTURE VESSEL
    10.
    发明公开
    COMPOSITION FOR FORMING COATING FILM, COATING FILM, AND CELL CULTURE VESSEL 审中-公开

    公开(公告)号：US20240287322A1

    公开(公告)日：2024-08-29

    申请号：US18567248

    申请日：2022-06-06

    申请人： Nissan Chemical Corporation

    发明人： Miya HIROI ,  Yoshiomi HIROI ,  Yuki UEDA ,  Kohei SUZUKI ,  Natsuki FUKASAWA

    IPC分类号： C09D5/16 ,  C09D131/04 ,  C12M1/00

    CPC分类号： C09D5/1668 ,  C09D131/04 ,  C12M23/20

    摘要： Provided is a coating film which is obtained by applying a composition for forming a coating film, the composition containing a copolymer, and which is used to suppress adhesion of a biological substance, in which the copolymer is water-insoluble, the copolymer contains a repeating unit (A) represented by the following Formula (A) and a repeating unit (B) represented by the following Formula (B), and a molar ratio (A:B) of the repeating unit (A) to the repeating unit (B) in the copolymer is 89:11 to 50:50.




    (In the formula, R1 to R3 each independently represent a hydrogen atom or an alkyl group having 1 to 5 carbon atoms, and X1 and X2 each independently represent a single bond, an ester bond, an ether bond, an amide bond, or an alkylene group having 1 to 5 carbon atoms which may be interrupted by an oxygen atom.)