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公开(公告)号：US08383344B2
公开(公告)日：2013-02-26
申请号：US12476193
申请日：2009-06-01
申请人： Nana Jacobsen , Lars Kongsbak , Sakari Kauppinen , Søren Morgenthaler Echwald , Peter Mouritzen , Peter Stein Nielsen , Mikkel Nørholm
发明人： Nana Jacobsen , Lars Kongsbak , Sakari Kauppinen , Søren Morgenthaler Echwald , Peter Mouritzen , Peter Stein Nielsen , Mikkel Nørholm
CPC分类号： C12Q1/6816 , C12Q1/6809 , C12Q2533/107 , C12Q2525/207 , C12Q2525/155 , C12Q2561/101
摘要： The invention relates to ribonucleic acids, probes and methods for detection, quantification as well as monitoring the expression of mature microRNAs and small interfering RNAs (siRNAs). The invention furthermore relates to methods for monitoring the expression of other non-coding RNAs, mRNA splice variants, as well as detecting and quantifying RNA editing, allelic variants of single transcripts, mutations, deletions, or duplications of particular exons in transcripts, e.g., alterations associated with human disease such as cancer. The invention furthermore relates to methods for detection, quantification as well as monitoring the expression of deoxy nucleic acids.
摘要翻译： 本发明涉及核糖核酸，探针和检测，定量的方法以及监测成熟微小RNA和小干扰RNA（siRNA）的表达。 本发明还涉及用于监测其他非编码RNA，mRNA剪接变体表达的方法，以及检测和定量RNA编辑，单个转录物的等位基因变体，突变，缺失或转录本中特定外显子的重复，例如， 与人类疾病如癌症相关的改变。 本发明还涉及用于检测，定量以及监测脱氧核酸表达的方法。
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公开(公告)号：US08192937B2
公开(公告)日：2012-06-05
申请号：US11100897
申请日：2005-04-07
申请人： Nana Jacobsen , Lars Kongsbak , Sakari Kauppinen , Søren Morgenthaler Echwald , Peter Mouritzen , Peter Stein Nielsen , Mikkel Nørholm
发明人： Nana Jacobsen , Lars Kongsbak , Sakari Kauppinen , Søren Morgenthaler Echwald , Peter Mouritzen , Peter Stein Nielsen , Mikkel Nørholm
CPC分类号： C12Q1/6816 , C12Q1/6809 , C12Q2533/107 , C12Q2525/207 , C12Q2525/155 , C12Q2561/101
摘要： The invention relates to ribonucleic acids, probes and methods for detection, quantification as well as monitoring the expression of mature microRNAs and small interfering RNAs (siRNAs). The invention furthermore relates to methods for monitoring the expression of other non-coding RNAs, mRNA splice variants, as well as detecting and quantifying RNA editing, allelic variants of single transcripts, mutations, deletions, or duplications of particular exons in transcripts, e.g., alterations associated with human disease such as cancer. The invention furthermore relates to methods for detection, quantification as well as monitoring the expression of deoxy nucleic acids.
摘要翻译： 本发明涉及核糖核酸，探针和检测，定量的方法以及监测成熟微小RNA和小干扰RNA（siRNA）的表达。 本发明还涉及用于监测其他非编码RNA，mRNA剪接变体表达的方法，以及检测和定量RNA编辑，单个转录物的等位基因变体，突变，缺失或转录本中特定外显子的重复，例如， 与人类疾病如癌症相关的改变。 本发明还涉及用于检测，定量以及监测脱氧核酸表达的方法。
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3.发明申请公开(公告)号：US20110076675A1
公开(公告)日：2011-03-31
申请号：US12476193
申请日：2009-06-01
申请人： Nana Jacobsen , Lars Kongsbak , Sakari Kauppinen , Søren Morgenthaler Echwald , Peter Mouritzen , Peter Stein Nielsen , Mikkel Nørholm
发明人： Nana Jacobsen , Lars Kongsbak , Sakari Kauppinen , Søren Morgenthaler Echwald , Peter Mouritzen , Peter Stein Nielsen , Mikkel Nørholm
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6816 , C12Q1/6809 , C12Q2533/107 , C12Q2525/207 , C12Q2525/155 , C12Q2561/101
摘要： The invention relates to ribonucleic acids, probes and methods for detection, quantification as well as monitoring the expression of mature microRNAs and small interfering RNAs (siRNAs). The invention furthermore relates to methods for monitoring the expression of other non-coding RNAs, mRNA splice variants, as well as detecting and quantifying RNA editing, allelic variants of single transcripts, mutations, deletions, or duplications of particular exons in transcripts, e.g., alterations associated with human disease such as cancer. The invention furthermore relates to methods for detection, quantification as well as monitoring the expression of deoxy nucleic acids.
