公开(公告)号：US11975489B2

公开(公告)日：2024-05-07

申请号：US17535546

申请日：2021-11-24

Applicant: NISSAN NORTH AMERICA, INC. ,  NORTHWESTERN UNIVERSITY

Inventor： Nanzhu Zhao ,  Sandeep Patil ,  Cheng Sun ,  Rihan Hai

IPC: B29C64/314 ,  B29C64/129 ,  B29C64/232 ,  B29C64/245 ,  B29C64/264 ,  B33Y30/00 ,  B33Y40/10

CPC classification number: B29C64/314 ,  B29C64/129 ,  B29C64/232 ,  B29C64/245 ,  B29C64/264 ,  B33Y30/00 ,  B33Y40/10

Abstract: A 3D printing system includes a tank containing a liquid photopolymer resin. The tank includes an optically transparent window through which light is configured to pass. A heat exchanger is connected to the tank and is configured to cool the liquid polymer resin. A transducer is connected to the tank. The transducer is configured to emit an acoustic wave toward the optically transparent window.

公开(公告)号：US11660815B1

公开(公告)日：2023-05-30

申请号：US17535540

申请日：2021-11-24

Applicant: NISSAN NORTH AMERICA, INC. ,  NORTHWESTERN UNIVERSITY

Inventor： Nanzhu Zhao ,  Sandeep Patil ,  Cheng Sun ,  Rihan Hai

IPC: B29C64/264 ,  B29C64/129 ,  B29C64/245 ,  B33Y30/00 ,  B29C64/232 ,  B29C64/30 ,  B33Y40/00

CPC classification number: B29C64/264 ,  B29C64/129 ,  B29C64/232 ,  B29C64/245 ,  B29C64/30 ,  B33Y30/00 ,  B33Y40/00

Abstract: A 3D printing system includes a tank containing a liquid photopolymer resin. A textured surface is connected to the tank. The textured surface is configured such that light passes therethrough and into the liquid polymer resin. A transducer is connected to the tank. The transducer is configured to emit an acoustic wave toward the textured surface.

公开(公告)号：US12134230B2

公开(公告)日：2024-11-05

申请号：US17463479

申请日：2021-08-31

Applicant: Nissan North America, Inc.

Inventor： Cheng Sun ,  Rihan Hai ,  Nanzhu Zhao ,  Sandeep Patil

IPC: B33Y10/00 ,  B29C64/124 ,  B29C64/277 ,  B29C64/30 ,  B29C64/393 ,  B33Y30/00 ,  B33Y40/20 ,  B33Y50/02

Abstract: A 3D printing system includes a vat containing a liquid photopolymer resin and a rigid base on which an object is configured to be printed. A control arm connected to the rigid base is configured to move the rigid base relative to the vat. A first light source is configured to emit light to the vat to form the object on the rigid base. A second light source is configured to emit light on the object externally of the liquid photopolymer resin in the vat to cure the object.

公开(公告)号：US12285909B2

公开(公告)日：2025-04-29

申请号：US16975458

申请日：2019-03-08

Applicant: Northwestern University

Inventor： Xiangfan Chen ,  Wenzhong Liu ,  Hao F. Zhang ,  Cheng Sun

IPC: B33Y10/00 ,  B29C64/129 ,  B33Y30/00 ,  B29C35/08 ,  B29K105/00 ,  B33Y70/00 ,  B33Y80/00

Abstract: In an aspect, a method for additive manufacture of a three-dimensional object based on a computational model comprises steps of: grayscale photohardening a precursor material to form a portion of the object; and applying a hardened meniscus coating at a feature of the object; wherein the three-dimensional object is formed via at least the combination of the steps of gray scale photohardening and applying the meniscus coating. In some embodiments, the grayscale photohardening step is a grayscale photopolymerization step. In some embodiments, the applying a hardened meniscus coating step is a meniscus equilibrium post-curing step.

公开(公告)号：US20230182137A1

公开(公告)日：2023-06-15

申请号：US18080067

申请日：2022-12-13

Applicant: Northwestern University

Inventor： Cheng Sun ,  Hao Zhang

IPC: B01L3/00

CPC classification number: B01L3/502761 ,  B01L3/502738 ,  B01L3/502715 ,  B01L2300/0816 ,  B01L2300/0867 ,  B01L2400/0487 ,  B01L2200/027

Abstract: A system for performing avidity-based screening includes a microfluidic circuit that has an inlet designed to receive target cells and CAR-T cells that bind to the target cells. A light source illuminates a portion of the microfluidic circuit that includes the CAR-T cells such that photoacoustic pressure is applied to the CAR-T cells. An imaging sensor captures images of the CAR-T cells. A processor is configured to analyze the images to determine if a CAR-T cell has detached from a target cell. Responsive to a determination that the CAR-T cell has detached, the processor records an amount of the photoacoustic pressure applied to the CAR-T cell. A desired avidity is determined based on a photoacoustic force spectrum, which is based on a plurality of photoacoustic pressures applied to a plurality of detached CAR-T cells. The processor also extracts one or more CAR-T cells that exhibit the desired avidity.

公开(公告)号：US20220133958A1

公开(公告)日：2022-05-05

申请号：US17310290

申请日：2020-01-29

Applicant: Northwestern University

Inventor： Banu Akar ,  Henry Oliver T. Ware ,  Cheng Sun ,  Guillermo A. Ameer

IPC: A61L31/04 ,  C09D167/04 ,  B29C64/124 ,  A61L27/26 ,  B33Y70/00 ,  B33Y10/00 ,  B29L31/00 ,  B33Y80/00

Abstract: Provided herein photo-reactive inks, thermal-curable materials and objects (e.g., medical implants, scaffolds, devices, etc.) made therefrom, and methods of preparation and use thereof.

