Soluble fusion proteins comprising heterologous polypeptides
    1.
    发明申请
    Soluble fusion proteins comprising heterologous polypeptides 有权
    包含异源多肽的可溶性融合蛋白

    公开(公告)号:US20090226970A1

    公开(公告)日:2009-09-10

    申请号:US12379808

    申请日:2009-03-02

    CPC分类号: C12N15/625 C07K2299/00

    摘要: A soluble fusion protein is disclosed. The soluble fusion protein comprises at least one soluble polypeptide and a heterologous polypeptide being fused thereto, the heterologous polypeptide being normally insoluble and/or suboptimally expressed when expressed in a cell, wherein the at least one soluble polypeptide has an amino acid sequence at least 65 percent similar to SEQ ID NO: 1 and/or 2, as determined using the Standard protein-protein BLAST [blastp] software of the NCBI.

    摘要翻译: 公开了可溶性融合蛋白。 所述可溶性融合蛋白包含至少一种可溶性多肽和与其融合的异源多肽,所述异源多肽通常在细胞中表达时通常不溶和/或次优化表达,其中所述至少一种可溶性多肽具有至少65个氨基酸序列 如使用NCBI的标准蛋白质 - 蛋白质BLAST [blastp]软件测定的,与SEQ ID NO:1和/或2相似的百分比。

    Soluble fusion proteins comprising heterologous polypeptides
    2.
    发明授权
    Soluble fusion proteins comprising heterologous polypeptides 有权
    包含异源多肽的可溶性融合蛋白

    公开(公告)号:US07989183B2

    公开(公告)日:2011-08-02

    申请号:US12379808

    申请日:2009-03-02

    IPC分类号: C07K19/00 C12N15/62

    CPC分类号: C12N15/625 C07K2299/00

    摘要: A soluble fusion protein is disclosed. The soluble fusion protein comprises at least one soluble polypeptide and a heterologous polypeptide being fused thereto, the heterologous polypeptide being normally insoluble and/or suboptimally expressed when expressed in a cell, wherein the at least one soluble polypeptide has an amino acid sequence at least 65 percent similar to SEQ ID NO: 1 and/or 2, as determined using the Standard protein-protein BLAST [blastp] software of the NCBI.

    摘要翻译: 公开了可溶性融合蛋白。 所述可溶性融合蛋白包含至少一种可溶性多肽和与其融合的异源多肽,所述异源多肽通常在细胞中表达时通常不溶和/或次优表达,其中所述至少一种可溶性多肽具有至少65 如使用NCBI的标准蛋白质 - 蛋白质BLAST [blastp]软件测定的,与SEQ ID NO:1和/或2相似的百分比。

    Soluble fusion proteins comprising heterologous polypeptides
    3.
    发明申请
    Soluble fusion proteins comprising heterologous polypeptides 失效
    包含异源多肽的可溶性融合蛋白

    公开(公告)号:US20070202573A1

    公开(公告)日:2007-08-30

    申请号:US11705106

    申请日:2007-02-12

    CPC分类号: C12N15/625 C07K2299/00

    摘要: A soluble fusion protein is disclosed. The soluble fusion protein comprises at least one soluble polypeptide and a heterologous polypeptide being fused thereto, the heterologous polypeptide being normally insoluble and/or suboptimally expressed when expressed in a cell, wherein the at least one soluble polypeptide has an amino acid sequence at least 65 percent similar to SEQ ID NO: 1 and/or 2, as determined using the Standard protein-protein BLAST [blastp] software of the NCBI.

    摘要翻译: 公开了可溶性融合蛋白。 所述可溶性融合蛋白包含至少一种可溶性多肽和与其融合的异源多肽,所述异源多肽通常在细胞中表达时通常不溶和/或次优化表达,其中所述至少一种可溶性多肽具有至少65个氨基酸序列 如使用NCBI的标准蛋白质 - 蛋白质BLAST [blastp]软件测定的,与SEQ ID NO:1和/或2相似的百分比。

    SYSTEMS, METHODS AND DEVICES FOR BUILDING ENVELOPE SYSTEM
    5.
    发明申请
    SYSTEMS, METHODS AND DEVICES FOR BUILDING ENVELOPE SYSTEM 审中-公开
    用于建筑环境系统的系统,方法和设备

    公开(公告)号:US20170051501A1

    公开(公告)日:2017-02-23

    申请号:US14927050

    申请日:2015-10-29

    摘要: A building envelope system includes several elements that aid in reducing heat transfer. Panels combining insulation and radiant barrier materials, a weather-resistant textile (e.g., canvas) cover, tube insulation, a vestibule and strip curtains can all contribute to reducing heat transfer and, correspondingly, reducing energy requirements for heating and/or cooling. The panel can include a tongue and groove or similar (e.g., dovetail) coupling allowing two panels to mate. The panel can include a top insulation layer, top air gap layer(s), radiant barrier layer(s), bottom air gap layer(s), phase change insulation layer(s) and a bottom insulation layer. By including an air gap on both sides of the radiant barrier, the radiant barrier is effective at reducing heat transfer in and out of the shelter.