摘要翻译： 本发明涉及核糖核酸，探针和检测，定量的方法以及监测成熟微小RNA和小干扰RNA（siRNA）的表达。 本发明还涉及用于监测其他非编码RNA，mRNA剪接变体表达的方法，以及检测和定量RNA编辑，单个转录物的等位基因变体，突变，缺失或转录本中特定外显子的重复，例如， 与人类疾病如癌症相关的改变。 本发明还涉及用于检测，定量以及监测脱氧核酸表达的方法。
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4.发明申请公开(公告)号：US20050272075A1
公开(公告)日：2005-12-08
申请号：US11100897
申请日：2005-04-07
申请人： Nana Jacobsen , Lars Kongsbak , Sakari Kauppinen , Soren Echwald , Peter Mouritzen , Peter Nielsen , Mikkel Norholm
发明人： Nana Jacobsen , Lars Kongsbak , Sakari Kauppinen , Soren Echwald , Peter Mouritzen , Peter Nielsen , Mikkel Norholm
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6816 , C12Q1/6809 , C12Q2533/107 , C12Q2525/207 , C12Q2525/155 , C12Q2561/101
摘要： The invention relates to ribonucleic acids, probes and methods for detection, quantification as well as monitoring the expression of mature microRNAs and small interfering RNAs (siRNAs). The invention furthermore relates to methods for monitoring the expression of other non-coding RNAs, mRNA splice variants, as well as detecting and quantifying RNA editing, allelic variants of single transcripts, mutations, deletions, or duplications of particular exons in transcripts, e.g., alterations associated with human disease such as cancer. The invention furthermore relates to methods for detection, quantification as well as monitoring the expression of deoxy nucleic acids.
摘要翻译： 本发明涉及核糖核酸，探针和检测，定量的方法以及监测成熟微小RNA和小干扰RNA（siRNA）的表达。 本发明还涉及用于监测其他非编码RNA，mRNA剪接变体表达的方法，以及检测和定量RNA编辑，单个转录物的等位基因变体，突变，缺失或转录本中特定外显子的重复，例如， 与人类疾病如癌症相关的改变。 本发明还涉及用于检测，定量以及监测脱氧核酸表达的方法。
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公开(公告)号：US06677147B2
公开(公告)日：2004-01-13
申请号：US10072152
申请日：2002-02-07
申请人： Lene Nonboe Andersen , Martin Schülein , Niels Erik Krebs Lange , Mads Eskelund Bjørnvad , Søren Møller , Sanne O. Schroder Glad , Markus Sakari Kauppinen , Kirk Schnorr , Lars Kongsbak
发明人： Lene Nonboe Andersen , Martin Schülein , Niels Erik Krebs Lange , Mads Eskelund Bjørnvad , Søren Møller , Sanne O. Schroder Glad , Markus Sakari Kauppinen , Kirk Schnorr , Lars Kongsbak
IPC分类号： C12N988
CPC分类号： C12N9/2465 , A23K10/14 , A23K20/189 , C07K2319/20 , C11D3/386 , C12N9/88 , D06L4/40 , D06M16/003 , D21C5/005 , Y10T442/20
摘要： The present invention relates to pectate lyases comprising the amino acid sequence Asn Leu Asn Ser Arg Val Pro (NLNSRVP) (SEQ ID NO: 2) belonging to Family 1 of polysaccharide lyases have good performance in industrial processes under neutral or alkaline conditions such as laundering and textile processing. The pectate lyase may be derivable from Bacillus species.