公开(公告)号：US10830639B2

公开(公告)日：2020-11-10

申请号：US15514084

申请日：2015-09-25

Applicant: Northwestern University

Inventor： Ben Urban ,  Hao F. Zhang ,  Cheng Sun ,  Biqin Dong

IPC: G01N21/64 ,  G01J1/42 ,  G02B21/36 ,  G01N21/65 ,  G02B21/00 ,  G02B27/58 ,  G01N21/84 ,  G01N33/483

Abstract: Certain examples disclose systems and methods for imaging a target. An example method includes: a) activating a subset of light-emitting molecules in a wide field area of a target using an excitation light; b) capturing one or more images of the light emitted from the subset of the molecules illuminated with the excitation light; c) localizing one or more activated light emitting molecules using one or more single molecule microscopic methods to obtain localization information; d) simultaneously capturing spectral information for the same localized activated light emitting molecules using one or more spectroscopic methods; e) resolving one or more non-diffraction limited images of the area of the target using a combination of the localization and spectral information for the localized activated light emitting molecules; and f) displaying the one or more non-diffraction limited images.

公开(公告)号：US20240009357A1

公开(公告)日：2024-01-11

申请号：US18162417

申请日：2023-01-31

Applicant: Northwestern University

Inventor： Jian Yang ,  Evan C. Baker ,  Henry O. T. Ware ,  Fan Zhou ,  Cheng Sun ,  Guillermo A. Ameer ,  Robert Van Lith

IPC: A61L31/06 ,  C08J3/24 ,  B33Y80/00 ,  B29C64/135 ,  B29C41/22 ,  B29C41/00 ,  B33Y30/00 ,  B33Y70/00 ,  B29C64/20 ,  A61L31/16 ,  A61L31/18 ,  C09D167/06

CPC classification number: A61L31/06 ,  C08J3/24 ,  B33Y80/00 ,  B29C64/135 ,  B29C41/22 ,  B29C41/00 ,  B33Y30/00 ,  B33Y70/00 ,  B29C64/20 ,  A61L31/16 ,  A61L31/18 ,  C09D167/06 ,  C08J2367/06 ,  B29K2995/0056 ,  B29L2031/7534

Abstract: Provided herein are methods, compositions, devices, and systems for the 3D printing of biomedical implants. In particular, methods and systems are provided for 3D printing of biomedical devices (e.g., endovascular stents) using photo-curable biomaterial inks (e.g., or methacrylated poly(diol citrate)).

公开(公告)号：US20180088048A1

公开(公告)日：2018-03-29

申请号：US15584018

申请日：2017-05-01

Applicant: Northwestern University

Inventor： Biqin Dong ,  Janel L. Davis ,  Cheng Sun ,  Hao F. Zhang ,  Kieren J. Patel ,  Ben Urban ,  Vadim Backman ,  Luay Almassalha ,  Yolanda Stypula-Cyrus ,  The-Quyen Nguyen

IPC: G01N21/64 ,  C12Q1/6825 ,  G01N33/53

CPC classification number: G01N21/6428 ,  C12Q1/6825 ,  C12Q1/6841 ,  G01N21/6458 ,  G01N33/5302 ,  G01N2021/6441

Abstract: The devices, methods, and systems of the present disclosure provide for spectroscopic super-resolution microscopic imaging. In some examples, spectroscopic super-resolution microscopic imaging may be referred to or comprise spectroscopic photon localization microscopy (SPLM), a method which may employ the use of extrinsic labels or tags in a test sample suitable for imaging. In some examples spectroscopic super-resolution microscopic or spectroscopic photon localization microscopy (SPLM) may not employ extrinsic labels and be performed using the intrinsic contrast of the test sample or test sample material.Generally, spectroscopic super-resolution microscopic imaging may comprise resolving one or more non-diffraction limited images of an area of a test sample by acquiring both localization information of a subset of molecules using microscopic methods known in the art, and simultaneously or substantially simultaneously, acquiring spectral data about the same or corresponding molecules in the subset. This method maybe useful to detect a variety of features in cellular material for the molecular characterization of cells and disease.

公开(公告)号：US11635607B2

公开(公告)日：2023-04-25

申请号：US17323302

申请日：2021-05-18

Applicant: Northwestern University

Inventor： Ki-Hee Song ,  Cheng Sun ,  Hao F. Zhang

IPC: G02B21/16 ,  G01N21/64 ,  G02B21/36 ,  G02B5/04 ,  G02B27/14

Abstract: A method of microscopy comprises collecting an emission light; symmetrically dispersing the collected emission light into a first order (“1st”) light and a negative first order (“−1st”) light using a grating; wherein the 1st light comprises spectral information and the −1st light comprises spectral information; capturing the 1st light and the −1st light using a camera, localizing the one or more light-emitting materials using localization information determined from both the first spectral image and the second spectral image; and determining spectral information from the one or more light-emitting materials using the first spectral image and/or the second spectral image; wherein the steps of localizing and obtaining are performed simultaneously. A spectrometer for a microscope comprises a dual-wedge prism (“DWP”) for receiving and spectrally dispersing a light beam, wherein the DWP comprises a first dispersive optical device and a second dispersive optical device adhered to each other.