    摘要翻译: 建筑物信封系统包括有助于减少热传递的几个元件。 结合绝缘和辐射阻挡材料的面板,耐候纺织品(例如帆布)盖,管绝缘件,前庭和带帘幕都可以有助于减少热传递,并且相应地减少加热和/或冷却的能量需求。 面板可以包括允许两个面板相配合的舌部和凹槽或类似(例如,燕尾形)联接。 面板可以包括顶部绝缘层,顶部气隙层,辐射阻挡层,底部气隙层,相变绝缘层和底部绝缘层。 通过在辐射屏障的两侧包括气隙,辐射屏障有效地减少进入和离开避难所的热量。

    Downhole tool string component that is protected from drilling stresses
    7.
    发明授权
    Downhole tool string component that is protected from drilling stresses 有权
    防止钻孔应力的井下工具组件

    公开(公告)号:US08201645B2

    公开(公告)日:2012-06-19

    申请号:US12616200

    申请日:2009-11-11

    IPC分类号: E21B17/10

    CPC分类号: E21B47/011

    摘要: In one aspect of the present invention, a downhole tool string component has a first and second threaded end on a mandrel, the first threaded end attached to a first sleeve and the second threaded end attached to a second sleeve. An intermediate sleeve assembly is disposed circumferentially around the mandrel and intermediate the first and second threaded ends, and the intermediate sleeve assembly is primarily isolated from stress of the first or second sleeve.

    摘要翻译: 在本发明的一个方面,井下工具串部件在心轴上具有第一和第二螺纹端,第一螺纹端附接到第一套筒,第二螺纹端附接到第二套筒。 中间套筒组件围绕心轴周向设置并且在第一和第二螺纹端部之间,并且中间套筒组件主要与第一或第二套筒的应力隔离。

    Segmented Tubular Body
    9.
    发明申请
    Segmented Tubular Body 有权
    分段管状体

    公开(公告)号:US20100155137A1

    公开(公告)日:2010-06-24

    申请号:US12339758

    申请日:2008-12-19

    CPC分类号: G01V5/10

    摘要: In one aspect of the invention, a downhole tool string component comprises a tubular body with a first and a second tool joint adapted to connect to adjacent tool string components, and a central bore adapted to pass drilling mud between the joints. A sleeve circumferentially disposed about an outer surface of the tubular body. The sleeve is rigidly attached to the outer surface at first and second sleeve ends and forming at least three stabilizer blades. A nuclear source and at least one nuclear detector are disposed within a gap formed between the inner surface of the sleeve and the outer surface of the tubular body.

    摘要翻译: 在本发明的一个方面,井下工具串组件包括具有适于连接到相邻工具组件的第一和第二工具接头以及适于在接头之间通过钻井泥浆的中心孔的管状体。 围绕管状体的外表面周向设置的套筒。 套筒在第一和第二套筒端部处刚性地附接到外表面并且形成至少三个稳定器叶片。 核源和至少一个核检测器设置在形成在套筒的内表面和管状体的外表面之间的间隙内。

    Spinous process fusion implants and insertion, compression, and locking instrumentation
    10.
    发明授权
    Spinous process fusion implants and insertion, compression, and locking instrumentation 有权
    旋转过程融合植入物和插入,压缩和锁定仪器

    公开(公告)号:US08721686B2

    公开(公告)日:2014-05-13

    申请号:US13188325

    申请日:2011-07-21

    IPC分类号: A61B17/70

    摘要: A bone plate assembly including at least one bone plate, polyaxially adjustable fixation elements and a polyaxially adjustable locking mechanism. A first plate includes at least one polyaxial element for lockable connection with a fixation pad, and a connection feature which allows the plate to translate and polyaxially rotate relative to the locking mechanism. A second plate includes at least one polyaxial element for connection with a fixation pad and a connection feature for non-rotatable connection with the locking mechanism. The locking mechanism allows translation and polyaxial adjustment of the first plate relative to the second plate and locks the first and second plates via a taper lock. The fixation pad includes a deflectable spacer configured to prevent premature locking of the pad. Methods for implantation of the bone plate assembly between bone structures are disclosed. Instrumentation for implantation, compression and locking of the bone plate assembly is disclosed.

    摘要翻译: 一种骨板组件,其包括至少一个骨板,可多轴调节的固定元件和可多轴调节的锁定机构。 第一板包括用于与固定垫可锁定连接的至少一个多轴元件,以及允许板相对于锁定机构平移和多轴旋转的连接特征。 第二板包括用于与固定垫连接的至少一个多轴元件和用于与锁定机构不可旋转连接的连接特征。 锁定机构允许第一板相对于第二板的平移和多轴调节,并通过锥形锁定第一和第二板。 固定垫包括可偏转间隔件,其构造成防止垫过早锁定。 公开了在骨结构之间植入骨板组件的方法。 公开了用于骨板组件的植入,压缩和锁定的仪器。