摘要翻译： 本发明涉及属于多糖裂解酶1族的氨基酸序列Asn Leu Asn Ser Arg Val Pro（NLNSRVP）（SEQ ID NO：2）的果胶酸裂解酶在中性或碱性条件下的工业过程中具有良好的性能，例如洗涤 和纺织加工。 果胶裂解酶可以衍生自芽孢杆菌属物种。
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公开(公告)号：US06368843B1
公开(公告)日：2002-04-09
申请号：US09694531
申请日：2000-10-23
申请人： Lene Nonboe Andersen , Martin Schülein , Niels Erik Krebs Lange , Mads Eskelund Bjørnvad , Søren Møller , Sanne O. Schrøder Glad , Markus Sakari Kauppinen , Kirk Schnorr , Lars Kongsbak
发明人： Lene Nonboe Andersen , Martin Schülein , Niels Erik Krebs Lange , Mads Eskelund Bjørnvad , Søren Møller , Sanne O. Schrøder Glad , Markus Sakari Kauppinen , Kirk Schnorr , Lars Kongsbak
IPC分类号： C12N926
CPC分类号： C12N9/2465 , A23K10/14 , A23K20/189 , C07K2319/20 , C11D3/386 , C12N9/88 , D06L4/40 , D06M16/003 , D21C5/005 , Y10T442/20
摘要： A novel group of pectate lyases comprising the amino acid sequence Asn Leu Asn Ser Arg Val Pro (NLNSRVP) belonging to Family 1 of polysaccharide lyases have good performance in industrial processes under neutral or alkaline conditions such as laundering and textile processing. The pectate lyase may be derivable from Bacillus species.
摘要翻译： 属于多糖裂解酶1族的氨基酸序列Asn Leu Asn Ser Arg Val Pro（NLNSRVP）的新一组果胶酸裂解酶在中性或碱性条件例如洗涤和纺织加工中在工业过程中具有良好的性能。 果胶裂解酶可以衍生自芽孢杆菌属物种。
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公开(公告)号：US06187580B1
公开(公告)日：2001-02-13
申请号：US09198955
申请日：1998-11-24
申请人： Lene Nonboe Andersen , Martin Schülein , Niels Erik Krebs Lange , Mads Eskelund Bjørnvad , Søren Møller , Sanne O. Schrøder Glad , Markus Sakari Kauppinen , Kirk Schnorr , Lars Kongsbak
发明人： Lene Nonboe Andersen , Martin Schülein , Niels Erik Krebs Lange , Mads Eskelund Bjørnvad , Søren Møller , Sanne O. Schrøder Glad , Markus Sakari Kauppinen , Kirk Schnorr , Lars Kongsbak
IPC分类号： C12N988
CPC分类号： C12N9/2465 , A23K10/14 , A23K20/189 , C07K2319/20 , C11D3/386 , C12N9/88 , D06L4/40 , D06M16/003 , D21C5/005 , Y10T442/20
摘要： A novel group of pectate lyases comprising the amino acid sequence Asn Leu Asn Ser Arg Val Pro (NLNSRVP) belonging to Family 1 of polysaccharide lyases have good performance in industrial processes under neutral or alkaline conditions such as laundering and textile processing. The pectate lyase are derivable from Bacillus species.
摘要翻译： 属于多糖裂解酶1族的氨基酸序列Asn Leu Asn Ser Arg Val Pro（NLNSRVP）的新一组果胶酸裂解酶在中性或碱性条件例如洗涤和纺织加工中在工业过程中具有良好的性能。 果胶裂解酶可从芽孢杆菌属物种衍生。
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公开(公告)号：US20070116744A1
公开(公告)日：2007-05-24
申请号：US11605148
申请日：2006-11-28
申请人： Lene Andersen , Martin Schulein , Niels Lange , Mads Bjornvad , Soren Moller , Sanne O Glad , Markus Kauppinen , Kirk Schnorr , Lars Kongsbak
发明人： Lene Andersen , Martin Schulein , Niels Lange , Mads Bjornvad , Soren Moller , Sanne O Glad , Markus Kauppinen , Kirk Schnorr , Lars Kongsbak
CPC分类号： C12N9/2465 , A23K10/14 , A23K20/189 , C07K2319/20 , C11D3/386 , C12N9/88 , D06L4/40 , D06M16/003 , D21C5/005 , Y10T442/20
摘要： The present invention relates to pectate lyases comprising the amino acid sequence Asn Leu Asn Ser Arg Val Pro (NLNSRVP) (amino acids 236-242 of SEQ ID NO: 2) belonging to Family 1 of polysaccharide lyases have good performance in industrial processes under neutral or alkaline conditions such as laundering and textile processing. The pectate lyase may be derivable from Bacillus species.
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9.发明申请公开(公告)号：US20050245449A1
公开(公告)日：2005-11-03
申请号：US11175639
申请日：2005-07-06
申请人： Lars Kongsbak , Niels Bergenhem , Lars Petersen , Ole Thastrup , Don Foster , Mirella Ezban , Agneta Siegbahn
发明人： Lars Kongsbak , Niels Bergenhem , Lars Petersen , Ole Thastrup , Don Foster , Mirella Ezban , Agneta Siegbahn
CPC分类号： G01N33/5041 , A61K38/36 , A61K38/4846 , G01N33/5008 , G01N33/5011 , G01N33/5044 , G01N33/5064 , G01N33/86 , G01N2333/96447
摘要： A novel intracellular signalling activity of coagulation factor VII (FVII) in cells expressing tissue factor (TF) is described. The present invention relates to use of FVIIa or another TF agonist, or FVIIai or another TF antagonist for the preparation of a medicament for modulation of FVIIa-induced activation of the MAPK signalling pathway in a patient. Moreover the present invention relates to a method of treatment, and a method of detecting the activity of compounds, in particular drug candidates, that interact with the FVIIa mediated intracellular signalling pathway.
摘要翻译： 描述了表达组织因子（TF）的细胞中凝血因子VII（FVII）的新型细胞内信号传导活性。 本发明涉及FVIIa或另一种TF激动剂或FVIIa或另一种TF拮抗剂在制备用于调节FVIIa诱导的患者中MAPK信号通路的激活的药物中的用途。 此外，本发明涉及一种治疗方法和检测与FVIIa介导的细胞内信号传导途径相互作用的化合物，特别是候选药物的活性的方法。
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10.发明授权Methods for modifying cell motility using factor VIIa or inactivated factor VIIa 有权使用因子VIIa或灭活因子Ⅶa修饰细胞运动的方法公开(公告)号：US06461610B1
公开(公告)日：2002-10-08
申请号：US09372888
申请日：1999-08-12
申请人： Lars Kongsbak , Niels Bergenhem , Lars Christian Petersen , Ole Thastrup , Don Foster , Mirella Ezban , Agneta Siegbahn
发明人： Lars Kongsbak , Niels Bergenhem , Lars Christian Petersen , Ole Thastrup , Don Foster , Mirella Ezban , Agneta Siegbahn
IPC分类号： A61K3848
CPC分类号： G01N33/5041 , A61K38/4846 , G01N33/5008 , G01N33/5011 , G01N33/5035 , G01N33/5044 , G01N33/5064 , G01N33/86 , G01N2333/96447
摘要： The present invention provides methods for modifying the motility of tissue factor (TF)-expressing cells, which are carried out by contacting such cells with an effective amount of Factor VIIai Factor VIIa agonist.
摘要翻译： 本发明提供了通过使这些细胞与有效量的因子VIIai因子VIIa激动剂接触而进行的改变组织因子（TF）表达细胞运动性的方法。
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